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Responses of flood peaks to land use and landscape patterns under extreme rainstorms in small catchments-A case study of the rainstorm of Typhoon Lekima in Shandong,China

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International Soil and Water Conservation Research 2022年第2期10卷 228-239页

作者： Yuanhao Liu Jianqiao Han Juying Jiao Baoyuan Liu Wenyan Ge qingbin pan Fei Wang Institute of Soil and Water Conservation Northwest A&F UniversityYangling712100Shaanxi ProvinceChina Key Laboratory of the Loess Plateau Soil Erosion and Water Loss Process and Control Ministry of Water ResourcesZhengzhou450003Henan ProvinceChina Institute of Soil and Water Conservation Chinese Academy of Sciences and Ministry of Water ResourcesYangling712100Shaanxi ProvinceChina China Institute of Water Resources and Hydropower Resea

Investigations of the formation mechanisms of flood peaks in small catchments facilitate flood prediction and disaster prevention under extreme ***,there have been few studies on the re-sponses of flood peaks to land use landscape patterns using field surveys during extreme rainstorm *** on field data from 17 small catchments near the rainstorm center of Typhoon Lekima,7 landscape indices were *** flood peak and its sensitivity to the land use landscape were investigated by combining remote sensing interpretation and related *** conclusions are as follows:(1)The peak discharge of the small catchment was 2.36e56.50 m3/s,the peak modulus was 8.00 e48.89 m3/(s$km2),and the flood index K ranged from 3.61 to 4.55.(2)Under similar rainfall conditions,the flood peak modulus,K and the proportion of sloping cropland had significantly positive correlations(p<0.05).The flood peak modulus was significantly negatively correlated with the proportion of forest-grassland and terrace(p<0.05),and K and the proportion of forest-grassland and terraced land exhibited a negative correlation.(3)The flood peak modulus and K were positively correlated with the landscape fragmentation.(4)The sensitivities of small catchments to floods were evaluated to be moderate compared to K values from other *** ability of small catchments to cope with extreme rain-storms can be improved by increasing the areas of forest-grassland,and terraces and reducing landscape *** results could be applied to provide a basis for land use planning and support for the response against disasters caused by extreme floods.

关键词： Extreme rainstorm Flood peak intensity Flood peak sensitivity Land use Landscape pattern

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苏北黄桥地区上第三系富氦天然气成因探讨

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石油与天然气地质 1991年第3期12卷 340-345页

作者：杨方之王金渝潘庆斌华东石油地质局

本文对苏北黄桥地区浅层含氦气藏的天然气主要组分进行了成因研究,指出浅层天然气来自深部和浅部不同气源,本区有良好的勘探前景。

关键词：第三纪氦天然气石油生成

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流域侵蚀输沙空间尺度效应及其影响因素研究进展

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水土保持研究 2022年第3期29卷 88-97,105页

作者：潘雅文马文龙潘庆宾韩剑桥张胜男河南黄河勘测规划设计研究院有限公司郑州450003 西北农林科技大学陕西杨凌712100 中国水利水电科学研究院国际泥沙研究培训中心北京100048 中国科学院水利部水土保持研究所陕西杨凌712100 中规院(北京)规划设计有限公司北京100044

侵蚀输沙空间变异及其尺度效应是流域水文过程研究的一个重要内容,对流域水土流失控制和水沙资源科学管理具有重要意义。通过对流域侵蚀输沙空间尺度效应研究成果的系统回顾,从坡面到流域,阐述了降雨、土壤和植被等环境要素对侵蚀输沙... 详细信息

侵蚀输沙空间变异及其尺度效应是流域水文过程研究的一个重要内容,对流域水土流失控制和水沙资源科学管理具有重要意义。通过对流域侵蚀输沙空间尺度效应研究成果的系统回顾,从坡面到流域,阐述了降雨、土壤和植被等环境要素对侵蚀输沙尺度效应的影响,梳理了尺度效应产生机制方面的认知,总结了不同条件下坡面产流和侵蚀输沙尺度转换的代表性方法。在此基础上,对流域侵蚀输沙空间尺度效应研究的发展趋势进行了讨论,未来应增加新技术和数据的应用,建立具有明确物理机制的侵蚀输沙空间尺度转换方法,同时,急需突破剧烈环境变化对空间尺度效应影响的研究。本文的梳理与总结可为流域侵蚀输沙过程的深入研究提供参考,为土壤侵蚀防治和河流水沙的综合管理提供一定的科学支持。

关键词：流域空间尺度效应产汇流土壤侵蚀泥沙输移

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Versatile Synthesis ofα-Oxygen Organoboron Compounds via Photo-Induced Siloxycarbene

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Chinese Journal of Chemistry 2024年第22期42卷 2712-2716页

作者： Xiongxiong Lu qingbin Zhao Dehai Cao pan Xu Xuenian Chen Zhenxing Liu College of Chemistry Zhengzhou UniversityZhengzhouHenan 450001China Henan Key Laboratory of Boron Chemistry and Advanced Materials Schoolof Chemistry and Chemical EngineeringHenan Normal UniversityXinxiangHenan 453007China

Comprehensive Summary A novel method for synthesizingα-oxygen organoboron compounds has been developed through acylsilane-based carbene insertion reactions into C—B *** coupling partners,readily available organoboron compounds(alkenyl,allyl,and allenyl B(pin))were *** on the substrates,pure insertion into C—B bonds or insertion followed by a siloxy group rearrangement process(from carbon to boron)would occur,delivering theα-oxygen organoboron compounds with great *** experiments demonstrated that the electronic effect of the substituents mainly controlled the rearrangement ***,no matter which isomer of substrate(Z or E)was used,the reaction withβ-aryl-substituted alkenyl B(pin)affords both isomers of products(Z and E,separable through column chromatography).Trapping experiments indicated the triplet energy transfer process was involved.

关键词： Acylsilanes Siloxy carbenes Organoboron compounds Isomerization Photocatalysis Rearrangement

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Potential one-step strategy for PET degradation and PHB biosynthesis through co-cultivation of two engineered microorganisms

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Engineering Microbiology 2021年第1期1卷 3-10页

作者： pan Liu Tong Zhang Yi Zheng qingbin Li Tianyuan Su Qingsheng Qi State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266237China

The management and recycling of plastic waste is a challenging global *** terephthalate(PET),one of the most widely used synthetic plastics,can be hydrolyzed by a series of ***,upcycling the resulting monomers is also a *** this study,we designed a co-cultivation system,in which PET degradation was coupled with polyhydroxybutyrate(PHB)***,PETase from Ideonalla sakaiensis was expressed in Yarrowia lipolytica Po1f with a signal peptide from *** engineered PETase-producing *** was confirmed to hydrolyze bis(2-hydroxyethyl)terephthalate(BHET)and PET powder into the monomers terephthalate(TPA)and ethylene glycol(EG).Simultaneously,a TPA-degrading Pseudomonas stutzeri strain isolated from PET waste was transformed with a recombinant plasmid containing the phb CAB operon from Ralstonia eutropha,which encodes enzymes for the biosynthesis of *** two co-cultivated engineered microbes could directly hydrolyze BHET to produce the bioplastic PHB in one fermentation *** this process,5.16 g/L BHET was hydrolyzed in 12 h,and 3.66 wt%PHB(3.54 g/L cell dry weight)accumulated in 54 h.A total of 0.31g/L TPA was produced from the hydrolyzation of PET in 228 *** PHB could not be synthesized directly from PET because of the low hydrolyzing efficiency of PETase,this study provides a new strategy for the biodegradation and upcycling of PET waste by artificial microflora.

关键词： Polyethylene terephthalate Upcycling Polyhydroxybutyrate PETase co-cultivation Yarrowia lipolytica Pseudomonas stutzeri

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Comparison of 1 Versus 2 Doses of Quadrivalent Influenza Vaccine in 3-8-Year-Old Children with Different Immunological States—Jiangsu Province,China,2021

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China CDC weekly 2024年第19期6卷 424-430,I0002-I0004页

作者： Qian Liu Pengfei Jin Jingxin Li Xiaoqin Chen Chenhao Wang qingbin Lu Wei Jiang Shixuan Zhang Lairun Jin Hongxin pan Xue Guo Fengcai Zhu School of Public Health Southeast UniversityNanjing CityJiangsu ProvinceChina Jiangsu Provincial Medical Innovation Center National Health Commission Key Laboratory of Enteric Pathogenic MicrobiologyJiangsu Provincial Center for Disease Control and PreventionNanjing CityJiangsu ProvinceChina Donghai County Center for Disease Control and Prevention Donghai CityJiangsu ProvinceChina Changchun Institute of Biological Products Co. Ltd.Changchun CityJilin ProvinceChina Department of Laboratorial Science and Technology&Vaccine Research Center School of Public HealthPeking UniversityBeijingChina Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijingChina

Summary What is already known about this topic?The quadrivalent influenza vaccine(QIV)provides protection against a broader range of influenza strains by including strains of influenza A/H1N1,A/H3N2,B/Yamagata,and B/*** is added by this report?This study aimed to assess the immunogenicity and safety of administering a single dose compared to two doses of QIV in children,taking into consideration their previous influenza vaccination history.

关键词： ent doses Jiangsu

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Modulating the function of ABCB1: in vitro and in vivo characterization of sitravatinib, a tyrosine kinase inhibitor

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Cancer Communications 2020年第7期40卷 285-300页

作者： Yuqi Yang Ning Ji Chao-Yun Cai Jing-Quan Wang Zi-Ning Lei Qiu-Xu Teng Zhuo-Xun Wu qingbin Cui Yihang pan Zhe-Sheng Chen Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNew York 11439USA State Key Laboratory of Experimental Hematology Chinese Academy of Medical Science and Peking Union Medical CollegeInstitute of Hematology and Blood Diseases HospitalTianjin 300020P.R.China School of Public Health Guangzhou Medical UniversityGuangzhouGuangdong 511436P.R.China Tomas Lindahl Nobel Laureate Laboratory the Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong 518107P.R.China

Background:Overexpression of ATP-binding cassette(ABC)transporter is a major contributor to multidrug resistance(MDR),in which cancer cells acquire resistance to a wide spectrum of chemotherapeutic *** this work,we evaluated the sensitizing effect of sitravatinib,a broad-spectrum tyrosine kinase inhibitor(TKI),on ATP-binding cassette subfamily B member 1(ABCB1)-and ATP-binding cassette subfamily C member 10(ABCC10)-mediated ***:MTT assay was conducted to examine cytotoxicity and evaluate the sensitizing effect of sitravatinib at non-toxic ***-labeled paclitaxel transportation,Western blotting,immunofluorescence analysis,and ATPase assay were carried out to elucidate the mechanism of sitravatinib-induced *** in vitro findings were translated into preclinical evaluation with the establishment of xenograft ***:Sitravatinib considerably reversed MDR mediated by ABCB1 and partially antagonized ABCC10-mediated *** in silico docking simulation analysis indicated that sitravatinib strongly and stably bound to the transmembrane domain of ABCB1 human-mouse chimeric ***,sitravatinib inhibited hydrolysis of ATP and synchronously decreased the efflux function of ***,sitravatinib could considerably enhance the intracellular concentration of anticancer ***,no significant alterations of both expression level and localization of ABCB1 were *** importantly,sitravatinib could remarkably restore the antitumor activity of vincristine in ABCB1-mediated xenograft model without observable toxic ***:The findings in this study suggest that the combination of sitrvatinib and substrate antineoplastic drugs of ABCB1 could attenuate the MDR mediated by the overexpression of ABCB1.

关键词： Sitravatinib

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Coassembly of Macrocyclic Amphiphiles for Anti-β-Amyloid Therapy of Alzheimer’s Disease

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CCS Chemistry 2021年第9期3卷 2485-2497页

作者： Yu-Chen pan Hui Wang Xinxin Xu Han-Wen Tian Hong Zhao Xin-Yue Hu Yu Zhao Yang Liu Guihua Ding qingbin Meng Bart Jan Ravoo Tao Zhang Dong-Sheng Guo College of Chemistry Key Laboratory of Functional Polymer MaterialsMinistry of EducationState Key Laboratory of Elemento-Organic ChemistryNankai UniversityTianjin 300071 College of Life Sciences Key Laboratory of Bioactive MaterialsMinistry of EducationNankai UniversityTianjin 300071 College of Chemistry Key Laboratory of Functional Polymer Materials(Ministry of EducationState Key Laboratory of Medicinal Chemical Biology)Nankai UniversityTianjin 300071 State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and ToxicologyBeijing 100850 Organic Chemistry Institute and Center for Soft Nanoscience(SoN) Westfälische Wilhelms-Universität MünsterMünster 48149

Based on the amyloid hypothesis,anti-β-amyloid(Aβ)therapy has dominated clinical trials for the prevention and treatment of Alzheimer’s disease(AD)in recent years.A key element of this strategy is the interaction between therapeutic agents and Aβ.However,the design and development of artificial receptors that may render selective and strong recognition toward Aβremains a huge challenge because of the complexity and size of peptide guests and their flexible conformation.

关键词： macrocyclic amphiphile heteromultivalent recognition fibril disintegration cognitive improvement Alzheimer’s disease

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煤矿锚杆轴力检测时锚固系统振动特性参数分析

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采矿与安全工程学报 2022年第3期39卷 567-575页

作者：郝阳吴宇张凯李盼孟庆彬中国矿业大学深部岩土力学与地下工程国家重点实验室江苏徐州221116 中国矿业大学力学与土木工程学院江苏徐州221116 安徽理工大学力学与光电物理学院安徽淮南232001

基于锚固系统振动特性的锚杆轴力动力无损检测技术在理论、试验及应用方面取得了一定进展,然而,现场应用中存在频谱曲线不够平整光滑、特征点难以识别的问题,给轴力分析造成困难,其关键原因在于影响锚固系统振动特性的参数尚不明确。基... 详细信息

基于锚固系统振动特性的锚杆轴力动力无损检测技术在理论、试验及应用方面取得了一定进展,然而,现场应用中存在频谱曲线不够平整光滑、特征点难以识别的问题,给轴力分析造成困难,其关键原因在于影响锚固系统振动特性的参数尚不明确。基于此,首先分析轴力、锚固段黏结刚度、托盘与围岩接触刚度与锚固系统一阶固有振动频率的关系,得到以上参数对频谱曲线的影响;然后分析不同激振方式下锚杆的振动特性,得到最优激振方式,提出现场锚杆轴力无损检测流程;最后在现场进行工业性试验,验证参数分析后的轴力与一阶固有频率的关系。锚固系统一阶固有频率随轴力增大变化最敏感,无损检测轴力分析中应当建立其与一阶固有频率之间的关系;一阶固有频率取值范围在0~2 000 Hz;树脂黏结等效刚度、托盘等效弹簧刚度与一阶固有频率表现为非线性正相关,随着树脂黏结等效刚度、托盘等效弹簧刚度的大小不断增大,系统的一阶固有频率逐渐表现为对数关系。振动最优激振选取为2 000 g带硬塑料头的刚性小锤进行激振,能够激发出法向激振力为20~25 N的振动,此时频谱曲线较为光滑平整,易于识别。现场锚杆轴力动力无损检测结果表明,锚杆实时轴力与一阶固有频率可以用对数关系来表达。

关键词：锚杆轴力无损检测频谱分析一阶固有频率参数分析

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基于要素适宜度视角的云南协调发展探析

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经济问题探索 2011年第7期 54-57页

作者：潘小春李清彬云南大学昆明650091 南开大学天津300071

云南省现实状况的不佳和旅游文化差异化发展模式的认识让我们反思区域追赶战略,并引入要素适宜度(FAD)的理念来重新审视云南省的协调发展战略。在要素适宜度的概念和理念基础上,从区域要素和非区域要素的角度梳理云南省的要素禀赋条件,... 详细信息

云南省现实状况的不佳和旅游文化差异化发展模式的认识让我们反思区域追赶战略,并引入要素适宜度(FAD)的理念来重新审视云南省的协调发展战略。在要素适宜度的概念和理念基础上,从区域要素和非区域要素的角度梳理云南省的要素禀赋条件,提出云南省的协调发展的总体目标应调整为云南省内部的要素适宜度最优化,具体努力方向应为最优化要素适宜度和改善要素禀赋条件,并依此提出了几条相应战略路径。

关键词：云南要素适宜度经济发展

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