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Effect of ellagitannin metabolites ellagic acid and urolithins A-D on the non-enzymatic glycation of human serum albumin and inhibiting mechanisms

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Food Science and Human Wellness 2024年

作者： Lu Zhang Chun-yan Peng wen-na Zhou Fei-yan Lu Lin-ju Xu qing-hui wen Xing Xie Zong-cai Tu National R&D Center of Freshwater Fish Processing， College of Life Science， Jiangxi Normal University State Key Laboratory of Food Science and Resources， Nanchang University

Effect of ellagitannins gut microbiota metabolites ellagic acid (EA) and urolithin A-urolithin D (UroA-UroD) on human serum albumin (HSA) glycation were firstly evaluated in this research. The inhibition mechanisms were investigated by methylglyoxal (MGO) trapping and radical scavenging ability assays， docking studies and Nano LC-Orbitrap-MS/MS technology. Results indicated that the inhibition of urolithins on HSA glycation was highly positive correlated with the number of phenolic hydroxy groups. Addition of UroD and EA could effectively enhance the content of free amino group， suppress dicarbonyl compounds and advanced glycation end-products (AGEs) formation， alleviated tryptophan and protein oxidation， inhibited HSA amyloid-like aggregation. They could also trap MGO and scavenge DPPH· and ABTS·+. Molecular docking indicated that EA and UroA-UroD interact with HSA mainly through hydrogen bound and hydrophobic interaction， among which two or three hydrogen bonds were formed. The number of glycation sites were reduced from 11 to 10， 10， 7， and 10， respectively， when 90 μmol/L of EA， UroA， UroC and UroD were added. However， weak inhibition was observed on UroA and UroB. These findings can provide scientific evidence for the application of ellagitannins-rich foods in alleviating diabetic complications.

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恶性梗阻性黄疸患者胆道分离细菌药敏与感染的相关因素分析

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复旦学报（医学版） 2017年第4期44卷 489-492页

作者：杨清慧李文涛复旦大学上海医学院肿瘤学系-复旦大学附属肿瘤医院介入科上海200032

目的分析恶性梗阻性黄疸(malignant obstructive jaundice,MOJ)患者胆汁致病菌分布及药物敏感情况,探讨梗阻类型、腹部手术史、梗阻程度及时间等因素与致病菌感染的相关性。方法选取2015年1月至2016年3月在我院就诊的93例MOJ患者资料行... 详细信息

目的分析恶性梗阻性黄疸(malignant obstructive jaundice,MOJ)患者胆汁致病菌分布及药物敏感情况,探讨梗阻类型、腹部手术史、梗阻程度及时间等因素与致病菌感染的相关性。方法选取2015年1月至2016年3月在我院就诊的93例MOJ患者资料行回顾性分析,所有病例行经皮肝穿胆汁引流术(pertutaneous transhepatic biliary drainage,PTBD),术中收集胆汁行细菌培养及药物敏感测试,对胆汁培养阳性者行相关性分析。结果共送检93份胆汁,其中培养阳性60.2%(56/93),共检出58株致病菌株,其中革兰阳性菌占36.2%(21/58),革兰阴性菌占63.8%(37/58),致病菌中以肠球菌、大肠埃希菌、肺炎克雷伯菌及葡萄球菌属等多见。结论胆道感染以肠道菌群为主,应根据药物敏感结果及时调整治疗。相关性分析显示低位梗阻及有腹部外伤史为胆系感染相关因素,梗阻时间及程度则与胆系感染无相关性。

关键词：细菌感染胆汁梗阻性黄疸经皮肝穿胆汁引流术

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Ideal Bi-Based Hybrid Anode Material for Ultrafast Charging of Sodium-Ion Batteries at Extremely Low Temperatures

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NANO-MICRO LETTERS 2025年第1期17卷 1-16页

作者： Bai, Jie Jia, Jian hui Wang, Yu Yang, Chun Cheng Jiang, qing Jilin Univ Key Lab Automobile Mat Sch Mat Sci & Engn Minist Educ Changchun 130022 Peoples R China

Metallic nanoparticles with excellent size controllability and high loading rate are obtained via ultrafast high temperature shock *** Bi/CNRs-15 electrode exhibits an unprecedented rate performance (237.9 mAh g-1 at 2 A g-1) at - 60 degrees C, while the energy density of the full cell can reach to 181.9 Wh kg-1 at - 40 degrees C.A novel strategy of high-rate activation is proposed to obtain high capacity and superior stability at low temperature by creating new active sites for interfacial reaction. Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at - 20 degrees C or lower. However, the key capability of ultrafast charging at ultralow temperature for SIBs is rarely reported. Herein, a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue, which is synthesized via a high temperature shock method. Such a hybrid shows an unprecedented rate performance (237.9 mAh g-1 at 2 A g-1) at - 60 degrees C, outperforming all reported SIB anode materials. Coupled with a Na3V2(PO4)3 cathode, the energy density of the full cell can reach to 181.9 Wh kg-1 at - 40 degrees C. Based on this work, a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： wenxuan Chen Xiu-qing Qiao Guo hui Bojing Sun Dongfang Hou Meidi Wang Xueqian Wu Tao Wu Dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第01期 201-208页

作者： hui-Feng Wang wen-Jie Shi Yu-Xin Yang Bao-Xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai Xiang wen-hui Wei Shu-hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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妊娠期慢性乙型肝炎55例

世界华人消化杂志 2010年第15期18卷 1602-1604页

作者：哈明昊黎小珊卢晓玲温庆辉张曼莉广东省东莞市人民医院感染科广东省东莞市523018

目的:分析妊娠期慢性乙型肝炎发病特点和临床特征.方法:回顾性分析55例妊娠期慢性乙型肝炎患者的临床资料,并与妊娠期乙型肝炎携带者(无症状妊娠组)及正常妊娠女性进行临床比较.结果:妊娠期慢性乙型肝炎发病集中于妊娠的中、晚期.与无... 详细信息

目的:分析妊娠期慢性乙型肝炎发病特点和临床特征.方法:回顾性分析55例妊娠期慢性乙型肝炎患者的临床资料,并与妊娠期乙型肝炎携带者(无症状妊娠组)及正常妊娠女性进行临床比较.结果:妊娠期慢性乙型肝炎发病集中于妊娠的中、晚期.与无症状妊娠组比较,慢乙型肝炎妊娠组患者肝功能损害表现为ALT、AST、TBIL及DBIL明显升高(210.2U/L±144.7U/L vs22.7U/L±11.6U/L;197.3U/L±113.8U/L vs19.1U/L±14.9U/L;64.9μmol/L±37.8μmol/L vs6.8μmol/L±5.8μmol/L;44.2μmol/L±23.8μmol/L vs4.8μmol/L±2.2μmol/L,均P<0.05),白蛋白、PTA降低(31.3G/L±7.3G/L vs35.8G/L±4.7G/L;66.4%±8.6%vs82.1%±8.7%,均P<0.05).患者的病毒学特征表现为HBeAg阳性和HBV DNA高滴度.结论:妊娠期慢性乙型肝炎的发生多集中于妊娠的中、晚期;临床类型以中、重度为主;HBeAg阳性和HBV DNA高滴度可作为妊娠期慢性乙型肝炎发生的预测指标.

关键词：妊娠期慢性乙型肝炎乙型肝炎病毒 E抗原

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新型氯基消毒剂烟熏消毒的效果验证

中国兽医杂志 2016年第12期52卷 35-37页

作者：薛宝君辛良樊富慧张飞陈健范庆增温会文王文琮陈默王宏钧常建宇中国农业大学动物医学院北京海淀100193 天津市中升挑战生物科技有限公司天津西青300380 上海康臣生物科技有限公司上海奉贤201411 天津市开发区宏景工贸有限公司天津塘沽300457

为了验证以二氯异氰尿酸钠为主要成分的粉状消毒剂的杀菌效果。采用种蛋检测方法进行试验观察。结果低湿度时,二氯异氰尿酸钠按照0.4、0.6、0.8、1 g/m^33熏蒸消毒30、60、120 min,对种蛋表面细菌杀灭率为73.49、77.23、77.72、74.90、7... 详细信息

为了验证以二氯异氰尿酸钠为主要成分的粉状消毒剂的杀菌效果。采用种蛋检测方法进行试验观察。结果低湿度时,二氯异氰尿酸钠按照0.4、0.6、0.8、1 g/m^33熏蒸消毒30、60、120 min,对种蛋表面细菌杀灭率为73.49、77.23、77.72、74.90、77.23、91.72、70.55、89.20、68.54%和84.36、80.12、89.16%。高湿度时,二氯异氰尿酸钠按照0.4、0.6、0.8、1 g/m^3熏蒸消毒30,60,120 min,对种蛋表面细菌杀灭率为81.33、91.25、84.65、84.74、91.15、69.53、91.25、93.87、78.48、91.27、94.17%和72.18%。表明湿度高对消毒剂杀菌效果有积极影响,该消毒剂杀菌效果好且使用方便。

关键词：二氯异氰尿酸钠湿度福尔马林消毒

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-hui Zhang Zhi-Lai Zhan Guang-Lu Chang Yan Gao Xia Li wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation