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Folic Acid Modified Polymeric Micelles for Intravesical Instilled Chemotherapy

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Chinese Journal of Polymer Science 2018年第4期36卷 479-487页

作者： Dan-Hua Zhou Guan Zhang qing-song yu Zhi-Hua Gan National University of Singapore Environmental Research Institute(NERI) National University of SingaporeSingapore 117576Singapore Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-inorganic Composite MaterialsCollege of Life Science and TechnologyBeijing University of Chemical TechnologyBeijing 100029China Department of Urology China-Japan Friendship HospitalBeijing 100029China

In this study, a targeting micellar drug delivery system was developed for intravesical instilled chemotherapy of bladder cancer. The amphiphilic diblock copolymer poly（？-caprolactone）-block-poly（ethylene glycol）（PCL-b-PEO） with functional amino group（NH2） at the end of PEO block was synthesized. Then the copolymer was conjugated with folic acid（FA） and fluorescein isothiocyannate（FITC） via the PEO-NH2 terminus, and then assembled into micelles with the target moiety and fluorescence labeling. In addition, drug loaded micelles were also fabricated with anticancer drug doxorubicin（DOX） encapsulated in the hydrophobic core. The micelles were characterized in terms of size, drug loaded efficiency and critical micellization concentration（CMC） by means of DLS, UV and fluorescence spectra. In vitro cellular uptake and cytotoxicity studies showed that FA modified PCL-b-PEO-FA micelles have a greater targeting efficiency to human bladder cancer cell（T-24 cell） compared to PCL-b-PEO-NH2 micelles due to the conjugation of FA on the surface, while no targeting effect to normal tissue originated human embryonic kidney 293（HEK-293） cells was observed, enabling the micelles a promising drug carrier for intravesical instilled chemotherapy of bladder cancer.

关键词： Targeted drug delivery Superficial bladder cancer Intravesical instilled chemotherapy Folic acid Micelles

Comb-like Poly(N-(2-hydroxypropyl) methacrylamide) Doxorubicin Conjugates: The Influence of Polymer Architecture and Composition on the Biological Properties

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Chinese Journal of Polymer Science 2018年第11期36卷 1225-1238页

作者： Hao Tang Jin Tang Yi Shen Wen-Xuan Guo Min Zhou Rui-Hua Wang Ni Jiang Zhi-Hua Gan qing-song yu The State Key Laboratory of Organic-inorganic Composites Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology College of Life Science and Technology Beijing University of Chemical Technology Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology

The synthesis and structure-property correlation of poly（N-（2-hydroxypropyl） methacrylamide）（PHPMA） conjugates with various architectures including random, block, branched or star-like structures and compositions have been thoroughly explored. However, related synthesis and structure-property data are still lacking for comb-like PHPMA. In this work, we report the synthesis of comb-like PHPMA copolymer-doxorubicin （DOX） conjugates with different backbone/side-chain lengths and location of drug moieties. Well-defined comb-like PHPMA-DOX conjugates are obtained via the combination of controlled radical polymerization and fractional precipitation techniques. The influences of structural factors on the biological properties such as cellular uptake, blood circulation and tumor accumulation have been investigated. Long blood circulation and efficient tumor accumulation can be achieved by proper control of the comb number, length and location of drug moieties. These facile comb-like structures possess great potentials in future theranostics for brachytherapy or surgical navigation.

关键词： Poly(N-(2-hydroxypropyl) methacrylamide) Comb-like copolymer Anticancer drug delivery Synthesis Structure-property correlation

PHOTOELECTROCHEMICAL BEHAVIOR OF POLYANILINE FILM

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Chinese Chemical Letters 1991年第1期2卷 77-80页

作者： qing song yu Zheng TAN Fo song WANG (Changchun Institute of Applied Chemistry,Changchun 130022)

The photoelectrochemical behavior of polyaniline(PAn)film was studied in aqueous electrolyte solution containing Fe(CN)_6^(3-)/Fe(CN)_+^(4-) redox *** was found that PAn films possess the properties of p-type semiconducter and a cathodic photocurrent as high as 700μA/cm^2 was observed when irradiated under polychromatic light of 100mW/cm^2.

关键词： SCE PHOTOELECTROCHEMICAL BEHAVIOR OF POLYANILINE FILM Wang

纳米药物在非肌层浸润性膀胱癌灌注治疗中的应用

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高分子学报 2023年第1期54卷 1-13页

作者：喻青松甘志华有机无机复合材料国家重点实验室生物医用材料(北京)实验室北京化工大学生命科学与技术学院北京100029

膀胱癌是泌尿系统最常见的肿瘤之一,其中非肌层浸润性膀胱癌(NMIBC)占比高达75%以上.鉴于单纯手术治疗后好复发、易进展的特点,多个指南均推荐手术切除结合术后灌注治疗作为其标准治疗方案.化疗作为膀胱灌注治疗的主要手段,对NMIBC治疗... 详细信息

膀胱癌是泌尿系统最常见的肿瘤之一,其中非肌层浸润性膀胱癌(NMIBC)占比高达75%以上.鉴于单纯手术治疗后好复发、易进展的特点,多个指南均推荐手术切除结合术后灌注治疗作为其标准治疗方案.化疗作为膀胱灌注治疗的主要手段,对NMIBC治疗具有重要意义.然而,尿液稀释、膀胱排空以及药物直接暴露等多重因素限制,极大地制约了小分子化疗药物在膀胱灌注治疗中的应用.为改善治疗过程的安全性和疗效,多种新型给药装置或技术相继被应用于NMIBC灌注治疗,但仍难以解决毒副作用难题.随着纳米技术的发展,其在膀胱灌注治疗中的应用逐渐受到重视,为灌注治疗过程的安全性改善带来机遇.本文简要总结了目前NMIBC临床治疗或临床研究中的用药方案及新兴给药技术,并对临床NMIBC灌注治疗中所使用的纳米递送技术进行了归纳.进一步结合作者和国内外同行在膀胱灌注化疗纳米药物研究方面所开展的系列研究工作,对本领域的最新研究进展进行了总结,最后对膀胱灌注治疗纳米药物的发展趋势做出展望.

关键词：癌症治疗非肌层浸润性膀胱癌膀胱灌注治疗纳米药物

Molecular-Cytological Identification and Chromosome Behavior Analysis of Telotetrasomic in Rice

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Rice science 2008年第3期15卷 161-165页

作者： GONG Zhi-yun GAO qing-song yu Heng-xiu YI Chuan-deng Gu Ming-hong Key Laboratory of Crop Genetics and Physiology of Jiangsu Province/Key Laboratory of Plant Functional Genomics Ministry of Education Yangzhou University Yangzhou 225009 China

From the progenies of a telotrisomic of chromosome 9 short arm of an indica rice variety, Zhongxian 3037, a phenotypical variant was selected. The variant plant had rolled leaves, dispersed plant type, as well as a low seed-setting rate. Cytological and molecular cytological investigations revealed two extra chromosomes, which were the shortest in somatic cells of the variant. Fluorescent in situ hybridization （FISH） analysis using a rice centromere specific DNA （RCS2） and a DNA sequence specific for chromosome 9 on premetaphase and pachytene chromosomes showed that these two chromosomes were the short arms of chromosome 9. That is to say, the variant was a telotetrasomic of chromosome 9. Among the 25 pachytene cells, the two telosomic chromosomes paired each other to form a bivalent and didn＇t pair with other normal chromosome 9 as multivalents in 96% cells. However, the bivalent was easy to disassociate in advance.

关键词： rice telotetrasomic meiosis fluorescent in situ hybridization molecular cytology chromosome behavior

射频消融后联合伊立替康与卡培他滨化疗在结肠癌伴肝转移治疗中的价值分析

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世界华人消化杂志 2018年第14期26卷 867-872页

作者：余清松嵊州市人民医院外二科浙江省嵊州市312400

目的观察在结肠癌伴肝转移患者中,应用射频消融联合伊立替康与卡培他滨化疗的方案的临床价值.方法回顾性分析2011-07/2016-07期间,嵊州市人民医院收治的150例结肠癌伴肝转移的临床资料,所选患者均行射频消融治疗,根据射频消融后的化疗... 详细信息

目的观察在结肠癌伴肝转移患者中,应用射频消融联合伊立替康与卡培他滨化疗的方案的临床价值.方法回顾性分析2011-07/2016-07期间,嵊州市人民医院收治的150例结肠癌伴肝转移的临床资料,所选患者均行射频消融治疗,根据射频消融后的化疗方案不同分为两组,其中70例患者给予伊立替康联合氟尿嘧啶方案进行治疗,将其作为对照组,80例患者给予伊立替康联合卡培他滨方案进行治疗,将其作为观察组.然后将两组患者的临床疗效、不良反应等指标进行比较.结果经过治疗后,观察组患者的治疗总有效率为71.25%,高于对照组的64.28%,差异无统计学意义(P>0.05);观察组患者的无进展生存时间、总生存时间分别为5.3±0.8、15.1±1.9,高于对照组的4.6±0.5、12.5±1.7,差异无统计学意义(P>0.05);两组患者在脱发、肝功能损害、血小板减少的发生率上无明显差异,无统计学意义(P>0.05);观察组患者的腹泻发生率为41.43%,明显高于对照组的13.75%,差异具有统计学意义(P<0.05);观察组患者恶心、呕吐发生率、白细胞减少发生率及贫血发生率均低于对照组(12.5%、10.00%、16.25%vs 44.29%、38.57%、42.86%),差异有统计学意义(P<0.05).结论在结肠癌伴肝转移患者中应用射频消融联合伊立替康与卡培他滨化疗的治疗方案,在保证临床疗效的同时,且具有较高的用药安全性.

关键词：结肠癌肝转移卡培他滨伊立替康

Conversion-type cathode materials for high energy density solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 409-425页

作者： yuhao Ma Shihong qing Hongyu Liu Chuntao Ma yuan yu Chuang yu Liping Wang School of Materials and Energy University of Electronic Science and Technology of China Zhejiang Provincial Key Laboratory of Fiber Materials and Manufacturing Technology Zhejiang Sci-Tech University State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic Engineering Huazhong University of Science and Technology

Solid-state lithium batteries （SSLBs） are regarded as an essential growth path in energy storage systems due to their excellent safety and high energy *** particular,SSLBs using conversion-type cathode materials have received widespread attention because of their high theoretical energy densities,low cost,and *** the great progress in research and development of SSLBs based on conversiontype cathodes,their practical applications still face challenges such as blocked ionic-electronic migration pathways,huge volume change,interfacial incompatibility,and expensive processing *** review focuses on the advantages and critical issues of coupling conversion-type cathodes with solid-state electrolytes （SSEs）,as well as state-of-the-art progress in various promising cathodes （e.g.,FeS2,CuS,FeF3,FeF2,and S） in ***,representative research on conversion-type solid-state full cells is discussed to offer enlightenment for their practical ***,the energy density exhibited by the S cathode stands out impressively,while sulfide SSEs and halide SSEs have demonstrated immense potential for coupling with conversion-type ***,perspectives on conversion-type cathodes are provided at the material,interface,composite electrode,and battery levels,with a view to accelerating the development of conversion-type cathodes for high-energy–density SSLBs.

关键词： Sulfur compounds

Ideal Bi‑Based Hybrid Anode Material for Ultrafast Charging of Sodium‑Ion Batteries at Extremely Low Temperatures

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Nano-Micro Letters 2025年第3期17卷 152-167页

作者： Jie Bai Jian Hui Jia yu Wang Chun Cheng Yang qing Jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at−20°C or ***,the key capability of ultrafast charging at ultralow temperature for SIBs is rarely ***,a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue,which is synthesized via a high temperature shock *** a hybrid shows an unprecedented rate performance(237.9 mAh g^(−1)at 2 A g^(−1))at−60℃,outperforming all reported SIB anode *** with a Na_(3)V_(2)(PO_(4))_(3)cathode,the energy density of the full cell can reach to 181.9 Wh kg^(−1)at−40°*** on this work,a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

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吸毒人群增量的社会结构因素研究

华中科技大学学报（社会科学版） 2015年第4期29卷 96-102页

作者：刘能宋庆宇北京大学社会学系北京100871

自20世纪最后十年起,吸毒在中国日益成为一个显著的社会问题。中国社会科学界关于吸毒现象的研究,以定性研究和政策评估为主,且大多从吸毒者个体层面出发,去理解这一成瘾行为获得和戒除的社会机制。本文则尝试去回答这样一个问题,即在... 详细信息

自20世纪最后十年起,吸毒在中国日益成为一个显著的社会问题。中国社会科学界关于吸毒现象的研究,以定性研究和政策评估为主,且大多从吸毒者个体层面出发,去理解这一成瘾行为获得和戒除的社会机制。本文则尝试去回答这样一个问题,即在县级建制区层面,究竟哪些结构性因素决定了区域内毒情的发展趋势。利用公安部禁毒局网络数据终端"禁毒效果评估平台"中"区县信息"板块2006—2008三个年度的相关信息,采用负二项分布模型,以"新增吸毒人口数"这个反映区域毒品流行趋势的高效度指标为因变量,本文对理论假设的多组自变量——区域经济发展水平、区域(有助于毒情扩散的)风险因素和区域毒品社会控制力度——进行检验。作为以行政区域为分析单位的一个尝试性定量研究,为毒品控制这一研究领域贡献了初步的可积累知识。

关键词：吸毒毒品控制区域特征负二项模型