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An Aggregation Cache Replacement Algorithm Based on Ontology Clustering

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Wuhan University Journal of Natural Sciences 2006年第5期11卷 1141-1146页

作者： ZHU Jiang SHEN qingguo TANG Tang li Yongqiang Institute of Communications Engineering PLAUniversity of Science and Technology Nanjing. 210007Jiangsu China

This paper describes the theory, implementation, and experimental evaluation of an Aggregation Cache Replacement （ ACR ） algorithm. By considering application background, carefully choosing weight values, using a special formula to calculate the similarity, and clustering ontologies by similarity for getting more embedded deep relations, ACR combines the ontology similarity with the value of object and decides which object is to be replaced. We demonstrate the usefulness of ACR through experiments. （a） It is found that the aggregation tree is created wholly differently according to the application cases. Therefore, clustering can direct the content adaptation more accurately according to the user perception and can satisfy the user with different preferences. （b） After comparing this new method with widely-used algorithm Last-Recently-Used （LRU） and First-in-First-out （FIFO） method, it is found that ACR outperforms the later two in accuracy and usability. （c） It has a better semantic explanation and makes adaptation more personalized and more precise.

关键词： ontology similarity replacement algorithm content adaptation semantic Web

New ent-kaurane diterpenes with chiral epoxyangelate moieties from Wedelia prostrata

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Chinese Chemical Letters 2019年第2期30卷 451-453页

作者： Zhongnan Wu Yubo Zhang Wen li Nenghua Chen Qianwen Niu Yingying li qingguo li Dan Yang Yaolan li Guocai Wang Institute of Traditional Chinese Medicine ξ Natural Products College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchJinan University Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan University School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine Department of Specific Diagnosis The 324th Military Hospital

Four new ent-kaurane diterpenes with chiral epoxyangelate moieties, (2′R,3′R)-3 a- (2′,3′-epoxyangeloyloxy)-kaur-16-en-19-oic acid (1), (2′S,3′S)-3 a- (2′,3′-epoxyangeloyloxy)-kaur-16-en-19-oic acid (2), (2′S,3′R)-3 a- (2',3'-epoxyangeloyloxy)-kaur-16-en-19-oic acid (3) and (2′R,3′S)-3α- (2′,3'-epoxyangeloyloxy)-kaur-16-en-19-oic acid (4), along with eight known diterpenes (5-12), were isolated from Wedelia prostrata. The absolute configurations of the new structures were determined by X-ray crystallography,ECD calculations and chemical methods. All compounds were evaluated for their cytotoxicity activities on human HepG-2 cells,with IC_(50) values of 11.72 ±0.22 μmol/L to 54.75±1.12 μmol/L.

关键词： Wedelia prostrata Chiral epoxyangelate moieties Ent-kaurane diterpenes Absolute configuration Cytotoxicity activities

Preparation and Characterization of Hybrid Luminescence Mesoporous MCM-48 Doped with Eu( Ⅲ ) Complex

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Journal of Rare Earths 2004年第Z1期22卷 144-146页

作者： Meng qingguo li Huanrong Peng Chunyun Zhang Hongjie Boutinaud P Franville A C Mahiou R Key Laboratory of Rare Earth Chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Laboratoire des Materiaux Inorganiques UMR CNRS 6002 Universite Blaise-Pascal et ENSCCF 24 Avenue des LandaisF-63177 Aubiere CedexFrance Key Laboratory of Rare Earth Chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Key Laboratory of Rare Earth Chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Key Laboratory of Rare Earth Chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Laboratoire des Materiaux Inorganiques UMR CNRS 6002 Universite Blaise-Pascal et ENSCCF 24 Avenue des Landais F-63177 Aubiere Cedex France Laboratoire des Materiaux Inorganiques UMR CNRS 6002 Universite Blaise-Pascal et ENSCCF 24 Avenue des Landais F-63177 Aubiere Cedex France Laboratoire des Materiaux Inorganiques UMR CNRS 6002 Universite Blaise-Pascal et ENSCCF 24 Avenue des Landais F-63177 Aubiere Cedex France

The preparation of hybrid mesoporous MCM-48 grafted by vinyl group via post-grafting process was reported and studied by X-ray diffraction, BET and 29Si solid MAS *** organic β-diketonate Europium complex the corresp... 详细信息

关键词： mesoporous hybrid materials rare earths

Primary structure of helix C to helix G of a new retinal protein in ***515

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Chinese Science Bulletin 2000年第12期45卷 1108-1113页

作者： Hui Wang Shuxuan Zhan Qingan Sun Deqiang Xu Wei Zhao Weida Huang qingguo li Fudan Univ Sch Life Sci Shanghai 200433 Peoples R China

The gene fragment encoding the retinal protein from helix C to helix G in a new strain of halobacteria, ***515 has been amplified by PCR method. The nucleotide sequence of this fragment has been determined. The deduced amino acid sequence has been compared with halobium br and other two br-like proteins, ar-1 and ar-2. Results show that those amino acid residues in br, essential for proton pumping and binding to retinal, are conserved. The residue M145 in br may be important for isomerization reaction of retinal.

关键词： halohactcria claret membrane archaerhodopsin PCR sequence.

Preparation of a gene-engineering mutant of bacteriorhodopsin BR-D96V and corresponding poly(vinyl alcohol)-based functional composite films

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Chinese Science Bulletin 2010年第33期55卷 3825-3830页

作者： ZHAO YingChun MING Ming HONG Jie MA DeWang WU Jia li qingguo HUANG WeiDa DING JianDong Key Laboratory of Molecular Engineering of Polymers of Ministry of Education Department of Macromolecular Science Fudan University Shanghai 200433 China Department of Biochemistry School of Life Sciences Fudan University Shanghai 200433 China Department of Physiology and Biophysics School of Life Sciences Fudan University Shanghai 200433 China

Bacteriorhodopsin(BR)exhibits,as a membrane protein in Halobacterium salinarum,unique photoresponsive behaviors,and shows promise as a functional information material.A new mutant of BR with the 96th aspartic acid replaced by valine(BR-D96V)was obtained and then a composite film of BR-D96V in a synthetic polymer matrix was prepared in this *** mutant BR-D96V was expressed in a bacterio-opsin deficient halobacterial strain(L33)by gene *** valine is very hydrophobic,this point mutant keeps the basic biological activities,namely,photoelectric and photochromic ***,the lifetime of M intermediate in the BR mutant is nearly two orders of magnitude longer than that of wild-type BR in neutral aqueous solution,which benefits its potential application as an information *** M lifetime is further significantly prolonged after embedding BR-D96V into poly(vinyl alcohol)(PVA).It was also found that BR-D96V is very sensitive to water content in comparison with wild-type BR and another BR mutant.

关键词：细菌视紫红质聚乙烯醇基因工程突变体复合膜 BR 制备聚合物基体

circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer

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Cancer Communications 2023年第1期43卷 100-122页

作者： Yufei Yang Dakui Luo Yang Shao Zezhi Shan Qi liu Junyong Weng Weijing He Ruoxin Zhang qingguo li Ziliang Wang Xinxiang li Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghai 200032P.R.China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China Cancer Institute Fudan University Shanghai Cancer CenterShanghai 200032P.R.China Shanghai Municipal Hospital of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 200071P.R.China

Background:Circular RNAs(circRNAs)generated by back-splicing of precursor mRNAs(pre-mRNAs)are often aberrantly expressed in cancer *** evidence has revealed that circRNAs play a critical role in the progression of several cancers,including colorectal cancer(CRC).However,the current understandings of the emerging functions of circRNAs in CRC lipid metabolism and the underlying molecular mechanisms are still ***,we aimed to explore the role of circCAPRIN1 in regulating CRC lipid metabolism and ***:circRNA microarray was performed with three pairs of tumor and non-tumor tissues from CRC *** expression of circRNAs were determined by quantitative PCR(qPCR)and in situ hybridization(ISH).The endogenous levels of circRNAs in CRC cells were manipulated by transfection with lentiviruses overexpressing or silencing *** regulatory roles of circRNAs in the occurrence of CRC were investigated both in vitro and in vivo using gene expression array,RNA pull-down/mass spectrometry,RNA immunoprecipitation assay,luciferase reporter assay,chromatin immunoprecipitation analysis,and fluorescence in situ hybridization(FISH).Results:Among circRNAs,circCAPRIN1 was most significantly upregulated in CRC tissue ***1 expression was positively correlated with the clinical stage and unfavorable prognosis of CRC *** of circCAPRIN1 suppressed proliferation,migration,and epithelial-mesenchymal transition of CRC cells,while circCAPRIN1 overexpression had opposite *** sequencing and gene ontology analysis indicated that circCAPRIN1 upregulated the expressions of genes involved in CRC lipid ***,circCAPRIN1 promoted lipid synthesis by enhancing Acetyl-CoA carboxylase 1(ACC1)*** mechanistic assays demonstrated that circCAPRIN1 directly bound signal transducer and activator of transcription 2(STAT2)to activate ACC1 transcription,thus regulating lipid metabolism and facilit

关键词： circRNA colorectal cancer circCAPRIN1 lipid metabolism STAT2 ACC1

De Morgan Algebra of Metric Ⅲ

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模糊系统与数学 1998年第3期 26-29页

作者： li qingguo (Department of Applied Mathematics ,Hunan University ,Changsha , 410082 )

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ＤｅＭｏｒｇａｎＡｌｇｅｂｒａｏｆＭｅｔｒｉｃⅢＤｅＭｏｒｇａｎＡｌｇｅｂｒａｏｆＭｅｔｒｉｃⅢＬｉＱｉｎｇｇｕｏ（ＤｅｐａｒｔｍｅｎｔｏｆＡｐｐｌｉｅｄＭａｔｈｅｍａｔｉｃｓ，ＨｕｎａｎＵｎｉｖｅｒｓｉｔｙ，Ｃｈａｎｇｓｈａ，４１００８２）Ａｂｓｔ...

关键词： Normal Dense Contraction mapping Fuzzy contraction mapping Fuzzy topology

Imaging bacteriorhodopsin-like molecules of claret-membranes from Tibet halobacteria xz515 by atomic force microscope

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Chinese Science Bulletin 2001年第22期46卷 1897-1900页

作者： TANG lin SUN Qing’an li qingguo HUANG Yibo WEI Qingqing ZHANG Yi HU Jun ZHANG Zhihong li Minqian YANG Fujia Laboratory of Detection and Manipulation of Single Molecule Shanghai Institute of Nuclear ResearchChinese Academy of SciencesShanghai 201800China liren Laboratory Department of Physiology and BiophysicsSchool of Life SciencesFudan UniversityShanghai 200433China Laboratory of Neurobiology Shanghai Institute of PhysiologyChinese Academy of SciencesShanghai 200031China Moden Institute of Physics Fudan UniversityShanghai 200433China Center for Bio-X Science Study Shanghai Jiao Tong UniversityShanghai 200030China

Halobacteria *** 515 was isolated from a salt lake in Tibet. Although proton release-and-uptake across claret membrane is in reverse order compared to bacteri-orhodopsin in purple membrane from Halobacterium Sali-narum, and its efficiency of proton pump is much lower, AFM image shows that the molecules are still arranged in a two-dimensional hexagonal lattice of trimers. Primary structure of C- to G-helix of the archaerhodopsin shows that it has only 56% homology with bacteriorhodopsin. But the interactive amino acid residues at the interface between B-and D-helixes are conserved. These amino acid residues are believed to play a significant role in the stability of protein oligomers.

关键词： atomic force microscope archaerhodopsin bacteri- orhodopsin hexagonal lattice halobacteria.

A　General　Theory　of　Estimation　of　Variance-Covariance　Components

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Systems Science and Systems Engineering 1997年第3期7卷 75-83页

作者： MA Chaoqun li qingguo International Business School of Hunan University, Hunan 410082

Starting from the more general functional model and being based on their work of K. R. Koch (1986) and Ou Ziqiang (1989), marginal likelihood function of variance components is derived and is identical to the orthogonal complement likelihood function in this paper. Minimum norm quadratic unibiased estimator (MINQUE) is developed, which expands the formula by C. R. Rao (1973). It is proved that Helmert type estimation, MINQUE, BQUE and maximum likelihood estimation are identical to one another. Besides, a universal formula for accuracy evalution is presented. Through these work, the paper establishes a universal theory of variance covariance components.

关键词： MINQUE maximum likelihood estimation variance covariance component