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Automatic extraction method of force chain information and its application in the flow photoelastic experiment of granular matter

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Particuology 2023年第12期83卷 142-155页

作者： qingfa chen Enlin Long Wenjing Niu Jun Liu Wenyu Fan Hangyu Li School of Civil Engineering and Architecture Key Laboratory of Disaster Prevention and Structural Safety of Ministry of EducationGuangxi UniversityNanning530004China School of Resources Environment and MaterialsGuangxi UniversityNanning530004China

The force chain is the core of the multi-scale analysis of granular matter.Accurately extracting the force chain information among particles is of great significance to the study of particle mechanics and geological hazards caused by particle flow.However,in the photoelastic experiment,the precise identification of the branching points of force chains has not been effectively realized.Therefore,this study proposes an automatic extraction method of force chain key information.First,based on the Hough transform and the Euclidean distance,a particle geometric information identification model is established and geometric information such as particle circle center coordinates,radius,contact point location,and contact angle is extracted.Then,a particle contact force information identification model is established following the color gradient mean square method.The model realizes the rapid calibration and extraction of a large number of particle media contact force information.Next,combined with the force chain composition criterion and its quasilinear feature,an automatic extraction method of force chain information is established,which solves the problem of the accurate identification of the force chain branch points.Finally,in the photoelastic experiment of ore drawing from a single drawpoint,the automatic extraction method of force chain information is verified.The results show that the macroscopic distribution of force chains during ore drawing from a single drawpoint is left–right symmetrical.Strong force chains are mostly located on the two sides of the model but in small numbers and they mainly develop vertically.Additionally,the ends are mostly in a combination of Y and inverted Y shapes,while the middle is mostly quasilinear.Weak force chains are abundant and mostly distributed in the middle of the model,and develop in different directions.The proposed extraction method accurately extracts the force chain network from the photoelastic experiment images and dynamically characterizes the force chains of granular

关键词： Granular matter Photoelastic experiment Digital image processing Force chain extraction method

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协同开采技术的演化原理与模型

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工程科学学报 2024年第6期46卷 1054-1064页

作者：黄昊陈庆发广西大学土木建筑工程学院南宁530004 广西大学资源环境与材料学院南宁530004

为推动传统开采技术变革,弥补协同开采技术基础理论的部分空缺.从技术分类、技术构成等方面对协同开采技术体系进行了完善;通过协同开采技术协同演化支持证据、自组织演化条件及自组织演化特征的分析,论证了协同开采技术的形成与实施过... 详细信息

为推动传统开采技术变革,弥补协同开采技术基础理论的部分空缺.从技术分类、技术构成等方面对协同开采技术体系进行了完善;通过协同开采技术协同演化支持证据、自组织演化条件及自组织演化特征的分析,论证了协同开采技术的形成与实施过程是协同演化的过程,揭示了协同开采技术的协同演化原理:前提是开放与非平衡态,动力是由竞争与协同产生的非线性相互作用,诱因是随机涨落,路径是相变与分叉;论证了基于哈肯模型构建协同开采技术演化模型的适用性,结合协同开采协同演化类型的分析,构建了普适于协同开采技术的协同演化模型,得出了协同开采技术的协同演化方程及势函数,指出了构建协同演化方程及势函数的意义;引入基于哈肯模型的实证分析方法,提出了协同开采技术协同演化模型的应用方法,主要分为指标体系构建、子系统状态测算、协同演化机制分析3个步骤.结合高峰矿105号矿体的协同开采技术实例,对模型进行了应用验证.研究结果可为协同开采技术的实践及决策提供理论依据.

关键词：协同开采自组织理论协同演化原理协同演化模型哈肯模型

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协同开采技术效应的动态演化模型及应用

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中国有色金属学报 2024年第2期34卷 668-682页

作者：黄昊陈庆发广西大学土木建筑工程学院南宁530004 广西大学资源环境与材料学院南宁530004

为量化表征协同开采技术的有序状态及协同效应,保证协同开采技术的持续高协同性能,构建了协同效应的动态演化模型。此演化模型主要分为5个步骤:基于协同学经典演化方程选择模型的关键参量,围绕协同效应内涵构建模型的底层计算逻辑;吸取... 详细信息

为量化表征协同开采技术的有序状态及协同效应,保证协同开采技术的持续高协同性能,构建了协同效应的动态演化模型。此演化模型主要分为5个步骤:基于协同学经典演化方程选择模型的关键参量,围绕协同效应内涵构建模型的底层计算逻辑;吸取改进的群决策层次分析法、熵权法及模糊综合评价法的优点对关键参量量化表征;根据模型的底层计算逻辑计算协同效应;基于灰色关联度计算控制参量与协同效应的关联度;结合计算结果对协同效应的动态演化及控制参量的调控能力进行分析,对工程实践给出评价及建议。最后以高峰矿105号矿体的协同开采技术为例对模型进行应用验证。

关键词：协同开采技术动态协同效应动态模型关联度分析综合评价

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隔离层下单漏斗放矿力链演变的参数敏感性分析

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中国有色金属学报 2024年第1期34卷 344-356页

作者：陈庆发刘军龙恩林广西大学资源环境与材料学院南宁530004 广西大学土木建筑工程学院南宁530004

利用PFC软件,以同步充填留矿法为背景,选取隔离层厚度A、隔离层界面摩擦因数B、矿石颗粒摩擦因数C及颗粒半径D作为正交试验的四种影响因素,对力链特征参数的一般变化规律进行分析,研究影响力链演变的参数及其敏感性。结果表明:力链数量... 详细信息

利用PFC软件,以同步充填留矿法为背景,选取隔离层厚度A、隔离层界面摩擦因数B、矿石颗粒摩擦因数C及颗粒半径D作为正交试验的四种影响因素,对力链特征参数的一般变化规律进行分析,研究影响力链演变的参数及其敏感性。结果表明:力链数量先减少后增加;力链长度的概率分布曲面呈指数形式递减,短力链所占比例逐渐减少,长力链所占比例逐渐增加;力链强度表现出先减少后增加的规律;力链强度的概率分布先呈指数式上升,后呈指数式递减;四种因素对正交试验指标影响的主次顺序为CDAB;对应的最优方案为颗粒摩擦因数0.8、颗粒半径0.008 m、隔离层厚度0.004 m、隔离层界面摩擦因数0.5,此时散体介质体系在放矿过程中最为稳定。

关键词：散体介质流力链表征正交试验参数敏感性矩阵分析

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水灰比对薄喷衬层材料抗拉性能影响的宏微观试验研究

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材料导报 2024年第8期38卷 277-283页

作者：陈庆发杨文雄吴家有牛文静广西大学工程防灾与结构安全教育部重点实验室南宁530004 广西大学资源环境与材料学院南宁530004 广西防灾减灾与工程安全重点实验室南宁530004

薄喷衬层材料TSL865作为一种新型高分子喷涂支护材料,可快速有效地抑制地下工程围岩变形、破坏。抗拉性能是TSL865材料的优势特征,但其受水灰比的影响规律与作用机制目前尚不清晰。为此,本研究开展两方面的工作:(1)通过开展宏观拉伸试验... 详细信息

薄喷衬层材料TSL865作为一种新型高分子喷涂支护材料,可快速有效地抑制地下工程围岩变形、破坏。抗拉性能是TSL865材料的优势特征,但其受水灰比的影响规律与作用机制目前尚不清晰。为此,本研究开展两方面的工作:(1)通过开展宏观拉伸试验,分析水灰比对TSL865试样应力-应变曲线特征、抗拉强度和抗拉韧性等力学性质的影响规律;(2)通过开展微观孔隙结构试验,分析水灰比对TSL865试样微观孔径分布、比表面积等几何性质的影响规律;计算不同水灰比下TSL865试样的孔径分形维数,从试样微观孔径结构分布特征角度,解译水灰比对TSL865试样抗拉性能的影响机制,并获取最佳水灰比。研究结果表明:TSL865试样的应力-应变曲线可以分为弹-塑-延-脆四个阶段,且柔性特征显著;TSL865试样抗拉性能较好的原因是其2~10 nm的无害孔占比较大;水灰比与试样的抗拉强度、孔径分形维数呈负相关关系,通过调节水灰比来改变TSL试样的微观孔隙结构,从而影响TSL试样的抗拉性能,其最优的水灰比为1∶2。研究成果有助于全面了解TSL865材料的抗拉性能与宏细观破断机制。

关键词：薄喷衬层材料 TSL 水灰比抗拉性能孔隙结构地下工程

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Development of stem cell-based therapy for Parkinson’s disease

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Translational Neurodegeneration 2015年第1期4卷 120-132页

作者： Fabin Han Deborah Baremberg Junyu Gao Jing Duan Xianjie Lu Nan Zhang qingfa chen Centre for Stem Cells and Regenerative Medicine The Liaocheng People’s Hospital/Affiliated Liaocheng HospitalTaishan Medical UniversityShandong 252000China

Parkinson’s disease(PD)is one of the most common neurodegenerative disorders of aging,characterized by the degeneration of dopamine neurons(DA neurons)in the substantial nigra,leading to the advent of both motor symptoms and non-motor symptoms.Current treatments include electrical stimulation of the affected brain areas and dopamine replacement therapy.Even though both categories are effective in treating PD patients,the disease progression cannot be stopped.The research advance into cell therapies provides exciting potential for the treatment of PD.Current cell sources include neural stem cells(NSCs)from fetal brain tissues,human embryonic stem cells(hESCs),induced pluripotent stem cells(iPSCs)and directly induced dopamine neurons(iDA neurons).Here,we evaluate the research progress in different cell sources with a focus on using iPSCs as a valuable source and propose key challenges for developing cells suitable for large-scale clinical applications in the treatment of PD.

关键词： Parkinson’s disease Dopamine neuron Neural stem cell Human embryonic stem cells Induced pluripotent stem cell Induced dopamine neuron

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Research Progress in the Regulation of Tumor Cells and Tumor Stem Cells at Multiple Targets by Antrodia camphorata

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Medicinal Plant 2020年第3期11卷 6-10页

作者： qingfa chen Yan XU Xiaodong SHI Chuanfei WEI HaitaoXIE Ruxi LV The Institute of Tissue Engineering and Regenerative Medicine Liaocheng People's Hospital Liaocheng 252000 China Department of Pain Liaocheng People's Hospital Liaocheng 252000 China Department of Neurosurgery Weifang Yidu Central Hospital Weifang 262500 China Centre for Research Xiankangda Biotech Corporation Dongguan 523000 China Department of Gastroenterology Liaocheng People's Hospital Liaocheng 252000 China

Extensive in vitro and in vivo research reveals multiple intracellular molecular targets of Antrodia camphorata,and these targets affect growth,apoptosis,angiogenesis,invasion and metastasis of cells.These targets include tumor suppressor,cell cycle regulator,transcription factor,angiogenesis and metastasis factor,apoptosis and survival regulator,etc.Additionally,more and more attention has been paid to the molecular mechanism of A.camphorata on the regulation of tumor stem cells.Meanwhile,there is evidence that the immunoregulation of A.camphorata is enhanced,which may lead cell cycle arrest or apoptosis.In this paper,molecular mechanism of tumor cells and tumor stem cells regulated at multiple targets by A.camphorata in vitro and in vivo in the past decade is summarized.

关键词： Antrodia camphorata Tumor stem cell Cell cycle regulation Apoptosis Transcription factor

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Modulation of fasting blood glucose by raw banana powder in alloxan-induced diabetic rats

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International Journal of Agricultural and Biological Engineering 2013年第3期6卷 94-102页

作者： Bai Yongliang Yu Ming Du Bing chen qingfa Yang Gongming College of Food Science South China Agricultural UniversityGuangzhou 510642China

This study aimed to observe the influence of raw banana powder(RBP)on fasting blood glucose(FBG),blood lipid and other biochemical indicators in type-2 diabetic rats and therefore to provide experimental evidences for developing suitable food from banana powder for diabetic patients.Eight Sprague-Dawley rats were selected randomly as the normal control group(NCG)before the experiment.After establishing type-2 diabetic rat models(11.1-16.7 mmoL/L)by alloxan,32 rats were divided into four groups:the diabetic control group(DCG,n=8),low-dose group(LDG,n=8),middle-dose group(MDG,n=8)and high-dose group(HDG,n=8).The LDG,MDG and HDG rats received gastric perfusion of RBP at the doses of 2 g/kg,4 g/kg and 6 g/kg per day,respectively.After four weeks,oral glucose tolerance test was carried out in each group,and then the FBG level,blood lipid,insulin,short chain fatty acids content,pH value of colon content and other biochemical indicators of rats in each group were determined and compared among the groups.Results showed that the levels of FBG significantly decreased in the LDG(11.97±0.83),MDG(8.95±0.45)and HDG(9.28±1.45),compared with their initial values(13.00±1.25,13.68±0.75 and 13.91±0.80,respectively).The FBG levels in these three groups were obviously lower than that in the DCG.However,there were no dramatic FBG changes in the NCG and DCG(5.77±0.59,14.14±0.72)compared with the initial stage(5.55±0.23,13.93±0.47).The RBP intervention increased insulin-sensitivity index and regulated postprandial blood glucose.Besides,RBP showed the positive effects on symptoms of type 2 diabetic rats,such as the reduction of weight gain and total cholesterol.

关键词： raw banana powder dietary fiber resistant starch fasting blood glucose diabetic rats

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基于协同学的协同开采科学内涵诠释

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金属矿山 2022年第5期51卷 37-44页

作者：陈庆发黄昊广西大学资源环境与材料学院广西南宁530004

“协同开采”已成为当前我国采矿工程领域研究的热点词汇之一,但业界对其内涵的把握程度尚需进一步深入。基于协同学理论,系统诠释了协同开采的科学内涵。首先,厘清了协同学主要概念及其在协同开采中的含义;其次,通过对协同开采定义的... 详细信息

“协同开采”已成为当前我国采矿工程领域研究的热点词汇之一,但业界对其内涵的把握程度尚需进一步深入。基于协同学理论,系统诠释了协同开采的科学内涵。首先,厘清了协同学主要概念及其在协同开采中的含义;其次,通过对协同开采定义的逆向剖析,提出了“开采活动前置条件”表述,分析了协同开采与开采活动前置条件中基础性因素之间的关系;然后,通过比较分析协同效应与整体效应之间的区别,阐明了协同开采系统的协同效应内涵;最后,论证了自组织理论在协同开采系统中的适用性,并对协同开采系统中的自组织过程进行了探讨。研究结果有助于促进业界准确理解协同开采的科学内涵,有助于促进协同开采理论与技术的深入发展。

关键词：协同开采科学内涵协同学协同效应自组织过程

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High-fat diet impairs gut barrier through intestinal microbiota-derived reactive oxygen species

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Science China(Life Sciences) 2024年第5期67卷 879-891页

作者： Nianyi Zeng Fan Wu Junqi Lu Xiang Li Shaomei Lin Lang Zhou Zhongwei Wang Guangyan Wu qingfa Huang Daowen Zheng Jie Gao Shan Wu Xiaojiao chen Muxuan chen Fanguo Meng Haitao Shang Yan He Peng chen Hong Wei Zhuang Li Hongwei Zhou Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510282China Department of Environmental Health Guangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public Health and Tropical MedicineSouthern Medical UniversityGuangzhou 510515China Redox Medical Center for Public Health Soochow UniversitySuzhou 215301China Precision Medicine Institute The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Pathophysiology Guangdong Provincial Key Laboratory of ProteomicsSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China

Gut barrier disruption is a key event in bridging gut microbiota dysbiosis and high-fat diet(HFD)-associated metabolic disorders.However,the underlying mechanism remains elusive.In the present study,by comparing HFD-and normal diet(ND)-treated mice,we found that the HFD instantly altered the composition of the gut microbiota and subsequently damaged the integrity of the gut barrier.Metagenomic sequencing revealed that the HFD upregulates gut microbial functions related to redox reactions,as confirmed by the increased reactive oxygen species(ROS)levels in fecal microbiota incubation in vitro and in the lumen,which were detected using in vivo fluorescence imaging.This microbial ROS-producing capability induced by HFD can be transferred through fecal microbiota transplantation(FMT)into germ-free(GF)mice,downregulating the gut barrier tight junctions.Similarly,mono-colonizing GF mice with an Enterococcus strain excelled in ROS production,damaged the gut barrier,induced mitochondrial malfunction and apoptosis of the intestinal epithelial cells,and exacerbated fatty liver,compared with other low-ROS-producing Enterococcus strains.Oral administration of recombinant high-stability-superoxide dismutase(SOD)significantly reduced intestinal ROS,protected the gut barrier,and improved fatty liver against the HFD.In conclusion,our study suggests that extracellular ROS derived from gut microbiota play a pivotal role in HFD-induced gut barrier disruption and is a potential therapeutic target for HFD-associated metabolic diseases.

关键词： fatty liver disease gut microbiota gut barrier high-fat diet oxidative stress reactive oxygen species

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