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Ethambutol-induced optic neuropathy with rare bilateral asymmetry onset:A case report

World Journal of Clinical Cases 2022年第2期10卷 663-670页

作者： Wen-Yan Sheng Shuang-qing Wu ling-Ya Su li-Wei Zhu Department of Ophthalmology Affiliated Hangzhou Chest HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Ethambutol-induced optic neuropathy(EON)most commonly manifests as bilateral symmetrical loss of vision and often cause serious and irreversible visual impairment because of the lack of early detection and effective *** followed a case of EON with rare binocular asymmetric clinical manifestations and observed the changes of visual function and retinal structure after drug withdrawal,so as to further understand the clinical characteristics of this *** SUMMARY A 54-year-old man complained of gradual visual decline in the left *** patient presented with best-corrected visual acuity of 20/20 in the right eye and 20/50 in the left *** vision examination revealed difficulty in reading green color plates in the left *** visual field manifested as concentric contraction in the left *** nearly a month of drug withdrawal,the right eye had a similar decline in visual *** the last visit,19 mo after drug withdrawal,the visual function significantly recovered in both *** follow-up optical coherence tomography(OCT)examination,both eyes manifested the thickness of the retinal nerve fiber layer from mild thickening to thinning and finally temporal atrophy,and the ganglion cell-inner plexiform layer showed significant *** difference was that a reversible structural disorder in the outer retina of the nasal macula was detected in the left eye by macular high-definition *** Nephropathy and high blood pressure,which damage the retinal microcirculation,may cause damage to the outer layer of the *** may influence photoreceptor as well as retinal ganglion cells.

关键词： Ethambutol-induced optic neuropathy Retinal nerve fiber layer Ganglion cell-inner plexiform layer Optical coherence tomography Asymmetry Case report

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5-Alkylpyrrole-2-carboxaldehyde derivatives from the Chinese sponge Mycale lissochela and their PTP1B inhibitory activities

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Chinese Chemical Letters 2017年第6期28卷 1190-1193页

作者： Duo-qing Xue Hai-li liu Si-Han Chen Ernesto Mollo Margherita Gavagnin Jia li Xu-Wen li Yue-Wei Guo State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China Institute of Biomolecular Chemistry (ICB) of the National Research Council (CNR) Via Campi Flegrei 34 80078 Pozzuoli Napoli Italy

Two new 5-alkylpyrrole-2-carboxaldehyde derivatives,mycalenitrile-15（1） and mycalenitrile-16（2）,along with five known related ones（3-7）,were isolated from the South China Sea sponge Mycale *** structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis and by comparison of their NMR data with those reported in the *** bioassay,compounds 1 and 7 exhibited significant PTPIB（Protein-tyrosine phosphatase 1B,a recognized target for diabetes and obesity） inhibitory activities with IC（50） values of 8.6 and 3.1 μmoI/L,respectively.A preliminary SAR analysis of the isolated compounds with their PTP1 B inhibitory effects was described.

关键词： 5-Alkylpyrrole-2-carboxaldehyde Sponge Mycale lissochela PTP1B inhibitor Marine natural product

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RKKY interaction in helical higher-order topological insulators

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Chinese Physics B 2024年第7期33卷 587-593页

作者：金莎李健李清旭朱家骥 School of Science Chongqing University of Posts and TelecommunicationsChongqing 400065China Institute for Advanced Sciences Chongqing University of Posts and TelecommunicationsChongqing 400065China Southwest Center for Theoretical Physics Chongqing UniversityChongqing 401331Chin

We theoretically investigate the Ruderman–Kittel–Kasuya–Yosida(RKKY) interaction in helical higher-order topological insulators(HOTIs), revealing distinct behaviors mediated by hinge and Dirac-type bulk carriers. Our findings show that hinge-mediated interactions consist of Heisenberg, Ising, and Dzyaloshinskii–Moriya(DM) terms, exhibiting a decay with impurity spacing z and oscillations with Fermi energy εF. These interactions demonstrate ferromagnetic behaviors for the Heisenberg and Ising terms and alternating behavior for the DM term. In contrast, bulk-mediated interactions include Heisenberg, twisted Ising, and DM terms, with a conventional cubic oscillating decay. This study highlights the nuanced interplay between hinge and bulk RKKY interactions in HOTIs, offering insights into designs of next-generation quantum devices based on HOTIs.

关键词： magnetic impurity interactions magnetic ordering spintronics topological phases

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Ethnic differences in genetic polymorphism associated with irritable bowel syndrome

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World Journal of Gastroenterology 2020年第17期26卷 2049-2063页

作者： Qi-Yun xiao Xiu-Cai Fang xiao-qing li Gui-Jun Fei Department of Gastroenterology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Genetic polymorphism is associated with irritable bowel syndrome(IBS)in terms of susceptibility and clinical *** studies have shown that genetic polymorphism might play a key role in the onset and progression of IBS by modulating components of its pathogenesis such as the gut-brain axis,gastrointestinal motility,inflammatory activity,and immune *** underlying pathophysiological mechanisms have not been fully clarified,the potential ethnic differences that are present in worldwide genetic studies of IBS deserve *** review surveyed numerous studies focusing on IBSassociated single nucleotide polymorphisms,and investigated the ethnic disparities revealed by *** results demonstrate the need for more attention on ethnic factors in IBS-related genetic *** ethnic backgrounds into accounts and placing emphasis on disparities potentially ascribed to ethnicity could help lay a solid and generalized foundation for transcultural,multi-ethnic,or secondary analyses in IBS,for example,a *** genetic studies considering ethnic factors are greatly needed to obtain a better understanding of the pathophysiological mechanisms of IBS and to improve the prevention,intervention,and treatment of this disease.

关键词： Irritable bowel syndrome Ethnicity Genetic polymorphism Single nucleotide polymorphism Genome-wide association Pathogenesis

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Clinical characteristics of drug-induced liver injury and primary biliary cirrhosis

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World Journal of Gastroenterology 2016年第33期22卷 7579-7586页

作者： Jun Yang Ya-li Yu Yu Jin Ying Zhang Chang-qing Zheng Division II Department of GastroenterologyShengjing HospitalChina Medical University

AIM To summarize and compare the clinical characteristics of drug-induced liver injury(DIli) and primary biliary cirrhosis(PBC).METHODS A total of 124 patients with DIli and 116 patients with PBC treated at Shengjing Hospital Affiliated to China Medical University from 2005 to 2013 were included. Demographic data(sex and age),biochemical indexes(total protein,albumin,alanine aminotransferase,aspartate aminotransferase,total bilirubin,direct bilirubin,indirect bilirubin,alkaline phosphatase,and gamma glutamyltransferase),immunological indexes [immunoglobulin(Ig) A,Ig G,Ig M,antinuclear antibody,anti-smooth muscle antibody,anti-mitochondrial antibody,and anti-mitochondrial antibodies] and pathological findings were compared in PBC patients,untyped DIli patients and patients with different types of DIli(hepatocellular type,cholestatic type and mixed type). RESULTS There were significant differences in age and gender distribution between DIli patients and PBC patients. Biochemical indexes(except ALB),immunological indexes,positive rates of autoantibodies(except SMA),and number of cases of patients with different ANA titers(except the group at a titer of 1:10000)significantly differed between DIli patients and PBC patients. Biochemical indexes,immunological indexes,and positive rate of autoantibodies were not quite similar in different types of DIli. PBC was histologically characterized mainly by edematous degeneration of hepatocytes(n = 30),inflammatory cell infiltration around bile ducts(n = 29),and atypical hyperplasia of small bile ducts(n = 28). DIli manifested mainly as fatty degeneration of hepatocytes(n = 15) and spotty necrosis or loss of hepatocytes(n = 14).CONCLUSION Although DIli and PBC share some similar laboratory tests(biochemical and immunological indexes) and pathological findings,they also show some distinct characteristics,which are helpful to the differential diagnosis of the two diseases.

关键词： Drug-induced liver injury Primary biliary cirrhosis Autoantibodies Immunoglobulin Differential diagnosis Pathological findings

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Effects of COX-2 inhibitor NS-398 on IL-10 expression in rat fungal keratitis

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International Journal of Ophthalmology(English edition) 2011年第2期4卷 165-169页

作者： Na li Cheng-Ye Che li-Ting Hu Jing lin qing Wang and Gui-Qiu Zhao Department of Ophthalmology the Affiliated Hospital of Qingdao University Qingdao 266003 Shandong Province China

AIM: To investigate the expression of interleukin-10 (IL-10) and the effect of NS-398 (COX-2 inhibitor) on the expression of IL-10 in fungal keratitis in rats, and analyze its effects on anti-fungus immunity. METHODS: Ninety Wister rats were randomly divided into 3 groups. Group A was blank control group (10 eyes). Group B was fungal keratitis group (40 eyes). Group C was fungal keratitis group treated with NS-398 (40 eyes). PAS staining, 100g/L potassium hydroxide (KOH) smear and fungal culture confirmed the successful establishment of fungal keratitis model. After the central epithelium was scraped, Fusarium solani colonies were applied and contact lens was put on the right cornea of group B and C, and plane contact lens was put on the left cornea of control eyes. Phosphate buffered saline (PBS) eyedrops were given for group B and NS-398 eyedrops for group C. The expression of IL-10 on corneas of group B and C on the 1(st) day, 3(rd) days, 75(th) days, and 14(th) days were detected by immunohistochemistry and semi- quantitative reverse transcription- polymerase chain reaction (RT-PCR). RESULTS: Histopathologic examination showed neutrophil infiltration and severe tissue necrosis in ulcer cornea. PAS staining confirmed the existence of hyphae and spores in the superficial layer of stroma. In the blank and control groups almost no expression of IL-10 was detected at any observing points. In group B the expression of IL-10 increased at first and decreased thereafter. Its expression also showed significant difference at any observing points (P lightly corneal

关键词： fungal keratitis immune regulation IL-10 NS-398

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Diffusion behavior of hydrogen isotopes in tungsten revisited by molecular dynamics simulations

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Chinese Physics B 2018年第7期27卷 268-275页

作者： Mingjie Qiu Lei Zhai Jiechao Cui Baoqin Fu Min li qing Hou Key Laboratory for Radiation Physics and Technology（Ministry of Education） Institute of Nuclear Science and TechnologySichuan UniversityChengdu 610064China

Molecular dynamics simulations were performed to study the diffusion behavior of hydrogen isotopes in single-crystal tungsten in the temperature range of 300-2000 K. The simulations show that the diffusion coefficient of H isotopes exhibits non-Arrhenius behavior, though this deviation from Arrhenius behavior is slight. Many-body and anharmonic effects of the potential surface may induce slight isotope-dependence by the activation energy; however, the dependence of the pre-factor of the diffusion coefficient on the isotope mass is diminished. The simulation results for H-atom migration near W surfaces suggest that no trap mutations occur for H atoms diffusing near either W{ 100} or W{ 111 } surfaces, in contrast to the findings for He diffusion near W surfaces. Based on the H behavior obtained by our MD simulations, the time evolution of the concentration distribution of interstitial H atoms in a semi-infinite W single crystal irradiated by energetic H projectiles was calculated. The effect of H concentration on H diffusion is discussed, and the applicability of the diffusion coefficients obtained for dilute H in W is assessed.

关键词： hydrogen isotopes tungsten diffusion molecular dynamics

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Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy

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SIGNAL TRANSDUCTION AND TARGETED THERAPY 2024年第1期9卷 266页

作者： li, qing Geng, Shan Luo, Hao Wang, Wei Mo, Ya-Qi Luo, qing Wang, Lu Song, Guan-Bin Sheng, Jian-Peng Xu, Bo Chongqing Univ Shapingba Hosp Chongqing Peoples R China Chongqing Univ Canc Hosp Chongqing Key Lab Intelligent Oncol Breast Canc Chongqing Peoples R China Chongqing Univ Sch Med Chongqing Peoples R China Chongqing Univ Coll Bioengn Minist Educ Minist Educ Chongqing Peoples R China Chongqing Med Univ Affiliated Dazu Hosp Cent Lab Chongqing Peoples R China Army Med Univ Daping Hosp Canc Ctr Chongqing Peoples R China Chongqing Municipal Hlth & Hlth Comm Chongqing Peoples R China Nanjing Univ Aeronaut & Astronaut Coll Artificial Intelligence Nanjing Peoples R China

Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide. Its complexity is influenced by various signal transduction networks that govern cellular proliferation, survival, differentiation, and apoptosis. The pathogenesis of CRC is a testament to the dysregulation of these signaling cascades, which culminates in the malignant transformation of colonic epithelium. This review aims to dissect the foundational signaling mechanisms implicated in CRC, to elucidate the generalized principles underpinning neoplastic evolution and progression. We discuss the molecular hallmarks of CRC, including the genomic, epigenomic and microbial features of CRC to highlight the role of signal transduction in the orchestration of the tumorigenic process. Concurrently, we review the advent of targeted and immune therapies in CRC, assessing their impact on the current clinical landscape. The development of these therapies has been informed by a deepening understanding of oncogenic signaling, leading to the identification of key nodes within these networks that can be exploited pharmacologically. Furthermore, we explore the potential of integrating AI to enhance the precision of therapeutic targeting and patient stratification, emphasizing their role in personalized medicine. In summary, our review captures the dynamic interplay between aberrant signaling in CRC pathogenesis and the concerted efforts to counteract these changes through targeted therapeutic strategies, ultimately aiming to pave the way for improved prognosis and personalized treatment modalities in colorectal cancer.

关键词： pathogenesis targeted colorectal

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Correlation between the warning symptoms and prognosis of cardiac arrest

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World Journal of Clinical Cases 2022年第22期10卷 7738-7748页

作者： Kang Zheng Yi Bai Qiang-Rong Zhai Lan-Fang Du Hong-xia Ge Guo-Xing Wang qing-Bian Ma Department of Emergency Medicine Peking University Third HospitalBeijing 100191China Department of Emergency Medicine Beijing Friendship HospitalBeijing 100050China

BACKGROUND A low survival rate in patients with cardiac arrest is associated with failure to recognize the condition in its initial ***,recognizing the warning symptoms of cardiac arrest in the early stage may play an important role in *** To investigate the warning symptoms of cardiac arrest and to determine the correlation between the symptoms and *** We included all adult patients with all-cause cardiac arrest who visited Peking University Third Hospital or Beijing Friendship Hospital between January 2012 and December *** on population,symptoms,resuscitation parameters,and outcomes were *** Of the 1021 patients in the study,65.9%had symptoms that presented before cardiac arrest,25.2%achieved restoration of spontaneous circulation(ROSC),and 7.2%survived to *** patients with symptoms had higher rates of an initial shockable rhythm(12.2%vs 7.5%,P=0.020),ROSC(29.1%vs 17.5%,P=0.001)and survival(9.2%vs 2.6%,P=0.001)than patients without *** with the out-of-hospital cardiac arrest(OHCA)without symptoms subgroup,the OHCA with symptoms subgroup had a higher rate of calls before arrest(81.6%vs 0.0%,P<0.001),health care provider-witnessed arrest(13.0%vs 1.4%,P=0.001)and bystander cardiopulmonary resuscitation(15.5%vs 4.9%,P=0.002);a shorter no flow time(11.7%vs 2.8%,P=0.002);and a higher ROSC rate(23.8%vs 13.2%,P=0.011).Compared to the in-hospital cardiac arrest(IHCA)without symptoms subgroup,the IHCA with symptoms subgroup had a higher mean age(66.2±15.2 vs 62.5±16.3 years,P=0.005),ROSC(32.0%vs 20.6%,P=0.003),and survival rates(10.6%vs 2.5%,P<0.001).The top five warning symptoms were dyspnea(48.7%),chest pain(18.3%),unconsciousness(15.2%),paralysis(4.3%),and vomiting(4.0%).Chest pain(20.9%vs 12.7%,P=0.011),cardiac etiology(44.3%vs 1.5%,P<0.001)and survival(33.9%vs 16.7%,P=0.001)were more common in males,whereas dyspnea(54.9%vs 45.9%,P=0.029)and a non-cardiac etiology(53.3%vs 41.7%,P=0.003)were mor

关键词： Cardiac arrest Warning symptoms Immediate recognition Etiology Cardiopulmonary resuscitation Prognosis

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Stability and Thermal Property Optimization of Propylene Glycol-Based MWCNT Nanofluids

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Fluid Dynamics & Materials Processing 2023年第9期19卷 2399-2416页

作者： Xi Wang Shan qing Zhumei Luo Yiqin liu Zichang Shi Jiachen li Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming650093China Faculty of Media and Information Engineering Yunnan Open UniversityKunming650093China

Propylene glycol-based MWCNT(multi-walled carbon nanotubes)nanoﬂuids were prepared in the framework of a two-step method and by using a suitable PVP(polyvinyl pyrrolidone)*** BBD(Box-Behnken design)model was exploited to analyze 17 sets of experiments and examine the sensitivity of the absorbance to three parameters,namely the concentration of MWCNT,the SN ratio(mass ratio of carbon nanotubes to sur-factants)and the sonication *** results have revealed that,while the SN ratio and concentration of MWCNT have a strong effect on the absorbance,the inﬂuence of the sonication time is less *** sta-tistical method of analysis of variance(ANOVA)was further used to determine the F-and p-values of the *** experiments were run to validate this *** sample 2 was found to display the greatest absorbance,it was selected for stability monitoring as well as thermal conductivity and viscosity *** sample has been found to be stable;the viscosity decreased with increasing temperature;the addition of MWCNT nano-particles was more effective in improving the thermal conductivity of propylene glycol than other methods in the ***,the MWCNT nanoﬂuid based on propylene glycol exhibited higher thermal conductivity at low temperatures.

关键词： Propylene glycol thermal conductivity response surface methodology stability viscosity

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