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Natural Products and Bioprospecting 2020年第4期10卷 227-241页

作者： Meilian Yang Yudan Wang Zhifeng Fan qingwang Xue Guy Sedar Singor Njateng Yaping Liu Jianxin Cao Tianrui Zhao Guiguang Cheng Faculty of Agriculture and Food Kunming University of Science and TechnologyKunming 650500People’s Republic of China Engineering Research Center of Biopolymer Functional Materials of Yunnan Yunnan Minzu UniversityKunming 650500People’s Republic of China Department of Chemistry Liaocheng UniversityLiaocheng 252059ShandongChina State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650204People’s Republic of China

Melodinus henryi is a good source of terpenoid indole alkaloids,and traditionally used as a folk medicine in the treatment of meningitis and *** order to further exploit their potential uses,its anti-inflammatory and immunosuppressive activi-ties,safety evaluations and chemical profiles have been *** to the crude methanol extract from *** and its non-alkaloidal fraction,the total alkaloidal fraction(MHTA)had the strongest anti-inflammatory and immunosup-pressive *** the acute oral toxicity assay,the half lethal dose(LD50)of MHTA was more than 2000 mg/*** sub-acute toxicity assay for consecutive 28 days exhibited MHTA at a lower concentrations of less than 500 mg/kg might be regarded as safe,and might damage spleen,liver,kidney,and heart when the dose is higher than 1000 mg/*** addition,a phytochemical investigation on MHTA led to the isolation of 15 monoterpenoid indole ***,in regard with the potent side effects of MHTA,it should be used with caution in the development of phytomedicine.

关键词： alkaloid alkaloids methanol

IL-17A,but not IL-17F,is indispensable for airway vascular remodeling induced by exaggerated Th17 cells in prolonged ovalbumin-challenged mice

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IL-17A,but not IL-17F,is indispensable for airway vascular r...

Discovery of IHMT-MST1-39 as a novel MST1 kinase inhibitor and AMPK activator for the treatment of diabetes mellitus

第九届全国免疫学学术大会

作者： ShanLu HequanLi RundiGao XuanGao FeiXu qingwang GuohuaLu DajingXia JianyingZhou Department of Respiratory and Critical Care Medicine First Affiliated Hospital of Zhejiang University School of Medicine Zhejiang University Department of Respiratory Diseases First Affiliated Hospital of Zhejiang Chinese Medicine University School of Public Health Zhejiang University

Rationale and Objective:Our previous study has depicted an essential role of Th17 cells in excessive mucus secretion and airway smooth muscle proliferation in a prolonged ovalbumin(OVA)-challenged C57BL/6 mouse ***,the impact of Th17 cells against vascular remodeling,another characteristic features of airway remodeling in asthma,remains *** this paper,we made further study to explore this ***:An asthmatic airway remodeling murine model was established by prolonged OVA exposure in sensitized C57BL/6 *** effect of Th17 cell and its cytokines on vascular remodeling,mobilization and recruitment of endothelial progenitor cells(EPCs),proliferation and tubule formation of pulmonary microvascular endothelia cells(PMVECs)were ***:The time-course experiments showed that progressively increasing levels of Th17 cells and IL-17A(not IL-17F)in the lungs of prolonged allergen-challenged mice were positively correlated with microvessel density(MVD)in perbronchial *** exaggerated airway vascular remodeling in such mouse model was aggravated by instillation of IL-17A or adoptive transfer of Th17,which dramatically ameliorated by anti-IL-17A antibody,but not anti-IL-17F antibody,***,Boyden chamber assay exhibited that IL-17A might accelerate EPCs ***,EPCs accumulation in the airway of allergen exposure mice resulted from adoptive transfer of Th17 can be eliminated by blockade of ***,we found that IL-17A promoted tubule-like formation rather than proliferation of PMVECs in ***:Collectively,our results raise the possibility that Th17 cells might contributes to the airway vascular remodeling by mediating EPCs chemotaxis as well as PMVECs tube formation via IL-17A rather than IL-17F in asthma.

关键词： Th17 Cells IL-17A Airway vascular remodeling Asthma

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2278-2290页

作者： Junjie Wang Ziping Qi Yun Wu Aoli Wang qingwang Liu Fengming Zou Beilei Wang Shuang Qi Jiangyan Cao Chen Hu Chenliang Shi Qianmao Liang Li Wang Jing Liu Wenchao Wang Qingsong Liu Anhui Province Key Laboratory of Medical Physics and Technology Institute of Health and Medical TechnologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui230031P.R.China University of Science and Technology of China HefeiAnhui230026P.R.China Hefei Cancer Hospital Chinese Academy of SciencesHefeiAnhui230031P.R.China Precision Medicine Research Laboratory of Anhui Province HefeiAnhui230088P.R.China

Insulin-producing pancreaticβcell death is the fundamental cause of type 1 diabetes(T1D)and a contributing factor to type 2 diabetes(T2D).Moreover,metabolic disorder is another hallmark of *** sterile 20-like kinase 1(MST1)contributes to the progression of diabetes mellitus through apoptosis induction and acceleration of pancreaticβcell ***-activated protein kinase(AMPK)is an energy sensing kinase and its activation has been suggested as a treatment option for metabolic ***,pharmacological inhibition of MST1 and activation of AMPK simultaneously represents a promising approach for diabetes ***,we discovered a novel selective MST1 kinase inhibitor IHMT-MST1-39,which exhibits anti-apoptosis efficacy and improves the survival of pancreaticβcells under diabetogenic conditions,as well as primary pancreatic islets in an ex vivo disease ***,IHMT-MST1-39 activated AMPK signaling pathway in hepatocytes in vitro,combination of IHMT-MST1-39 and metformin synergistically prevented hyperglycemia and significantly ameliorated glucose tolerance and insulin resistance in diabetic *** together,IHMT-MST1-39 is a promising anti-diabetic candidate as a single agent or in combination therapy for both T1D and T2D.

关键词： diabetes mellitus treatment

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股市大跌影响的新评估

海外经济评论 2007年第47期 16-19页

作者： qingwang

[摩根士丹利10月24日]我们在5月底曾发布《中国股市大跌，影响究竟有几何》一文，讨论股市泡沫破裂可能造成的影响。目前，上证指数已经比“530”之后的低点上涨了60％，9月份的静态市盈率已达64倍的历史高点。这种情况下，股市泡沫破... 详细信息

[摩根士丹利10月24日]我们在5月底曾发布《中国股市大跌，影响究竟有几何》一文，讨论股市泡沫破裂可能造成的影响。目前，上证指数已经比“530”之后的低点上涨了60％，9月份的静态市盈率已达64倍的历史高点。这种情况下，股市泡沫破裂将会造成的严重后果又一次引起了人们的担忧。投资者尤其担心实体经济有可能受到三方面的严重影响，即负面“财富效应”对居民消费的影响、企业固定资产投资的融资渠道受到的影响以及银行财务状况受到的影响。

关键词：中国股市评估 “财富效应” 固定资产投资股市泡沫摩根士丹利静态市盈率上证指数

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基于“天地人三气同步”理论辨治膝骨关节炎

中国民族民间医药 2024年第14期33卷 5-8页

作者：吴健陆庆旺邹异黄泳朝曾坚祥韦建深陈小刚沈春萍广西国际壮医医院明秀分院骨伤科广西南宁530001

膝骨关节炎是骨伤科常见疾病,其发病时多表现有疼痛、活动受限等,对患者日常生活及工作造成了极大的影响。临床多采用中西医结合治疗,疗效不一。壮医把膝骨关节炎称为“骆芡”,通过“天地人三气同步”理论进行辨证施治,临床屡获良效。... 详细信息

膝骨关节炎是骨伤科常见疾病,其发病时多表现有疼痛、活动受限等,对患者日常生活及工作造成了极大的影响。临床多采用中西医结合治疗,疗效不一。壮医把膝骨关节炎称为“骆芡”,通过“天地人三气同步”理论进行辨证施治,临床屡获良效。故文章基于壮医“天地人三气同步”理论探讨膝骨关节炎的辨治,以期为临床诊治膝骨关节炎提供理论支持。

关键词：膝骨关节炎壮医阴阳

Performance Evaluation of a New Type of Polymer Profile Control Agent

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Materials Sciences and Applications 2015年第5期6卷 348-352页

作者： qingwang Liu Zhe Zhang Zhenzhong Fan Zhenzhong Fan Jigang Wang EOR Key Laboratory of the Ministry of Education Northeast Petroleum University Daqing City China

The low-permeability oil and gas resources of our country are quite common and abundant. Their reserve has accounted for one-fifth of total oil reserves of our country, and their yield has constituted the important part of national petroleum annual yield, but its development is very difficult. Polymer gel technology is a technical method of improving sweep efficiency in recent years which substantially increases the viscosity of the polymer solution by adding a crosslinking agent to the polymer produced by intramolecular or intermolecular crosslinking.

关键词： Low-Permeability Polymer Gel Profile Control Agent

Construction of Forest and Grass Industry Economic Belt Using Land Resources in Road Side Slope

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Asian Agricultural Research 2017年第7期9卷 70-75,79页

作者： Zhaohua ZHU qingwang LAI Guogang XU Guoliang CHI Xiaorong CHEN Damaged Slope Eco-reconstruction Technology Center of Guangdong Province/Shenzhen Master Ecology & Environment Co. Ltd.

The construction of expressway and high-speed rail is at the sacrifice of the soil ecological environment. It brings about much damaged land and bare slope. It is necessary to restore vegetation and rebuild landscape. In the design of target plant community and configuration plants,it is required to select as far as possible plants that can blossom and bear fruit or pods. Then seeds of these plants can be harvested,processed and sold,and applied for other projects,so as to develop into a complete forest and grass seed industry chain. This not only reasonably utilizes land resources,but also provides a new approach to the problem of insufficient fine forest seed sources in China. This paper discussed the use of land resources in road side slope and forest and grass seed selection and breeding technology,and elaborated the industrialized development paths for forest and grass seed industries in road side slope. Finally,it arrived at following recommendations.( i) The construction of forest and grass industry economic belt using land resources in road side slope can realize maximum land value. Building a road can help people there get rich,and the type of land and water cultivates its type of forest and grass.( ii) It can make up for the losses incurred from construction of expressway and high-speed rail or destroying forest land,and it can increase farmers' income.( iii) It can increase the supply of domestic seeds,reduce seed import,save foreign exchange,and partly solve the problem of insufficient supply of forest and grass seeds.( iv) It is able to form a complete forest and grass seed industry economic cycle chain,increase employment,and provide new approaches for enriching and benefiting farmers.

关键词： Road side slope Land resources Forest and grass species Forest and grass seed industry economic belt

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选煤厂筛分车间粉尘浓度分布规律数值研究

矿业安全与环保 2023年第1期50卷 37-41页

作者：刘茜尧连清旺太原理工大学安全与应急管理工程学院山西太原030024 太原理工大学原位改性采矿教育部重点实验室山西太原030024

针对选煤厂筛分车间粉尘污染严重的问题,以马脊梁选煤厂为研究对象,采用数值模拟与现场试验相结合的方法,使用Fluent软件对筛分车间振动筛处粉尘运移规律进行模拟。分析粉尘在风流作用下随时间和空间的运动变化规律,提出应用喷雾与密闭... 详细信息

针对选煤厂筛分车间粉尘污染严重的问题,以马脊梁选煤厂为研究对象,采用数值模拟与现场试验相结合的方法,使用Fluent软件对筛分车间振动筛处粉尘运移规律进行模拟。分析粉尘在风流作用下随时间和空间的运动变化规律,提出应用喷雾与密闭罩相结合的方法治理粉尘。研究结果表明:由落料管落料和振动筛工作产生的粉尘大量聚积在振动筛筛面,粉尘质量浓度最高达60 mg/m3,随着与振动筛距离的增大粉尘浓度逐渐降低;车间内风流流速随着运移距离的增大而减小;将喷雾与密闭罩相结合的粉尘治理方法应用到现场,平均降尘效率达92.3%。

关键词：选煤厂筛分车间振动筛粉尘运移 Fluent 数值模拟粉尘治理

Synthesis and Performance Evaluation of Organic Bentonite Modifier Dimethyldistearylammonium Bromide (DODMAB)

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Open Journal of Composite Materials 2014年第4期4卷 220-223页

作者： qingwang Liu Ao Sun Zhenzhong Fan Jiguang Wang Tong Zhang Dong Cheng Northeast Petroleum University Daqing China

Dimethyldistearylammonium Bromide (DODMAB) is a bentonite modifier with good performance. In this experiment, 1-Bromooctadecane is the raw material, and completes tertiary amination and quaternization successively by changing the condition of experiment. The result is that the productivity can achieve 78.94% in the synthesis of DODMAB. It has been used in the experiment of bentonite modification and achieves good results;compared with using trimethylstearylammonium bromide as the organic modifier, the synthetic organic bentonite has better performance than the common organic modifier when used in the oil base drilling fluid of oilfield operation.

关键词： Organic Modifier Stepwise Synthesis Performance Evaluation

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马兰井田异常煤层气井的成因分析

煤矿安全 2018年第11期49卷 172-175,179页

作者：李驰连清旺太原理工大学山西太原030024

通常煤层的含气量越高,对应的煤层气井开发潜力越大,然而受地质、工程、排采因素影响,高含气煤层气井也时有低产或不产气的状况发生,导致煤层气开发出现严重亏损。通过分析马兰井田内异常井(高含气不产气)的地质、压裂、排采特征,得出... 详细信息

通常煤层的含气量越高,对应的煤层气井开发潜力越大,然而受地质、工程、排采因素影响,高含气煤层气井也时有低产或不产气的状况发生,导致煤层气开发出现严重亏损。通过分析马兰井田内异常井(高含气不产气)的地质、压裂、排采特征,得出了其成因机理及提出了相应的改造措施:异常井具有高含气不产气、压裂曲线异常、异常高产水、水化学异常的特点,各异常特征存在因果联系;导致异常井高含气却不产气的直接原因是长期高产水,而根本原因钻井过程中造成了2号煤层与含水层的连通;针对异常井的成因,建议通过封堵2号煤层处的射孔,仅对8号煤层进行采气。

关键词：马兰井田成因分析气井改造异常井煤层气井