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Long-term outcomes of gemcitabine and cisplatin in patients with recurrent or metastatic esophageal squamous cell carcinoma： a phase Ⅱ trial

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Chinese Medical Journal 2011年第23期124卷 4012-4017页

作者： HUANG Jing FAN qing-xia CHEN li liU Ai-na CAI Rui-gang HAO Xue-zhi WANG Jin-wan SUN Yan Department of Medical Oncology Cancer Institute ＆ Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100021 China

Background Esophageal cancer is the sixth most common cause of cancer-related death worldwide. Prior studies had demonstrated potential synergistic antitumor activity of gemcitabine in combination with cisplatin. Therefore, we studied the efficacy and tolerability of such combination for esophageal cancer. Methods Between October 2003 and October 2006, thirty-eight patients with metastatic or recurrent advanced squamous cell carcinoma of the esophagus were enrolled. The median number of treatment cycles per patient was 4 （range 1-7）. Gemcitabine was given at 1000 mg/m2 over 30 minutes on days 1, 8 and cisplatin 40 mg/m2 was given on days 1,2 in an every 21-day cycle. Results The median follow-up for all 38 patients was 76 months （range 11-88 months）. The overall response rate was 42.1% （95%Cl, 25.5%-56.5%）. Median progression-free survival and median survival for all patients were 4.1 months （95%C/, 3.0-5.7 months） and 10 months （95%C/, 7-12 months）, respectively. Patients with a response had significantly longer median survival compared with the patients without a response （11 months vs. 7.5 months, P=0.0069）. Overall survival at 1 year was 36.8%, at 2 years was 10.5%, and at 5 years was 5.3%. The most common grade 3-4 toxicity for all patients was leucopenia （44.7%）. Conclusions This cisplatin-gemcitabine regimen was manageable and had significant efficacy in patients with esophageal squamous cell carcinoma. Patients with a response had improved survival time. Furthermore, a small number of the Datients with metastatic esoohaaeal cancer were still alive in 5 vears with this reaimen.

关键词： chemotherapy gemcitabine cisplatin esophageal cancer

Efficient OpenMP Based Z-curve Encoding and Decoding Algorithms

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Computers, Materials & Continua 2025年第1期82卷 1313-1327页

作者： Zicheng Zhou Shaowen Sun Teng liang Mengjuan li Fengling xia School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming650500China School of Communications Information Engineering Yunnan Communications Vocational and Technical CollegeKunming650500China library Yunnan Normal UniversityKunming650500China Faculty of Civil Aviation and Aeronautics Kunming University of Science and TechnologyKunming650500China

Z-curve’s encoding and decoding algorithms are primely important in many Z-curve-based *** bit interleaving algorithm is the current state-of-the-art algorithm for encoding and decoding *** simple,its efficiency is hindered by the step-by-step coordinate shifting and bitwise *** tackle this problem,we first propose the efficient encoding algorithm LTFe and the corresponding decoding algorithm LTFd,which adopt two optimization methods to boost the algorithm’s efficiency:1)we design efficient lookup tables(LT)that convert encoding and decoding operations into table-lookup operations;2)we design a bit detection mechanism that skips partial order of a coordinate or a Z-value with consecutive 0s in the front,avoiding unnecessary iterative *** propose order-parallel and point-parallel OpenMP-based algorithms to exploit the modern multi-core *** results on discrete,skewed,and real datasets indicate that our point-parallel algorithms can be up to 12.6×faster than the existing algorithms.

关键词： Z-curve lookup table OpenMP bit detection mechanism

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黄冈市特色旅游发展浅析

湖北农业科学 2012年第9期51卷 1926-1929页

作者：陈丽军夏庆利王庆黄冈师范学院商学院湖北黄冈438000

在分析黄冈市特色旅游资源的基础上,提出黄冈市特色旅游发展应依据区域资源的独特性采取以教育旅游和名人旅游为主打品牌,以禅宗旅游、生态旅游和红色旅游为次要品牌,以其他特色旅游资源为补充的发展模式。

关键词：黄冈市特色旅游资源开发

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基于农业多功能视角的大别山试验区发展战略

湖北农业科学 2012年第17期51卷 3922-3928,F0003页

作者：夏庆利程水源王庆黄冈师范学院湖北黄冈438000

从粮食供给能力、资源环境压力、农村劳动力就业、农民增收、农耕文化传承和弘扬等方面阐述了中国农业的环境保护、农村脱贫、粮食安全和农村社会生存功能;从土地、劳动力、资本、特色农林产品资源、红色文化资源、绿色生态资源、古色... 详细信息

从粮食供给能力、资源环境压力、农村劳动力就业、农民增收、农耕文化传承和弘扬等方面阐述了中国农业的环境保护、农村脱贫、粮食安全和农村社会生存功能;从土地、劳动力、资本、特色农林产品资源、红色文化资源、绿色生态资源、古色名人资源等方面分析了大别山试验区的竞争优势;从社会经济基础、融资约束、试验区农业劳动生产率、红色旅游资源转化、环境生态压力、技术研发能力不强等方面剖析了大别山试验区发展的瓶颈。提出了发展特色种植业,保护试验区自然生态;发展生态循环农业,增强试验区可持续发展能力;发展都市休闲观光农业,带动农民就业增收;挖掘区域人文资源,唱响"四色"旅游品牌等大别山试验区发展战略。

关键词：农业多功能视角大别山试验区发展战略

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甄别湖北省低碳农业发展现状的实证分析

湖北农业科学 2013年第6期52卷 1460-1464页

作者：罗芳夏庆利黄冈师范学院商学院湖北黄冈438000

根据湖北省1980～2009年样本数据,将农业总产值指数对农业机械总动力、化肥施用量、大牲畜存栏头数、生猪存栏头数和造林面积等进行回归分析,其中,造林面积用于表征"低碳",其余解释变量代表"高碳",以此甄别湖北省低碳农业发展现状。结... 详细信息

根据湖北省1980～2009年样本数据,将农业总产值指数对农业机械总动力、化肥施用量、大牲畜存栏头数、生猪存栏头数和造林面积等进行回归分析,其中,造林面积用于表征"低碳",其余解释变量代表"高碳",以此甄别湖北省低碳农业发展现状。结果表明,仅农业机械总动力和化肥施用量对农业总产值指数有显著影响,说明湖北省农业仍处于"高碳"发展路径,低碳农业有着广阔的发展空间。计算了两个主要因素对农业总产值的贡献率后,提出了湖北省发展低碳农业的前景方略。

关键词：湖北省低碳农业现状前景

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我国农业集约化规模经营的瓶颈、根源及对策

农业现代化研究 2006年第4期27卷 266-269页

作者：夏庆利易法海华中农业大学经贸学院湖北武汉437000

本文认为:农业集约化规模经营的瓶颈是农业生产力水平不高,农民就业和保障单一,小农意识浓厚;根源是农地产权不清晰。为了解决小农经济对接大市场的困难,缓解农村人地高度紧张矛盾。文章提出:在目前政府实行一系列惠农、利农政策的有利... 详细信息

本文认为:农业集约化规模经营的瓶颈是农业生产力水平不高,农民就业和保障单一,小农意识浓厚;根源是农地产权不清晰。为了解决小农经济对接大市场的困难,缓解农村人地高度紧张矛盾。文章提出:在目前政府实行一系列惠农、利农政策的有利形势下,农业完全可以适时提出集约化规模经营;政府需要特别关注的是农地承包经营权方面的法律体系建设,加快农村土地承包经营权转让的市场建设,加大农村富余劳动力的培养力度,真正实现农民自觉参与农业集约化规模经营中来,彻底解决当前小农户、大市场的矛盾。

关键词：农业集约经营规模经营

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农民合作经济组织的发展与农业增效

湖北农业科学 2012年第24期51卷 5825-5828页

作者：王庆夏庆利程水源黄冈师范学院湖北黄冈438000

随着改革开放的深入,农业小生产与大市场之间的矛盾日益制约着广大农户融入农业市场化的进程,农业增效、农民增收面临着严峻的挑战。从农业的生产、农产品的流通和消费等3个环节分析了农业比较效益低下的成因,提出了以建立农民合作经济... 详细信息

随着改革开放的深入,农业小生产与大市场之间的矛盾日益制约着广大农户融入农业市场化的进程,农业增效、农民增收面临着严峻的挑战。从农业的生产、农产品的流通和消费等3个环节分析了农业比较效益低下的成因,提出了以建立农民合作经济组织实现农业规模经济和提高农民在市场竞争中地位的途径,从而有效促进农业的增效和农民的增收。

关键词：农业比较效益农民合作经济组织农业增效

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang Jiang Wu Xueshun Xie Pengfei xia Jinxin Lu Jiale liu Lei Bai xiang li Zhengquan Yu Haiying li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PliN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PliN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PliN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

建设项目中常见的内分泌干扰物的污染和控制建议

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中国环境监测 2018年第2期34卷 57-63页

作者：尤洋夏青李文攀敬红中国环境监测总站国家环境保护环境监测质量控制重点实验室北京100012

建设项目常见排放的内分泌干扰物主要包括二噁英类、多氯联苯和多溴联苯、砷及重金属、双酚A、苯并[a]芘和氯乙烯等。生物质燃烧和掺烧污泥的锅炉废气中的二噁英、掺烧石油焦的锅炉废气中的苯并[a]芘和化工项目排放的双酚A等均存在执行... 详细信息

建设项目常见排放的内分泌干扰物主要包括二噁英类、多氯联苯和多溴联苯、砷及重金属、双酚A、苯并[a]芘和氯乙烯等。生物质燃烧和掺烧污泥的锅炉废气中的二噁英、掺烧石油焦的锅炉废气中的苯并[a]芘和化工项目排放的双酚A等均存在执行标准缺失问题。电子类项目中的多氯联苯和多溴联苯、冶炼项目中的砷及重金属、化工类项目中的氯乙烯等也应加强全过程监管。建议研究建立优控清单,系统地提出相关控制政策,管理建设项目环境激素类的产生和排放。

关键词：内分泌干扰物二口恶英类砷及重金属双酚A 苯并[a]芘氯乙烯