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糖尿病足患者截肢相关危险因素分析

重庆医学 2020年第23期49卷 3889-3892,3896页

作者：童涛田欣杨文健周兴建程庆丰周波湖北医药学院附属襄阳市第一人民医院内分泌科 441000 重庆医科大学附属第一医院内分泌科 400016

目的探讨糖尿病足(DF)患者截肢的危险因素。方法回顾性分析2015年1月至2019年3月于重庆医科大学附属第一医院住院的391例DF患者临床资料,按照住院期间是否截肢分为截肢组及非截肢组,比较两组一般资料、实验室检查、糖尿病并发症及合并... 详细信息

目的探讨糖尿病足(DF)患者截肢的危险因素。方法回顾性分析2015年1月至2019年3月于重庆医科大学附属第一医院住院的391例DF患者临床资料,按照住院期间是否截肢分为截肢组及非截肢组,比较两组一般资料、实验室检查、糖尿病并发症及合并症、足溃疡的特征及治疗等方面的差异,多因素回归分析DF患者截肢的相关危险因素。结果截肢组患者较非截肢组患者年龄更大、白细胞总数更高、感染程度更重,独居、合并有外周动脉疾病、深溃疡、Wagner≥3级、清创、使用2种及以上的抗生素、下肢血运重建的比例更多,但有更低的清蛋白水平。多因素logistic回归分析显示Wagner分级(OR=1.813,95%CI:1.115~2.847,P=0.010)、外周动脉疾病(OR=5.681,95%CI:2.801~11.524,P=0.001)、感染(OR=2.881,95%CI:1.088~3.449,P=0.025)及独居(OR=4.924,95%CI:1.700~14.262,P=0.003)是DF患者截肢的独立危险因素。结论Wagner分级、下肢血供较差、严重的感染及独居与DF患者截肢密切相关,临床医师应早期识别并进行干预。

关键词：糖尿病足截肢术危险因素感染独居

Chiral AuCu heterostructures with site-specific geometric control and tailored plasmonic chirality

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Science China Chemistry 2023年第11期66卷 3280-3289页

作者： Guizeng Yang Lichao Sun Yunlong Tao Qingqing cheng Xuehao Sun Chuang Liu qingfeng Zhang College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072China

Rational design and construction of chiral-achiral hybrid structures are of great importance to realize the multifunctional complex chiral structures toward emerging technological applications. However, significant challenges remain due to the lack of fine control over the heterostructure. Here, we have developed a general bottom-up synthetic strategy for the site-selective growth of Cu nanodomains on intrinsically chiral Au nanocrystals. Chiral AuCu heterostructures with three distinct architectures were achieved by controlling the overgrowth of Cu nanodomains in a site-specific manner. The geometry-dependent plasmonic chirality of the heterostructures was demonstrated experimentally by circular dichroism spectroscopy and theoretically through finite-difference time-domain simulations. The site-specific geometric control of chiral AuCu heterostructures was also extended to employ anisotropic chiral Au nanoplates and nanorods as the building blocks. By virtue of the galvanic replacement reactions between metal ions and Cu atoms, chiral heterostructures with increasing architectural complexity and compositional diversity can be further achieved. The current work not only opens up a promising strategy to synthesize complex chiral hybrid nanostructures but also provides an important knowledge framework that guides the rational design of multifunctional chiral hybrid nanostructures toward chiroptical applications.

关键词： chiral nanomaterials AuCu heterostructures site-selective growth plasmonic chirality galvanic replacement reaction

Current state and exploration of fat grafting

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Chinese Journal of Plastic and Reconstructive Surgery 2021年第4期3卷 209-212页

作者： Chen cheng Yun Xie qingfeng Li Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Fat grafting has become one of the most frequently used techniques in plastic and reconstructive *** studies have focused on optimizing procedures,such as donor site selection,harvesting,processing,and *** basic techniques include Coleman’s and“3L3M”techniques.A new technique called compartment-based targeted fat grafting(CTFG)has gradually been established based on anatomical findings of the facial and hand *** achieved precise restoration of the fat volume in the anatomical ***-based fat grafting has introduced new fields involving tissue repair and regeneration,including facial rejuvenation and scar improvement,among *** this review,we summarize the timeline for the development of fat grafting.

关键词： Fat grafting Fat compartment Regenerative treatment

冷冻在电子支气管镜下肉芽组织清除术中的疗效观察

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中国内镜杂志 2024年第7期30卷 1-8页

作者：何成廖冬菊刘阳廖庆峰简勇江西省新余市人民医院呼吸与危重症医学科江西新余330800

目的探讨冷冻在电子支气管镜下肉芽组织清除术中的应用疗效,以期为肉芽组织清除术患者找到一种高效、安全的辅助技术。方法选择2021年6月-2022年6月该院收治的41例行肉芽组织清除术的患者作为研究对象,采用单双号对患者进行分组,21例分... 详细信息

目的探讨冷冻在电子支气管镜下肉芽组织清除术中的应用疗效,以期为肉芽组织清除术患者找到一种高效、安全的辅助技术。方法选择2021年6月-2022年6月该院收治的41例行肉芽组织清除术的患者作为研究对象,采用单双号对患者进行分组,21例分到单号者为对照组,20例分到双号者为观察组。两组患者均行电子支气管镜下肉芽组织清除术治疗。术中,对照组给予氩等离子体凝固术(APC)治疗,观察组给予冷冻治疗,比较两组患者治疗前后的免疫功能指标水平(CD4^(+)、CD8^(+)和CD4^(+)/CD8^(+)等)、术后恢复相关指标和治疗总有效率等。结果治疗前,两组患者CD4^(+)和CD4^(+)/CD8^(+)比较,差异均无统计学意义(P>0.05),治疗后,观察组CD4^(+)和CD4^(+)/CD8^(+)明显高于对照组,差异均有统计学意义(P0.05),治疗后,观察组CD8^(+)明显低于对照组,差异有统计学意义(P<0.05);观察组有效率为95.00%,高于对照组的80.95%,观察组术后疼痛视觉模拟评分法(VAS)为(2.14±0.18)分,明显低于对照组的(6.09±0.95)分,差异均有统计学意义(P<0.05);观察组术后首次进食时间为(6.08±0.76)h,住院时间为(5.12±0.68)d,明显短于对照组的(15.39±2.97)h和(7.08±0.93)d,观察组治疗费用为(10500.60±80.70)元,明显低于对照组的(19800.00±126.00)元,差异均有统计学意义(P<0.05);观察组术后并发症发生率为5.00%,明显低于对照组的23.81%,差异有统计学意义(P<0.05)。结论冷冻在电子支气管镜下肉芽组织清除术中的应用较好,不仅能提高治疗效果,改善机体免疫指标水平,还能减轻术后疼痛,降低术后并发症发生率,缩短预后周期,且治疗费用低,值得临床推广应用。

关键词：冷冻电子支气管镜肉芽组织清除术氩等离子体凝固术(APC) 疗效

两种化学发光检测系统检测血浆醛固酮和肾素浓度的比较

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中华内分泌外科杂志 2019年第5期13卷 413-418页

作者：杨秀勇郑枫凡宋颖杨淑敏胡金波何文雯汪志红程庆丰李启富重庆医科大学附属第一医院内分泌科重大代谢性疾病转化医学重庆市高校重点实验室400016 遵义市第一人民医院内分泌科 563000

目的了解用进口(意大利索灵)和国产(深圳迈瑞)全自动化学发光系统测量血浆醛固酮浓度(plasma aldosterone concentration,PAC)、血浆肾素浓度(plasma rennin concentration,PRC)的相关性;建立健康成人立位PAC、PRC的参考值范围。方法以... 详细信息

目的了解用进口(意大利索灵)和国产(深圳迈瑞)全自动化学发光系统测量血浆醛固酮浓度(plasma aldosterone concentration,PAC)、血浆肾素浓度(plasma rennin concentration,PRC)的相关性;建立健康成人立位PAC、PRC的参考值范围。方法以意大利索灵公司Liaison○RXL全自动化学放光免疫分析仪和配套试剂盒作为参比系统,以深圳迈瑞公司CL2000i全自动化学发光免疫分析仪和配套试剂盒作为待评系统,检测143例健康成人及73例高血压患者(其中原发性醛固酮增多症16例)的PAC、PRC,评价两种系统检测结果的相关性;基于143名健康成人检测结果,建立其参考值范围(P2.5~P97.5)。结果两种系统测定的醛固酮(r=0.914,P<0.01)和肾素(r=0.977,P<0.01)浓度相关性好;PAC和PRC在健康成人中呈偏态分布;进口检测系统测定的PAC和PRC参考值范围分别为30.8~344.6 pg/ml和2.4~90.0 μIU/ml;国产检测系统测定的PAC和PRC参考值范围分别为29.4~473.3 pg/ml和3.6~98.3 μIU/ml。结论两种化学发光检测系统测定血浆醛固酮和肾素浓度具有良好相关性。

关键词：醛固酮肾素化学发光法参考值范围

Numerical modeling of SiC by low-pressure chemical vapor deposition from methyltrichlorosilane

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Chinese Journal of Chemical Engineering 2020年第6期28卷 1733-1743页

作者： Kang Guan Yong Gao qingfeng Zeng Xingang Luan Yi Zhang Laifei cheng Jianqing Wu Zhenya Lu School of Materials Science and Engineering South China University of TechnologyGuangzhou 510640China Science and Technology on Thermostructural Composite Materials Laboratory School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi'an 710072China MSEA International Institute for Materials Genome Gu'an 065500China

The development of functional relationships between the observed deposition rate and the experimental conditions is an important step toward understanding and optimizing low-pressure chemical vapor deposition(LPCVD)or low-pressure chemical vapor infiltration(LPCVI).In the field of ceramic matrix composites(CMCs),methyltrichlorosilane(CH3 SiCl3,MTS)is the most widely used source gas system for SiC,because stoichiometric SiC deposit can be facilitated at 900°C–1300°***,the reliability and accuracy of existing numerical models for these processing conditions are rarely *** this study,a comprehensive transport model was coupled with gas-phase and surface *** resulting gas-phase kinetics was confirmed via the measured concentration of gaseous *** relationship between deposition rate and 24 gaseous species has been effectively evaluated by combining the special superiority of the novel extreme machine learning method and the conventional sticking coefficient *** kinetics were then proposed and shown to reproduce the experimental *** proposed simulation strategy can be used for different material systems.

关键词： Chemical vapor deposition MTS/H2 Gas-phase and surface kinetics Extreme learning machine method Numerical model

简易胰岛素敏感性指数评估PCOS胰岛素抵抗

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内分泌外科杂志 2007年第2期1卷 111-113页

作者：刘秀容程庆丰冯静白晓苏何燕李启富重庆医科大学附属第一医院内分泌科重庆400016

目的：寻求一个简单可靠的胰岛素敏感性指数用于评估多囊卵巢综合征（PCOS）患者胰岛素抵抗程度。方法：对47名PCOS患者（按BMI分为肥胖组和非肥胖组）和20名健康女性（正常对照组）行口服葡萄糖耐量试验（OGTT）与Botnia钳夹术。结果... 详细信息

目的：寻求一个简单可靠的胰岛素敏感性指数用于评估多囊卵巢综合征（PCOS）患者胰岛素抵抗程度。方法：对47名PCOS患者（按BMI分为肥胖组和非肥胖组）和20名健康女性（正常对照组）行口服葡萄糖耐量试验（OGTT）与Botnia钳夹术。结果：在三组行两两比较Botnia钳夹术获得的M值，均有统计学意义，全部P〈0．05，而肥胖组的M值最低。来源于OGTF的胰岛素抵抗指数Sumal与Botnia钳夹术获得的M值相关性好（r=-0.642，p〈0.001）。结论：在评估PCOS患者胰岛素抵抗程度时，Sumal是个比较可靠的简易指数。

关键词：多囊卵巢综合征胰岛素抵抗

重庆地区汉族人群TRB3基因+251A/G多态性与多囊卵巢综合征的相关性分析

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第三军医大学学报 2011年第15期33卷 1559-1562页

作者：田波李启富龚莉琳宋颖钟立杨淑敏赵长虹黄佳祎程庆丰梅枚夏伟罗梅重庆医科大学附属第一医院内分泌科重庆400016

目的了解中国重庆地区汉族人群TRB3基因外显子+251A/G的基因型分布,探讨该基因多态性与多囊卵巢综合征(PCOS)及其糖脂代谢、胰岛素抵抗等的相关性。方法应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法对139例PCOS患者和120例正... 详细信息

目的了解中国重庆地区汉族人群TRB3基因外显子+251A/G的基因型分布,探讨该基因多态性与多囊卵巢综合征(PCOS)及其糖脂代谢、胰岛素抵抗等的相关性。方法应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法对139例PCOS患者和120例正常对照者TRB3基因第2外显子+251A/G位点进行基因分型,同时进行人体测量学及代谢指标的检测,并对其中的107例PCOS患者和20例正常对照行高胰岛素-正葡萄糖钳夹实验。结果 TRB3基因+251A/G多态性位点的3种基因型AA、AG、GG频率在PCOS组中分别为62.59%、33.09%、4.32%,与对照组(60.83%、36.67%、2.5%)相比,差异无统计学意义(χ2=0.88,P=0.64)。PCOS组和对照组等位基因频率分布差异亦无统计学意义(P=0.99)。PCOS组AG/GG基因型的LDL-c和HDL-c水平明显低于AA基因型(P=0.028,P=0.036)。结论 TRB3基因+251A/G多态性与重庆地区汉族人群多囊卵巢综合征的发生无关,但可能与PCOS患者血脂代谢紊乱有关。

关键词：多态性,单核苷酸 TRB3基因多囊卵巢综合征

Powder metallurgy synthesis of porous Ni-Fe alloy for oxygen evolution reaction and overall water splitting

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Journal of Materials Science & Technology 2020年第2期37卷 154-160页

作者： Wenbo Li qingfeng Hu Yunwei Liu Mengmeng Zhang Jiajun Wang Xiaopeng Han cheng Zhong Wenbin Hu Yida Deng Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin 300072China School of Chemical Engineering and Technology Collaborative Innovation Center of Chemical Science and EngineeringTianjin UniversityTianjin 300072China

Developing inexpensive and high efficient catalysts is essential for generating oxygen and hydrogen via water ***,based on powder metallurgy,a Ni-Fe based compound(Ni8Fe2 alloy)with unique porous structure and controllable phase has been designed and *** using a solvent or template,the alloy exhibits a porous structure with uniformly distributed *** obtained Ni8Fe2 alloy exhibits an efficient oxygen evolution reaction(OER)performance and good longterm stability in alkaline electrolyte(i.e.1.0 M KOH).Additionally,an alkaline water splitting device has been assembled using porous Ni8Fe2 alloy as both anode and cathode *** system requires a cell voltage of 1.65 V to reach the 10 mA cm-2 current density for overall water splitting and maintains good stability for 25 *** efficient electrocatalytic performance of the Ni8Fe2 alloy is owing to the unique porous microstructure,increased active sites and accelerated charge ***,the reaction kinetics of OER are significantly promoted.

关键词： Water splitting Oxygen evolution reaction Ni-Fe alloy Porous structure