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A green synthesis of dihydropyrimidinones by Biginelli reaction over Nafion-H catalyst

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Chinese Chemical Letters 2007年第5期18卷 502-504页

作者： Hai Xia Lin qing jie zhao Bin Xu Xiao Hong Wang Department of Chemistry Shanghai University Shanghai 200444 China

A Nation-H catalyzed, single step and environmentally friendly process for synthesis of dihydropyrimidinones is described. This adopted protocol for Biginelli reaction has the advantages of reusability of the catalyst... 详细信息

关键词： Nation-H Dihydropyrimidinone Biginelli reaction Catalysis

Design, synthesis and antifungal activity of novel triazole derivatives

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Chinese Chemical Letters 2007年第6期18卷 670-672页

作者： qing jie zhao Yan Song Hong Gang Hu Shi Chong Yu Qiu Ye Wu School of Pharmary Second Military Medical University Shanghai 200433 China

Twenty-three 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-cycloproyl-N-substituted-amino)-2-propanols were designed and synthesized on the basis of the active site of lanosterol 14α-demethylase. In vitro antifungal activities showed that some of the title compounds had higher antifungal activity and broader antifungal spectrum than fluconazole.

关键词： Antifungal Tiazole Synthesis

A new triterpenoid from Kadsura coccinea

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Chinese Chemical Letters 2010年第11期21卷 1352-1354页

作者： Yan Song qing jie zhao Yong Sheng Jin Chuan Wei Feng Hai Sheng Chen Department of Phytochemistry School of Pharmacy Second Military Medical University Shanghai 200433 China Department of Organic Chemistry School of Pharmacy Second Military Medical University Shanghai 200433 China

A new triterpenoid,possessing a lanost-9（11）-3-one skeleton,was isolated from the roots of Kadsura coccinea,based on the spectral analysis,its structure was elucidated as 3-hydroxy-12-acetoxycoccinic acid.

关键词： Kadsura coccinea Triterpene Coccinic acid

Preparing high-purity iron by direct reduction?smelting separation of ultra-high-grade iron concentrate

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International Journal of Minerals,Metallurgy and Materials 2020年第4期27卷 454-462页

作者： Feng Li qing-jie zhao Man-sheng Chu Jue Tang Zheng-gen Liu Jia-xin Wang Sheng-kang Li School of Metallurgy Northeastern UniversityShenyang 110819China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China

A new process for preparing high-purity iron(HPI)was proposed,and it was investigated by laboratory experiments and pilot *** results show that under conditions of a reduced temperature of 1075°C,reduced time of 5 h,and CaO content of 2.5wt%,a DRI with a metallization rate of 96.5%was obtained through coal-based direct reduction of ultra-high-grade iron ***,an HPI with a Fe purity of 99.95%and C,Si,Mn,and P contents as low as 0.0008wt%,0.0006wt%,0.0014wt%,and 0.0015wt%,respectively,was prepared by smelting separation of the DRI using a smelting temperature of 1625°C,smelting time of 45 min,and CaO content of 9.3wt%.The product of the pilot test with a scale of 0.01 Mt/a had a lower impurity content than the Chinese industry *** HPI with a Fe purity of 99.98wt%can be produced through the direct reduction?smelting separation of ultra-high-grade iron concentrate at relatively low *** proposed process shows a promising prospect for application in the future.

关键词： ultra-high-grade iron concentrate high-purity iron coal-based direct reduction smelting separation pilot test

Synthesis of novel analogues of zanamivir as neuraminidase inhibitors

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Chinese Chemical Letters 2010年第11期21卷 1338-1341页

作者： Rui Sheng Xiong qing jie zhao Hang Hang Zhu Zheng Liu Ya Bing Wei Jing Shan Shen Shanghai Institute of Maieria Medica Chinese Academy of Sciences Shanghai 201203 China College of Materials Science and Engineering Nanjing University of Technology Nanjing 210009 China Topharman Shanghai Co. Ltd. Shanghai 201209 China

A versatile synthesis of novel zanamivir analogues modified at C-4 and C-8 positions was *** formation of amides from the acid with corresponding amines,followed by click chemistry generated the triazole substituted c... 详细信息

关键词： Zanamivir Triazole Click chemistry

Synthesis of mangiferin derivates and study their potent PTP1B inhibitory activity

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Chinese Chemical Letters 2007年第11期18卷 1323-1326页

作者： Hong Gang Hu Ming Juan Wang qing jie zhao Shi Chong Yu Chao Mei Liu Qiu Ye Wu Department of Chemistry College of Science Wayne State University Detroit MI 48202 United States Department of Organic Chemistry School of Pharmacy Second Military Medical University Shanghai 200433 China

Protein tyrosine phosphatase 1 B （PTP1 B） has received considerable attention from the drug industry as a potential treatment for diabetes mellitus. Mangiferin has been reported to possess significant antidiabetic activity. Based on the previous study, eight new mangiferin derivates were synthesized and evaluated for their PTP1B inhibitory activity. Some of them displayed good inhibitory activity on PTP1B.

关键词： Mangiferin Protein tyrosine phosphatase 1B Dedvates Inhibition

One-pot synthesis of 7-bromo-1-[4-(1-cyano-1-methylethyl)]-phenyl-[1,2,4]-triazole-[4,3-a]-quinoxalin

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Chinese Chemical Letters 2009年第1期20卷 52-54页

作者： Yan Yang Hong Gang Hu qing jie zhao Shi Chong Yu Zhi Gang Dan Yan Zou Qiu Ye Wu Department of Organic Chemistry School of Pharmacy Second Military Medical University Shanghai 200433 China

[1,2,4]-Triazole-[4,3-a]-quinoxaline is an important component of many drugs. The yield of the reported methods for triazole cyclization step was usually as low as 20%. In this article, the triazole cyclization step w... 详细信息

关键词： -Triazole-[4,3-a]-quinoxaline Microwave Synthesis

Study on how to elevate the discriminating ability of the discriminating model of the financial statement fraud

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Chinese Business Review 2010年第12期9卷 60-65页

作者： CHEN qing-jie zhao Hong-jin Management School University of Shanghai for Science and Technology Shanghai 200093 China

By summarizing the factor of the financial statement fraud in existing research outcome, the paper confirms the discriminating characteristic of the financial statement fraud and sets up a theoretic model to discriminate the financial statement fraud. Using radial basis function neural network, regarding to the swatch that the listed company that is punished by the Securities Regulatory Commission or the Ministry of Finance, and according to the clustering elements, validating across by set one aside, the paper verifies respectively the 22 characteristics and 31 characteristics of discriminating model. According to the clustering elements, validating across by set one aside, the paper verifies respectively the 31 characteristics and 8 characteristics selected by Fisher-ratio of discriminating model. The research outcome indicates the discriminating ability of the model including 8 characteristics is better elevated than the traditional model including 31 characteristics by comparing the disciplinary error and the forecast precision.

关键词： Fisher-ratio the discriminating ability financial statement fraud

Miller fisher syndrome with positive anti-GQ1b/GT1a antibodies associated with COVID-19 infection:A case report

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World Journal of Clinical Cases 2024年第31期12卷 6500-6505页

作者： Cheng-Qun Wei Xuan Yu Yuan-Yuan Wu qing-jie zhao Department of Neurology Huai’an HospitalHuai’an Cancer HospitalHuai’an 223001Jiangsu ProvinceChina Department of Neurology The First Affiliated Hospital of Harbin Medical UniversityHarbin 150081Heilongjiang ProvinceChina

BACKGROUND Miller fisher syndrome(MFS)is a variant of Guillain-Barrésyndrome,an acute immune-mediated peripheral neuropathy that is often secondary to viral ***-ganglioside antibodies play crucial roles in the development of *** positive rate of ganglioside antibodies is exceptionally high in MFS patients,particularly for anti-GQ1b ***,the presence of other ganglioside antibodies does not exclude *** SUMMARY We present a 56-year-old female patient who suddenly developed right blepharoptosis and progressively worsening vision in both *** were flu symptoms prior to onset,and a coronavirus disease 2019 test was *** physical examination,the patient exhibited bilateral extraocular muscle paralysis,weakened reflexes in both limbs,and impaired *** cerebrospinal fluid examination results showed no obvious *** peroneal nerve F-waves were not *** anti-GD1b IgG and anti-GT1a IgG antibodies were *** patient received intravenous methylprednisolone(1000 mg/day),with the dosage gradually ***,intravenous high-dose immunoglobulin treatment was administered for 5 days(0.4 g/kg/day)from day 2 to day 6 of *** patient’s symptoms improved after treatment with immunoglobulins and *** Positive ganglioside antibodies may be used as supporting evidence for the diagnosis;however,the diagnosis of MFS is more reliant on clinical symptoms.

关键词： Miller fisher syndrome Guillain-Barre syndrome COVID-19 Anti-GQ1b antibody Anti-GT1a antibody Case report