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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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Resilient and Safe Platooning Control of Connected Automated Vehicles Against Intermittent Denial-of-Service Attacks

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IEEE/CAA Journal of Automatica Sinica 2023年第5期10卷 1234-1251页

作者： Xiaohua ge qing-Long Han qing Wu Xian-Ming Zhang the School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia the School of Engineering and Technology Central Queensland UniversityRockhampton QLD 4701Australia

Connected automated vehicles(CAVs)serve as a promising enabler for future intelligent transportation systems because of their capabilities in improving traffic efficiency and driving safety,and reducing fuel consumption and vehicle emissions.A fundamental issue in CAVs is platooning control that empowers a convoy of CAVs to be cooperatively maneuvered with desired longitudinal spacings and identical velocities on *** paper addresses the issue of resilient and safe platooning control of CAVs subject to intermittent denial-of-service(DoS)attacks that disrupt vehicle-to-vehicle ***,a heterogeneous and uncertain vehicle longitudinal dynamic model is presented to accommodate a variety of uncertainties,including diverse vehicle masses and engine inertial delays,unknown and nonlinear resistance forces,and a dynamic platoon ***,a resilient and safe distributed longitudinal platooning control law is constructed with an aim to preserve simultaneous individual vehicle stability,attack resilience,platoon safety and ***,a numerically efficient offline design algorithm for determining the desired platoon control law is developed,under which the platoon resilience against DoS attacks can be maximized but the anticipated stability,safety and scalability requirements remain ***,extensive numerical experiments are provided to substantiate the efficacy of the proposed platooning method.

关键词： Connected automated vehicles(CAVs) cooperative adaptive cruise control denial-of-service(DoS)attacks resilient control vehicle platooning vehicle-to-vehicle communication

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日本知识界认知中的五四运动

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河北学刊 2025年第1期45卷 210-217页

作者：曹萌中国社会科学院

五四运动爆发后,日本主流舆论将其定性为“排日运动”,多指责中国青年学生排斥日本,认为英美势力与中国亲英美派政客煽动青年学生促成了“暴动”。部分日本在华媒体人和以吉野作造为代表的日本新知识分子以及大阪报刊《大正日日新闻》... 详细信息

五四运动爆发后,日本主流舆论将其定性为“排日运动”,多指责中国青年学生排斥日本,认为英美势力与中国亲英美派政客煽动青年学生促成了“暴动”。部分日本在华媒体人和以吉野作造为代表的日本新知识分子以及大阪报刊《大正日日新闻》却肯定了五四运动体现出的进步思想,呼吁日本民众理性看待中国的民众运动。其中,《大正日日新闻》1920年新年号连载“中国名士之对日意见”,这些意见集中介绍了五四运动、新思想运动的真义,体现了五四运动后日本知识界对中国新思想的关注,同时也呈现出日本对华观的多面性与复杂性。

关键词：五四运动中日关系吉野作造《大正日日新闻》

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Spin-modulated near-infrared-Ⅰ emission in a xanthene-decorated Fe(Ⅱ) spin-crossover complex

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Science China Chemistry 2025年

作者： Cheng Yi Duyong Chen Shihui Zhang Rui Cai Chunying Duan Yinshan meng Tao Liu State Key Laboratory of Fine Chemicals Frontier Science Center for Smart Materials and Chemical Engineering School of Chemical Engineering Dalian University of Technology Instrumental Analysis Center Dalian University of Technology School of Chemistry Dalian University of Technology Liaoning Binhai Laboratory

Molecular materials showing synergetic coupling of near-infrared （NIR） fluorescence and spin-crossover （SCO） are promisingly applicable in in-vivo bioimaging,temperature sensing,and spintronic *** the related study faces formidable *** this work we graft the NIR fluorophore xanthene onto the dipyridyl substituted triazole ligand and construct a new Febased SCO material,{FeⅡ（ddxc-abpt）2[N（CN）2]2}(1,ddxc-abpt:（E）-4-(((3,5-di（pyridin-2-yl）-4H-1,2,4-triazol-4-yl)imino)methyl)-N,N-diethyl-2,3-dihydro-1H-xanthen-6-amine).Magnetic studies indicate that compound 1 exhibits thermally induced SCO property in both the solid and solution ***-temperature fluorescence emission spectra reveal a remarkable 7-fold increase in photoluminescence intensity upon the transition from the low-spin state at 110 K to the high-spin state at 280 K,which is the record of all reported coupled fluorescence-SCO ***-temperature ultraviolet-visible （UV-Vis）absorption spectra show a significant change in absorption intensity within the fluorescence emission window,consistent with the F?rster resonance energy transfer （FRET） ***-dependent density functional theory （TD-DFT） calculations demonstrate that the strong coupling is attributed to disrupted energy transfer between the xanthene fluorophore and high-spin *** work provides a feasible approach for expanding the synergetic SCO-fluorescence materials to the NIR-Iwavelength region,and hopefully contributes to the applications of tunable NIR-SCO molecule-based sensors and devices.

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Self-Organized Criticality in Small-World Networks Based on the Social Balance Dynamics

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Chinese Physics Letters 2011年第11期28卷 275-277页

作者： meng qing-Kuan School of Science Shandong University of TechnologyZibo 255049

A node model is proposed to study the self-organized criticality in the small-world networks which represent the social *** on the node model and the social balance dynamics,the social networks are mapped to the thermodynamic systems and the phenomena are studied with physical *** is found that the avalanche in the small-world networks at the critical state satisfies the power-law distribution spatially and temporally.

关键词： Small networks avalanche

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Decentralized Dynamic Event-Triggered Communication and Active Suspension Control of In-Wheel Motor Driven Electric Vehicles with Dynamic Damping

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IEEE/CAA Journal of Automatica Sinica 2021年第5期8卷 971-986页

作者： Iftikhar Ahmad Xiaohua ge qing-Long Han the School of Software and Electrical Engineering Swinburne University of TechnologyMelbourneVIC 3122Australia

This paper addresses the co-design problem of decentralized dynamic event-triggered communication and active suspension control for an in-wheel motor driven electric vehicle equipped with a dynamic damper. The main objective is to simultaneously improve the desired suspension performance caused by various road disturbances and alleviate the network resource utilization for the concerned in-vehicle networked suspension system. First, a T-S fuzzy active suspension model of an electric vehicle under dynamic damping is established. Second,a novel decentralized dynamic event-triggered communication mechanism is developed to regulate each sensor's data transmissions such that sampled data packets on each sensor are scheduled in an independent manner. In contrast to the traditional static triggering mechanisms, a key feature of the proposed mechanism is that the threshold parameter in the event trigger is adjusted adaptively over time to reduce the network resources occupancy. Third, co-design criteria for the desired event-triggered fuzzy controller and dynamic triggering mechanisms are derived. Finally, comprehensive comparative simulation studies of a 3-degrees-of-freedom quarter suspension model are provided under both bump road disturbance and ISO-2631 classified random road disturbance to validate the effectiveness of the proposed co-design approach. It is shown that ride comfort can be greatly improved in either road disturbance case and the suspension deflection, dynamic tyre load and actuator control input are all kept below the prescribed maximum allowable limits, while simultaneously maintaining desirable communication efficiency.

关键词： Active suspension control decentralized eventtriggered control dynamic damper dynamic eventtriggered communication in-wheel motor driven electric vehicle

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Benzobisthiazole Polymer with Resonance-assisted Hydrogen Bonds for High-performance Transistor and Solar Cell Applications

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Chinese Journal of Polymer Science 2022年第2期40卷 147-156页

作者： Bing-Yong Liu Cong Xie Cong-Wu ge meng-meng Cui Wei Yang Zai-Fei Ma Xi-Ke Gao Yin-Hua Zhou qing Zhang Shanghai Key Laboratory of Electrical Insulation and Thermal Aging School of Chemistry and Chemical EngineeringShanghai Jiaotong UniversityShanghai 200240China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Center for Advanced Low-dimension MaterialsDonghua UniversityShanghai 201620China

Benzobisthiazole polymer with resonance-assisted hydrogen bonds(RAHBs)has been synthesized for both organic field-effect transistor and polymer solar cell *** properties of the hydrogen bonded polymer are compared with the reference polymer without ***-crystal X-ray diffraction analyses of the building block reveal that the RAHB interactions are formed between the carbamate hydrogen and imine nitrogen of the *** hydrogen donor and acceptor are connected byπ-conjugated molecular framework and the hydrogen-bridged quasi aromatic rings lock the conformation of the building *** building block adopted a layered sandwich packing in crystal instead of slipped herringbone stacking which was often found in the crystal of benzobisthiazole *** polymer PCBTZ-TT with RAHBs showed deeper HOMO/LUMO energy level(about 0.2 eV)than reference *** PCBTZ-TT demonstrated the hole mobility of0.96 cm^(2)·V^(-1)·s^(-1) in field-effect transistor devices and achieved power conversion efficiency of 13.6%in solar cell devices with Y6 as acceptor without any additive.

关键词： Resonance-assisted hydrogen bonding Benzobisthiazole Thiazole OFET OPV

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Exact explicit solitary wave and periodic wave solutions and their dynamical behaviors for the Schamel–Korteweg–de Vries equation

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Chinese Physics B 2021年第6期30卷 62-76页

作者： Bin He qing meng College of Mathematics and Statistics Honghe UniversityMengzi 661100China

The Schamel–Korteweg–de Vries equation is investigated by the approach of *** existences of solitary wave including ω-shape solitary wave and periodic wave are proved via investigating the dynamical behaviors with phase space *** sufficient conditions to guarantee the existences of the above solutions in different regions of the parametric space are *** possible exact explicit parametric representations of the waves are also *** with the details of the analyses,the analytical results are numerically simulated lastly.

关键词： Schamel–Korteweg–de Vries equation dynamical behavior solitary wave solution periodic wave solution

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A comprehensive study of treatment of arsenic in water combining oxidation,coagulation,and filtration

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Journal of Environmental Sciences 2015年第10期27卷 178-180页

作者： Terracciano Amalia ge Jie meng Xiaoguang Center for Environmental Engineering Stevens Institute of Technology

Arsenic is one of the most common inorganic contaminants in groundwater worldwide,mainly due to the release of naturally occurring arsenic from aquifer sediments（Amini et al.,2008;Li and Cai,2015;Rahman et al.,2015）... 详细信息

关键词： arsenic coagulation filtration predominantly ferric inorganic hydroxide groundwater remove adsorbed

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Manipulation of a temporal electron-spin splitter via aδ-potential in an embedded magnetic-electric-barrier microstructure

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Communications in Theoretical Physics 2021年第12期73卷 180-185页

作者： Gui-Xiang Liu ge Tang Jian-Lin Liu qing-meng Guo Shuai-Quan Yang Shi-Shi Xie College of Science Shaoyang UniversityShaoyang 422000China

We theoretically explore the manipulation of a temporal electron-spin splitter by aδ-potential in an embedded magnetic-elec tric-barrier micro structure(EMEBM),which is constructed by patterning a ferromagnetic stripe and a Schottky-metal stripe on the top and bottom of an InAs/Al_(x)In_(1-x)As heterostructure,*** polarization of the dwell time remains,even though aδ-potential is inserted by atomic-layer *** the magnitude and sign of the spinpolarized dwell time can be manipulated by changing the weight or position of the ***,a structurally controllable temporal electron-spin splitter can be obtained for spintronics device applications.

关键词： embedded magnetic-electric-barrier microstructure(EMEBM) δ-potential dwell time spin polarization manipulable temporal spin splitter

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