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Conservation genomics provides insights into genetic resilience and adaptation of the endangered Chinese hazelnut, Corylus chinensis

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Plant Diversity 2024年第3期46卷 294-308页

作者： Zhen Yang Lisong Liang Weibo Xiang Lujun Wang qinghua ma Zhaoshan Wang Key Laboratory of Tree Breeding and Cultivation National Forestry and Grassland AdministrationResearch Institute of ForestryChinese Academy of ForestryBeijing 100091China National Engineering Research Center of Eco-Environment Protection for Yangtze River Economic Belt China Three Gorges CorporationBeijing 100083China Rare Plants Research Institute of Yangtze River China Three Gorges CorporationYichang 443133China Research Institute of Economic Forest Cultivation and Processing Anhui Academy of ForestryHefei 230031China

Global climate change has increased concerns regarding biodiversity loss.However,many key conservation issues still required further research,including demographic history,deleterious mutation load,adaptive evolution,and putative introgression.Here we generated the first chromosome-level genome of the endangered Chinese hazelnut,Corylus chinensis,and compared the genomic signatures with its sympatric widespread C.kwechowensis-C yunnanensis complex.We found large genome rearrangements across all Corylus species and identified species-specific expanded gene families that may be involved in adaptation.Population genomics revealed that both C.chinensis and the C.kwechowensis-C.yunnanensis complex had diverged into two genetic lineages,forming a consistent pattern of southwestern-northern differentiation.Population size of the narrow southwestern lineages of both species have decreased continuously since the late Miocene,whereas the widespread northern lineages have remained stable(C.chinensis) or have even recovered from population bottlenecks(C.kwechowensis-C.yunnanensis complex) during the Quaternary.Compared with C.kwechowensis-C. yunnanensis complex,C.chinensis showed significantly lower genomic diversity and higher inbreeding level.However,C.chinensis carried significantly fewer deleterious mutations than C.kwechowensis-C. yunnanensis complex,as more effective purging selection reduced the accumulation of homozygous variants.We also detected signals of positive selection and adaptive introgression in different lineages,which facilitated the accumulation of favorable variants and formation of local adaptation.Hence,both types of selection and exogenous introgression could have mitigated inbreeding and facilitated survival and persistence of C.chinensis.Overall,our study provides critical insights into lineage differentiation,local adaptation,and the potential for future recovery of endangered trees.

关键词： Conservation genomics Demographic history Inbreeding Genetic load Runs of homozygosity Local adaptation

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Population genomics reveals demographic history and selection signatures of hazelnut (Corylus)

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Horticulture Research 2023年第5期10卷 247-259页

作者： Zhen Yang Wenxu ma Lujun Wang Xiaohong Yang Tiantian Zhao Lisong Liang Guixi Wang qinghua ma Key Laboratory of Tree Breeding and Cultivation National Forestry and Grassland AdministrationResearch Institute of ForestryChinese Academy of ForestryBeijing100091China Forest Botany and Tree Physiology University of GoettingenGoettingen37077Germany Research Institute of Economic Forest Cultivation and Processing Anhui Academy of ForestryHefei230031China Research Institute of Walnut Guizhou Academy of ForestryGuiyang550005China

Hazelnut(Corylus spp.)is known as one of the four famous tree nuts in the world due to its pleasant taste and nutritional benefits.However,hazelnut promotion worldwide is increasingly challenged by global climate change,limiting its production to a few regions.Focusing on the eurytopic Section Phyllochlamys,we conducted whole-genome resequencing of 125 diverse accessions from five geo-ecological zones in Eurasia to elucidate the genomic basis of adaptation and improvement.Population structure inference outlined five distinct genetic lineages corresponding to climate conditions and breeding background,and highlighted the differentiation between European and Asian lineages.Demographic dynamics and ecological niche modeling revealed that Pleistocene climatic oscillations dominantly shaped the extant genetic patterns,and multiple environmental factors have contributed to the lineage divergence.Whole-genome scans identified 279,111,and 164 selective sweeps that underlie local adaptation in Corylus heterophylla,Corylus kweichowensis,and Corylus yunnanensis,respectively.Relevant positively selected genes were mainly involved in regulating signaling pathways,growth and development,and stress resistance.The improvement signatures of hybrid hazelnut were concentrated in 312 and 316 selected genes,when compared to C.heterophylla and Corylus avellana,respectively,including those that regulate protein polymerization,photosynthesis,and response to water deprivation.Among these loci,22 candidate genes were highly associated with the regulation of biological quality.Our study provides insights into evolutionary processes and the molecular basis of how sibling species adapt to contrasting environments,and offers valuable resources for future climate-resilient breeding.

关键词： breeding Population signature

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Seroprevalence of neutralizing antibodies against adenovirus type 26 and 35 in healthy populations from Guangdong and Shandong provinces,China

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Virologica Sinica 2022年第5期37卷 716-723页

作者： Haisu Yi Qian Wang Jiankai Deng Hengchun Li Yingkun Zhang Zhilong Chen Tianxin Ji Wenming Liu Xuehua Zheng qinghua ma Xinxin Sun Yudi Zhang Xuegao Yu Mengzhang He Ling Chen Ying Feng State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510120China Department of Laboratory Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China Center for Infection and Immunity Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou510530China Clinical Laboratory Pingyi Hospital of Chinese MedicineLinyi273399China Xiamen Institutes of Respiratory Health Xiamen361013China Department of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510260China University of Chinese Academy of Science Beijing100049China Guangzhou Laboratory&Bioland Laboratory Guangzhou510320China

Human adenoviruses type 26(HAdV26)and type 35(HAdV35)have increasingly become the choice of adenovirus vectors for vaccine application.However,the population pre-existing immunity to these two adenoviruses in China,which may reduce vaccine efficacy,remains largely unknown.Here,we established micro-neutralizing(MN)assays to investigate the seroprevalence of neutralizing antibodies(nAbs)against HAdV26 and HAdV35 in the general population of Guangdong and Shandong provinces,China.A total of 1184 serum samples were collected,47.0%and 15.8%of which showed HAdV26 and HAdV35 nAb activity,respectively.HAdV26-seropositive individuals tended to have more moderate nAbs titers(201-1000),while HAdV35-seropositive individuals appeared to have more low nAbs titers(72-200).The seropositive rates of HAdV26 and HAdV35 in individuals younger than 20 years old were very low.The seropositive rates of HAdV26 increased with age before 70 years old and decreased thereafter,while HAdV35 seropositive rates did not show similar characteristics.Notably,the seropositive rates and nAb levels of both HAdV26 and HAdV35 were higher in Guangdong Province than in Shandong Province,but did not exert significant differences between males and females.The seroprevalence between HAdV26 and HAdV35 showed little correlation,and no significant cross-neutralizing activity was detected.These results clarified the characteristics of the herd immunity against HAdV26 and HAdV35,and provided information for the rational development and application of HAdV26 and HAdV35 as vaccine vectors in China.

关键词： Human adenovirus type 26(HAdV 26) Human adenovirus type 35(HAdV 35) Neutralizing antibody(nAb) Seroprevalence Guangdong and shandong provinces

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Diversity analysis of space-time-frequency coded broadband MIMO-OFDM system with correlation across space time and frequency

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Frontiers of Electrical and Electronic Engineering in China 2008年第3期3卷 295-300页

作者： qinghua ma Luxi YANG Zhenya HE School of Information Science and Engineering Southeast UniversityNanjing 210096China

For the frequency selective and time variant multiple-input multiple-output(MIMO)channel model taking into account transmitting and receiving antenna correlation,the diversity of space-time-frequency coded broadband orthogonal frequency division multiplexing(MIMO-OFDM)system is analyzed.Based on the average pairwise error probability(PEP),the design criterion of space-time-frequency code(STFC)is expanded.For a given STFC,it is found that the achievable diversity order is related to the transmitter and the receiver correlation matrix as well as the time correlation and frequency correlation matrix.The maximum available diversity of STFC over the correlation channel is Lrank(P)rank(Q)rank(RT).The space-time code and space-frequency code are special cases in our approach.Simulation results validate the findings.

关键词： diversity multiple-input multiple-output(MIMO) orthogonal frequency division multiplexing pairwise error probability space-time-frequency coding

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陈玉燕治疗难治性抽动障碍痰火扰神证经验介绍

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新中医 2024年第4期56卷 208-211页

作者：马青华陈玉燕(指导) 浙江中医药大学第一临床医学院浙江杭州310053 浙江省中医院儿科浙江杭州310003

介绍陈玉燕主任医师治疗难治性抽动障碍痰火扰神证的临床经验。陈玉燕主任认为难治性抽动障碍患儿大多病程日久,虚实夹杂,不可单纯拘泥于痰火扰神证。急性期应重在治标,以祛邪为主,治以清热豁痰,平肝熄风止动,病位着重于心、肝、脾三脏... 详细信息

介绍陈玉燕主任医师治疗难治性抽动障碍痰火扰神证的临床经验。陈玉燕主任认为难治性抽动障碍患儿大多病程日久,虚实夹杂,不可单纯拘泥于痰火扰神证。急性期应重在治标,以祛邪为主,治以清热豁痰,平肝熄风止动,病位着重于心、肝、脾三脏。缓解期应标本兼治,治以平肝熄风,兼补益心脾,病位着重于心、脾、肝三脏。巩固期应以治本为主,兼以治标,治以滋水涵木、柔肝熄风,病位责之于肝、肾二脏。同时重视对患儿的心理辅导,不忘对家长进行心理疏导,提醒家长为患儿创造温馨和睦的家庭环境,多角度联合治疗。

关键词：难治性抽动障碍痰火扰神证陈玉燕

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Elevated Kir2.1/nuclear N2ICD defines a highly malignant subtype of non-WNT/SHH medulloblastomas

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1243-1257页

作者： Yan-Xia Wang Haibo Wu Yong Ren Shengqing Lv Chengdong Ji Dongfang Xiang Mengsi Zhang Huimin Lu Wenjuan Fu Qing Liu Zexuan Yan qinghua ma Jingya Miao Ruili Cai Xi Lan Bin Wu Wenying Wang Yinhua Liu Dai-Zhong Wang Mianfu Cao Zhicheng He Yu Shi Yifang Ping Xiaohong Yao Xia Zhang Peng Zhang Ji Ming Wang Yan Wang Youhong Cui Xiu-Wu Bian Institute of Pathology and Southwest Cancer Center Southwest HospitalArmy Medical University(former Third Military Medical University)400038 ChongqingChina Department of Pathology The First Affiliated Hospital of University of Science and Technology of China230036 HefeiAnhuiChina Intelligent Pathology Institute Division of Life Sciences and MedicineUniversity of Science and Technology of China230036 HefeiAnhuiChina Department of Pathology General Hospital of Central Theater Command of PLA627 Wuluo RoadHongshan District430070 WuhanHubeiChina Xinqiao Hospital Army Medical University400038 ChongqingChina Department of Pathology The First Affiliated Hospital of Wannan Medical College241001 WuhuAnhuiChina Department of Pathology Taihe HospitalHubei University of Medicine442000 ShiyanHubeiChina Laboratory of Cancer and Immunometabolism Center for Cancer ResearchNational Cancer Institute at FrederickFrederickMD 21703US

Medulloblastoma(MB)is one of the most common childhood malignant brain tumors(WHO grade IV),traditionally divided into WNT,SHH,Group 3,and Group 4 subgroups based on the transcription profiles,somatic DNA alterations,and clinical outcomes.Unlike WNT and SHH subgroup MBs,Group 3 and Group 4 MBs have similar transcriptomes and lack clearly specific drivers and targeted therapeutic options.The recently revised WHO Classification of CNS Tumors has assigned Group 3 and 4 to a provisional non-WNT/SHH entity.In the present study,we demonstrate that Kir2.1,an inwardly-rectifying potassium channel,is highly expressed in non-WNT/SHH MBs,which promotes tumor cell invasion and metastasis by recruiting Adam10 to enhance S2 cleavage of Notch2 thereby activating the Notch2 signaling pathway.Disruption of the Notch2 pathway markedly inhibited the growth and metastasis of Kir2.1-overexpressing MB cell-derived xenograft tumors in mice.Moreover,Kir2.1^(high)/nuclear N2ICD^(high)MBs are associated with the significantly shorter lifespan of the patients.Thus,Kir2.1^(high)/nuclear N2ICD^(high)can be used as a biomarker to define a novel subtype of non-WNT/SHH MBs.Our findings are important for the modification of treatment regimens and the development of novel-targeted therapies for non-WNT/SHH MBs.

关键词： Kir2.1 invasion markedly

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皖北平欧杂种榛优势品种坚果性状评价

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西北植物学报 2024年第4期44卷 644-653页

作者：王陆军孙璟周米生梁丽松马庆华安徽省林业科学研究院合肥230031 宿州市夹沟国有林场安徽宿州234102 国家林业和草原局林木培育重点实验室中国林业科学研究院林业研究所北京100091

【目的】平欧杂种榛是中国野生平榛和欧洲榛种间杂交获得的新种质,具有抗寒、丰产和适应性强等特点。对皖北地区平欧杂种榛优势品种坚果进行性状评价,明确品种加工适宜性,可为平欧杂种榛选择与推广提供科学依据。【方法】依据适应性和... 详细信息

【目的】平欧杂种榛是中国野生平榛和欧洲榛种间杂交获得的新种质,具有抗寒、丰产和适应性强等特点。对皖北地区平欧杂种榛优势品种坚果进行性状评价,明确品种加工适宜性,可为平欧杂种榛选择与推广提供科学依据。【方法】依据适应性和丰产性等指标,在皖北地区筛选出9个平欧杂种榛优势品种坚果,从烤制、仁用、油用、鲜食等不同加工利用角度进行分析评价。【结果】(1)皖北地区9个优势品种单粒坚果质量为2.54~4.40 g,三径(纵径、横径、侧径)均值为18.99~21.49 mm,形状指数为0.67~1.02,单粒榛仁质量为1.00~1.66 g,果壳厚度为1.53~2.41 mm,出仁率为34.36%~47.01%,榛仁脂肪含量为50.50~58.00 g/(100 g),蛋白质含量为21.10~25.10 g/(100 g),可溶性糖含量为4.08%~4.94%。(2)油脂中鉴定出8种脂肪酸成分,其中油酸含量最高,为81.21%~88.53%,不饱和脂肪酸含量为92.19%~94.61%。榛仁中钾、磷、钙和镁含量较为丰富。(3)9个优势品种单株坚果产量为1.52~2.20 kg,单株脂肪产量为330.50~503.47 g,单株蛋白质产量为141.68~224.40 g。【结论】根据不同榛果加工方式,皖北9个优势品种中‘辽榛3号’最适作为带壳烤制品种;‘辽榛3号’、‘达维’和‘辽榛4号’最适作为仁用加工品种,‘辽榛4号’可作为油用加工品种;‘辽榛1号’可作为功能性蛋白饮料加工品种;‘达维’和‘辽榛9号’可作为高钙类加工品种;‘达维’、‘辽榛3号’、‘平欧545号’是较为适宜的鲜食品种。

关键词：平欧杂种榛优势品种经济性状矿质成分脂肪酸营养物质

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冠状动脉CTA联合动态心电图诊断冠心病心肌缺血价值分析

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影像研究与医学应用 2024年第11期8卷 33-35,38页

作者：马清华杨树国陈懂懂临沂市中心医院心血管内科山东临沂276400

目的:探讨冠状动脉CT血管造影(CTA)联合动态心电图对冠心病心肌缺血诊断的临床价值。方法:选取2022年1月—2023年2月临沂市中心医院收治的68例高度疑似冠心病心肌缺血患者为研究对象,所有患者均接受冠状动脉CTA和动态心电图检查,并以冠... 详细信息

目的:探讨冠状动脉CT血管造影(CTA)联合动态心电图对冠心病心肌缺血诊断的临床价值。方法:选取2022年1月—2023年2月临沂市中心医院收治的68例高度疑似冠心病心肌缺血患者为研究对象,所有患者均接受冠状动脉CTA和动态心电图检查,并以冠状动脉造影结果作为诊断“金标准”分析冠状动脉CTA和动态心电图单独及联合检查冠心病心肌缺血的诊断效能,比较冠心病心肌缺血和非冠心病心肌缺血患者灌注参数。结果:冠状动脉造影结果显示,68例患者中冠心病心肌缺血42例。以冠状动脉造影结果为金标准,冠状动脉CTA检出冠心病心肌缺血36例、漏诊12例、误诊6例,Kappa值为0.463;动态心电图检出冠心病心肌缺血35例、漏诊11例、误诊4例,Kappa值为0.556;冠状动脉CTA联合动态心电图检出冠心病心肌缺血42例、漏诊3例、误诊3例,Kappa值为0.813,准确率、灵敏度均高于冠状动脉CTA与动态心电图单独检查,差异有统计学意义(P<0.05)。冠心病心肌缺血患者QRS时限低于非冠心病心肌缺血患者,差异有统计学意义(P<0.05)。结论:冠状动脉CTA和动态心电图联合用于冠心病心肌缺血的诊断具有较高的临床价值。

关键词：冠心病动态心电图 CT血管造影心肌缺血

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疏肝和胃汤加减联合常规西药方案治疗慢性萎缩性胃炎肝气犯胃证的效果及对miR-26a、miR-32表达的影响

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临床医学研究与实践 2024年第8期9卷 117-120页

作者：马清华刘芳芳王捷虹西安市中心医院消化内科陕西西安710005 陕西中医药大学附属医院消化一科陕西咸阳712000

目的探讨疏肝和胃汤加减联合常规西药方案治疗慢性萎缩性胃炎(CAG)肝气犯胃证的效果。方法择取2020年8月至2022年8月就诊的80例CAG患者为研究对象,将其随机分为对照组和观察组,各40例。对照组采用常规西药方案治疗,观察组在对照组基础... 详细信息

目的探讨疏肝和胃汤加减联合常规西药方案治疗慢性萎缩性胃炎(CAG)肝气犯胃证的效果。方法择取2020年8月至2022年8月就诊的80例CAG患者为研究对象,将其随机分为对照组和观察组,各40例。对照组采用常规西药方案治疗,观察组在对照组基础上加疏肝和胃汤加减。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的白细胞介素-2(IL-2)、白细胞介素-1β(IL-1β)水平及Cyclin E低于对照组,E-钙黏蛋白(E-Cad)水平高于对照组(P<0.05)。治疗后,观察组的miR-26a表达水平高于对照组,miR-32表达水平低于对照组(P<0.05)。结论疏肝和胃汤加减联合常规西药方案治疗CAG能够提升临床效果,减轻炎症反应,调节miR-26a、miR-32表达,值得推广。

关键词：疏肝和胃汤慢性萎缩性胃炎肝气犯胃证炎性因子

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旋覆花汤合温胆汤加减治疗痰瘀阻络证慢性萎缩性胃炎伴低级别上皮内瘤变的效果及对EGF、CDX2水平的影响

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临床医学研究与实践 2024年第10期9卷 94-97页

作者：刘芳芳马清华王捷虹陕西中医药大学附属医院消化一科陕西咸阳712000 西安市中心医院消化内科陕西西安710005

目的探究旋覆花汤合温胆汤加减治疗痰瘀阻络证慢性萎缩性胃炎(CAG)伴低级别上皮内瘤变的效果。方法选择2021年4月至2022年6月收治的100例痰瘀阻络证CAG伴低级别上皮内瘤变患者作为研究对象,根据抽签法将其分为对照组和观察组,各50例。... 详细信息

目的探究旋覆花汤合温胆汤加减治疗痰瘀阻络证慢性萎缩性胃炎(CAG)伴低级别上皮内瘤变的效果。方法选择2021年4月至2022年6月收治的100例痰瘀阻络证CAG伴低级别上皮内瘤变患者作为研究对象,根据抽签法将其分为对照组和观察组,各50例。对照组接受雷贝拉唑钠治疗,观察组在对照组基础上联合旋覆花汤合温胆汤加减治疗。比较两组的治疗效果。结果治疗后,观察组的胃黏膜萎缩、肠上皮化生、异型增生积分低于对照组(P<0.05)。治疗后,观察组的表皮细胞生长因子(EGF)水平高于对照组,尾侧型同源转录因子2(CDX2)表达低于对照组(P<0.05)。治疗后,观察组的白细胞介素-32(IL-32)、可溶性白细胞介素2受体(sIL-2R)、白细胞介素-23(IL-23)水平低于对照组(P<0.05)。结论旋覆花汤合温胆汤加减治疗痰瘀阻络证CAG伴低级别上皮内瘤变可调节EGF、CDX2及炎性因子水平,降低胃黏膜病理积分,值得推广。

关键词：旋覆花汤合温胆汤加减慢性萎缩性胃炎低级别上皮内瘤变炎症因子

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