检索结果-南通市图书馆

Dexamethasone protects the glycocalyx on the kidney microvascular endothelium during severe acute pancreatitis

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第4期20卷 355-362页

作者： Wen-qiao YU Shao-yang ZHANG Shui-qiao fu qing-hui fu Wei-na LU Jian ZHANG Zhong-yan LIANG Yun ZHANG Ting-bo LIANG Department of Hepatobiliary and Pancreatic Surgery and Intensive Care Unit the First Affiliated Hospital School of Medicine Zhejiang University Department of Surgical Intensive Care Unit the Second Affiliated Hospital School of Medicine Zhejiang University Department of Reproductive Medicine Women's Hospital School of Medicine Zhejiang University

Objective: This study demonstrated that dexamethasone(DEX) protects the endothelial glycocalyx from damage induced by the inflammatory stimulus tumor necrosis factor-α(TNF-α) during severe acute pancreatitis(SAP), and improves the renal microcirculation. Methods: Ninety mice were evenly divided into 3 groups(Sham, SAP, and SAP+DEX). The SAP mice model was established by ligature of pancreatic duct and intraperitoneal injection of cerulein. Renal perfusion and function, and morphological changes of the glycocalyx were evaluated by laser Doppler velocimetry, electron microscopy, and histopathology(hematoxylin and eosin(H&E) staining), respectively. Serum levels of syndecan-1 and TNF-α were assessed by enzyme-linked immunosorbent assay(ELISA). The proàtectiveì effects of dexamethasone on the glycocalyx and renal microcirculation were evaluated. Results: Significantly high levels of serum TNF-α were detected 3 h after the onset of SAP. These levels might induce degradation of the glycocalyx and kidney hypoperfusion, resulting in kidney microcirculation dysfunction. The application of dexamethasone reduced the degradation of the glycocalyx and improved perfusion of kidney. Conclusions: Dexamethasone protects the endothelial glycocalyx from inflammatory degradation possibly initiated by TNF-α during SAP. This is might be a significant discovery that helps to prevent tissue edema and hypoperfusion in the future.

关键词： Severe acute pancreatitis(SAP) Acute kidney injury(AKI) Glycocalyx Dexamethasone Tumor necrosis factor-α(TNF-α)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

引用

Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-qing Qiao Guo hui Bojing Sun Dongfang Hou Meidi Wang Xueqian Wu Tao Wu Dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

引用

Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai fu Zhiyi Wei Ai-hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pancreatic stent improves the success rate of needle-knife papillotomy in patients with difficult biliary cannulation

引用

World Journal of Gastroenterology 2025年第1期31卷 58-67页

作者： Mu-Hsien Lee Cheng-hui Lin Chi-Huan Wu Yung-Kuan Tsou Kai-Feng Sung Sheng-fu Wang Nai-Jen Liu Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital and Chang Gung University College of MedicineTaoyuan 33305Taiwan School of Medicine Chang Gung UniversityTaoyuan 33305Taiwan

BACKGROUND Needle-knife precut papillotomy(NKP)is typically performed ***,it remains unclear whether pancreatic stent(PS)placement can improve the outcomes of *** To explore whether PS placement improves the success rate of NKP in patients with difficult biliary *** This single-center retrospective study included 190 patients who underwent NKP between January 2017 and December 2021 after failed conventional biliary *** cases with incidental pancreatic duct cannulation during conventional biliary cannulation,the decision for pre-NKP PS placement was made at the endoscopist's *** primary outcome was the difference in the NKP success rate between patients with and without PS placement;the secondary outcome was the adverse event *** Among the 190 participants,82 received pre-NKP PS(PS-NKP group)whereas 108 did not[freehand or freehand NKP(FH-NKP)group].Post-NKP selective biliary cannulation was successful in 167(87.9%)patients,and the PS-NKP had a significantly higher success rate than the FH-NKP group(93.9%vs 83.3%,P=0.027).The overall adverse event rates were 7.3%and 11.1%in the PS-NKP and FH-NKP groups,respectively(P=0.493).A periampullary diverticulum(PAD)and significant intraoperative bleeding during NKP were independently associated with NKP failure;however,a pre-NKP PS was the only predictor of NKP *** the 44 participants with PADs,the PS-NKP group had a non-significantly higher NKP success rate than the FH-NKP group(87.5%and 65%,respectively;P=0.076).CONCLUSION PS significantly improved the success rate of NKP in patients with difficult biliary cannulation.

关键词： Difficult biliary cannulation Endoscopic retrograde cholangiopancreatography Needle-knife papillotomy Pancreatic stent Selective biliary cannulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

不同激素和外植体对柱花草愈伤组织诱导及体细胞胚的影响

引用

中国草地学报 2016年第6期38卷 15-21页

作者：靳慧卿米福贵闫利军云雅聪冀晓婷富海江内蒙古农业大学生态环境学院内蒙古呼和浩特010019 四川省草原科学研究院四川成都611743

以MS为基本培养基,以柱花草无菌苗的幼根、下胚轴、子叶、茎和真叶为材料,采用正交设计方法,研究不同外植体和激素对柱花草愈伤组织诱导和体细胞胚的影响。结果表明:外植体类型及2,4-D、KT、NAA、6-BA浓度对愈伤组织诱导率的影响均达极... 详细信息

以MS为基本培养基,以柱花草无菌苗的幼根、下胚轴、子叶、茎和真叶为材料,采用正交设计方法,研究不同外植体和激素对柱花草愈伤组织诱导和体细胞胚的影响。结果表明:外植体类型及2,4-D、KT、NAA、6-BA浓度对愈伤组织诱导率的影响均达极显著水平(P<0.01),其中2,4-D浓度是最主要的影响因素,其次为外植体类型。下胚轴和真叶为柱花草愈伤组织诱导的理想外植体,愈伤诱导培养基的最优配方为MS+1.0mg/L 2,4-D+0.5mg/L KT+0.01mg/L NAA+0.1mg/L 6-BA。NAA、6-BA浓度对柱花草体细胞胚产生率的影响达极显著水平(P<0.01),NAA浓度是主要影响因素,体细胞胚产生的最佳培养基配方为MS+1.0mg/L NAA+1.0mg/L 6-BA+2.0g/L CH。

关键词：柱花草外植体植物激素愈伤组织体细胞胚

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

STUDY ON THE BURDEN OF STROKE SCALE FOR ACUPUNCTURE TREATMENT IN STROKE PATIENTS

引用

Journal of Integrative Medicine 2014年第3期 296-296页

作者： Jian Pei Xiao-xin You Yue-hua Gu qing-hui fu Yi Song Longhua Hospital Shanghai University of TCM Putuo Hospital Shanghai University of TCM

Objective: To evaluate the clinical effect of acupuncture on the patient-reported outcomes(PROs) of patients with acute ischemic ***: A total of 112 patients with acute ischemic stroke were recruited and randomly divided into the acupuncture group and the control group from 2010 to *** acupuncture group received acupunctural treatment plus routine Western *** control group only received routine Western ***, including the NIH Stroke Scale, the fugl-Meyer Assessment of Motor function(FMA), the Burden of Stroke Scale(BOSS) and the Stroke Specific Quality of Life Measure(SS-QOL), were assessed in the acupuncture group and the control group before and after ***: The baseline including the NIH Stroke Scale and the FMA was assessed in the acupuncture and the control *** difference between the two groups has no significance on statistics(P>0.05).FMA in 14 and 28 days after acupuncture treatment was better than that in the control group, showing a significant difference on statistics(Pfunction in patients with acute ischemic *** including SS-QOL and BOSS could be improved in patients with acute ischemic stroke after acupuncture treatment.

关键词： FMA QOL STUDY ON THE BURDEN OF STROKE SCALE FOR ACUPUNCTURE TREATMENT IN STROKE PATIENTS BOSS

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Relationship between parenting stress and behavioral and emotional problems in preschool children: A mediation effect analysis

引用

World Journal of Psychiatry 2025年第1期15卷 128-136页

作者： Zhi-Wei fu Yue-Jing Li Ran Yu Rui-qing Guo Li-Xia Gao Sheng-Xia Zhao Department of Children's Health Shijiazhuang Maternity and Child Healthcare HospitalShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age *** To investigate the current status of family rearing,parental stress,and behavioral and emotional problems of preschool children and to analyze the mediating effect of the current status of family rearing on parental stress and behavioral/emo-tional *** We use convenience sampling to select 258 preschool children in the physical examination center of our hospital from October 2021 to September *** children and their parents were evaluated using a questionnaire ***'s correlation was used to analyze the correlation between child behavioral and emotional problems and parental stress and family rearing,and the structural equation model was constructed to test the mediating *** The score for behavioral/emotional problems of 258 preschool children was(27.54±3.63),the score for parental stress was(87.64±11.34),and the score for parental family rearing was(31.54±5.24).There was a positive correlation between the behavioral and emotional problems of the children and the“hostile/mandatory”parenting style;meanwhile,showed a negative correlation with the“support/participation”parenting style(all P<0.05).The intermediary effect value between the family upbringing of parents in parental stress and children's behavior problems was 29.89%.CONCLUSION Parental family upbringing has a mediating effect between parental stress and behavioral and emotional problems of *** paying attention to the behavioral and emotional problems of preschool-age children,clinical medical staff should provide correct and reasonable parenting advice to their parents to promote the mental health of preschool-age children.

关键词： Preschool children Parenting stress Children's behavioral and emotional problems Family rearing Mediating effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chiral effective Lagrangian for excited heavy-light mesons from QCD

引用

Communications in Theoretical Physics 2021年第6期73卷 94-101页

作者： qing-Sen Chen hui-Feng fu Yong-Liang Ma qing Wang Center for Theoretical Physics College of PhysicsJilin UniversityChangchun 130012China School of fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou310024China International Center for Theoretical Physics Asia-Pacific(ICTP-AP)(Beijing/Hangzhou) UCASBeijing 100190China Department of Physics Tsinghua UniversityBeijing 100084China Center for High Energy Physics Tsinghua UniversityBeijing 100084China

We derive the chiral effective Lagrangian for excited heavy-light mesons from QCD under proper *** focus on the chiral partners with j_(l)^(P)=3+/2 and j_(l)^(P)=3-/2 which amounts to(1^(+),2^(+))and(1^(-),2^(-))states *** low energy constants including the masses of the chiral partners are *** calculated spectrum for the excited mesons are found roughly consistent with experimental *** addition,our results indicate that quantum numbers of B_(J)(5970)can be identified with 1^(-)or 2^(-).

关键词： chiral effective Lagrangian heavy-light meson QCD chiral partner

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Roll angular rate extraction based on modified spline-kernelled chirplet transform

引用

Defence Technology（防务技术） 2022年第5期18卷 876-890页

作者： hui Zhao Zhong Su qing Li fu-chao Liu Ning Liu School of Automation Beijing Institute of TechnologyBeijing100081China Beijing Key Laboratory of High Dynamic Navigation Technology Beijing Information Science and Technology UniversityBeijing100192China

The roll angular rate is much crucial for the guidance and control of the *** the high-speed rotation of the projectile brings severe challenges to the direct measurement of the roll angular ***,the radial magnetometer signal is modulated by the high-speed rotation,thus the roll angular rate can be achieved by extracting the instantaneous frequency of the radial magnetometer *** objective of this study is to find out a precise instantaneous frequency extraction method to obtain an accurate roll angular *** reach this goal,a modified spline-kernelled chirplet transform(MSCT)algorithm is proposed in this *** to the nonlinear frequency modulation characteristics of the radial magnetometer signal,the existing time-frequency analysis methods in literature cannot obtain an excellent energy concentration in the time-frequency plane,thereby leading to a terrible instantaneous frequency extraction ***,the MSCT can overcome the problem of bad energy concentration by replacing the short-time Fourier transform operator with the Chirp Z-transform operator based on the original spline-kernelled chirplet *** introduction of Chirp Z-transform can improve the construction accuracy of the transform *** the construction accuracy of the transform kernel determines the concentration of time-frequency distribution,the MSCT can obtain a more precise instantaneous *** performance of the MSCT was evaluated by a series of numerical simulations,high-speed turntable experiments,and real flight *** evaluation results show that the MSCT has an excellent ability to process the nonlinear frequency modulation signal,and can accurately extract the roll angular rate for the high spinning projectiles.

关键词： High spinning projectile Roll angular rate Time-frequency analysis Spline-kernelled chirplet transform Chirp Z-transform

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Cyclic Annealing on Microstructure and Mechanical Properties of Medium Carbon Steel

引用

Journal of Iron and Steel Research International 2016年第2期23卷 145-150页

作者： Zhi-qing LÜ hui-fang ZHANG qing MENG Zhen-hua WANG Wan-tang fu College of Mechanical Engineering Yanshan UniversityQinhuangdao 066004HebeiChina State Key Laboratory of Metastable Material Science and Technology Yanshan UniversityQinhuangdao 066004HebeiChina

The microstructure and mechanical properties of medium carbon steel after cyclic heat treatment were in- vestigated. The effects of cyclic numbers and long time annealing on the microstructure and mechanical properties of the experimental steel were compared. A short duration （5 min） holding at 1023 K （above A1 temperature） and a short-duration （3 min） holding at 893 K are adopted in each cyclic heat treatment. The spheroidization is accelerated during cyclic heat treatment, and the spheroidizing ratio grows with cyclic numbers. After 12-cycle heat treatments, there are few incompletely spheroidized regions in the specimens, and cementite lamellae mostly change into cement- ite particles. The morphological character of cementite for 12 cycles is similar to that undergoing annealing for 10 h at 973 K. The strength of the experimental steel after 5-cycle heat treatment is the lowest in the following cyclic heat treatment, but it is still higher than that of specimens with subcritical annealing over a long period （10 h）. After 12- cycle heat treatment, the strength of the experimental steel is close to that of the normalized steel, and the plasticity is the best in all heat treated specimens.

关键词： rapid spheroidizing mechanical property cyclic annealing cementite medium carbon steel

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：