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CircR-ZC3HC1 mediates MiR-384-5p/SIRT1 axis to promote neuronal autophagy and relieves ischemic stroke

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BIOCELL 2024年第3期48卷 491-499页

作者： MIN SHEN XIAOmaN XU GUANGLING SUN LIANGZHU WANG TAO YING HANG SU WEI WANG qinghua CAO ZHEZHE SUN Department of Neurology The First Affiliated Hospital of Ningbo UniversityNingbo315010China School of Medicine Ningbo UniversityNingbo315211China

Objective:Circular RNAs(circRNAs)have been shown to involve in pathological processes of ischemic stroke(IS),including *** study was designed to explore the effect of circR-ZC3HC1 on neuronal autophagy in IS and the related ***:Expression of circR-ZC3HC1 in blood samples of IS patients and healthy controls was *** neurons were treated with oxygen and glucose deprivation(OGD)to establish IS in vitro *** expression of LC3 and p62 and the number of autophagosomes were examined to evaluate the autophagy level of OGD induced neurons using western blotting and transmission electron *** apoptosis rate and the expression of cleaved caspase-3,Bax,and Bcl-2 were assessed byﬂow cytometry and western *** binding relationships among circR-ZC3HC1,miR-384-5p,and SIRT1 were predicted and veriﬁ***:Low expression of circR-ZC3HC1 was found in blood samples of IS patients and OGD-treated *** circR-ZC3HC1 or inhibited miR-384-5p expression promoted autophagy and inhibited apoptosis of OGD-treated neurons,which could be reversed by further 3-ma ***,circR-ZC3HC1 targeted miR-384-5p to mediate SIRT1 ***-384-5p overexpression or SIRT1 knockdown in the presence of circR-ZC3HC1 overexpression in OGD-treated neurons lead to reduced autophagy and enhanced ***:Collectively,circR-ZC3HC1 promoted neuronal autophagy to attenuate IS via miR-384-5p/SIRT1 axis.

关键词： Ischemic stroke circR-ZC3HC1 miR-384-5p SIRT1 Autophagy

Elevated Kir2.1/nuclear N2ICD defines a highly malignant subtype of non-WNT/SHH medulloblastomas

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1243-1257页

作者： Yan-Xia Wang Haibo Wu Yong Ren Shengqing Lv Chengdong Ji Dongfang Xiang Mengsi Zhang Huimin Lu Wenjuan Fu Qing Liu Zexuan Yan qinghua ma Jingya Miao Ruili Cai Xi Lan Bin Wu Wenying Wang Yinhua Liu Dai-Zhong Wang Mianfu Cao Zhicheng He Yu Shi Yifang Ping Xiaohong Yao Xia Zhang Peng Zhang Ji Ming Wang Yan Wang Youhong Cui Xiu-Wu Bian Institute of Pathology and Southwest Cancer Center Southwest HospitalArmy Medical University(former Third Military Medical University)400038 ChongqingChina Department of Pathology The First Affiliated Hospital of University of Science and Technology of China230036 HefeiAnhuiChina Intelligent Pathology Institute Division of Life Sciences and MedicineUniversity of Science and Technology of China230036 HefeiAnhuiChina Department of Pathology General Hospital of Central Theater Command of PLA627 Wuluo RoadHongshan District430070 WuhanHubeiChina Xinqiao Hospital Army Medical University400038 ChongqingChina Department of Pathology The First Affiliated Hospital of Wannan Medical College241001 WuhuAnhuiChina Department of Pathology Taihe HospitalHubei University of Medicine442000 ShiyanHubeiChina Laboratory of Cancer and Immunometabolism Center for Cancer ResearchNational Cancer Institute at FrederickFrederickMD 21703US

Medulloblastoma(MB)is one of the most common childhood malignant brain tumors(WHO grade IV),traditionally divided into WNT,SHH,Group 3,and Group 4 subgroups based on the transcription profiles,somatic DNA alterations,and clinical *** WNT and SHH subgroup MBs,Group 3 and Group 4 MBs have similar transcriptomes and lack clearly specific drivers and targeted therapeutic *** recently revised WHO Classification of CNS Tumors has assigned Group 3 and 4 to a provisional non-WNT/SHH *** the present study,we demonstrate that Kir2.1,an inwardly-rectifying potassium channel,is highly expressed in non-WNT/SHH MBs,which promotes tumor cell invasion and metastasis by recruiting Adam10 to enhance S2 cleavage of Notch2 thereby activating the Notch2 signaling *** of the Notch2 pathway markedly inhibited the growth and metastasis of Kir2.1-overexpressing MB cell-derived xenograft tumors in ***,Kir2.1^(high)/nuclear N2ICD^(high)MBs are associated with the significantly shorter lifespan of the ***,Kir2.1^(high)/nuclear N2ICD^(high)can be used as a biomarker to define a novel subtype of non-WNT/SHH *** findings are important for the modification of treatment regimens and the development of novel-targeted therapies for non-WNT/SHH MBs.

关键词： Kir2.1 invasion markedly

Field-of-View Constrained Hybrid Guidance Law against Moving Targets in Crosswind

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Field-of-View Constrained Hybrid Guidance Law against Moving...

Nickel-iron in the second coordination shell boost single-atomicsite iridium catalysts for high-performance urea electrooxidation

第三十九届中国控制会议

作者： Rui Li Yangyang Zhao qinghua ma Xi’an Institute of Modern Control Technology

Because of the additional sideslip angle and the strap-down seeker’s narrow field-of-view（FOV）, the crosswind and moving target make it difficult for missiles to maintain lock-on condition. A novel hybrid guidance（HG） law is proposed in this paper, which can keep the target within FOV all the flight time despite crosswind and unknown maneuverability of the target. The crosswind and the moving target are unified as a generalized target model to simplify the guidance problem. Based on the generalized target model, a new form of the additional sideslip is proposed. We combine two guidance laws in the HG law. One is a FOV constrained sliding mode control guidance law（FOVSMC） and the other is a pure proportional navigation guidance law（PPN）. Numerical simulations are conducted and the results prove the proposed law’s validity.

关键词： Field-of-view constraint hybrid guidance law crosswind moving targets

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Nano Research 2024年第5期17卷 3919-3926页

作者： Xiaoyu Chen Jiawei Wan Jing Chai Liang Zhang Fang Zhang qinghua Zhang Lin Gu Lirong Zheng Ranbo Yu Department of Physical Chemistry School of Metallurgical and Ecological EngineeringUniversity of Science and Technology BeijingBeijing 100083China State Key Laboratory of Biochemical Engineering Key Laboratory of Biopharmaceutical Preparation and DeliveryChinese Academy of SciencesInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Center for Combustion Energy School of Vehicle and MobilityState Key Laboratory of Intelligent Green Vehicle and MobilityTsinghua UniversityBeijing 100084China Analysis and Testing Center Beijing Institute of TechnologyBeijing 100081China Beijing National Laboratory for Condensed matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Beijing National Center for Electron Microscopy and Laboratory of Advanced materials Department of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

Single-atom catalysts(SACs)with high catalytic activity as well as great stability are demonstrating great promotion in electrocatalytic energy conversion,which is also a big challenge to ***,we proposed a facile synthetic strategy to construct nickel-iron bimetallic hydroxide nanoribbon stabilized single-atom iridium catalysts(Ir-NiFe-OH),where the nickel-iron hydroxide nanoribbon not only can serve as good electronic conductor,but also can well stabilize and fully expose single-atom *** as catalyst for urea oxidation reaction(UOR),it exhibited excellent UOR performance that it only needed a low operated potential of 1.38 V to achieve the current density of 100 ma·cm^(-2).In-situ Fourier transform infrared spectroscopy,X-ray absorption spectrum,and density functional theory calculations proved that Ir species are active centers and the existence of both Ni and Fe in the local structure of Ir atom can optimize the d-band center of Ir species,promoting the adsorption of intermediates and desorption of products for *** hydrogen evolution reaction(HER)/UOR electrocatalytic cell demanded voltages of 1.46 and 1.50 V to achieve 50 and 100 ma·cm^(-2),respectively,which demonstrated a higher activity and better stability than those of conventional *** work opens a new avenue to develop catalysts for UORs with boosted activity and stability.

关键词： single-atom iridium coordinate structure nanoribbon urea electrooxidation

青海湖裸鲤盐碱耐受过程中的渗透、免疫、代谢相关基因筛选和分析

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水产学报 2023年第12期47卷 19-38页

作者：张海琛马清花许保可阿琳林梁健青海大学生态环境工程学院省部共建三江源生态与高原农牧业国家重点实验室

为探究青海湖裸鲤在盐碱耐受过程中的基因表达变化，对青海湖河口水域以及入湖淡水河——泉吉河中的青海湖裸鲤的鳃、肾脏组织进行转录组测序，筛选青海湖裸鲤耐盐碱过程中发挥作用的免疫、代谢、渗透相关基因。结果显示，使用Trinity... 详细信息

为探究青海湖裸鲤在盐碱耐受过程中的基因表达变化，对青海湖河口水域以及入湖淡水河——泉吉河中的青海湖裸鲤的鳃、肾脏组织进行转录组测序，筛选青海湖裸鲤耐盐碱过程中发挥作用的免疫、代谢、渗透相关基因。结果显示，使用Trinity对所有样本质控数据(clean data)进行从头组装后共得到541 429个非冗余的序列(unigene),N50平均长度达612 bp。经差异表达分析发现，共有832个基因在2个区域中的青海湖裸鲤鳃、肾脏中共表达。经GO功能注释分析，注释到结合(binding)、细胞过程(cellular process)、代谢过程(metabolic process)、单一生物过程(single-organism process)的DEGs占比较多。KEGG通路分析结果表明，与免疫、代谢、渗透相关的通路得到了富集。根据差异表达基因的GO注释和KEGG信号通路富集分析，实验初步筛选到了青海湖裸鲤渗透相关基因，主要包括钠/钾转运ATP酶(sodium/potassium-transporting, ATPase)、钙/钙调蛋白依赖性蛋白激酶(calcium/calmodulin-dependent protein kinase)、丝裂原活化蛋白激酶(mitogen-activated protein kinase)、溶质载体家族(solute carrier family)等；免疫相关基因主要包括白细胞介素(interleukin)、补体(complement)、整合素(integrin)等；代谢相关基因主要有一氧化氮合酶(nitric oxide synthase)、1, 25-二羟基维生素D(3) 24-羟化酶(1, 25-dihydroxyvitamin D(3) 24-hydroxylase)、细胞色素P450 (cytochrome P450)等。本实验为青海湖裸鲤的组学研究提供了相关数据，同时也为青海湖裸鲤在盐碱耐受方面的适应性研究奠定了基础。

关键词：青海湖裸鲤转录组测序盐碱耐受差异表达基因

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论叹词形义关系的原始性

语言科学 2011年第5期10卷 482-496页

作者：马清华南京大学文学院江苏南京210093

文章研究发现,叹词形义关系存在着迥异于其他所有词类的原始特征(如生物性、类语言性等)和规则化水平较低的独特运作原理(如生理理据、词形的职能分化、音素的广谱替换)。由叹词分化出的生理要素、物理要素、辨义要素存在渗透、转化、... 详细信息

文章研究发现,叹词形义关系存在着迥异于其他所有词类的原始特征(如生物性、类语言性等)和规则化水平较低的独特运作原理(如生理理据、词形的职能分化、音素的广谱替换)。由叹词分化出的生理要素、物理要素、辨义要素存在渗透、转化、演化、复合等一系列简单的系统活动。叹词在发生学上,为语言系统的形成提供了基础。其形义关系的原始性不仅从叹词自身缘起上得到证明,而且从继起效应上也得到了回溯证明。

关键词：叹词形义关系生理理据职能分化广谱替换简单系统活动

唯频率标准的不自足性——论面向汉语国际教育的词汇大纲设计标准

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世界汉语教学 2008年第2期22卷 119-134页

作者：马清华南京大学海外教育学院

要制定出一套行之有效的词汇大纲，必先有科学、正确的设计标准。无论理论上还是实践上，将频率作为设计词汇大纲的标准已经成为人们的共识。本文结合《大纲》缺陷，从五个不同方面证明唯频率标准的不自足性，认为在唯频率标准下不可能... 详细信息

要制定出一套行之有效的词汇大纲，必先有科学、正确的设计标准。无论理论上还是实践上，将频率作为设计词汇大纲的标准已经成为人们的共识。本文结合《大纲》缺陷，从五个不同方面证明唯频率标准的不自足性，认为在唯频率标准下不可能科学地制定出符合第二语言教学实际的词汇大纲，词汇大纲的设计原则应以词频为基础原则，以词类差异性、心理便捷性、内容现实性、任务针对性、高能优先为干预原则，做到语用、语义和句法三种标准的结合，词频只是其中最重要的语用标准，它跟各种非频率标准一起，构成一个有序的操作流程。

关键词：汉语国际教育词汇大纲设计标准唯频率标准不自足性

丹芪通脉胶囊联合穴位贴敷治疗冠心病心绞痛患者临床疗效分析

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中外医疗 2023年第25期42卷 116-120页

作者：马清华范平菏泽市中医医院心血管二科山东菏泽274035

目的分析在冠状动脉粥样硬化性心脏病(简称冠心病)心绞痛患者的临床治疗中实施丹芪通脉胶囊联合穴位贴敷的效果。方法随机选取2021年3月—2022年11月菏泽市中医医院治疗的冠心病心绞痛患者100例,通过双盲法分为参照组(n=50,实施常规治疗... 详细信息

目的分析在冠状动脉粥样硬化性心脏病(简称冠心病)心绞痛患者的临床治疗中实施丹芪通脉胶囊联合穴位贴敷的效果。方法随机选取2021年3月—2022年11月菏泽市中医医院治疗的冠心病心绞痛患者100例,通过双盲法分为参照组(n=50,实施常规治疗)与观察组(n=50,在参照组基础上实施丹芪通脉胶囊联合穴位贴敷治疗),比较两组患者治疗前后心功能指标以及心绞痛发作情况、中医证候积分、治疗效果。结果治疗后,观察组各项心功能指标与心绞痛发作情况均优于参照组,差异有统计学意义(P<0.05)。治疗后,观察组的中医证候积分比参照组低,差异有统计学意义(P<0.05)。观察组治疗效果为96.00%,高于参照组的82.00%,差异有统计学意义(χ^(2)=5.005,P<0.05)。结论在冠心病心绞痛患者中实施丹芪通脉胶囊联合穴位贴敷的治疗效果比较显著,不但能改善患者的心功能,还能改善患者的心绞痛发作情况,改善患者症状,值得推广。

关键词：丹芪通脉胶囊穴位贴敷冠心病心绞痛治疗效果心功能

数字创业企业成长机理——基于杭州遥望的纵向单案例研究

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管理评论 2024年第3期36卷 258-268,288页

作者：马鸿佳林樾蒲清华吉林大学商学与管理学院长春130012

在数字经济快速发展的背景下,数字创业成为企业利用数字红利创造价值的关键途径,数字创业理论亟待完善。本文在文献梳理的基础上提出“MOA—数字创业网络构建—创新绩效”的理论研究框架,以杭州遥望网络科技有限公司的数字创业成长过程... 详细信息

在数字经济快速发展的背景下,数字创业成为企业利用数字红利创造价值的关键途径,数字创业理论亟待完善。本文在文献梳理的基础上提出“MOA—数字创业网络构建—创新绩效”的理论研究框架,以杭州遥望网络科技有限公司的数字创业成长过程为研究对象,运用纵向单案例的研究方法,构建数字创业企业成长机理理论模型。研究发现,从数字创业的前因条件来看,数字创业过程中的动机(motivation)由学习导向向技术导向再向市场导向演化;机会(opportunity)来源于市场匹配,即数字技术与市场需求之间的匹配性;能力(ability)来源于通过不断创新和完善数字平台和数字技术实现数字赋能过程,使企业获得可持续的竞争优势。成长过程通过数字创业网络中的多主体互动实现,网络结构由初创时期的政府、金融机构、合作企业和数字用户四个基本主体构成,逐渐增加孵化器和大学及科研机构,数字创业网络的广度、强度和多样性随着企业的成长而增加。在价值增长方面,每个阶段产生的创新绩效通过资源积累和资源循环,使企业逐渐形成成熟的核心数字技术和数字平台,拥有稳定的数字用户群体,在多领域建立合作关系,在多元化经营的基础上形成全产业链生态圈。

关键词：数字创业企业数字创业成长机理案例研究