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Temperature elevated N ion implantation of Ti6A14V alloys using the plasma source

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Nuclear Science and Techniques 2001年第3期12卷 177-182页

作者： zhao qing, zheng Yong-Zhen, Mo Zhi-Tao, TONG Hong-Hui, GENG Man (Southwestern Institute of Physics, Chengdu 610041 核工业总公司西南物理研究院四川成都 610041

Specimens of Ti6A14V alloy were implanted with nitrogen ions of 4× 1018 cm-2 at temperatures from 100 to 600℃. Auger Electron Spectroscopy (AES), microhardness measurements and pin-on-disk wear testing, Scanning Electron Mi- croscopy (SEM), and Glancing angle X-ray Diffraction. (XRD) were utilized to evaluate the surface property improvements. The thickness of implanted layers increased by about an order of magnitude when the temperature was elevated from 100 to 6000℃. Higher surface hardness and wear resistance were also obtained in the high tempera-ture implantation. The XRD image showed the presence of nitrides of titanium at the implanted surface.

关键词：等离子体 Ti6Al4V合金高温氮离子移植

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人乳头瘤病毒治疗性疫苗研究进展

中国医学科学院学报 2007年第5期29卷 685-690页

作者：刘波赵清正中国医学科学院北京协和医学院肿瘤研究所细胞生物学与分子生物学研究室北京100021

人乳头瘤病毒(HPV)感染引起的疾病流行广泛,但现有治疗手段有限。尽管HPV预防性疫苗即将在世界范围内推广,但从中受益还需数十年时间,而且对于已感染HPV且出现病变的患者,预防性疫苗作用不大。HPV治疗性疫苗主要是针对已感染HPV的患者,... 详细信息

人乳头瘤病毒(HPV)感染引起的疾病流行广泛,但现有治疗手段有限。尽管HPV预防性疫苗即将在世界范围内推广,但从中受益还需数十年时间,而且对于已感染HPV且出现病变的患者,预防性疫苗作用不大。HPV治疗性疫苗主要是针对已感染HPV的患者,其类型有病毒/细菌载体疫苗、肽疫苗、蛋白疫苗、DNA疫苗、细胞疫苗等。

关键词：人乳头瘤病毒疫苗治疗

Correlation between 1,5-anhydroglucitol and glycemic excursions in type 2 diabetic patients

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Chinese Medical Journal 2011年第22期124卷 3641-3645页

作者： SUN Jie DOU Jing-tao WANG Xian-ling YANG Guo-qing LU zhao-hui zheng Hua MA Fang-ling LU Ju-ming MU Yi-ming Department of Endocrinology Chinese People＇s Liberation Army General Hospital Beijing 100853 China

Background The accurate and comprehensive assessment of glycemic control in patients with diabetes is important for optimizing glycemic management and for formulating personalized diabetic treatment schemes. This study aimed to analyze the correlation between 1,5-anhydroglucitol （1,5-AG） and glycemic excursions in type 2 diabetic patients. Methods Seventy-one outpatients with type 2 diabetes mellitus were randomly recruited from Chinese People＇s Liberation Army General Hospital. Using a continuous glucose monitoring system （CGMS）, these patients＇ blood glucose levels were monitored for three consecutive days to obtain mean blood glucose （MBG） data. Intraday glycemic excursions were evaluated using the mean amplitude of glycemic excursions （MAGE）, the largest amplitude of glycemic excursions （LAGE）, standard deviation of blood glucose （SDBG） and the M-value. Interday glycemic excursion was assessed by absolute mean of daily difference （MODD）. Postprandial glycemic fluctuations were evaluated using postprandial glucose excursions （PPGE） and postprandial incremental area under the curve （iAUC）. Fasting venous blood samples were collected to measure serum 1,5-AG, whole-blood hemoglobin Alc （HbAlc） and serum glycated albumin （GA）. Clinical markers of glycemia and parameters of glycemic excursions from CGMS were analyzed using the Pearson correlation coefficient and multivariate stepwise regression. Results Pearson correlation analysis revealed that 1,5-AG was significantly correlated with MAGE, SDBG, M-value, LAGE, PPGE and iAUC （r values were-0.509,-0.430,-0.530,-0.462,-0.416 and-0.435, respectively, P 〈0.01）, especially in moderately and well-controlled patients, based on defined HbAlc levels. Multivariate stepwise regression analysis revealed a negative correlation between 1,5-AG and the above parameters, but not HbAlc and GA. Finally, HbAlc and GA were positively correlated with MBG and fasting blood glucose （FBG）. Conclusions 1,5-AG was much better than HbAlc and GA

关键词： 1,5-anhydroglucitol type 2 diabetes mellitus glycemic excursions

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia Ma Ke Ye Xue zhao Fangliang Ge Feifei zheng Lulu Liu Xu Gao Dayong Wang qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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热塑料板膜工艺与热塑料教具

物理实验 2003年第6期23卷 19-21页

作者：赵志清赵政江苏大学江苏镇江212003

热塑料板膜工艺是用热成型方法制作单件塑料教具和塑料配件的一种技术 ,它为无塑料制品生产能力的大、中院校物理、化学、生物实验室在研制教学仪器或做仿真制品时提供可行的石膏——锡模方法 .教师采用该工艺 ,可在无现成模具和无注塑... 详细信息

热塑料板膜工艺是用热成型方法制作单件塑料教具和塑料配件的一种技术 ,它为无塑料制品生产能力的大、中院校物理、化学、生物实验室在研制教学仪器或做仿真制品时提供可行的石膏——锡模方法 .教师采用该工艺 ,可在无现成模具和无注塑设备的条件下生产塑料教具 ,并可为计算机虚拟教学 ,提供实体模型 .

关键词：热塑料板膜工艺热成型塑料教具石膏-锡模方法教学仪器菲涅耳透镜热塑性塑料

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多阶并联式磁流变缓冲器可控性分析

浙江大学学报（工学版） 2017年第5期51卷 961-968页

作者：欧阳青李赵春郑佳佳王炅南京理工大学机械工程学院江苏南京210094 南京林业大学机械电子工程学院江苏南京210094

为了实现磁流变缓冲器多维灵活可调的阻尼输出,设计多阶并联式线圈结构的磁流变缓冲器,并以火炮后坐缓冲为研究背景,讨论该新型缓冲器动态特性.利用各线圈可独立加载控制特点,对不同工作线圈、电流组合加载及各线圈延时加载进行冲击试验... 详细信息

为了实现磁流变缓冲器多维灵活可调的阻尼输出,设计多阶并联式线圈结构的磁流变缓冲器,并以火炮后坐缓冲为研究背景,讨论该新型缓冲器动态特性.利用各线圈可独立加载控制特点,对不同工作线圈、电流组合加载及各线圈延时加载进行冲击试验,分别分析磁流变效应在几何维度、时间维度上的变化对缓冲性能的影响.对比分析并联式磁流变缓冲器的优势.结合后坐缓冲模型及冲击试验结果,分析缓冲器在火炮后坐缓冲的可控性.研究表明:多阶并联式磁流变缓冲器可以通过改变几何维度及时间维度上电流加载实现多变的阻尼特性输出,然而由于缓冲器结构未能优化设计,导致缓冲器的可调系数不高,当最大后坐速度小于2.16m/s时可以实现部分后坐输出理想阻尼力.

关键词：磁流变液缓冲器反后坐装置冲击载荷可控特性

Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China

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Chinese Medical Journal 2011年第14期124卷 2113-2116页

作者： HAO Ying WU Bao-gang SHI Jin CHEN Yan-li SUN zhao-qing zheng Li-qiang ZHANG Xin-gang GENG Ning LI Tie-jun LI Hong SUN Ying-xian Department of Cardiology First Hospital of China Medical University Shenyang Liaoning 110001 China

Background Genetic mechanisms contribute to blood pressure regulation. This study investigated whether glutathione peroxidase （GPx-3） tag single nucleotide polymorphisms （SNPs） are associated with hypertension in the rural areas of Fuxin county, Liaoning province, *** Indigenous Fuxin Han people participated, 523 unrelated hypertensives and 547 controls were recruited. All tag SNPs of GPx-3 gene were selected. We estimated SNP allele frequency in DNA pools with *** Before Bonferroni correction, C allele frequency for rs8177417 was significantly higher in hypertensives than those in controls （23.4% vs. 19.3%, P=0.014）; T allele frequency for rs3828599 was significantly lower in hypertensives than those in controls （35.6% vs. 40.8%,P=0.009）. However, when a Bonferroni correction for multiple testing was applied, only the polymorphisms rs3828599 of GPx-3 gene was associated with hypertension （P=0.045, OR： 0.833, 95%CI： 0.695-0.998）.Conclusion The polymorphism of rs3828599 of GPx-3 gene might be associated with hypertension in rural Han Chinese from Fuxin, Liaoning.

关键词： hypertension Han Chinese GPx-3 gene association

Preparation of FeCoNi medium entropy alloy from Fe^(3+)-Co^(2+)-Ni^(2+)solution system

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 92-101页

作者： Zongyou Cheng qing zhao Mengjie Tao Jijun Du Xingxi Huang Chengjun Liu Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical *** controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower *** this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen *** phases and magnetic properties of FeCoNi medium entropy alloy were *** showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal *** alloy prepared by hydrogen reduction was uniform and showed a relatively high ***,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.

关键词： medium entropy alloy sol-gel co-precipitation carbothermal hydrogen reduction

Precise gradient separation of nanoparticles using reduced graphene oxide-polyoxomolybdate membranes

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Science China Chemistry 2025年第01期 209-216页

作者： Yixin Yang Wanlei zhao Ruoxuan zheng Hongqiang Li Wei Chen Yu-Fei Song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Quzhou Institute for Innovation in Resource Chemical Engineering

The purification and size sieving of nanoparticles （NPs） represents a significant scientific ***,the r GO-polyoxometalates (POMs=PMo12,Mo132and Mo368) membranes were fabricated successfully via a simple and scalable POMsassisted in-situ photoreduction *** the mass ratio of r GO to PMo12was 1:30,the resultant r GO-PMo12membranes with highly ordered and uniform nanochannels of 1.0 nm can be obtained,which showed an accurate carbon quantum dots（CQDs） separation with a cut-off size approximately 1.0 *** increase of the size of the interlayered POMs from PMo12（1.0 nm）,{Mo132}（2.9 nm） to{Mo368}（3.8 nm）,the resultant r GO-PMo12,r GO-Mo132and r GO-Mo368exhibited precise gradient separation of CQDs and Au nanoparticles by size exclusion *** results pave a promising way to construct new twodimensional （2D） membranes for highly efficient size-selective separation.

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