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Impacts of Climate Change on Human Health and Adaptation Strategies in South China

Advances in Climate Change Research 2013年第4期4卷 208-214页

作者： DU Yao-Dong WANG Xian-Wei YANG Xiao-Feng MA wen-Jun AI hui WU Xiao-Xuan Regional Climate Center of South China Center of Integrated Geographic Information Analysis School of Geography and Planning/Guangdong Key Laboratory for Urbanization and Geo-SimulationSun Yat-Sen University Third Outpatient Department Guangdong Provincial Hospital of Traditional Chinese Medicine Guangdong Institute of Public Health

This study reviews the impacts of climate change on human health and presents corresponding adaptation strategies in South China. The daily mean surface air temperatures above or below 26.4~C increase the death risk for people in Guangzhou, especially the elderly are vulnerable to variations in temperature. Heat waves can cause insomnia, fatigue, clinical exacerbation, or death from heatstroke etc., while cold spells show increases in patients with fractures. During a cold spell period, the rates of both on-site emergency rescues and non-implementable rescues increase, and the risk of non-accidental deaths and respiratory disease deaths significantly rise as well. Both time series of hazy days and ozone concentrations have significant positive correlations with the number of patients with cardiovascular diseases. Both malaria and dengue fever reach higher altitudes and mountainous areas due to climate warming. Climate change is likely to bring stronger heat waves in the future, thereby increasing heat wave-related illnesses and deaths, particularly in the metropolitan areas of the Pearl River Delta. The projected increase of consecutive cold days in Guangdong province and parts of northern Guangxi province will affect residents＇ health in the future. The rising temperature exaggerates ozone pollution, but it is not clear whether climate change is aggravating or mitigating haze pollution. The transmission potential of malaria in South China will increase by 39%-140% and the transmission season will extend by 1 2 months with an air temperature increase of 1-2~C. By 2050, most areas in Hainan province are projected to convert from non-endemic dengue into endemic dengue areas. The aging population will cause more vulnerable people. To mitigate the adverse impacts of climate change on human health, sound and scientific adaptation strategies must be adopted in advance, such as strengthening the surveillance of epidemic diseases in potential transmission areas, conducting

关键词： climate change human health impact assessment adaptation strategy

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Electrochemical Reduction Characteristics of α-Nitronaphthalene inSulfuric Acid Solution

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Chinese Chemical Letters 1999年第11期10卷 945-948页

作者： Chun An MA wen Km ZHANG Yong Ping GAN hui HUANG Mei Chao LI Shao Ping TONG(Department of Applied Chemistry, Zhejiang Universily of Technology, Hangzhou 310014) Department of Applied Chemistry Zhejiang University of Technology Hangzhou 310014 China

The'electrochemical reduction characteristics of α-nitronaphthalene in sulfuric acidsolution were first reported in this paper. The results showed that the 1-amino-5-naphthol can beprepared by electrodeduction from α-nitronaphthalene and reduction peak corresponding to thereaction of α-nitronaphthalene to 1-amino-3-naphthol was in the range of -0.40~0.60V(vs, D.H.E )on the amalgamated copper cathode in the presence of SnCl2 additives. The mechanism of α-nitronaphthalene electroreduction to 1-amino-5-naphthol was also investigated, the overallelectroreduction reaction was composed of two intermediate steps and two intermediate productsexisted in solution. The electrochemical reduction mechanism was similar to that of nitrobenzeneto para-aminophenol.

关键词： Electrochemical reduction α-nitronaphthalene 1-amino-5-naphthol.

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The radiation response of androgen-refractory prostate cancer cell line C4-2 derived from androgen-sensitive cell line LNCaP

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Asian Journal of Andrology 2010年第3期12卷 405-414,I0011页

作者： Bang-Xiang Xie hui Zhang Lan Yu Jian Wang Bo Pang Rui-Qin Wu Xiao-Long Qian Shan-Hu Li qing-Guo Shi Le-Le Wang Jian-Guang Zhou Laboratory of Molecular Biology of Medicine Beijing Institute of Bioteehnology Beijing 100850 China National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100052 China

Radiation therapy is a relatively effective therapeutic method for localized prostate cancer （PCa） patients. However, radioresistance occurs in nearly 30% of patients treated with potentially curative doses. Therapeutic synergy between radiotherapy and androgen ablation treatment provides a promising strategy for improving the clinical outcome. Accordingly, the androgen deprivation-induced signaling pathway may also mediate radiosensitivity in PCa cells. The C4-2 cell line was derived from the androgen-sensitive LNCaP parent line under androgen-depleted condition and had acquired androgen-refractory characteristics. In our study, the response to radiation was evaluated in both LNCaP and C4-2. Results showed that C4-2 cells were more likely to survive from irradiation and appeared more aggressive in their resistance to radiation treatment compared with LNCaP, as measured by clonogenic assays and cell viability and cell cycle analyses. Gene expression analyses revealed that a set of genes involved in cell cycle arrest and DNA repair were differentially regulated in LNCaP and C4-2 in response to radiation, which was also consistent with the radiation-resistant property observed in C4-2 cells. These results strongly suggested that the radiation-resistant property may develop with progression of PCa to androgen- independent status. Not only can the LNCaP and C4-2 PCa progression model be applied for investigating androgen-refractory progression, but it can also be used to explore the development of radiation resistance in PCa.

关键词： LNCaP C4-2 prostate cancer radiation response

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Parallel mining and application of fuzzy association rules

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Frontiers of Electrical and Electronic Engineering in China 2006年第2期1卷 177-182页

作者： LU Jian-jiang XU Bao-wen ZOU Xiao-feng KANG Da-zhou LI Yan-hui ZHOU Jin Institute of Command Automation PLA University of Science and TechnologyNanjing 210007China Department of Computer Science and Engineering Southeast UniversityNanjing 210096China

Quantitative attributes are partitioned into several fuzzy sets by using fuzzy c-means *** c-means algorithm can embody the actual distribution of the data,and fuzzy sets can soften the partition ***,we improve the search technology of apriori algorithm and present the algorithm for mining fuzzy association *** the database size becomes larger and larger,a better way is to mine fuzzy association rules in *** the parallel mining algorithm,quantitative attributes are partitioned into several fuzzy sets by using parallel fuzzy c-means *** parallel algorithm is improved to discover frequent fuzzy attribute set,and the fuzzy association rules with at least a minimum confidence are generated on all *** experiment results implemented on the distributed linked PC/workstation show that the parallel mining algorithm has fine scaleup,sizeup and ***,we discuss the application of fuzzy association rules in the *** example shows that the accuracy of classification systems of the fuzzy association rules is better than that of the two popular classification methods:C4.5 and CBA.

关键词： Data mining Association rules Fuzzy Parallel Classification

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Forty years of practice against gastric cancer in Linqu County, a high-risk area of gastric cancer in China

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Malignancy Spectrum 2024年第3期1卷 141-146页

作者： Kai-Feng Pan wen-qing Li Wei-Cheng You State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Cancer Epidemiology Peking University Cancer Hospital & Institute Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Cancer Epidemiology Peking University Cancer Hospital & Institute

Gastric cancer(GC) is a global public health burden, with nearly one million new cases diagnosed each year worldwide. To investigate the risk factors and the prevention strategies for GC, in the past 40 years, a series of epidemiological studies have been carried out in Linqu County, Shandong Province, a high-risk area of GC in China. Here, we briefly review the major efforts of 40-year practices against GC in Linqu County, particularly highlighting a case-control study to identify GC risk factors, a cohort study to determine the associations between the risk factors and the progression of gastric lesions, and an intervention trial to prevent GC development.

关键词： gastric cancer precancerous gastric lesions Helicobacter pylori risk factor prevention

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高频大功率CSAMT发射技术研究

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地球物理学报 2017年第11期60卷 4160-4164页

作者：真齐辉底青云中国科学院地质与地球物理研究所中国科学院页岩气与地质工程院重点实验室北京100029 中国科学院地球科学研究院北京100029 中国科学院大学北京100049

近年来,随着我国对矿产资源需求量的逐年增加,人工源大地电磁法作为地球电性探测的感应类电法得到了迅猛发展,自主研制的地球物理仪器陆续推出.电磁法仪器的出现逐步摆脱了对国外相关仪器的依赖,可控源音频大地电磁法(CSAMT)发射机作为... 详细信息

近年来,随着我国对矿产资源需求量的逐年增加,人工源大地电磁法作为地球电性探测的感应类电法得到了迅猛发展,自主研制的地球物理仪器陆续推出.电磁法仪器的出现逐步摆脱了对国外相关仪器的依赖,可控源音频大地电磁法(CSAMT)发射机作为该方法的电偶极子源具有举足轻重的作用,然而,当前野外施工所用的CSAMT发射机普遍存在高频电流发射受阻,发射功率较小,收发距的大小受到很大的限制;到低频区,较小的收发距,使得接收机进入近场区,待后续数据处理时需要做近场校正,不仅增加了一个校正工序,也带来了校正数据误差,同时,较小的收发距,限制了野外施工的效率.另外,随着CSAMT的研究逐步深入,CSAMT三维阵列式探测也逐渐引起学者的重视,实现高频大电流的发射,为CSAMT三维阵列式探测提供了有利支持.本文详细分析了实现高频大功率发射技术的方法,通过模型建立和方程求解,获得了影响发射电流的主要因素,进而,有望达到高频发射电流大于低频发射电流的目的.

关键词：大功率 CSAMT 双发射系统高频电流

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Nitrogen-rich metal-organic framework mediated Cu-N-C composite catalysts for the electrochemical reduction of CO_(2)

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Journal of Energy Chemistry 2021年第3期30卷 555-563页

作者： Si-Min Cao Hua-Bo Chen Bao-Xia Dong Qiu-hui Zheng Yan-Xia Ding Meng-Jie Liu She-Liang Qian Yun-Lei Teng Zong-Wei Li wen-Long Liu School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002ZhejiangChina

Cu-based MOFs,i.e.,HKUST-1,etc.,have been pertinently chosen as the pristine materials for CO_(2) ER due to the unique ability of copper for generation hydrocarbon ***,the limited conductivity and stability become the stumbling-block that prevents the development of *** exploring of MOFsderived M-C materials starts a new chapter for the MOFs precursors,which provides a remarkable electronic connection between carbon matrix and metals/metal oxides.N-doped M-N-C with extensive M-N sites scattering into the carbon matrix are more popular because of their impressive contribution to catalytic activity and specific product ***,Cu-N-C system remained undeveloped up to *** lack of ideal precursor,the sensitivity of Cu to be oxidized,and the difficulties in the synthesis of small size Cu nanoparticles are thus known as the main barriers to the development of Cu-N-C ***,a nitrogen-rich Cu-BTT MOF is employed for the derivation of N-doped Cu-N-CT composite electrocatalysts by the pyrolyze ***-temperature pyrolysis product of Cu-N-C1100exhibits the best catalytic activity for productions of CO(-0.6 V ***,jCO=0.4 mA/cm^(2))and HCOOH(-0.9 V ***,jHCOOH=1.4 mA/cm^(2)).

关键词： Carbon mono-oxide Formic acid Metal-organic framework Nitrogen-rich Copper nanoparticle Catalyst

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美国高等体育院系体育休闲娱乐教育概况研究

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北京体育大学学报 2007年第5期30卷 610-611,628页

作者：彭文革余惠清广东商学院体育部广东广州510320

美国是公认的世界体育强国,高等体育休闲娱乐教育也早已进入专业教育阵地,不仅培养层次多,课程设置门类广,还交叉融合,各有特色,涵盖了与休闲娱乐密切相关的运动、管理、旅游、康复保健等领域,为美国体育休闲娱乐业的巨大市场发展,培养... 详细信息

美国是公认的世界体育强国,高等体育休闲娱乐教育也早已进入专业教育阵地,不仅培养层次多,课程设置门类广,还交叉融合,各有特色,涵盖了与休闲娱乐密切相关的运动、管理、旅游、康复保健等领域,为美国体育休闲娱乐业的巨大市场发展,培养和输送了大量体育休闲娱乐管理人才。采用文献资料法、上网法和统计法,对美国高等体育休闲娱乐教育概况及发展历程作了研究,并提出了几点建议。

关键词：美国体育休闲娱乐教育高等教育

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Cytochalasins from Xylaria sp. CFL5, an Endophytic Fungus of Cephalotaxus fortunei

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Natural Products and Bioprospecting 2021年第1期11卷 87-98页

作者： Kai-Liang Ma Shi-hui Dong Hang-Ying Li wen-Jun Wei Yong-Qiang Tu Kun Gao State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000People’s Republic of China

Three previously undescribed cytochalasins,named xylariasins A‒C(1‒3),together with six known ones(4‒9)were iso-lated from Xylaria ***5,an endophytic fungus of Cephalotaxus *** chemical structures of all new compounds were elucidated on the basis of extensive spectroscopic data analyses and electronic circular dichroism calculation,as well as optical rotation *** activities of compounds 1,4‒9 were evaluated,including cytotoxic,LAG3/MHC II binding inhibition and LAG3/FGL1 binding inhibition *** 6 and 9 possessed cytotoxicity against AGS cells at 5μM,with inhibition rates of 94%and 64%,*** addition,all tested isolates,except compound 6,exhibited obvious inhibitory activity against the interaction of both LAG3/MHC II and LAG3/*** 1,5,7,and 8 inhibited LAG3/MHC II with IC50 values ranging from 2.37 to 4.74μ***,the IC50 values of compounds 1,7,and 8 against LAG3/FGL1 were 11.78,4.39,and 7.45μM,respectively.

关键词： Cytochalasin Xylaria sp. Cephalotaxus fortunei LAG3/MHC II binding inhibition LAG3/FGL1 binding inhibition

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Simulation study on cuttings transport of the backreaming operation for long horizontal section wells

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Petroleum Science 2024年第2期21卷 1149-1170页

作者： Yu-Fei Chen hui Zhang wen-Xin Wu Jun Li Yong Ouyang Zong-Yu Lu De-Xin Ma Yong-Chuan Wu Jun-Bo Liu Ke-Rou Liu Zhuo-Xin Dong China University of Petroleum(Beijing) Beijing102249China Beijing Normal University at Zhuhai Experimental and Practical Education Innovation CenterZhuhai519087GuangdongChina Oil&Gas Technology Research Institute of PetroChina Changqing Oilfield Company Xi'an710016ShaanxiChina PetroChina Xinjiang Oilfield Company Karamay834002XinjiangChina China Oilfield Services Ltd. Tianjin300459China

The backreaming operation plays a significant role in safe drilling for horizontal wellbores, while it may cause severe stuck pipe accidents. To lower the risk of the stuck pipe in backreaming operations, the mechanism of cuttings transport needs to be carefully investigated. In this research, a transient cuttings transport with multiple flow patterns model is developed to predict the evolution of cuttings transported in the annulus while backreaming. The established model can provide predictions of the distribution of cuttings bed along the wellbore considering the bulldozer effect caused by large-size drilling tools(LSDTs). The sensitivity analyses of the size of LSDTs, and backreaming operating parameters are conducted in Section 4. And a new theory is proposed to explain the mechanism of cuttings transport in the backreaming operation, in which both the bit and LSDTs have the “cleaning effect” and “plugging effect”.The results demonstrate that the cuttings bed in annuli is in a state of dynamic equilibrium, but the overall trend and the distribution pattern are obvious. First, larger diameters and longer drilling tools could lead to a higher risk of the stuck pipe. Second, we find that it is not the case that the higher flow rate is always better for hole cleaning, so three flow-rate intervals are discussed separately under the given conditions. When the “dangerous flow rate”(35 L/s in Case 4),the higher the flow rate, the better the cleaning effect of cuttings beds. Third, an interval of tripping velocity called “dangerous velocity” is proposed, in which the cuttings bed accumulation near the LSDTs is more serious than

关键词： Backreaming Stuck pipe Hole cleaning Transient solid transport Multiple flow patterns

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