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柑橘PGIP的B细胞抗原表位分析和原核表达

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现代食品科技 2018年第4期34卷 18-22,29页

作者：陈波罗庆华谭雅芹闫慧清贵州师范大学生命科学学院贵州贵阳550001

柑橘是重要的经济园艺植物,但是部分人群在食用柑橘后会造成过敏现象,其中多聚半乳糖醛酸酶抑制蛋白(PGIP)是柑橘中重要的过敏原。本文利用Jameson-Wolf法、Kyte-Doolittle法、Emini法和Karplus-Schulz法对柑橘过敏原蛋白PGIP的抗原指... 详细信息

柑橘是重要的经济园艺植物,但是部分人群在食用柑橘后会造成过敏现象,其中多聚半乳糖醛酸酶抑制蛋白(PGIP)是柑橘中重要的过敏原。本文利用Jameson-Wolf法、Kyte-Doolittle法、Emini法和Karplus-Schulz法对柑橘过敏原蛋白PGIP的抗原指数、亲水性、蛋白表面可及性及柔韧性进行分析,通过构建PET-28 a-PGIP载体转移到大肠杆菌(Escherichia coli)中进行原核表达。结果表明:当PGIP二级结构是β-转角和无规则卷曲,同时氨基酸序列的抗原指数>0、柔韧性>0、亲水性>0和蛋白表面可及性>1时的氨基酸时,过敏原蛋白PGIP的B细胞表位结合氨基酸的序列区域是在19~22、37~41、49~52、68~69、117~120、163~164、173~177、221~226、236~240。通过分析氨基酸的区域及原核表达,为寻找柑橘过敏原蛋白PGIP的B细胞抗原表位的最佳优势区域提供支持,同时也为消除柑橘过敏原蛋白PGIP对人体的影响的进一步研究提供理论基础。

关键词：柑橘多聚半乳糖醛酸酶抑制蛋白 B细胞表位

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan yang Zhi-Cheng Zhang Qi Dai Xiao-yan Bao Lin-Jie Wu ya-Xin Qin Xin tan Xiao-yan Sun Xu-Fang Ying Zhi-qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

A mathematical model of cortical bone remodeling at cellular level under mechanical stimulus

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Acta Mechanica Sinica 2012年第6期28卷 1678-1692页

作者： qing-Hua Qin ya-Nan Wang Research School of Engineering The Australian National University

A bone cell population dynamics model for cor- tical bone remodeling under mechanical stimulus is devel- oped in this paper. The external experiments extracted from the literature which have not been used in the creation of the model are used to test the validity of the model. Not only can the model compare reasonably well with these ex- perimental results such as the increase percentage of final values of bone mineral content （BMC） and bone fracture en- ergy （BFE） among different loading schemes （which proves the validity of the model）, but also predict the realtime devel- opment pattern of BMC and BFE, as well as the dynamics of osteoblasts （OBA）, osteoclasts （OCA）, nitric oxide （NO） and prostaglandin E2 （PGE2） for each loading scheme, which can hardly be monitored through experiment. In conclusion, the model is the first of its kind that is able to provide an in- sight into the quantitative mechanism of bone remodeling at cellular level by which bone cells are activated by mechan- ical stimulus in order to start resorption/formation of bone mass. More importantly, this model has laid a solid foun- dation based on which future work such as systemic control theory analysis of bone remodeling under mechanical stimu- lus can be investigated. The to-be identified control mecha- nism will help to develop effective drugs and combined non- pharmacological therapies to combat bone loss pathologies. Also this deeper understanding of how mechanical forces quantitatively interact with skeletal tissue is essential for the generation of bone tissue for tissue replacement purposes in tissue engineering.

关键词： Cortical bone remodeling Cell population dy-namics Mechanotransduction Mechanosensitivity Bonefracture energy - Bone mineral content

Mechanism Study on Char Formation of Zinc Acetylacetonate on ABS Resin

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Chinese Journal of Polymer Science 2015年第5期33卷 772-782页

作者： ya-qing Ma 庞永艳 Polymers and Composites Division Ningbo Institute of Materials Technology & EngineeringChinese Academy of Sciences

The mechanism of char formation effect of zinc acetylacetonate（Zn（acac）2） on acrylonitrile-butadiene-styrene copolymer（ABS） was studied. Thermal gravimetric analysis（TGA） was used to study the mass loss and char yield of ABS composites. In situ temperature-dependent Fourier transform infrared spectroscopy（FTIR） was used to characterize the chemical change during thermal decomposition. Roman spectroscopy and scanning electron microscopy（SEM） were applied to characterize the structure and morphology of the char after combustion. Results showed that the presence of Zn（acac）2 not only slowed down thermal decomposition of the ABS composites, but also increased the charred residue. A more compact and denser char layer with higher graphitization degree was formed for ABS composites with Zn（acac）2. To study the char formation mechanism of Zn（acac）2 on ABS, thermal decomposition was analyzed for the composites of Zn（acac）2 with PB, PS and SAN, respectively. Also, the chemical structure change was investigated for Zn（acac）2 during thermal decomposition. Based on these results, it was deduced that the increase of char yield of ABS composites was probably attributed to the interaction between the units of acrylonitrile in ABS and zinc acetate, produced during the thermal decomposition of Zn（acac）2. A proposed mechanism for crosslinking and the subsequent char formation was presented.

关键词： Char formation ABS Zinc acetylacetonate Mechanism Decomposition

Projected increases in population exposure of daily climate extremes in eastern China by 2050

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Advances in Climate Change Research 2021年第6期12卷 804-813页

作者： SUN Shao DAI tan-Long WANG Zun-ya CHOU Jie-Ming CHAO qing-Chen SHI Pei-Jun Laboratory for Climate Studies National Climate CenterChina Meteorological AdministrationBeijing100081China Cooperative Institute for Research in Environmental Sciences University of ColoradoBoulderCO80309USA Faculty of Geographical Science Beijing Normal UniversityBeijing100875China

Climate extremes pose severe threats to human health,economic stability and environmental sustainability,especially in densely populated *** is generally believed that global warming drives increase in frequency,intensity and duration of climate extremes,and socioeconomic exposure plays a dominant role in climate *** order to promote climate risk governance at regional level,the historical and projected trends in the population exposure to climate extremes are quantified in eastern China using downscaled climate simulations and population growth *** frequency of temperature extremes(tx35days)is projected to more than double by 2050 in nearly half of prefecture-level cities in eastern China,leading to an 81.8%increment of total exposure under SSP2-4.5 *** increasing trend is also detectable in the frequency of precipitation extremes(r20mm)in eastern China,and the exposure increment is projected to be 22.9%by 2050,with a near equivalent contributions of both climate change and population ***,temperature exposure mainly grows in southern Hebei,western Shandong and inland Guangdong provinces,while precipitation exposure raises principally in southeast coastal areas of *** on the historical baseline and projected amplification of population exposure,we identify some hotspot cities such as Guangzhou,Shanghai,Dongguan and Hangzhou that response to climate change dramatically and confront greater potential risk of climate extremes in the coming future.

关键词： Climate projection Extreme events Population exposure Future scenario Eastern China

Effects of phosphate solubilization and phytohormone production of Trichoderma asperellum Q1 on promoting cucumber growth under salt stress

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Journal of Integrative Agriculture 2015年第8期14卷 1588-1597页

作者： ZHAO Lei ZHANG ya-qing College of Life Science Shandong Normal University

Salinity is one of the major abiotic stresses limiting crop growth and *** study investigated the underlying mechanisms of Trichoderma asperellum Q1 in promoting cucumber growth under salt stress, including the abilities of the strain to solubilize phosphate and to produce *** results showed that *** Q1 could solubilize inorganic or organic phosphate and the activities of phosphatases and phytase could be detected in the culture *** hydroponic experiments, the growth of cucumber seedlings was increased in the hydroponic system treated by culture filtrate of strain Q1 with tricalcium phosphate or calcium phytate under salt *** strain also exhibited the ability to produce indole acetic acid（IAA）, gibberellic acid（GA） and abscisic acid（ABA） in liquid medium without any *** levels of those three phytohormones in cucumber seedling leaves also increased after inoculated with this strain, along with increased root growth and root activities of the *** results demonstrated the mechanisms of *** Q1 in alleviating the suppression effect of salt stress involving the change of phytohormone levels in cucumber plant and its ability of phosphate solubilization.

关键词： Trichoderma asperellum Q1 cucumber seedlings phosphate solubilization phytohormone salt stress

Scutellaria baicalensis, the golden herb from the garden of Chinese medicinal plants

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Science Bulletin 2016年第18期61卷 1391-1398页

作者： qing Zhao Xiao-ya Chen Cathie Martin Plant Science Research Center Shanghai Chenshan Botanical Garden Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai 201602 China Department of Metabolic Biology John Innes CentreNorwich NR4 7UH UK Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of SciencesShanghai 200032 China

Scutellaria baicalensis Georgi, or Chinese skullcap, has been widely used as a medicinal plant in China for thousands of years, where the preparation from its roots is called Huang-Qin. It has been applied in the treatment of diarrhea, dysentery, hypertension, hemorrhaging, insomnia,inflammation and respiratory infections. Flavones such as baicalin, wogonoside and their aglycones baicalein wogonin are the major bioactive compounds extracted from the root of S. baicalensis. These flavones have been reported to have various pharmacological functions, including anti-cancer,hepatoprotection, antibacterial and antiviral, antioxidant,anticonvulsant and neuroprotective effects. In this review,we focus on clinical applications and the pharmacological properties of the medicinal plant and the flavones extracted from it. We also describe biotechnological and metabolic methods that have been used to elucidate the biosynthetic pathways of the bioactive compounds in Scutellaria.

关键词： Scutellaria baicalensis Flavonoids Anti-cancer Metabolic biology Medicinal plants

Decentralized and Privacy-Preserving Low-Rank Matrix Completion

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Journal of the Operations Research Society of China 2015年第2期3卷 189-205页

作者： An-ya Lin qing Ling Department of Automation University of Science and Technology of ChinaHefeiChina

In this paper,we propose a decentralized algorithm to solve the low-rank matrix completion problem and analyze its privacy-preserving *** that we want to recover a low-rank matrix D=[D1,D2,・・・,DL]from a subset of its *** a network composed of L agents,each agent i observes some entries of *** factorize the unknown matrix D as the product of a public matrix X which is common to all agents and a private matrix Y=[Y1,Y2,・・・,YL]of which Yi is held by agent i *** agent i updates Yi and its local estimate of X,denoted by X(i),in an alternating *** exchanging information with neighbors,all the agents move toward a consensus on the estimates X(i).Once the consensus is(nearly)reached throughout the network,each agent i recovers Di=X(i)Yi,thus D is *** this progress,communication through the network may disclose sensitive information about the data matrices Di to a malicious *** prove that in the proposed algorithm,D-LMaFit,if the network topology is well designed,the malicious agent is unable to reconstruct the sensitive information from others.

关键词： Decentralized algorithm Matrix completion Privacy-preserving

A New Inequality for Weakly (K_1,K_2)-Quasiregular Mappings

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Acta Mathematica Sinica,English Series 2007年第12期23卷 2241-2246页

作者： Hong ya GAO Shu qing ZHOU ChinaCollege of Mathematics and Computer Hebei University Baoding 071002 P. R. Mathematical Study Center of Hebei Province Shijiazhuang 050016 P. R. China College of Mathematics and Computational Sciences Hu'nan Normal University Changsha 410081 P. R. China

We obtain a new inequality for weakly （K1,K2）-quasiregular mappings by using the McShane extension method. This inequality can be used to derive the self-improving regularity of （K1, K2）-Quasiregular Mappings.

关键词： (K1 K2)-Quasiregular mapping regularity McShane extension