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Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie liu qinghua zeng qing Tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

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Changes in Plasma Angiotensin II and Circadian Rhythm of Blood Pressure in Hypertensive Patients with Sleep Apnea Syndrome Before and After Treatment

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Chinese Medical Sciences Journal 2011年第1期26卷 9-13页

作者： Hai-ling Wang Yu Wang Ying Zhang Yun-dai Chen Xin-chun Wang Zhi-xuan liu Guo-li Jing Hai-feng Tong Yuan Tian qing-zeng liu Department of Heart and Circulation 263 Clinical Department of Beijing PLA General Hospital Beijing 101149 China Department of Otolaryngology-Head and Neck Surgery 263 Clinical Department of Beijing PLA General Hospital Beijing 101149 China Department of Cardiology Chinese PLA General Hospital Beijing 100853 China Department of Emergency the 2nd Affiliated Hospital of Harbin Medical University Harbin 150001 China

Objective To explore the changes in plasma angiotensin II （Ang Ⅱ） and circadian rhythm of blood pressure among hypertensive patients with sleep apnea syndrome （SAS） before and after continuous positive airway pressure （CPAP） or surgical treatment. Methods A total of 180 essential hypertension patients were enrolled in our study. The determination of plasma Ang Ⅱ concentration, ambulatory blood pressure （ABP）, and polysomnography （PSG） monitoring were performed before and 3 months after CPAP or surgical treatment. Results Patients were classified into three groups by their apnea-hypopnea index （AHI）： essential hypertension group （EH group, n=72; AHI〈5）, essential hypertension with mild SAS group （EH＋mild SAS group, n=60, 5≤AHI〈20）, and essential hypertension with moderate and severe SAS group （EH＋moderate-severe SAS group, n=48, AHI_〉20）. The concentrations of plasma AngⅡ in the above three groups were 13.42±3.27, 16.17±3.82, and 18.73±4.05 ng/mL respectively before treatment, and AngⅡ concentration in EH patients combined with SAS was significantly higher than that in EH group （all P〈0.05）. After treatment the values in the latter two groups significantly decreased to 14.67±2.56 and 15.03±3.41 ng/mL respectively （P〈0.05）. The incidence of non-dipper blood pressure curve in EH patients was 31.9%, and those in hypertensive patients with mild SAS and moderate-severe SAS were 51.7% and 58.3%, respectively before treatment. The incidence of non-dipper blood pressure curve in the EH patients with mild SAS was significantly higher than that of patients with EH alone （P〈0.05）. After CPAP treatment or surgery, the incidence of non-dipper blood pressure curve in the two SAS groups was significantly decreased to 38.3% and 39.6%, respectively （P〈0.05）. Conclusions Ang Ⅱ might play a role in blood pressure variability in patients with obstructive SAS. CPAP or surgical treatment can improve blood pressure disorder and decrease plasma Ang Ⅱ level in patients with obstructive SA

关键词： hypertension sleep apnea syndrome circadian rhythm of blood pressure angiotensin Ⅱ continuous positive airway pressure surgery

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Preparation of FeCoNi medium entropy alloy from Fe^(3+)-Co^(2+)-Ni^(2+)solution system

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 92-101页

作者： Zongyou Cheng qing Zhao Mengjie Tao Jijun Du Xingxi Huang Chengjun liu Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical *** controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower *** this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen *** phases and magnetic properties of FeCoNi medium entropy alloy were *** showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal *** alloy prepared by hydrogen reduction was uniform and showed a relatively high ***,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.

关键词： medium entropy alloy sol-gel co-precipitation carbothermal hydrogen reduction

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惯性信息辅助的快速大视角图像匹配方法

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中国惯性技术学报 2016年第4期24卷 504-510页

作者：王云舒刘建业曾庆化刘昇南京航空航天大学自动化学院南京211106 卫星通信与导航协同创新中心南京211106 中航工业洛阳电光设备研究所洛阳471009

大视角图像匹配算法的鲁棒性与实时性直接影响飞行器对远距离目标定位的性能。针对目前仿射不变图像匹配算法实时性较差的问题,提出一种惯性信息辅助的快速大视角图像匹配方法。该方法对现有的快速图像匹配算法进行改进,避免了构建高斯... 详细信息

大视角图像匹配算法的鲁棒性与实时性直接影响飞行器对远距离目标定位的性能。针对目前仿射不变图像匹配算法实时性较差的问题,提出一种惯性信息辅助的快速大视角图像匹配方法。该方法对现有的快速图像匹配算法进行改进,避免了构建高斯金字塔,提高了算法效率。然后利用机载惯性导航信息求解实时图与参考图之间的单应性矩阵,并对实时图进行模拟视角变换以此减小图像间视角差异,克服了现有的大视角图像匹配算法盲目多次的匹配计算,实现了大视角图像的快速匹配。实验结果表明,惯性信息辅助的大视角图像匹配算法与现有的快速仿射不变性匹配算法相比,匹配效率提高了至少2倍。

关键词：大视角图像仿射不变性惯性导航图像匹配目标定位

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Conversion-type cathode materials for high energy density solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 409-425页

作者： Yuhao Ma Shihong qing Hongyu liu Chuntao Ma Yuan Yu Chuang Yu Liping Wang School of Materials and Energy University of Electronic Science and Technology of China Zhejiang Provincial Key Laboratory of Fiber Materials and Manufacturing Technology Zhejiang Sci-Tech University State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic Engineering Huazhong University of Science and Technology

Solid-state lithium batteries （SSLBs） are regarded as an essential growth path in energy storage systems due to their excellent safety and high energy *** particular,SSLBs using conversion-type cathode materials have received widespread attention because of their high theoretical energy densities,low cost,and *** the great progress in research and development of SSLBs based on conversiontype cathodes,their practical applications still face challenges such as blocked ionic-electronic migration pathways,huge volume change,interfacial incompatibility,and expensive processing *** review focuses on the advantages and critical issues of coupling conversion-type cathodes with solid-state electrolytes （SSEs）,as well as state-of-the-art progress in various promising cathodes （e.g.,FeS2,CuS,FeF3,FeF2,and S） in ***,representative research on conversion-type solid-state full cells is discussed to offer enlightenment for their practical ***,the energy density exhibited by the S cathode stands out impressively,while sulfide SSEs and halide SSEs have demonstrated immense potential for coupling with conversion-type ***,perspectives on conversion-type cathodes are provided at the material,interface,composite electrode,and battery levels,with a view to accelerating the development of conversion-type cathodes for high-energy–density SSLBs.

关键词： Sulfur compounds

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Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing liu Hongli Li Lemei Zhu Lingfeng zeng Zhen Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

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论“团一大”的召开及其历史意义

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广东青年研究 2022年第2期36卷 52-57页

作者：曾庆榴中共广东省委党校中共广东省委党史研究室广州市团校广东省团校、广东青年干部学院广东省团校、广东青年政治学院粤港澳大湾区青年学院广东省团校、广东青年政治学院青年发展研究院

习近平总书记在庆祝中国共产主义青年团成立100周年大会上的重要讲话中指出:“1922年5月5日,在中国共产党直接关怀和领导下,中国共产主义青年团宣告成立。这在中国革命史和青年运动史上具有里程碑意义!”参见习近平:《在庆祝中国共产主... 详细信息

习近平总书记在庆祝中国共产主义青年团成立100周年大会上的重要讲话中指出:“1922年5月5日,在中国共产党直接关怀和领导下,中国共产主义青年团宣告成立。这在中国革命史和青年运动史上具有里程碑意义!”参见习近平:《在庆祝中国共产主义青年团成立100周年大会上的讲话》,北京:人民出版社2022年版,第2-3页。中国社会主义青年团第一次全国代表大会(以下简称“团一大”)在广州召开,是广州共产党、青年团组织从实际出发,审时度势,主动向中央提请的结果,主要是因为当时广州的社会政治环境“比较的自由”;“团一大”宗旨明确,主义昭彰,高举马克思主义的旗帜,对中国青年运动具有举旗意义;“团一大”的《中国社会主义青年团纲领》(以下简称《纲领》)和有关“议决案”的提出,是党的观念更新、理论创新、方针政策调整的前奏,是党面向国民革命(民主革命)、同国民党合作的探索之作,具有理论破冰的意义;“团一大”对轰轰烈烈的国民革命运动起了铺垫作用。

关键词：中国青年运动中国社会主义青年团团一大从实际出发社会政治环境中国革命史国民革命方针政策

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Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： Lei Xue Tong Shi Chenhui Han Heng Zhang Fenrong liu Haorun Li Yan Wang Xiaojun Gu Shanghong zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Nanorods

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读黄埔军校共产党人存文

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岭南文史 2024年第1期 1-4页

作者：曾庆榴中共广东省委党校

大革命时期黄埔军校共产党员有千人以上。他们在工作、学习时在各种报刊上发表了大量马克思主义中国化的起步之作,成为研究黄埔军校,乃至中国政治思想史的十分珍贵的历史文献,也是今天弘扬革命文化、传承红色基因的重要内容,应该引起充... 详细信息

大革命时期黄埔军校共产党员有千人以上。他们在工作、学习时在各种报刊上发表了大量马克思主义中国化的起步之作,成为研究黄埔军校,乃至中国政治思想史的十分珍贵的历史文献,也是今天弘扬革命文化、传承红色基因的重要内容,应该引起充分重视,加强对这些作品的搜集、整理、研究和利用工作。

关键词：黄埔军校共产党人之作意义

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共产党人在广东参加国民党军队抗日的若干史实

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岭南学刊 2005年第5期 21-25页

作者：曾庆榴中共广东省委党校

抗日时期共产党员在广东参加国民党军队抗日,是中共广东省委的一项重要决策,也是在国共合作的大气候下广东部分抗日将领的一项开明举措。当时参与的中共党员人数不少,涉及的部队或军事组织较多,坚持的时间也比较长,对壮大抗日民族统一战... 详细信息

抗日时期共产党员在广东参加国民党军队抗日,是中共广东省委的一项重要决策,也是在国共合作的大气候下广东部分抗日将领的一项开明举措。当时参与的中共党员人数不少,涉及的部队或军事组织较多,坚持的时间也比较长,对壮大抗日民族统一战线,推动广东国民党军队抗日,坚持持久抗战,起了重要和积极的作用。这是华南抗战史的一个重要组成部分。

关键词：华南抗战国共合作广东地方党史

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