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Hepatocellular carcinoma and macrophage interaction induced tumor immunosuppressionvia Treg requires TLR4 signaling

World Journal of Gastroenterology 2012年第23期18卷 2938-2947页

作者： Jing Yang Jin-Xiang Zhang hui Wang Guo-Liang Wang qing-gang hu Qi-Chang Zheng Department of Hepatobiliary Surgery Union Hospital of Tongji Medical Col- lege Huazhong University of Science and Technology Wuhan 430022 Hubei Province China Department of Emergency Surgery Union Hospital of Tongji Medical College HuazhongUniversity of Science and Technology Wuhan 430022 HubeiProvince China Department of Medical Genetics Tongji Medical College Huazhong University of Science and Technology Wu- han 430030 Hubei Province China

AIM: To investigated the interaction between toll-like receptor 4 (TLR4)-activated hepatoma cells and macrophages in the induction of tumor-immune suppression mediated by CD4+CD25high family of transcription factor P3 (FOXP3) regulatory T cells (Tregs). METHODS: The proportion of FOXP3+ Tregs was identified in peripheral blood and tumor tissues of 60 hepatocellular carcinoma (HCC) patients. TLR4 expression was examined in tumor tissues and cell lines. The correlation was examined between FOXP3+ Tregs in peripheral blood and TLR4 expression of HCC tissues. Following activation of TLR4 in H22 murine hepatoma cells pre-incubated with lipopolysaccharide (LPS) and co-cultured with macrophage cell line RAW246.7, the synthesis of cytokines tumor necrosis factor-α, CCL22, and interleukin (IL)-10 by the two cell lines was detected and analyzed. RESULTS: FOXP3+ Tregs were enriched in tumor sites, and circulating FOXP3+ Tregs were increased in HCC patients in correlation with multiple tumor foci and up-regulated TLR4 expression in HCC tissues. Semi-quantitative analysis indicated that TLR4 was over-expressed in HCC compared with the matched normal tissues. Cell cultivation experiments indicated that the mRNAs of IL-10 and CCL22 were significantly up-regulated in the RAW246.7 cell line when co-cultured with LPS preincubated H22 cells. CONCLUSION: In hepatoma cell lines, TLR4 may indirectly facilitate the recruitment of Tregs to the tumor site and promote intrahepatic metastasis through its interaction with macrophages.

关键词： CD4+CD25^high FOXP3+ regulatory T cell Toll-like receptor Tumor immunity Hepatocellular car-cinoma Macrophage

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MiR-183-5p-PNPT1 Axis Enhances Cisplatin-induced Apoptosis in Bladder Cancer Cells

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Current Medical Science 2022年第4期42卷 785-796页

作者： qing-gang hu Zhi YANG Jia-wei CHEN Gallina KAZOBINKA Liang TIAN Wen-cheng LI Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Hepatobiliary Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Urology Luoshan County People’s HospitalXinyang 464000China Urology Unit La Nouvelle Polyclinique Centrale de BujumburaBujumbura 378Burundi Department of Urology Wuhan Red Cross HospitalWuhan 430015China

Objective:It has been reported that intrinsic apoptosis is associated with the progression of bladder cancer(BC).Recent evidence suggests that polyribonucleotide nucleotidyltransferase 1(PNPT1)is a pivotal mediator involved in RNA decay and cell ***,the regulation and roles of PNPT1 in bladder cancer remain largely ***:The upstream miRNA regulators were predicted by in silico *** expression levels of PNPT1 were evaluated by real-time PCR,Western blotting,and immunohistochemistry(IHC),while miR-183-5p levels were evaluated by qPCR in BC cell lines and *** vitro and in vivo assays were performed to investigate the function of miR-183-5p and PNPT1 in apoptotic RNA decay and the tumorigenic capability of bladder cancer ***:PNPT1 expression was decreased in BC tissues and cell *** of PNPT1 significantly promoted cisplatin-induced intrinsic apoptosis of BC cells,whereas depletion of PNPT1 potently alleviated these ***,oncogenic miR183-5p directly targeted the 3′UTR of PNPT1 and reversed the tumor suppressive role of ***,miR-183-5p modulated not only PNPT1 but also Bcl2 modifying factor(BMF)to inhibit the mitochondrial outer membrane permeabilization(MOMP)in BC ***:Our results provide new insight into the mechanisms underlying intrinsic apoptosis in BC,suggesting that the miR-183-5p-PNPT1 regulatory axis regulates the apoptosis of BC cells and might represent a potential therapeutic avenue for the treatment of BC.

关键词： bladder cancer polyribonucleotide nucleotidyltransferase 1 bcl2 modifying factor mitochondrial outer membrane permeabilization microRNA

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Serum carbohydrate antigen (CA) 19-9 as a prognostic factorin cholangiocarcinoma: A meta-analysis

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Frontiers of Medicine 2010年第4期4卷 457-462页

作者： Shang-Long LIU Zi-Fang SONG qing-gang hu Duo SHAN Shao-Bo hu Jun LI Qi-Chang ZHENG Department of Hepatobiliary Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China

This study was performed to determine the prognostic role of preoperative serum carbohydrate antigen(CA)19-9 levels in the survival of patients with *** published up to June 1st,2010 that evaluated preoperative CA19-9 levels and the prognosis of cholangiocarcinoma were collected for *** required information for calculating indivi-dual relative risk(RR)was extracted from the studies,and a combined overall RR was *** eligible studies were *** study dealt with extra-hepatic cholangiocarcinoma,while the other eight studies analyzed intra-hepatic *** mean methodolo-gical quality score was 74.1%,ranging from 65.5%to 82.5%.The overall RR for the nine studies was 1.28(95%conﬁdence interval=1.10–1.46),and the Z-score for overall effect was 13.83(P<0.001).The association between serum CA19-9 level and lymph node involvement was also *** combined RR was 1.471(95%conﬁdence interval=0.411–5.264)and Z-score for overall effect was 0.59(P=0.553).CA19-9 levels were associated signiﬁcantly with the prognosis of patients with *** meta-analysis shows that elevation of preoperative CA19-9 levels is correlated with a poor prognosis of patients with ***,larger scale and randomized studies are needed to draw a more substantive conclusion.

关键词： cholangiocarcinoma prognostic factors serum carbohydrate antigen 19-9

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The influence of Enteral Nutrition in postoperative patients with poor liver function

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World Journal of Gastroenterology 2003年第4期9卷 843-846页

作者： qing-gang hu Qi-Chang Zheng Department of Surgery,Xiehe hospital,Tongji Medical College,huazhong University of Science and Technology,Wuhan 430022,hubei Province,China Department of Surgery Xiehe hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Hubei Province China. mailbox_1@***

AIM: To investigate the safety, rationality and the practicality of enteral nutritional (EN) support in the postoperative patients with damaged liver function and the protective effect of EN on the gut ***: 135 patients with liver function of Child B or C grade were randomly allocated to enteral nutrition group (EN, 65 cases), total parenteral nutrition group (TPN, 40cases) and control group (CON, 30 cases). Nutritional parameters, hepatic and kidney function indexes were measured at the day before operation, 5th and 10th day after the operation respectively. Comparison was made to evaluate the efficacy of different nutritional support. Urinary concentrations of lactulose(L) and mannitol(M) were measured by pulsed electrochemical detection(HPLC-PED)and the L/M ratio calculated to evaluate their effectiveness on protection of gut ***: No significant damages in hepatic and kidney function were observed in both EN and TPN groups between pre- and postoperatively. EN group was the earliest one reaching the positive nitrogen balance after operation and with the lowest loss of body weight and there was no change in L/M ratio after the operation (0.026±0.004) at the day 1before operation, 0.030±0.004 at the day 5 postoperative and 0.027±0.005 at the day 10 postoperative), but the change in TPN group was significant at the day 5postoperative (0.027±0.003 vs 0.038±0.009,P＜0.01).CONCLUSION: EN is a rational and effective method in patients with hepatic dysfunction after operation and has significant protection effect on the gut barrier.

关键词：肠内营养肝功能术后肾功能消化道屏障

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代理人状态不可验证契约纳什实施惟一性分析

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山东大学学报（理学版） 2009年第6期44卷 33-39页

作者：朱军谭清美胡钢南京航空航天大学经济与管理学院江苏南京210016

围绕代理人逆向选择导致委托人无法直接识别代理人类型状态,研究真实状态下委托人契约实施惟一性问题。分析讨论了完全信息下委托人的最优契约和逆向选择下的次优契约,建立了信号空间上的纳什均衡与有效配置的映射关系,并推广到逆向选... 详细信息

围绕代理人逆向选择导致委托人无法直接识别代理人类型状态,研究真实状态下委托人契约实施惟一性问题。分析讨论了完全信息下委托人的最优契约和逆向选择下的次优契约,建立了信号空间上的纳什均衡与有效配置的映射关系,并推广到逆向选择问题中的类型空间,将委托人契约与代理人状态联系起来,最后研究分析委托人契约纳什实施惟一性问题。研究表明,委托人提供的完全信息下最优契约不具备纳什实施惟一性,而满足代理人激励相容约束的次优契约具备纳什实施的惟一性,并为合理、有效的激励契约设计提供了检验途径。

关键词：委托-代理契约不可验证性纳什实施

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利用微卫星标记分析家鸡的群体遗传变异

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四川大学学报（自然科学版） 2000年第S1期37卷 148-152页

作者：杨勇朱庆胡刚安四川农业大学动物科技学院雅安625014 广东省农科院畜牧研究所广州510640

作者选用 10对微卫星引物分析了 8个家鸡品种 (系 )及两个杂交群体的遗传变异、群体内杂合度 ,并用计算出的遗传距离对 10个家鸡群体进行了UPGMA聚类分析 .试验结果表明 ,微卫星标记具有丰富的多态性 ,所有微卫星的PCR扩增结果全部能重... 详细信息

作者选用 10对微卫星引物分析了 8个家鸡品种 (系 )及两个杂交群体的遗传变异、群体内杂合度 ,并用计算出的遗传距离对 10个家鸡群体进行了UPGMA聚类分析 .试验结果表明 ,微卫星标记具有丰富的多态性 ,所有微卫星的PCR扩增结果全部能重复 .所用 10个微卫星标记平均每对引物可检测 5.4个等位基因 ;微卫星标记可以准确反映 10个试验家鸡群体的真实杂合度 .

关键词：鸡微卫星分子标记群体遗传变异杂种优势

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发展银发经济的战略设计、焦点难点及路径优化

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 59-69,F0002页

作者：黄石松胡清中国人民大学国家发展与战略研究院北京100872 中国人民大学老年学研究所北京100872

我国正处于由中度老龄化社会步入重度老龄化社会的进程,银发经济将逐步从“以政府为主导的事业发展”阶段转向“事业和产业协同发展”的新阶段。准确把握这一转型发展特征,适时调整工作重心和节奏,注重运用市场机制推进产业发展迫在眉... 详细信息

我国正处于由中度老龄化社会步入重度老龄化社会的进程,银发经济将逐步从“以政府为主导的事业发展”阶段转向“事业和产业协同发展”的新阶段。准确把握这一转型发展特征,适时调整工作重心和节奏,注重运用市场机制推进产业发展迫在眉睫。对银发产业进行业态划分是制定产业组织政策、产业管理政策、产业发展政策的前提和基础,文本尝试将我国银发产业划分为基础性产业、延伸性产业和战略性产业,并据此分析三类产业在发展中存在的焦点难点问题,按照分类精准施策原则,提出优化我国银发经济发展路径的政策建议。

关键词：银发经济老龄产业老龄事业战略设计业态划分

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Recent advances in efficient computation of deep convolutional neural networks

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Frontiers of Information Technology & Electronic Engineering 2018年第1期19卷 64-77页

作者： Jian CHENG Pei-song WANG gang LI qing-hao hu Han-qing LU National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China

Deep neural networks have evolved remarkably over the past few years and they are currently the fundamental tools of many intelligent *** the same time,the computational complexity and resource consumption of these networks continue to *** poses a significant challenge to the deployment of such networks,especially in real-time applications or on resource-limited ***,network acceleration has become a hot topic within the deep learning *** for hardware implementation of deep neural networks,a batch of accelerators based on a field-programmable gate array(FPGA) or an application-specific integrated circuit(ASIC)have been proposed in recent *** this paper,we provide a comprehensive survey of recent advances in network acceleration,compression,and accelerator design from both algorithm and hardware points of ***,we provide a thorough analysis of each of the following topics:network pruning,low-rank approximation,network quantization,teacher–student networks,compact network design,and hardware ***,we introduce and discuss a few possible future directions.

关键词： Deep neural networks Acceleration Compression Hardware accelerator

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Aldehyde dehydrogenase ALDH3F1 involvement in flowering time regulation through histone acetylation modulation on FLOWERING LOCUS C

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Journal of Integrative Plant Biology 2020年第8期62卷 1080-1092页

作者： Danyun Xu qing Liu gang Chen Zhiqiang Yan Honghong hu National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China College of Life Science and Technology Huazhong Agricultural UniversityWuhan 430070China

Flowering time regulation is one of the most important processes in the whole life of flowering plants and FLOWERING LOCUS C(FLC)is a central repressor of flowering ***,whether metabolic acetate level affects flowering time is *** we report that ALDEHYDE DEHYDROGENASE ALDH3F1 plays essential roles in floral transition via FLC-dependent *** the aldh3f1-1 mutant,the flowering time was significant earlier than Col-0 and the FLC expression level was ***3F1 had aldehyde dehydrogenase activity to affect the acetate level in plants,and the amino acids of E214 and C252 are essential for its catalytic ***,aldh3f1 mutation reduced acetate level and the total acetylation on histone *** H3K9Ac level on FLC locus was decreased in aldh3f1-1,which reduced FLC *** of ALDH3F1 could rescue the decreased H3K9Ac level on FLC,FLC expression and also the early-flowering phenotype of aldh3f1-1,however ALDH3F1E214A or ALDH3F1C252A could *** findings demonstrate that ALDH3F1 participates in flowering time regulation through modulating the supply of acetate for acetyl-CoA,which functions as histone acetylation donor to modulate H3K9Ac on FLC locus.

关键词： donor finding acetate

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A robust beam tracking scheme for millimeter wave HetNets

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Digital Communications and Networks 2022年第6期8卷 1115-1121页

作者： qing Xue gang Feng Chongqing Key Laboratory of Mobile Communications Technology Chongqing University of Posts and Telecommunications(CQUPT)Chongqing400065China National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of China(UESTC)Chengdu611731China State Key Laboratory of Internet of Things for Smart City University of MacaoMacaoChina

Millimeter Wave(mmWave)communication has been widely acknowledged as an attractive solution to address high-speed transmission of massive data in 5G and beyond 5G systems due to the promising spectrum ***,mmWave signals are highly susceptible to blockage and may suffer from rapidly changing ***,directional/beam tracking becomes imperative yet essential for robust mmWave *** address this challenge,we propose a robust beam tracking scheme for mmWave Heterogeneous Networks(HetNets)with *** from most existing schemes,the proposed beam tracking scheme is effective for outage *** first discuss theμWave-assisted beam tracking procedure with and without candidate beams,and then analyze the inherent correlation between mmWave link quality and the operating beamwidth and occlusion range to derive the optimal *** and numerical results show that the proposed beam tracking scheme can improve the robustness of mmWave communications while guaranteeing the rate performance.

关键词： Millimeter wave(mmWave)communication Beam tracking Multi-connectivity Robust

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