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Two new benzofuran lignan glycosides from Gelsemium elegans

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Chinese Chemical Letters 2008年第11期19卷 1327-1329页

作者： Wei Hua qing chun zhao Jia Yang Guo Bing Shi Li Jun Wu Zao Guo School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China Department of Pharmacy Shenyang Northern Hospital Shenyang 110016 China

Two new benzofuran lignan glycosides, gelsemiunoside A and B, were isolated from the whole plant of Gelsemium elegans Benth. Their structures were elucidated on the basis of spectroscopic evidence. Furthermore, gelsem... 详细信息

关键词： Gelsemium elegans Benzofuran lignan glycoside Gelsemiunoside A Gelsemiunoside B

Neuroprotective effects of kukoamine A on 6-OHDA-induced Parkinson’s model through apoptosis and iron accumulation inhibition

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Chinese Herbal Medicines 2021年第1期13卷 105-115页

作者： Xin Li Xiao-wen Jiang Hai-xiao Chu qing-chun zhao Huai-wei Ding Chao-hong Cai Department of Pharmacy General Hospital of Northern Theater CommandShenyang 110840China Key Laboratory of Structure-Based Drug Design and Discovery Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China Department of Traditional Chinese Medicine Shenyang Pharmaceutical UniversityShenyang 110016China

Objective: Parkinson’s disease(PD) is characterized by the loss of dopaminergic neurons in substantia nigra(SN). Our previous study demonstrated kukoamine A(KuA) to exhibit strong neuroprotective effects through antioxidative stress, and autophagy in MPTP/MPP+-induced PD models in vivo and in vitro. It is necessary to evaluate the efficacy of the anti-PD effects under various ***: In the present study, total chemical synthesis was used to obtain KuA, which performed low content in Lycii Cortex. Then, 6-OHDA-induced PD model of PC12 cells was used to investigate the effects of KuA on ***: Our results demonstrated that KuA ameliorated cell loss and mitochondrial membrane potential(MMP) loss, and inhibited Bax/Bcl-2 ratio increase that were induced by 6-OHDA. Iron accumulation in SN is thought to participate in neuronal death in PD, which subsequently resulted in oxidative stress and overexpression of a-synuclein caused by iron metabolism protein disorder. In our study, KuA could chelate cellular iron content and decrease iron influx. Moreover, KuA could upregulate the expression of ferroportin1 and Hephaestin, downregulate the expression of DMT1, TfR, and Ferritin to maintain cellular iron homeostasis avoiding neuronal death from cellular iron deposition. Moreover, KuA could decrease the expression of a-synuclein in cells. All the results indicated that KuA protected against neurotoxininduced PD due to the apoptosis inhibition and iron homeostasis ***: KuA treatment might represent a neuroprotective treatment for PD.

关键词： 6-OHDA iron chelation iron homeostasis kukoamine A neuroprotection Parkinson’s disease

Influence of PPV,PRV and PRRSV on Efficacy of the Lapinized Hog Cholera Vaccine and Pathogenicity of Classical swine fever virus

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Journal of Integrative Agriculture 2012年第11期11卷 1892-1897页

作者： NING Yi-bao zhao Yun WANG Qin FAN Xue-zheng QIN Yu-ming ZHANG Guang-chuan XU Lu QIU Hui-shen WANG Zai-shi SONG Li SHEN qing-chun zhao Qi-zu China National Classical Swine Fever Reference Laboratory/China Institute of Veterinary Drug Control Beijing 100081 P.R. China

Classical swine fever caused by Classical swine fever virus （CSFV） is a serious problem for swine industries in developing countries, which successful control of the disease have been relying on vaccination. However, classical swine fever still occurs in some immunized swine herds for various reasons. In this study, we conducted animal experiments to examine the influence of single or mixed infection with Porcine parvo virus （PPV）, Pseudorabies virus （PRV） and Porcine reproductive and respiratory syndrome virus （PRRSV） on the protective immunity induced by the Lapinized hog cholera virus （HCLV） vaccine and the pathogenicity of CSFV. In experiment 1, pigs were first inoculated with PPV, PRV or PRRSV, then immunized with HCLV, and finally challenged with a highly virulent CSFV Shimen strain. All of the pigs immunized with HCLV survived after the challenge, while all of the pigs in the non-immunized control group died after the challenge. The pigs in the group immunized with HCLV did not show any clinical symptoms of classical swine fever and were negative with CSFV after the challenge. The pigs infected with the non-CSFV before HCLV immunization did not display any clinical symptoms after the challenge with CSFV Shiman strain, but 11 of the 12 pigs were positive with CSFV. In experiment 2, pre-infections with PPV, PRV, and PRRSV were followed by inoculation with a low-virulence CSFV strain （CSFV 39）, and then the pigs were challenged with the CSFV Shimen strain. Infections by either PPV, PRV or PRRSV did not enhance the virulence of CSFV-39, but pigs infected by a mixture of the 3 viruses developed clinical symptoms after inoculation with CSFV-39. The mixed infection also increased mortality caused by the challenge with the CSFV Shimen strain. Together, these results showed PPV, PRV and PRRSV infections in pigs can reduce the efficacy of the HCLV vaccine and enhance the pathogenicity of CSFV, which may partly explain the immunization failure against CSFV in some swine

关键词： Lapinized hog cholera virus vaccination pathogenicity mixed infection influence

Is tumor necrosis factor-α monoclonal therapy with proactive therapeutic drug monitoring optimized for inflammatory bowel disease? Network meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 571-584页

作者： Fang-Yuan Zheng Kai-Si Yang Wen-Cheng Min Xin-Zhu Li Yu Xing Shuai Wang Ying-Shi Zhang qing-chun zhao Teaching Hospital of Shenyang Pharmaceutical University General Hospital of Northern Theater CommandShenyang 110016Liaoning ProvinceChina

BACKGROUND The efficacy and safety of anti-tumor necrosis factor-α(TNF-α)monoclonal antibody therapy[adalimumab(ADA)and infliximab(IFX)]with therapeutic drug monitoring(TDM),which has been proposed for inflammatory bowel disease(IBD)patients,are still *** To determine the efficacy and safety of anti-TNF-αmonoclonal antibody therapy with proactive TDM in patients with IBD and to determine which subtype of IBD patients is most suitable for proactive TDM *** As of July 2023,we searched for randomized controlled trials(RCTs)and observa-tional studies in PubMed,Embase,and the Cochrane Library to compare anti-TNF-αmonoclonal antibody therapy with proactive TDM with therapy with reactive TDM or empiric *** and network meta-analyses were used to determine the IBD patient subtype that achieved clinical remission and to determine the need for *** This systematic review and meta-analysis yielded 13 studies after exclusion,and the baseline indicators were *** found a significant increase in the number of patients who achieved clinical remission in the ADA[odds ratio(OR)=1.416,95%confidence interval(CI):1.196-1.676]and RCT(OR=1.393,95%CI:1.182-1.641)subgroups and a significant decrease in the number of patients who needed surgery in the proactive vs reactive(OR=0.237,95%CI:0.101-0.558)and IFX+ADA(OR=0.137,95%CI:0.032-0.588)subgroups,and the overall risk of adverse events was reduced(OR=0.579,95%CI:0.391-0.858)according to the pairwise ***,the network meta-analysis results suggested that patients with IBD treated with ADA(OR=1.39,95%CI:1.19-1.63)were more likely to undergo TDM,especially in comparison with patients with reactive TDM(OR=1.38,95%CI:1.07-1.77).CONCLUSION Proactive TDM is more suitable for IBD patients treated with ADA and has obvious advantages over reactive *** recommend proactive TDM in IBD patients who are treated with ADA.

关键词： Inflammatory bowel disease Therapeutic drug monitoring Adalimumab Infliximab Network meta-analysis

Thalidomide-based Regimens for Elderly and/or Transplant Ineligible Patients with Multiple Myeloma： A Meta-analysis

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Chinese Medical Journal 2016年第3期129卷 320-325页

作者： Wen-Wen Lyu qing-chun zhao De-Hai Song Jin-Jie Zhang zhao-Xing Ding Bao-Yuan Li Chuan-Mei Wei Department of Pharmacy Binzhou Medical University Hospital Binzhou Shandong 256603 China School of Pharmacy Shenyang Pharmaceutical University Shenyang Liaoning 110016 China

Background： Thalidomide is an immunomodulatory and anti-angiogenic drug that has shown promise in patients with *** comparing efficacy of standard melphalan and prednisone （MP） therapy with MP plus thalidomide （MPT） in transplant-ineligible or elderly patients with multiple myeloma （MM） have provided conflicting *** meta-analysis aimed to determine the efficacy and toxicity of thalidomide in previously untreated elderly patients with ***： Medline, the Cochrane Controlled Trials register, conference proceedings of the American Society of Hematology （1995-2014）, the American Society of Clinical Oncology （1995-2014）, and CBM, VIP, and CNKI databases were searched for randomized control trials with the use of the medical subject headings ＆quot;MM＆quot; and ＆quot;thalidomide＆quot;.Trials were assessed by two reviewers for ***-analysis was conducted using a fixed effects *** analysis was performed to test the robustness of the ***： Overall, seven trials were identified, covering a total of 1821 *** summary hazard ratio （thalidomide ***） was 0.82 （95% confidence interval [CI]： 0.72-0.94） for overall survival （OS）, and 0.65 （95% CI： 0.58-0.73） for progression-free survival, in favor of thalidomide treated *** risk ratio of complete response with induction thalidomide was 3.48 （95% CI： 2.24-5.41）.A higher rate of Ⅲ/Ⅳ adverse events were observed in MPT arm compared with the MP ***, analysis of sub-groups administering anticoagulation as venous thromboembolism prophylaxis suggested no difference in relative risk of thrombotic events between two arms （RR =1.47, 95% CI： 0.43-5.07, P =0.54）.Further analysis of trials on the treatment effects of MPT versus MP on adverse events-related mortality showed no statistical difference between two arms （RR =1.24, 95% CI： [0.95-1.63], P =0.120）.Conclusion： Thalidomide appears to improve the OS of elderly and/or transplant-ineligible patie

关键词： Elderly Meta-analysis Multiple Myelolna Thalidomide

Preparation of FeCoNi medium entropy alloy from Fe^(3+)-Co^(2+)-Ni^(2+)solution system

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 92-101页

作者： Zongyou Cheng qing zhao Mengjie Tao Jijun Du Xingxi Huang Chengjun Liu Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical *** controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower *** this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen *** phases and magnetic properties of FeCoNi medium entropy alloy were *** showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal *** alloy prepared by hydrogen reduction was uniform and showed a relatively high ***,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.

关键词： medium entropy alloy sol-gel co-precipitation carbothermal hydrogen reduction

1,5-O-Dicaffeoyl-quinic Acid as a Novel Potential NMDA Receptor Inhibitor from Traditional Chinese Medicine Database by Virtual Screening

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Chinese Herbal Medicines 2016年第4期8卷 366-370页

作者： Xing Tian Jian Wang Jun Zhu Yan-hua Fan Wei-hong Meng Rong Fan qing-chun zhao Department of Pharmacy General Hospital of Shenyang Military Area Command Department of Pharmacy Shihezi University Department of Life Science and Biochemistry Shenyang Pharmaceutical University

Objective Neurodegenerative diseases, such as ischemia, traumatic injury, Alzheimer＇s disease, and Parkinson＇s disease are characterized by neuronal loss and dysfunction. It is known that glutamate-induced toxicity plays an important role in neurodegenerative diseases. Glutamate toxicity seems to be mediated by excessive influx of Ca^（2＋） into neuronal cells through activation of N-methyl-D-aspartate（NMDA） receptor. To search for potential NMDA receptor inhibitors in traditional Chinese medicine. Methods A series of computer methods including drug-likeness evaluation, ADMET tests as well as molecular docking have been used. Results 1,5-O-dicaffeoyl-quinic acid was identified as NMDA receptor inhibitor by virtual screening. Its neuroprotective activity was further confirmed by in vitro test. 1,5-O-dicaffeoyl-quinic acid showed strong neuroprotection against NMDA-induced cell injury. Conclusion 1,5-O-Dicaffeoylquinic acid may be regarded as a potential NMDA receptor inhibitor for the prevention and treatment of neurodegenerative disorders.

关键词： 1 5-O-dicaffeoyl-quinic acid glutamate neurodegenerative diseases N-methyl-D-aspartate receptor virtual screen

Prophylaxis of chronic kidney disease after liver transplantation-experience from west China

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World Journal of Gastroenterology 2012年第9期18卷 991-998页

作者： Zhen-Yong Shao Lu-Nan Yan Wen-Tao Wang Bo Li Tian-Fu Wen Jia-Yin Yang Ming-qing Xu Ji-chun zhao Yong-Gang Wei Liver Transplantation Center Department of LiverSurgery West China Hospital of Sichuan University Chengdu610041 Sichuan Province China

AIM： TO evaluate the prophylaxis of chronic kidney dis- ease （CKD） after liver transplantation （LT） with low-dose calcineurin inhibitor （CNI） and mycophenolate mofetil （MMF）.

关键词： Liver transplantation Chronic kidney dis-ease Calcineurin inhibitor Mycophenolate mofetil Riskfactor

论含油气系统的复杂性及其研究方法——兼论含油气系统综合模拟的科学思维和发展方向

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石油学报 2003年第6期24卷 1-6页

作者：张庆春赵文智中国石油勘探开发研究院北京100083

从系统学和复杂性科学上分析,含油气系统是一个开放的复杂动力系统。其主要特点是:整体功能大于局部功能之和;物质组成的多样性和不确定性;系统结构和油气藏类型的多样性;成藏过程和成藏作用的多样性、关联性;系统演化的阶段性、非线性... 详细信息

从系统学和复杂性科学上分析,含油气系统是一个开放的复杂动力系统。其主要特点是:整体功能大于局部功能之和;物质组成的多样性和不确定性;系统结构和油气藏类型的多样性;成藏过程和成藏作用的多样性、关联性;系统演化的阶段性、非线性、动态性;系统的开放性、耗散性;系统涉及学科的多样性;系统的自组织性和油气分布的有序性。研究复杂系统需要新的方法论,以含油气系统模拟为核心的集科学理论、专家系统和计算技术为一体的综合集成方法是认识含油气系统复杂性的重要手段,其科学思维体现了定性与定量的统一、静态与动态的统一、还原论与整体论的统一、确定性与随机性的统一。文中阐述了含油气系统模拟技术的5个发展趋势。

关键词：系统论复杂性方法论含油气系统数值模拟