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Numerical analysis of water inrush from working-face floor during mining

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Journal of China University of Mining and Technology 2008年第2期18卷 159-163页

作者： ZHU qing-hua feng Mei-mei MAO Xian-biao School of Sciences China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

Confined water in the Ordovician limestone is one of the hidden troubles that threaten safe production of mines in north China. A numerical model of the key strata was developed. It included the structural characteristics and mechanical properties of the floor rock at the working face of a particular coal mine. The model was used to predict failure modes and to help establish rules for safe mining above the aquifer. The distribution of deformation, failure and seepage was simulated by using Dilian Mechsoft's Real- istic Failure Process Analysis (RFPA2D) program. The stress distribution, the deformation and the flow vectors were also obtained. The results indicate that: 1) The original balance of the stress and seepage fields is disturbed due to coal mining; and 2) As the working face advances different deformation, or failure, appears in the surrounding rocks, the water-resisting strata in floor may be destroyed and the passage of water from the aquifer into the mine may occur. The combined action of mining stress and water pressure ultimately lead to water inrush from the floor.

关键词： water inrush from floor stress field seepage field passageway of water-transmit numerical simulation

Removal of Methylene Blue with Hemicellulose/Clay Hybrid Hydrogels

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Chinese Journal of Polymer Science 2016年第6期34卷 709-719页

作者： He-li Cheng qing-hua feng Chuan-an Liao Yu Liu Dong-bei Wu 王启刚 Department of Chemistry Tongji University Institute of Pulp and Papermaking Hubei University of Technology Pharmaceutical College Guangxi Medical University Key Laboratory of Pulp and Paper Science & Technology of Ministry of Education of China Qilu University of Technology

In this study, we chose corn stover hemicellulose for the preparation of hydrogels with admirable adsorption properties under mild alkaline conditions. Clay nanosheets were introduced to this system and hemicellulose/clay hybrid hydrogels were prepared. Morphological, mechanical properties and the methylene blue adsorption behaviors of the prepared hydrogels were studied. Results suggested that the addition of clay not only improved the mechanical strength of hemicellulose-based hydrogels, but also increased the adsorption capacity on methylene blue. Moreover, the adsorptions were confirmed to follow pseudo-second order equation for both gels with and without clay. The maximum adsorption capacities on methylene blue for hemicellulose-based hydrogels with or without clay reached 148.8 and 95.6 mg/g, respectively. These results implied that hemicellulose-based hydrogels could be used as promising adsorbents for the removal of methylene blue from waste water.

关键词： Hemicellulose Hybrid hydrogel Clay Adsorption.

Searching for new drugs to treat Alzheimer’s disease dementia through multiple pathways

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World Journal of Clinical Cases 2025年第1期13卷 22-28页

作者： hua Bai Xiao-feng feng Department of Neurology The Third Affiliated Hospital of Guizhou Medical UniversityDuyun 558099Guizhou ProvinceChina Department of Neurology Wulong Branch of the People's Hospital Affiliated to Chongqing UniversityWulong 408500ChongqingChina Department of Neurology Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

Dementia is a group of diseases,including Alzheimer's disease(AD),vascular dementia,Lewy body dementia,frontotemporal dementia,Parkinson's disease dementia,metabolic dementia and toxic *** treatment of dementia mainly includes symptomatic treatment by controlling the primary disease and accompanying symptoms,nutritional support therapy for repairing nerve cells,psychological auxiliary treatment,and treatment that improves cognitive function through *** them,drug therapy to improve cognitive function is *** review focuses on introducing and commenting on some recent progress in exploring drugs to improve cognitive function,especially the new progress in drug treatment for *** mainly discuss the opportunities and challenges in finding and developing new therapeutic drugs from the aspects of acetylcholinesterase,N-methyl-D-aspartate glutamate receptor,amyloid protein,tau protein and chronic immune inflammation.

关键词： Alzheimer's disease Dementia Cholinesterase inhibitor Beta amyloid Tau protein

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血清性激素水平在肺癌早期诊断中的意义

医学与哲学（B） 2016年第11期37卷 36-39页

作者：张清华李仙凤曹丽华大连医科大学附属第二医院辽宁大连116023

探讨性激素能否作为一种潜在的标志物用于肺癌早期诊断。纳入65例患者分为良性结节组和肺癌组。区分性别与病理类型,比较两组雌二醇、睾酮、孕酮的水平变化。比较癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)和睾酮、雌二醇、孕酮对肺... 详细信息

探讨性激素能否作为一种潜在的标志物用于肺癌早期诊断。纳入65例患者分为良性结节组和肺癌组。区分性别与病理类型,比较两组雌二醇、睾酮、孕酮的水平变化。比较癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)和睾酮、雌二醇、孕酮对肺癌早期诊断的敏感性。结果表明男性肺癌患者血清睾酮、雌二醇、孕酮水平低于良性结节组(P<0.05)。女性良性结节组与肺癌组性激素水平差异无统计学意义。男性肺鳞癌与腺癌组血清睾酮、雌二醇、孕酮水平差异无统计学意义。血清睾酮、雌二醇、孕酮对肺癌早期诊断的敏感性高于CEA和CYFRA21-1。性激素可能作为男性肺癌早期诊断潜在的标志物。

关键词：肺癌性激素肿瘤标志物

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质子旋进式海洋地磁日变站的设计与实现

海洋科学进展 2020年第3期38卷 446-454页

作者：李先锋郑彦鹏华清峰刘凯马龙张林清自然资源部第一海洋研究所山东青岛266061 自然资源部海洋地质与成矿作用重点实验室山东青岛266061 青岛海洋科学与技术试点国家实验室海洋地质过程与环境功能实验室山东青岛266061

目前国内在深远海地磁测量中普遍采用潜标加挂磁力仪的作业方式测量地磁日变,针对其布放、回收操作复杂且劳动强度大的缺点,设计了一套新的一体化便携式质子旋进式海洋地磁日变站。基于质子旋进式地磁测量的工作原理,采用多周期同步测... 详细信息

目前国内在深远海地磁测量中普遍采用潜标加挂磁力仪的作业方式测量地磁日变,针对其布放、回收操作复杂且劳动强度大的缺点,设计了一套新的一体化便携式质子旋进式海洋地磁日变站。基于质子旋进式地磁测量的工作原理,采用多周期同步测量法和线性插值的过零数频算法提高了拉莫尔旋进信号的测频精度;在现有声学释放系统的基础上对声学应答和释放过程进行了改进,采用Goertzel算法提高了声学释放信号频率检测的计算效率和可靠性;将研制的仪器与国际商用仪器进行了陆地对比测试和海上实验。结果表明,研制的海洋地磁日变站性能指标满足海洋地磁测量数据的日变改正精度要求,可靠性高,而且海上操作便捷,可替代传统的海洋地磁日变测量的作业方式。

关键词：海洋地磁日变站一体化质子旋进式原理海洋地磁测量

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楚科奇海北部浅地层结构对古冰川活动的指示

海洋科学进展 2021年第3期39卷 393-402页

作者：李官保周庆杰华清峰王景强刘晨光刘保华自然资源部第一海洋研究所山东青岛266061 自然资源部海洋地质与成矿作用重点实验室山东青岛266061 国家深海基地管理中心山东青岛266237

北极周边陆架海域第四纪时期曾多次受到冰川活动的影响,但楚科奇海作为北极陆架海之一,其第四纪古冰川活动的存在尚需要更多数据的支持。本文利用2019年中国第十次北极科学考察中获取的楚科奇海北部的陆架和陆坡上700余km的高分辨率浅... 详细信息

北极周边陆架海域第四纪时期曾多次受到冰川活动的影响,但楚科奇海作为北极陆架海之一,其第四纪古冰川活动的存在尚需要更多数据的支持。本文利用2019年中国第十次北极科学考察中获取的楚科奇海北部的陆架和陆坡上700余km的高分辨率浅地层剖面数据,在剖面上识别出了冰川接地带楔状体、冰成碎屑流沉积、冰下混杂沉积和冰下水流沉积等多种类型的冰成沉积结构,可知研究区曾受到古冰川作用的影响。陆架坡折处被半远洋沉积隔开的上下两套接地带楔状体、隆起东南宽海槽中冰成混杂沉积中的层状泥质透镜体都指示研究区存在不止一期古冰川活动,且均曾扩展到楚科奇陆架边缘。

关键词：浅地层剖面古冰川地层结构楚科奇海北极

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序列关联并行挖掘算法研究

计算机科学 2003年第8期30卷 114-116页

作者：李庆华赵峰国家高性能计算中心武汉430074 华中科技大学计算机科学与技术学院武汉430074

Ming sequential associations is becoming increasing essential in many scientific and commercial *** parallel algorithm becomes quite challenging depending on enormous size of available dataset and possiblylarge number of mined associations ,the nature of input data and the timing constraints imposed on the desired associa-tions. In this paper ,we discuss several different parallel algorithms that cater to various situations to speed up thecurrent mining process.

关键词：数据仓库序列关联并行挖掘算法数据挖掘数据集数据库

Effect of Jianpi Huoxue Decoction(健脾活血方)-containing Serum on Tumor Necrosis Factor-α Secretion and Gene Expression of Endotoxin Receptors in RAW264.7 Cells Induced by Lipopolysaccharide

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Chinese Journal of Integrative Medicine 2009年第3期15卷 198-203页

作者：彭景华胡义扬冯琴成扬许丽莉陈少东陶庆李风华 Institute of Liver Diseases Shuguang Hospital Shanghai University of Traditional Chinese Medicine

Objective:To evaluate the effect of Jianpi Huoxue decoction(健脾活血方,JHD)-containing serum on tumor necrosis factor-α(TNF-α) secretion and endotoxin receptor gene expression in RAW264.7 cells induced by lipopolysaccharide(LPS).Methods:The cytotoxicity of blank-control serum and JHD-containing serum at different concentrations were evaluated through the lactate dehydrogenase(LDH) assay in RAW264.7 ***264.7 cells were divided into six groups:5%blank-control serum group(C1,n=3),5%blank-control serum plus LP...

关键词： Jianpi Huoxue decoction-containing serum lipopolysaccharide cytokine endotoxin receptor

Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing Liu Hangxing Wang Aizhen Zuo Cen Jin Nan Wang Huiqi Sun Luqian feng hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics