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Changes and significance of serum ubiquitin carboxyl-terminal hydrolase L1 and glial fibrillary acidic protein in patients with glioma

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World Journal of Clinical Cases 2023年第14期11卷 3158-3166页

作者： qing-hua zhu Jing-Kun Wu Gao-Lei Hou Department of Neurosurgery Affiliated Hospital of Hebei Engineering UniversityHandan 056002Hebei ProvinceChina

BACKGROUND Brain gliomas are malignant tumors with high postoperative recurrence *** prediction of prognosis using specific indicators is of great *** To assess changes in ubiquitin carboxy-terminal hydrolase L1(UCH-L1)and glial fibrillary acidic protein(GFAP)levels in patients with glioma pre-and *** Between June 2018 and June 2021,91 patients with gliomas who underwent surgery at our hospital were enrolled in the glioma *** healthy volunteers were included in the control *** UCH-L1 and GFAP levels were measured in peripheral blood collected from patients with glioma before and 3 d after ***-L1 and GFAP levels in patients with glioma with different clinicopathological characteristics were compared before and after *** patients were followed-up until February *** glioma recurrence was recorded to determine the serum UCH-L1 and GFAP levels,which could assist in predicting postoperative glioma *** UCH-L1 and GFAP levels in patients with glioma decreased significantly 3 d after surgery compared to those before therapy(P0.05).Serum UCH-L1 and GFAP levels were significantly lower in the patients with WHO grade I-II tumors than in those with gradeⅢ-IV tumors(P5 cm,in which the differences were statistically significant(P<0.05).Glioma recurred in 22 *** preoperative and 3-d postoperative serum UCH-L1 and GFAP levels were significantly higher in the recurrence group than these in the non-recurrence group(P<

关键词： Glioma Ubiquitin carboxy-terminal hydrolase L1 Glial fibrillary acidic protein Surgery Prognosis Clinical significance

TRPC6 Knockout Alleviates Renal Fibrosis through PI3K/AKT/GSK3B Pathway

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Current Medical Science 2024年第3期44卷 589-602页

作者： An-bang SUN Fang-hua LI Lin zhu Xi-xi ZENG Min zhu qing-hua LEI Yan-hong LIAO Department of Anatomy School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Transfusion Medicine Wuhan Hospital of Traditional Chinese and Western MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Nephrology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Department of Thoracic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China National Basic Medical Teaching Demonstration Center Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Key Laboratory of Neurological Diseases of Ministry of Education Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Renal fibrosis is the ultimate pathway of various forms of acute and chronic kidney ***,the knockout of transient receptor potential channel 6(TRPC6)has shown promise in alleviating renal ***,the regulatory impact of TRPC6 on renal fibrosis remains *** In vivo,TRPC6 knockout(TRPC6−/−)mice and age-matched 129 SvEv(WT)mice underwent unilateral renal ischemia-reperfusion(uIR)injury surgery on the left renal pedicle or sham *** and serum were collected on days 7,14,21,and 28 after *** vitro,primary tubular epithelial cells(PTECs)were isolated from TRPC6−/−and WT mice,followed by treatment with transforming growth factorβ1(TGFβ1)for 72 *** anti-fibrotic effect of TRPC6−/−and the underlying mechanisms were assessed through hematoxylin-eosin staining,Masson staining,immunostaining,qRT-PCR,and Western *** Increased TRPC6 expression was observed in uIR mice and PTECs treated with TGFβ***6−/−alleviated renal fibrosis by reducing the expression of fibrotic markers(Col-1,α-SMA,and vimentin),as well as decreasing the apoptosis and inflammation of PTECs during fibrotic progression both in vivo and in ***,we found that the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/glycogen synthase kinase 3 beta(GSK3β)signaling pathway,a pivotal player in renal fibrosis,was down-regulated following TRPC6 *** These results suggest that the ablation of TRPC6 may mitigate renal fibrosis by inhibiting the apoptosis and inflammation of PTECs through down-regulation of the PI3K/AKT/GSK3β*** TRPC6 could be a novel therapeutic strategy for preventing chronic kidney disease.

关键词： transient receptor potential channel 6 ischemia-reperfusion injury renal fibrosis renal tubular epithelial cells

Different responses of two adjacent artificial beaches to Typhoon Hato in zhuhai,China

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Journal of Oceanology and Limnology 2024年第2期42卷 511-521页

作者： Jun zhu qing WANG Chao ZHAN Fengjuan SUN Wenhao hua Jianhui LIU Hongshuai QI Yu YANG Coastal Research Institute Ludong UniversityYantai 264025China Third Institute of Oceanography Ministry of Natural ResourcesXiamen 261005China

Major differences in beach erosion between two neighboring artificial beaches Xiangluwan Beach(XL beach)and Meiliwan Beach(ML beach)in zhuhai,China,were studied after Super Typhoon *** this study,a fully nonlinear Boussinesq wave model(FUNWAVE)-Total Variation Diminishing(TVD)was used to distinguish the main impact factors,their relative contributions,and the hydrodynamic mechanisms underlying the different beach *** show that compared to the ML beach,the main reason for the relatively weak erosion on Xiangluwan(XL)beach was the smaller beach berm height(accounting for approximately 75.9%of the erosion response).Regarding the beach with a higher berm,the stronger wave-induced undertow flow,along with the higher sediment concentration,led to a higher offshore sediment transport flux,resulting in more severe erosion relative to the beach with a smaller berm *** second most important reason explaining the weak erosion on XL beach was the absence of seawalls(accounting for approximately 17.9%of the erosion response).Wave reflection induced by the seawall could cause higher suspended sediment concentration,resulting in a toe scouring near the *** offshore submerged breakwater protected XL beach slightly(accounting for approximately 6.1%of the erosion response).Due to the higher water level induced by storm surge,most of the wave energy could penetrate through the submerged *** effect of the larger berm width of XL beach was *** to the beach with a larger berm width,the erosion/deposition regions in the beach with a narrower berm width showed shoreward migration,without significant changes in the erosion/deposition *** of this,the larger berm width could reduce the wave energy reaching the *** study of the storm stability of artificial beaches may be applied to beach restoration design.

关键词： beach erosion berm height berm width seawall fully nonlinear Boussinesq wave model(FUNWAVE)

Task Scheduling for Multi-Cloud Computing Subject to Security and Reliability Constraints

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IEEE/CAA Journal of Automatica Sinica 2021年第4期8卷 848-865页

作者： qing-hua zhu huan Tang Jia-Jie huang Yan Hou School of Computer Science and Technology Guangdong University of TechnologyGuangzhou 510006China

The rise of multi-cloud systems has been *** safety-critical missions,it is important to guarantee their security and *** address trust constraints in a heterogeneous multi-cloud environment,this work proposes a novel scheduling method called matching and multi-round allocation(MMA)to optimize the makespan and total cost for all submitted tasks subject to security and reliability *** method is divided into two phases for task *** first phase is to find the best matching candidate resources for the tasks to meet their preferential demands including performance,security,and reliability in a multi-cloud environment;the second one iteratively performs multiple rounds of re-allocating to optimize tasks execution time and cost by minimizing the variance of the estimated completion *** proposed algorithm,the modified cuckoo search(MCS),hybrid chaotic particle search(HCPS),modified artificial bee colony(MABC),max-min,and min-min algorithms are implemented in CloudSim to create *** simulations and experimental results show that our proposed method achieves shorter makespan,lower cost,higher resource utilization,and better trade-off between time and economic *** is more stable and efficient.

关键词： Multi-cloud environment multi-quality of service(QoS) reliability security task scheduling

Synergistic catalysis of the N-hydroxyphthalimide on flower-like bimetallic metal-organic frameworks for boosting oxidative desulfurization

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Petroleum Science 2024年第1期21卷 674-682页

作者： Jing He Kun zhu Wei Jiang Dong-Ao zhu Lin-hua zhu Hai-Yan huang Wen-Shuai zhu hua-Ming Li Institute for Energy Research Jiangsu UniversityZhenjiang212013JiangsuChina College of Chemistry and Chemical Engineering Hainan Normal UniversityKey Laboratory of Water Pollution Treatment and Resource Reuse of Hainan ProvinceHaikou571158HainanChina

Synergic catalytic effect between active sites and supports greatly determines the catalytic activity for the aerobic oxidative desulfurization of fuel *** this work,Ni-doped Co-based bimetallic metal-organic framework(CoNi-MOF)is fabricated to disperse N-hydroxyphthalimide(NHPI),in which the whole catalyst provides plentiful synergic catalytic effect to improve the performance of oxidative desulfurization(ODS).As a bimetallic MOF,the second metal Ni doping results in the flower-like morphology and the modification of electronic properties,which ensure the exposure of NHPI and strengthen the synergistic effect of the overall *** with the monometallic Co-MOF and naked NHPI,the NHPI@CoNi-MOF triggers the efficient activation of molecular oxygen and improves the ODS performance without an *** sulfur removal of dibenzothiophene-based model oil reaches 96.4%over the NHPI@CoNi-MOF catalyst in 8 h of ***,the catalytic product of this aerobic ODS reaction is sulfone,which is adsorbed on the catalyst surface due to the difference in *** work provides new insight and strategy for the design of a strong synergic catalytic effect between NHPI and bimetallic supports toward high-activity aerobic ODS materials.

关键词： Metal-organic frameworks Doped Bimetallic N-hydroxyphthalimide Aerobic processes Oxidative desulfurization

Post-Processing Time-Aware Optimal Scheduling of Single Robotic Cluster Tools

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IEEE/CAA Journal of Automatica Sinica 2020年第2期7卷 597-605页

作者： qing hua zhu Yan Qiao NaiQi Wu Yan Hou School of Computer Science and Technology Guangdong University of TechnologyGuangzhou 510006China Institute of Systems Engineering Macao University of Science and TechnologyTaipa 999078MacaoChina State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006China

Integrated circuit chips are produced on silicon *** cluster tools are widely used since they provide a reconfigurable and efficient environment for most wafer fabrication *** advances in new semiconductor materials bring about new functionality for integrated *** a wafer is processed in a processing chamber,the wafer should be removed from there as fast as possible to guarantee its high-quality integrated ***,maximization of the throughput of robotic cluster tools is *** work aims to perform post-processing time-aware scheduling for such tools subject to wafer residencytime *** do so,closed-form expression algorithms are derived to compute robot waiting time accurately upon the analysis of particular events of robot waiting for singlearm cluster *** are given to show the application and effectiveness of the proposed algorithms.

关键词： Cluster tool discrete event systems optimization robotic systems scheduling

An Image Fingerprint and Attention Mechanism Based Load Estimation Algorithm for Electric Power System

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 577-591页

作者： qing zhu Linlin Gu Huijie Lin Electricity Technology Branch Nari Technology Co.Ltd.Nanjing211106China NARI-TECH Nanjing Control Systems Co. Ltd.Nanjing211106China

With the rapid development of electric power systems,load estimation plays an important role in system operation and ***,load estimation techniques contain traditional,time series,regression analysis-based,and machine learning-based *** the machine learning-based method can lead to better performance,in this paper,a deep learning-based load estimation algorithm using image fingerprint and attention mechanism is ***,an image fingerprint construction is proposed for training *** the data preprocessing,the training data matrix is constructed by the cyclic shift and cubic spline ***,the linear mapping and the gray-color transformation method are proposed to form the color image ***,a convolutional neural network(CNN)combined with an attentionmechanism is proposed for training performance *** last,an experiment is carried out to evaluate the estimation *** with the support vector machine method,CNN method and long short-term memory method,the proposed algorithm has the best load estimation performance.

关键词： Load estimation deep learning attention mechanism image fingerprint construction

Ni/Co bimetallic organic frameworks nanospheres for highperformance electrochemical energy storage

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Nano Research 2024年第6期17卷 5122-5130页

作者： Jianru Guan Minlu Liu Limin zhu Jiamei Wang qing Han Xiaoxia Yang Weibo hua Lingling Xie Xiaoyu Cao School of Chemistry and Chemical Engineering Key Laboratory of High Specific Energy Materials for Electrochemical Power Sources of Zhengzhou CityHenan University of TechnologyZhengzhou 450001China School of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’an 710049China School of Environmental Engineering Henan University of TechnologyZhengzhou 450001China

In addition to their many well-known advantages(e.g.,ultra-high porosity,good pore size distribution,easy functionalization,and structural tolerability),metal-organic frameworks(MOFs)are a new class of advanced functional ***,their backbones are highly susceptible to deformation after exposure to acidic or alkaline *** a result of lithium-ion batteries embedding or detaching directly from MOFs,they irreversibly *** a result,they fail to maintain their electrochemical *** factors have hindered the development of MOFs as direct electrode materials,making the design of MOF materials with controlled morphology and stable dimensions a new *** this study,we adopted a versatile and effective method to synthesize a novel MOF material(NiCo-BP(BP=BTC/phen and BTC=1,3,5-benzenetricarboxylic acid))using the rigid ligands 1,10-phenanthroline and homobenzotrizoic acid,and the emergence of the Ni-O/N and Co-O/N coordination layers was observed by extended X-ray absorption fine structure(EXAFS)tests,indicating that Ni and Co were coordinated with heterocyclic N-given atoms to form a stable p-πconjugated ***,the metal-ion is attached to the carboxylic acid ligand on the other side,making the metal-organic skeleton complete and *** nanosphere structure of NiCo-BP(~400 nm)allows for full exposure and utilisation of the active sites,especially the Ni,Co,and phenanthroline units,and exhibit impressively high specific capacity and cycling *** a high current density of 1.0 A·g^(−1),a high discharge specific capacity of 631.6 mAh·g^(−1)was obtained after 1000 *** co-participation of two organic ligands in the coordination is in accordance with the theory of soft and hard acids and bases,which contributes to the ability of the material to maintain a high capacity in cycling as well as its cyclic stability.

关键词： lithium-ion batteries metal organic frame electrochemical energy storage dual ligand hard-soft-acid-base

Structure and 2p decay mechanism of^(18)Mg

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Nuclear Science and Techniques 2024年第6期35卷 145-154页

作者： Long Zhou De-qing Fang Si-Min Wang Hui hua Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan UniversityShanghai 200438China School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China

The recently discovered,extremely proton-rich nuclide 18 Mg exhibits ground-state decay via two sequential two-proton(2p)emissions through the intermediate nucleus,*** study investigates the structure and the initial 2p decay mechanism of^(18)Mgby examining the density and correlations of the valence protons using a three-body Gamow coupled-channel *** results show that the ground state of^(18)Mgis significantly influenced by the continuum,resulting in a significant s-wave ***,based on the current framework,this does not lead to a significant deviation in mirror symmetry in either the structure or spectroscopy of the 18Mg-18C ***,the time evolution analysis of the^(18)Mgground state suggests a simultaneous 2p emission during the first step of *** observed nucleon-nucleon correlations align with those of the light-mass 2p emitters,indicating a consistent decay behavior within this nuclear region.

关键词： Structure of^(18)Mg Two-proton decay Proton-proton correlation