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The Second mKdV Equation and Its Hereditary Symmetry and Hamiltonian Structure

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Communications in Theoretical Physics 2007年第1期47卷 22-24页

作者： YAO Yu-Qin LIU Yu-qing JI jie chen Deng-Yuan Department of Mathematics Shanghai University Shanghai 200444 China

The isospectral problem of the second mKdV equation is found out firstly. It follows that the strong hereditary symmetry and the Hamiltonian structure of the second mKdV equation are presented.

关键词： the second mKdV equation hereditary symmetry Hamiltonian structure

SYNTHESIS OF CYCLIC PEPTIDES USING BBC REAGENT

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Chinese Chemical Letters 1993年第10期4卷 847-850页

作者： Shao qing chen jie cheng XU Shanghai Institute of Organic Chemistry,Academia Sinica,Shanghai 200032

We report here the synthesis of cyclic peptides using benzotriazolyloxy-bis(pyrrolidino)-carbonium hexafluoro- phosphate(BBC)as a coupling reagent with high yield and speed even in low concentration compared with the ... 详细信息

关键词： Gly BBC SYNTHESIS OF CYCLIC PEPTIDES USING BBC REAGENT

A NOVEL COUPLING REAGENT(PENTAFLUOROPHENYL DIPHENYLPHOSPHPATE)FOR THE PEPTIDE SYNTHESIS

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Chinese Chemical Letters 1993年第4期4卷 303-306页

作者： Shao qing chen jie Chang XU Shanghai Institute of Organic Chemistry,Academia Sinica 345 Lingling Road,Shanghai 200032

Pentafluorophenyl diphenylphosphate was found to be a novel convenient coupling reagent for the peptide synthesis with several *** yield and lower racemization were found with this reagent than DCCI.

关键词： chen A NOVEL COUPLING REAGENT PENTAFLUOROPHENYL DIPHENYLPHOSPHPATE)FOR THE PEPTIDE SYNTHESIS

Jiao-tai-wan Up-regulates Hypothalamic and Peripheral Circadian Clock Gene Cryptochrome and Activates PI3K/AKT Signaling in Partially Sleep-deprived Rats

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Current Medical Science 2018年第4期38卷 704-713页

作者： Wen-ya HUANG Xin ZOU Fu-er LU Hao SU Chu ZHANG Yan-lin REN Ke FANG Li-jun XU Kai- fu WANG qing-jie chen Hui DONG Institute of Integrated Traditional Chinese and Western Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Biochemistry and Molecular Biology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

This study aims to explore the effect and mechanism of Jiao-tai-wan （JTW） on systemic and tissue-specific inflammation and insulin resistance in obesity-resistant （OR） rats with chronic partial sleep deprivation （PSD）. OR rats with PSD were orally given JTW and Estazolam for 4 weeks. The amount of food intake and metabolic parameters such as body weight increase rate, fasting plasma glucose （FPG）, fasting insulin （FINS）, homeostasis model assessment-insulin resistance （HOMA-IR） and plasma inflammatory markers were measured. The expression levels of circadian proteins cryptochrome 1 （Cryl） and cryptochrome 2 （Cry2） in hypothalamus, adipose and liver tissues were also determined. Meanwhile, the mRNA expression of inflammatory markers, activity of nuclear factor kappa B （NF-κB） p65 protein, as well as the expression levels of insulin signaling pathway proteins in hypothalamus, adipose and liver tissues were measured. Additionally, cyclic adenosine 3＇, 5＇-monophosphate （cAMP） and activity of vasodilator-stimulated phosphoprotein （VASP） in hypothalamus tissue were measured. JTW significantly decreased the body weight increase rate and food intake, ameliorated systemic inflammation and insulin resistance. JTW effectively ameliorated inflammation and increased PI3K/AKT signaling activation in hypothalamus, adipose and liver. Interestingly, all these changes were associated with the up-regulation of circadian gene Cryl and Cry2 protein expression. We also found that in hypothalamus tissue of PSD rats, down-regulation of Cryl and Cry2 activated cAMP/PKA signaling and then led to inflammation, while JTW inhibited this signaling. These results suggested that JTW has the beneficial effect on ameliorating inflammation and insulin resistance in partially sleep-deprived rats by up-regulating Cry expression.

关键词： Jiao-tai-wan PI3K/AKT signaling cryptochrome sleep deprivation inflammation insulin resistance

Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第1期 249-256页

作者： qing-Yun Fang chengyihan Gu Yinghan chen Wencheng Yan Yong Liang Weipeng Li chengjian Zhu jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

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Cyano migration-mediated radical-polar crossover cyclopropanation

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Science China Chemistry 2025年第01期 241-248页

作者： Ziqiang Wang Yasu chen jie Li chen Zhu Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials ScienceSoochow University Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study and Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University

We report a novel cyano migration-mediated radical-polar crossover process, whereby both the sulfonylcyanation of aliphatic alkenes and the formation of cyclopropanes are concurrently achieved. This transformation yields a diverse array of multisubstituted cyclopropanes under mild photocatalytic conditions. Mechanistic studies elucidate that the reaction proceeds via intramolecular nucleophilic substitution, leading to the formation of the cyclopropane derivatives.

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Efficacy and apoptosis activity of recombinant adeno-associated virus-mediated NT4-TAT-6×His-VHLβ fusion peptide for renal cell carcinoma

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Efficacy and apoptosis activity of recombinant adeno-associa...

Dynamic behaviors of graphene platelets-reinforced metal foam piezoelectric beams with velocity feedback control

第十五届全国泌尿外科学术会议

作者： LIU qing-yong,chen jie Jinan central hospital Affiliated to Shandong University,Jinan,250013,China 250013

Introduction: The specific amino acid sequence (104–123) in the β-domain of the pVHL is sufficient to inhibit growth and invasion of renal cell carcinoma(RCC). However, like other peptide the VHL β domain peptide u... 详细信息

关键词： VHL β-domain RCC supressor peptide fusion peptide renal cell carcinoma rAAV

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 63-80页

作者： jie chen Xinyue ZHANG Mingyang FAN School of Mathematics Statistics and Mechanics Beijing University of Technology College of Mechanical & Energy Engineering Beijing University of Technology

Graphene platelets(GPLs)-reinforced metal foam structures enhance the mechanical properties while maintaining the lightweight characteristics of metal foams. Further bonding piezoelectric actuator and sensor layers on the surfaces of GPLs-reinforced metal foam beams enables active vibration control, greatly expanding their applications in the aerospace industry. For the first time, this paper investigates the vibration characteristics and active vibration control of GPLs-reinforced metal foam beams with surfacebonded piezoelectric layers. The constant velocity feedback scheme is used to design the closed-loop controller including piezoelectric actuators and sensors. The effects of the GPLs on the linear and nonlinear free vibrations of the beams are numerically *** Newmark-β method combined with Newton's iteration technique is used to calculate the nonlinear responses of the beams under different load forms including harmonic loads,impact loads, and moving loads. Additionally, special attention is given to the vibration reduction performance of the velocity feedback control on the responses of the beam.

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THE PATTERN DISTRIBUTION OF DOMINATED POPULATION IN HELINTHEMUM SOONGORICUM COMMUNITIES IN WEST EORDS

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THE PATTERN DISTRIBUTION OF DOMINATED POPULATION IN HELINTHE...