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Colony-stimulating factor-1 receptor inhibition combined with paclitaxel exerts effective antitumor effects in the treatment of ovarian cancer

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Genes & Diseases 2024年第3期11卷 400-416页

作者： Meijia Yu Yiming Wu qingfang li Weiqi Hong Yang Yang Xiaoyi Hu Yanfei Yang Tianqi Lu Xia Zhao Xiawei Wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Gynecology and Obstetrics Development and Related Disease of Women and Children Key Laboratory of Sichuan ProvinceKey Laboratory of Birth Defects and Related Diseases of Women and ChildrenMinistry of EducationWest China Second HospitalSichuan UniversityChengduSichuan 610041China Department of Obstetrics and Gynecology The First Affiliated HospitalArmy Medical UniversityChongqing 400038China

Ovarian cancer is the tumor with the highest mortality among gynecological malig-nancies.Studies have confirmed that paclitaxel chemoresistance is associated with increased infiltration of tumor-associated macrophages(TAMs)in the microenvironment.Colony-stimu-lating factor 1(CSF-1)receptor(CSF-1R)plays a key role in regulating the number and differ-entiation of macrophages in certain solid tumors.There are few reports on the effects of targeted inhibition of CSF-1R in combination with chemotherapy on ovarian cancer and the tu-mor microenvironment.Here,we explored the antitumor efficacy and possible mechanisms of the CSF-1R inhibitor pexidartinib(PLX3397)when combined with the first-line chemothera-peutic agent paclitaxel in the treatment of ovarian cancer.We found that CSF-1R is highly ex-pressed in ovarian cancer cells and correlates with poor prognosis.Treatment by PLX3397 in combination with paclitaxel significantly inhibited the growth of ovarian cancer both in vitro and in vivo.Blockade of CSF-1R altered the macrophage phenotype and reprogrammed the immunosuppressive cell population in the tumor microenvironment.

关键词： CSF-1R Ovariancancer Paclitaxel PLX3397 Targeted therapy Tumor-associated macrophages

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Recognition and chirality sensing of guanosine-containing nucleotides by an achiral tetraphenylethene-based octacationic cage in water

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Chinese Chemical Letters 2024年第1期35卷 267-270页

作者： Honghong Duan Ting Yang qingfang li Fan Cao Pingxia Wang liping Cao College of Chemistry and Materials Science Northwest UniversityXi'an 710069China

The development of molecular probes or systems with the ability of multiple orthogonal responses is an effective approach to precisely detect biomolecules with similar chemical structures.Herein,we report the synthesis of a water-soluble TPE-based octacationic cage(1)with the compressed TPE-containing bilayer,which endows it with good fluorescence properties and potential conformation chirality.As a result,1 exhibits molecular recognition for anionic nucleotides within its two“claw”-like cavities to form 1:2 host-guest complexes in water,companying with selective turn-off fluorescence and turn-on CD responses to G/GTP over other nucleotides.

关键词： Host-guest recognition Chirality sensing Tetraphenylethene Achiral cage Nucleotide

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Successive construction of cucurbit[8]uril-based covalent organic frameworks from a supramolecular organic framework through photochemical reactions in water

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Science China Chemistry 2022年第7期65卷 1279-1285页

作者： Yawen li Chaochao Yan qingfang li liping Cao College of Chemistry and Materials Science Northwest UniversityXi’an 710069China Frontier Institute of Science and Technology Xi’an Jiaotong UniversityXi’an710054China

Functional framework materials have been developed for many applications including adsorption, asymmetric catalysis, sensing,drug delivery, optical device, and so on. Here, we report the successive construction of two cucurbit[8]uril-based covalent organic frameworks(COFs) including tetraphenylethene-based COF(COF-1) and phenanthrene-based COF(COF-2) from a two-dimensional(2D) periodic cucurbit[8]uril-based supramolecular organic framework(SOF-1) as the prearranged structure via the intermolecular photocycloaddition of the coumarin units and the intramolecular photocyclization of the tetraphenylethene(TPE) units under ultraviolet(UV) irradiation(365 nm) in water. In this case, oxygen(O_(2)) plays an important role in the photocyclization of the TPE units into the phenanthrene units in the transform process from SOF-1 or COF-1 to COF-2. As the TPE units further form phenanthrenes after UV-irradiation, COF-2 exhibits aggregation-caused quenching effect and weak green emission, while COF-1 displays a strong yellow emission due to the aggregation-induced emission. Besides, the adaptive chirality of cationic COF-1 as a biomolecular sensor can be efficiently induced by chiral anionic biomolecules including adenosine-5′-triphosphate(ATP) and adenosine-5′-diphosphate(ADP) to exhibit sensitive negative circular dichroism responses in water. This supramolecular approach to construct COF from SOF via photochemical reactions may open a new opportunity for the construction and application of the water-soluble COFs with well structural controllability, unique photophysical properties,and favorable biocompatibility.

关键词： covalent organic framework supramolecular organic framework cucurbituril photochemical reaction adaptive chirality

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Targeted therapy for head and neck cancer:signaling pathways and clinical studies

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Signal Transduction and Targeted Therapy 2023年第2期8卷 530-557页

作者： qingfang li Yan Tie Aqu Alu Xuelei Ma Huashan Shi Department of Biotherapy Cancer CenterWest China HospitalSichuan UniversityChengduChina

Head and neck cancer(HNC)is malignant,genetically complex and difficult to treat and is the sixth most frequent cancer,with tobacco,alcohol and human papillomavirus being major risk factors.Based on epigenetic data,HNC is remarkably heterogeneous,and treatment remains challenging.There is a lack of significant improvement in survival and quality of life in patients with HNC.Over half of HNC patients experience locoregional recurrence or distal metastasis despite the current multiple traditional therapeutic strategies and immunotherapy.In addition,resistance to chemotherapy,radiotherapy and some targeted therapies is common.Therefore,it is urgent to explore more effective and tolerable targeted therapies to improve the clinical outcomes of HNC patients.Recent targeted therapy studies have focused on identifying promising biomarkers and developing more effective targeted therapies.A well understanding of the pathogenesis of HNC contributes to learning more about its inner association,which provides novel insight into the development of small molecule inhibitors.In this review,we summarized the vital signaling pathways and discussed the current potential therapeutic targets against critical molecules in HNC,as well as presenting preclinical animal models and ongoing or completed clinical studies about targeted therapy,which may contribute to a more favorable prognosis of HNC.Targeted therapy in combination with other therapies and its limitations were also discussed.

关键词： clinical summarized alcohol

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Stabilization and Multiple-Responsive Recognition of Natural Base Pairs in Water by a Cationic Cage

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CCS Chemistry 2022年第9期4卷 2914-2920页

作者： lin Cheng Ping Tian qingfang li Anyang li liping Cao College of Chemistry and Materials Science Northwest UniversityXi’an 710069

The hydrogen-bonded(H-bonded)base pairs,double H-bonded A•T and triple H-bonded G•C in DNA,are important units for storing,encoding,and expressing genetic information.Owing to the interference from water,however,the formation of H-bonded base pairs from short deoxynucleotide fragments such as mono-or di-deoxynucleotide are not easily achieved in aqueous solutions.

关键词： host–guest chemistry chiral recognition adaptive chirality tetraphenylethene-based cationic cage base pair

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面向交通场景的轻量级行人检测算法

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郑州大学学报（理学版） 2024年第4期56卷 48-55页

作者：王清芳胡传平李静郑州大学计算机与人工智能学院河南郑州450001 郑州大学网络空间安全学院河南郑州450002

针对交通场景下行人检测模型网络复杂、参数量大以及难以在低性能设备上部署的问题,基于YOLOv5s网络模型提出了一种改进的轻量级行人检测算法。首先,使用Ghost模块重构YOLOv5s网络进行特征提取,降低模型的参数量和计算量,提高推理速度... 详细信息

针对交通场景下行人检测模型网络复杂、参数量大以及难以在低性能设备上部署的问题,基于YOLOv5s网络模型提出了一种改进的轻量级行人检测算法。首先,使用Ghost模块重构YOLOv5s网络进行特征提取,降低模型的参数量和计算量,提高推理速度。其次,引入坐标注意力机制提高模型对目标特征的提取能力,提升其对小目标行人的检测效果。最后,采用SIoU损失函数加快模型的收敛速度,提高模型的识别准确率。实验结果表明,改进后的算法能保证较高的检测精度,与原始YOLOv5s算法相比参数量减少47.1%,计算量减少48.7%,提高了交通场景下行人检测的速度且易于部署。

关键词：行人检测交通安全 YOLOv5网络轻量化 Ghost模块

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Aggregation-induced emission and self-assembly of functional tetraphenylethene-based tetracationic dicyclophanes for selective detection of ATP in water

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Chinese Chemical Letters 2021年第11期32卷 3531-3534页

作者： Chunyan Qin Yawen li qingfang li Chaochao Yan liping Cao College of Chemistry and Materials Science Northwest UniversityXi'an 710069China

Functional dicyclophanes with various substituents(e.g.,NO_(2),Br,OCH_(3)and OH)were synthesized via one-pot S_(N)2 reaction.Dicyclophanes can form nanospheres via the head-to-tail self-assembly between the cavities and the TPE units to exhibit aggregation-induced emission(AIE)in aqueous solution.These AIE-active nanospheres with cationic feature exhibited selective recognition with fluorescence response for anionic ATP via electrostatic interactions and hydrophobic effects in water.

关键词： Aggregation-induced emission Dicyclophanes Tetraphenylethene Adenosine derivatives Fluorescence

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Distribution pattern of Caragana species under the influence of climate gradient in the Inner Mongolia region, China

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Journal of Arid Land 2014年第3期6卷 311-323页

作者： liNa XIE ChengCang MA HongYu GUO qingfang li YuBao GAO Tianjin Key Laboratory of Animal and Plant Resistance College of Life Sciences Tianjin Normal University College of life Sciences Nankai University

There is a strong climate gradient in the Inner Mongolia region, China, with solar radiation and air temperature increasing but precipitation decreasing gradually from the northeast to the southwest. Sixteen Cara- gana species exist in the Inner Mongolia region. These Caragana species exhibit a distribution pattern across moisture zones and form a geographical replacement series. In order to examine the mechanisms responsible for Caragana species distribution pattern, we selected 12 Caragana species that exhibit a distinct distribution pattern across multiple moisture zones in the Inner Mongolia region, and determined the relationships between the leaf ecological and physiological traits of these Caragana species and the aridity index and solar radiation. Along with the climatic drought gradient and the solar radiation intensification from the northeast to the southwest, leaf eco- logical characteristics of Caragana species changed drastically, i.e. the leaf shape gradually turned from flat into tegular or tubbish; the leaf hair became denser, longer and lighter in color; the leaf area, leaf biomass and specific leaf area （SLA） decreased significantly; the leaf thickness and the ratio of leaf thickness to leaf area increased sig- nificantly; and the leaf chlorophyll content decreased significantly. As the climatic drought stress increased, osmotic potentials of the main osmotic adjustment substances and the cytoplasmic ion concentration of Caragana species increased significantly. Meanwhile, the total and free water contents and water potential of leaves decreased sig- nificantly; the ratio of bound to free water increased significantly; the stomatal conductance and transpiration rate reduced significantly; and the water use efficiency （WUE） increased significantly. In addition, with the intensification of climatic drought stress, peroxidase （POD） and superoxide dismutase （SOD） activities in leaves increased significantly. As a result, the malondialdehyde （MDA） content increased while the oxygen free radical cont

关键词： adaptation climatic gradient morphological trait osmotic potential water state water metabolism antioxidative enzyme

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Influence of exchange bias on spin torque ferromagnetic resonance for quantification of spin–orbit torque efficiency

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Chinese Physics B 2024年第5期33卷 688-694页

作者：赵乾张腾飞何斌李子木张森富于国强王建波刘青芳魏晋武 Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education Lanzhou UniversityLanzhou 730000China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Special Functional Materials and Structural Design Ministry of EducationLanzhou UniversityLanzhou 730000China

Antiferromagnet(AFM)/ferromagnet(FM)heterostructure is a popular system for studying the spin–orbit torque(SOT)of AFMs.However,the interfacial exchange bias field induces that the magnetization in FM layer is noncollinear to the external magnetic field,namely the magnetic moment drag effect,which further influences the characteristic of SOT efficiency.In this work,we study the SOT efficiencies of IrMn/NiFe bilayers with strong interfacial exchange bias by using spin-torque ferromagnetic resonance(ST-FMR)method.A full analysis on the AFM/FM systems with exchange bias is performed,and the angular dependence of magnetization on external magnetic field is determined through the minimum rule of free energy.The ST-FMR results can be well fitted by this model.We obtained the relative accurate SOT efficiencyξ_(DL)=0.058 for the IrMn film.This work provides a useful method to analyze the angular dependence of ST-FMR results and facilitates the accurate measurement of SOT efficiency for the AFM/FM heterostructures with strong exchange bias.

关键词： antiferromagnets spin-orbit torque exchange bias spin torque ferromagnetic resonance

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良性肝功能异常的临床意义

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临床肝胆病杂志 2024年第2期40卷 408-412页

作者：韩旭李嘉熊清芳杨永峰天津市第二人民医院消化内科天津300192 南京中医药大学附属南京医院(南京市第二医院)肝病科南京210003 天津肝病研究所天津300192

肝生化指标检测是临床上判断肝功能的重要方法,但肝生化指标异常不完全等同于肝损伤。一些遗传、免疫因素也可引起肝生化指标异常,但预后大多良好。本文归纳了一些良性肝生化指标异常的原因及检测方法,以提醒临床医生拓宽诊治思路,考虑... 详细信息

肝生化指标检测是临床上判断肝功能的重要方法,但肝生化指标异常不完全等同于肝损伤。一些遗传、免疫因素也可引起肝生化指标异常,但预后大多良好。本文归纳了一些良性肝生化指标异常的原因及检测方法,以提醒临床医生拓宽诊治思路,考虑到遗传、免疫等因素,避免误诊误治。

关键词：肝疾病诊断肝功能试验

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