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Effects of host identity on the gut microbiota:A comparative study on three microtinae species

Animal Models and Experimental Medicine 2024年第2期7卷 98-105页

作者： Zhen Yao Wenli Zhao Baohong Tang qinghua li Zhenlong Wang School of life Sciences Zhengzhou UniversityZhengzhouHenan ProvinceP.R.China

Background:Gut microbiota exert an immense effect on host health and host environmental adaptation.Furthermore,the composition and structure of gut microbiota are determined by the environment and host genetic factors.However,the relative contribution of the environment and host genetic factors toward shaping the structure of gut microbiota has been poorly understood.Methods:In this study,we characterized the fecal microbial communities of the closely related voles Neodon fuscus,Lasiopodomys brandtii,and L.mandarinus after caged feeding in the laboratory for 6 months,through high-throughput sequencing and bioinformatics analysis.Results:The results of pairwise comparisons of N.fuscus vs.L.brandtii and L.mandarinus vs.L.brandtii revealed significant differences in bacterial diversity and composition after domestication.While 991 same operational taxonomic units(OTUs)were shared in three voles,there were 362,291,and 303 species-specific OTUs in N.fuscus,L.brandtii,and L.mandarinus,respectively.The relative abundances of Proteobacteria and Prevotella,which are reported to be enriched in high-altitude populations,were significantly higher in high-altitude N.fuscus than in low-altitude L.brandtii after domestication.Firmicutes,which produce various digestive enzymes for energy metabolism,and Spirochaetes,which can degrade cellulose,were found in higher abundance in subterranean L.mandarinus than that in L.brandtii which dwells on the earth surface.Conclusion:Our findings showed that some components of gut microbiota still maintained dominance even when different host species are reared under the same environmental conditions,suggesting that these bacteria are substantially influenced by host factors.

关键词： gut microbiota high-altitude Lasiopodomys brandtii Neodon fuscus

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Efficient Polytelluride Anchoring for Ultralong-life Potassium Storage: Combined Physical Barrier and Chemisorption in Nanogrid-in-Nanofiber

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Nano-Micro Letters 2024年第4期16卷 364-378页

作者： qinghua li Dandan Yu Jian Peng Wei Zhang Jianlian Huang Zhixin liang Junling Wang Zeyu lin Shiyun Xiong Jiazhao Wang Shaoming Huang Guangzhou Key Laboratory of Low‑Dimensional Materials and Energy Storage Devices School of Materials and EnergyGuangdong University of TechnologyGuangzhou 510006People’s Republic of China College of Materials and Chemistry China Jiliang UniversityHangzhou 310018People’s Republic of China Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of WollongongInnovation CampusSquires WayNorth WollongongNSW 2522Australia

Metal tellurides(MTes) are highly attractive as promising anodes for high-performance potassium-ion batteries. The capacity attenuation of most reported MTe anodes is attributed to their poor electrical conductivity and large volume variation. The evolution mechanisms, dissolution properties, and corresponding manipulation strategies of intermediates(K-polytellurides, K-pTe_(x)) are rarely mentioned. Herein,we propose a novel structural engineering strategy to confine ultrafine CoTe_(2) nanodots in hierarchical nanogrid-in-nanofiber carbon substrates(CoTe_(2)@NC@NSPCNFs) for smooth immobilization of K-pTe_(x) and highly reversible conversion of CoTe_(2) by manipulating the intense electrochemical reaction process. Various in situ/ex situ techniques and density functional theory calculations have been performed to clarify the formation, transformation, and dissolution of K-pTe_(x)(K_(5)Te_(3) and K_(2)Te), as well as verifying the robust physical barrier and the strong chemisorption of K_(5)Te_(3) and K_(2)Te on S, N co-doped dual-type carbon substrates. Additionally, the hierarchical nanogrid-in-nanofiber nanostructure increases the chemical anchoring sites for K-pTe_(x), provides sufficient volume buffer space, and constructs highly interconnected conductive microcircuits, further propelling the battery reaction to new heights(3500 cycles at 2.0 A g^(-1)). Furthermore, the full cells further demonstrate the potential for practical applications. This work provides new insights into manipulating K-pTe_(x) in the design of ultralong-cycling MTe anodes for advanced PIBs.

关键词： Polytelluride dissolution Nanogrid-in-nanofiber structure Physicochemical adsorption Reaction mechanism Ultralonglife potassium storage

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Co-incorporation of Chinese milk vetch(Astragalus sinicus L.)and chemical fertilizers alters microbial functional genes supporting short-time scale positive nitrogen priming effects in paddy soils

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Pedosphere 2024年第3期34卷 567-576页

作者： limin WANG Chunmei HE Dongfeng HUANG Juhua YU Cailing liU qinghua li Yibin HUANG Juan li Fei WANG Institute of Resources Environment and Soil FertilizerSoil and Fertilizer InstituteFujian Academy of Agricultural SciencesFuzhou 350012(China) School of Resources and Environment Engineering Anhui UniversityHefei 230601(China)

Nitrogen(N)priming is a microbially mediated biochemical process as affected by different incorporation practices.However,little information is known about the microbial mechanisms driving the response of N priming to co-operation of Chinese milk vetch(CMV,Astragalus sinicus L.)and different rates of chemical fertilizers in paddy soils in South China.Here,an anaerobic incubation experiment was conducted to study N priming effects(PE)and their relationships with soil microbial functional genes after CMV incorporation alone(M),co-incorporation of CMV with 100%(normal dosage)chemical fertilizers(MC100),and co-incorporation of CMV with 80% chemical fertilizers(MC80).Co-incorporation of CMV and chemical fertilizers enhanced the short-time scale(the first 20 d of incubation)positive PE of N,while no significant differences existed among the three treatments on day 60 or 90 of incubation(P>0.05).Compared with the M treatment,gross priming effect(GPE)in the MC100 and MC80 treatments significantly increased by 34.0% and 31.3%,respectively,and net priming effect(NPE)increased by 47.7% and 47.8%,respectively,during the first 20 d of incubation(Plikely attributed to soil nutrient availability and added substrate quality.The MC100 and MC80 treatments increased the gdhA gene abundance by 5.0% and 9.8%,increased the gdh2 gene abundance by 12.7% and 45.7%,and increased the nasB gene abundance by 9.5% and 41.4%,respectively,in comparison with the M treatment on day 20 of incubation.Correlation analyses indicated that soil microbial functional genes involved in N mineralization(gdhA and gdh2),assimilatory nitrate reduction(nasB),and nitrification(amoB)were significantly correlated with N priming under different incorporation practices during the incubation period(Plizers can regulate soil microbial community functional gene structure,which may accelerate mineralization and assimilatory nitrate reduction and inhibit nitrification,thereby increasing the short-term

关键词： green manure gross priming effect incorporation practice microbial mechanism net priming effect rice field soil

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Universal architecture and defect engineering dual strategy for hierarchical antimony phosphate composite toward fast and durable sodium storage

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Journal of Energy Chemistry 2024年第3期90卷 110-119,I0004页

作者： Jiawei Wu Gaoyu Wang Wei Zhang lixiang Wang Jian Peng qinghua li Zhixin liang Wenbo Fan Jiazhao Wang Shaoming Huang School of Materials and Energy Guangzhou Key Laboratory of Low-Dimensional Materials and Energy Storage DevicesGuangdong University of TechnologyGuangzhou 510006GuangdongChina School of Mechanical and Electrical Engineering Jiaxing Nanhu UniversityJiaxing 314001ZhejiangChina Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of WollongongInnovation CampusSquires WayNorth WollongongNSW2522Australia

Antimony(Sb)-ba sed anode materials are feasible candidates for sodium-ion batteries(SIBs) due to their high theoretical specific capacity and excellent electrical conductivity.However,they still suffer from volume distortion,structural collapse,and ionic conduction interruption upon cycling.Herein,a hierarchical array-like nanofiber structure was designed to address these limitations by combining architecture engineering and anion tuning strategy,in which SbPO_(4-x) with oxygen vacancy nanosheet arrays are anchored on the surface of interwoven carbon nanofibers(SbPO_(4-x)@CNFs).In particular,bulky PO_(4)^(3-) anions mitigate the large volume distortion and generate Na_(3)PO_(4) with high ionic conductivity,collectively improving cyclic stability and ionic transport efficiency.The abundant oxygen vacancies substantially boost the intrinsic electronic conductivity of SbPO_4,further accelerating the reaction dynamics.In addition,hierarchical fibrous structures provide abundant active sites,construct efficient conducting networks,and enhance the electron/ion transport capacity.Benefiting from the advanced structural design,the SbPO_(4-x)@CNFs electrodes exhibit outstanding cycling stability(1000 cycles at 1.0 A g^(-1) with capacity decay of 0.05% per cycle) and rapid sodium storage performance(293.8 mA h g^(-1) at 5.0 A g^(-1)).Importantly,systematic in-/ex-situ techniques have revealed the "multi-step conversion-alloying" reaction process and the "battery-capacitor dual-mode" sodium-storage mechanism.This work provides valuable insights into the design of anode materials for advanced SIBs with elevated stability and superior rate performance.

关键词： SbPO_(4) anodes Hierarchical nanostructures Oxygen vacancy Stress dispersion Sodium-ion batteries

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Mechanisms of glutamate metabolic function and dysfunction in vasculardementia

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Neuroprotection 2024年第1期2卷 33-48页

作者： Jiawen Wang Yingmei Zhang Ning Tian Dongshan Ya Jiaxin Yang Yanlin Jiang Xiaoxia li Xiaohui lin Bin Yang qinghua li Rujia liao Laboratory of Neuroscience Afliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxiChina Department of Neurology Affliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxiChina Department of Pharmacology Affliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxiChina Department of Geriatrics Affliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxiChina Guangxi Clinical Research Center for NeurologicalDiseases Afiliated Hospitalof Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxiChina

As the global population ages,research on the pathogenesis and treatment options for older patients with dementia has become increasingly important.Vascular dementia(VaD),the second most frequent type of dementia,is characterized by vascular impairment caused by inadequate blood supply to the brain.VaD is a complex neurological disorder involving multiple cells and signaling pathways,and its prevention and treatment pose clinical challenges with significant behavioral implications.Glutamate,the most abundant amino acid in the brain,plays a critical role as an excitatory neurotransmitter,impacting cognitive function,learning,and memory.Abnormal glutamate metabolism has been closely linked to dementia,and reduced blood flow to the brain can lead to excessive glutamate accumulation,resulting in neuronal death.This article highlights the connection between VaD and glutamate metabolism,aiming to identify better methods for preventing and treating VaD via regulating glutamate metabolism.

关键词： glutamate ionotropic glutamate receptors metabolism metabotropic glutamate receptors vasculardementia

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On the electric behaviour of conductive grease inside the contact zone

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Friction 2024年第4期12卷 683-697页

作者： Yuxin ZHOU Jinjie liU Xinming li He CHONG Bo HAN qinghua BAI SKF(Shanghai)Automotive Technologies Co. Ltd.Shanghai 201814China School of Mechanical and Automotive Engineering Qingdao University of TechnologyQingdao 266250China

Conductive grease has been considered as a potential solution in addressing electric erosion issue inside motor bearings.Understanding the conductive grease performance,especially the electric and tribological behaviour is crucial for its application.This paper combines bulk grease characterization and contact film study considering both electrical and tribological loading conditions.The results show that the electric performance for the selected conductive grease sample is electric field dependent,including both frequency and voltage amplitude.Its film impedance inside the contact area is closely related to the external electric field,running condition,and lubrication regime.The following film impedance calculation tells that not only bulk grease electric parameters,but the contact parameter,lubricant film contour and lubrication condition should be considered when performing the overall bearing electrical modelling.

关键词： Electric erosion lubricant conductivity grease film impedance

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When Does Sora Show:The Beginning of TAO to Imaginative Intelligence and Scenarios Engineering

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 809-815页

作者： Fei-Yue Wang Qinghai Miao lingxi li qinghua Ni Xuan li Juanjuan li lili Fan Yonglin Tian Qing-Long Han School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190China Faculty of Innovation Engineering Macao University of Science and TechnologyMacao 999078China Department of Electrical and Computer Engineering Indiana University-Purdue University IndianapolisIndianapolisIN 46202USA Faculty of Innovation Engineering Macao University of Science and TechnologyMacao 999078China Virtual Reality Fundamental Research Laboratory Department of Mathematics and TheoriesPeng Cheng LaboratoryShenzhen 518000China State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourneVIC 3122Australia

DURING our discussion at workshops for writing“What Does ChatGPT Say:The DAO from Algorithmic Intelligence to linguistic Intelligence”[1],we had expected the next milestone for Artificial Intelligence(AI)would be in the direction of Imaginative Intelligence(II),i.e.,something similar to automatic wordsto-videos generation or intelligent digital movies/theater technology that could be used for conducting new“Artificiofactual Experiments”[2]to replace conventional“Counterfactual Experiments”in scientific research and technical development for both natural and social studies[2]-[6].Now we have OpenAI’s Sora,so soon,but this is not the final,actually far away,and it is just the beginning.

关键词： something Intelligence replace

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Refractive index sensing based on a twisted nano-kirigami metasurface

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Photonics Research 2024年第2期12卷 218-225页

作者： SHUQI QIAO XIAOCHEN ZHANG qinghua liANG YANG WANG CHANG-YIN JI XIAOWEI li LAN JIANG SHUAI FENG HONGliAN GUO JIAFANG li School of Science Minzu University of ChinaBeijing 100081China Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(Ministry of Education) Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic Systemsand School of PhysicsBeijing Institute of TechnologyBeijing 100081China Laser Micro/Nano Fabrication Laboratory School of Mechanical EngineeringBeijing Institute of TechnologyBeijing 100081China

Plasmonic sensing technology has attracted considerable attention for high sensitivity due to the ability to effectively localize and manipulate light.In this study,we demonstrate a refractive index(RI)sensing scheme based on open-loop twisted meta-molecule arrays using the versatile nano-kirigami principle.RI sensing has the features of a small footprint,flexible control,and simple preparation.By engineering the morphology of meta-molecules or the RI of the ambient medium,the chiral surface lattice resonances can be significantly enhanced,and the wavelength,intensity,and sign of circular dichroism(CD)can be flexibly tailored.Utilizing the relation between the wavelength of the CD peak and the RI of the superstrate,the RI sensor achieves a sensitivity of 1133 nm/RIU.Additionally,we analyze these chiroptical responses by performing electromagnetic multipolar decomposition and electric field distributions.Our study may serve as an ideal platform for applications of RI measurement and provide new insights into the manipulation of chiral light–matter interactions.

关键词： twisted chiral index

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Material basis and pharmacodynamic mechanism of YangshenDingzhi granules in the intervention of viral pneumonia:Based on serum pharmacochemistry and network pharmacology

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Animal Models and Experimental Medicine 2024年第3期7卷 259-274页

作者： Huirong Xu Meiyue Dong Ruikun Du Chengcheng Zhang Zinuo Chen Guangyu Tian qinghua Cui Kejian li College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinanChina Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese MedicineJinanChina Qingdao Academy of Chinese Medical Sciences Shandong University of Traditional Chinese MedicineQingdaoChina College of Pharmacy Shandong University of Traditional Chinese MedicineJinanChina

Background:YangshenDingzhi granules(YSDZ)are clinically effective in preventing and treating COVID-19.The present study elucidates the underlying mechanism of YSDZ intervention in viral pneumonia by employing serum pharmacochemistry and network pharmacology.Methods:The chemical constituents of YSDZ in the blood were examined using ultraperformance liquid chromatography-quadrupole/orbitrap high-resolution mass spectrometry(UPLC-Q-Exactive Orbitrap MS).Potential protein targets were obtained from the SwissTargetPrediction database,and the target genes associated with viral pneumonia were identified using GeneCards,DisGeNET,and Online Mendelian Inheritance in Man(OMIM)databases.The intersection of blood component-related targets and disease-related targets was determined using Venny 2.1.Protein-protein interaction networks were constructed using the STRING database.The Metascape database was employed to perform enrichment analyses of Gene Ontology(GO)functions and Kyoto Encyclopedia of Genes and Genomes(KEGG)signaling pathways for the targets,while the Cytoscape 3.9.1 software was utilized to construct drug-component-disease-target-pathway networks.Further,in vitro and in vivo experiments were performed to establish the therapeutic effectiveness of YSDZ against viral pneumonia.Results:Fifteen compounds and 124 targets linked to viral pneumonia were detected in serum.Among these,MAPK1,MAPK3,AKT1,EGFR,and TNF play significant roles.In vitro tests revealed that the medicated serum suppressed the replication of H1N1,RSV,and SARS-CoV-2 replicon.Further,in vivo testing analysis shows that YSDZ decreases the viral load in the lungs of mice infected with RSV and H1N1.Conclusion:The chemical constituents of YSDZ in the blood may elicit therapeutic effects against viral pneumonia by targeting multiple proteins and pathways.

关键词： network pharmacology pharmacodynamical material basis serum pharmacochemistry viral pneumonia YangshenDingzhi granules

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Diagnostic Study of an Extreme Explosive Cyclone over the Kuroshio/Kuroshio Extension Region

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Journal of Ocean University of China 2024年第3期23卷 605-617页

作者： ZHANG Shuqin liAO qinghua liU Chunlei GAO Xiaoyu LONG Jingchao li Pengyuan XU Jianjun College of Ocean and Meteorology Guangdong Ocean UniversityZhanjiang 524088China South China Sea Institute of Marine Meteorology Guangdong Ocean UniversityZhanjiang 524088China CMA-GDOU Joint Laboratory for Marine Meteorology Guangdong Ocean UniversityZhanjiang 524088China Key Laboratory of Climate Resources and Environment in Continental Shelf Sea and Deep Sea of Department of Education of Guangdong ProvinceGuangdong Ocean UniversityZhanjiang 524088China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Department of Marine Meteorology Ocean-Atmosphere Interaction and Climate LaboratoryKey Laboratory of Physical OceanographyOcean University of ChinaQingdao 266100China

Explosive cyclones(ECs)occur frequently over the Kuroshio/Kuroshio Extension region.The most rapidly intensified EC over the Kuroshio/Kuroshio Extension region during the 42 years(1979-2020)of cold seasons(October-April)was studied to reveal the variations of the key factors at different explosive-developing stages.This EC had weak low-level baroclinicity,mid-level cyclonic-vorticity advection,and strong low-level water vapor convergence at the initial explosive-developing stage.The low-level baroclinicity and mid-level cyclonic-vorticity advection increased substantially during the maximum-deepening-rate stage.The diagnostic analyses using the Zwack-Okossi equation showed that diabatic heating was the main contributor to the initial rapid intensification of this EC.The cyclonic-vorticity advection and warm-air advection enhanced rapidly in the middle and upper troposphere and contributed to the maximum rapid intensification,whereas the diabatic heating weakened slightly in the mid-low troposphere.The relative contribution of the diabatic heating decreased from the initial explosive-developing stage to the maximum-deepening-rate stage due to the enhancement of other factors(the cyclonic-vorticity advection and warm-air advection).Furthermore,the physical factors contributing to this EC varied with the explosive-developing stage.The non-key factors at the initial explosive-developing stage need attention to forecast the rapid intensification.

关键词： explosive cyclone diabatic heating cyclonic-vorticity advection rapid intensification the Kuroshio/Kuroshio Extension region

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