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Cloning and functional analysis of a novel ascorbate peroxidase(APX) gene from Anthurium andraeanum

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第12期14卷 1110-1120页

作者： Hui-chun LIU Dan-qing TIAN Jian-xin LIU Guang-ying MA qing-cheng zou Zhu-jun ZHU College of Agriculture & Biotechnology Zhejiang University Research & Development Center of Flower Zhejiang Academy of Agricultural Sciences School of Agricultural and Food Science Zhejiang A&F University

An 888-bp ful-length ascorbate peroxidase （APX） complementary DNA （cDNA） gene was cloned from Anthurium andraeanum, and designated as AnAPX. It contains a 110-bp 5′-noncoding region, a 28-bp 3′-noncoding region, and a 750-bp open reading frame （ORF）. This protein is hydrophilic with an aliphatic index of 81.64 and its structure consisting ofα-helixes,β-turns, and random coils. The AnAPX protein showed 93%, 87%, 87%, 87%, and 86% similarities to the APX homologs from Zantedeschia aethiopica, Vitis pseudoreticulata, Gossypium hirsutum, Elaeis guineensis, and Zea mays, respectively. AnAPX gene transcript was measured non-significantly in roots, stems, leaves, spathes, and spadices by real-time polymerase chain reaction （RT-PCR） analysis. Interestingly, this gene expression was remarkably up-regulated in response to a cold stress under 6 °C, implying that AnAPX might play an important role in A. andraeanum tolerance to cold stress. To confirm this function we overexpressed AnAPX in tobacco plants by transformation with an AnAPX expression construct driven by CaMV 35S promoter. The transformed tobacco seedlings under 4 °C showed less electrolyte leakage （EL） and malondialdehyde （MDA） content than the control. The content of MDA was correlated with chilling tolerance in these transgenic plants. These results show that AnAPX can prevent the chilling challenged plant from cellmembrane damage and ultimately enhance the plant cold tolerance.

关键词： AnAPX Gene expression Cold stress Anthurium andraeanum

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Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng Deng Dan Yang Lingxi qing Yifei Chen Jilian zou Meiling Jia Qian Wang Runda Jiang Lihua Huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological *** coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological *** study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

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A step deformation method for superplasticity improvement of coarse-grained Ti–15V–3Cr-3Sn-3Al

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Chinese Journal of Aeronautics 2018年第7期31卷 1619-1624页

作者： cheng-Hong zou qing ZHOU Lei WANG College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics

Ti–15V–3Cr–3Sn–3Al（Ti–15–3）, a kind of metastable beta titanium which has high specific strength and good cold-formability, is highlighted for applications in the aerospace manufacture industry. However, the technique for improving its formability at elevated temperatures is still a challenge at present. In this work, a step deformation method is proposed for superplasticity improvement of coarse grained Ti–15–3 plates at temperatures around its beta transus. The effects of the strain rate and the strain at the first stage on the superplasticity are investigated. The results show an increase of the strain rate sensitivity and a decrease of the flow stress under the step deformation mode compared to those obtained under constant strain rates at 780℃. The maximum strain to failure obtained in the step mode is 93% higher than that deformed in the constant strain rate mode. Strain rates, strains at the first stage, and temperatures have influences on the superplasticity improvement. The deformation mechanism is concluded as subgrain formation accommodated by grain boundary sliding rate-controlled by dislocation climb. The improved m value in the step deformation is accounted to the extra dislocation density produced during the strain rate reduction.

关键词： Dynamic recrystatlization Strain rate sensitivity Subgrain Superplasticity Titanium alloy

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Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou Gao Qin Dong Dan zou Zhijun Yang Lili Guo Ruxiang Xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

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UiLog： Improving Log-Based Fault Diagnosis by Log Analysis

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Journal of Computer Science & Technology 2016年第5期31卷 1038-1052页

作者： De-qing zou Services Computing Technology and System Laboratory Huazhong University of Science and Technology Wuhan ~3007~ China Big Data Technology and System Laboratory Huazhong University of Science and Technology Wuhan 430074 China Cluster and Grid Computing Laboratory Huazhong University of Science and Technology Wuhan 430074 China School of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

In modern computer systems, system event logs have always been the primary source for checking system status. As computer systems become more and more complex, the interaction between software and hardware increases frequently. The components will generate enormous log information, including running reports and fault information. The sheer quantity of data is a great challenge for analysis relying on the manual method. In this paper, we implement a management and analysis system of log information, which can assist system administrators to understand the real-time status of the entire system, classify logs into different fault types, and determine the root cause of the faults. In addition, we improve the existing fault correlation analysis method based on the results of system log classification. We apply the system in a cloud computing environment for evaluation. The results show that our system can classify fault logs automatically and effectively. With the proposed system, administrators can easily detect the root cause of faults.

关键词： fault diagnosis system event log log classification fault correlation analysis

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A high performance approach for solving the high voltage direct current ion flow field problem by tensor-structured finite element method

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High Voltage 2023年第1期8卷 128-137页

作者： Qiwen cheng Jun zou Department of Electrical Engineering Tsinghua UniversityBeijingChina

In order to achieve high performance for solving the ion flow field problem,an approach is proposed with the tensor-structured finite element method(FEM)to accelerate the Newton *** Poisson equation and the continuity equation are reformulated into the tensor expressions,*** element level evaluation phase is decomposed into the concatenated tensor contraction operations,which is implemented by the highly optimised arithmetic operation provided in *** contrast to the traditional implemented FEM,the tensor-structured FEM has significantly improved the throughput and achieved high *** accuracy and efficiency of the tensorbased algorithm are verified under the unipolar and bipolar model,*** tensor-based algorithm provides one order of magnitude speedup over the traditional algorithm in the elemental evaluation phase.‘Tensorization’is an efficient way to bridge the algorithm and the hardware.

关键词： tensor element finite

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The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling Zhong Wenjiao Tai Meng-Lu Liu Shuaipeng Ma Tianjin Shen Yuhua zou Chun-Li Zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

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Co-design for an SoC embedded network controller

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第4期7卷 591-596页

作者： zou Lian-ying zou Xue-cheng Department of Electronic Science ＆ Technology Huazhong University of Science ＆ Technology Wuhan 430074 China

With the development of Ethernet systems and the growing capacity of modem silicon technology, embedded communication networks are playing an increasingly important role in embedded and safety critical systems. Hardware/software co-design is a methodology for solving design problems in processor based embedded systems. In this work, we implemented a new 1-cycle pipeline microprocessor and a fast Ethemet transceiver and established a low cost, high performance embedded network controller, and designed a TCP/IP stack to access the Intemet. We discussed the hardware/software architecture in the forepart, and then the whole system-on-a-chip on Altera Stratix EP1S25F780C6 device. Using the FPGA environment and SmartBit tester, we tested the system＇s throughput. Our simulation results showed that the maximum throughput of Ethemet packets is up to 7 Mbps, that of UDP packets is up to 5.8 Mbps, and that of TCP packets is up to 3.4 Mbps, which showed that this embedded system can easily transmit basic voice and video signals through Ethemet, and that using only one chip can realize that many electronic devices access to the Intemet directly and get high performance.

关键词： System-on-Chip (SoC) Embedded Microprocessor Network controller TCP/IP Co-design

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Mechanical-electro-magnetic coupling in strained bilayer CrI3

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Science China(Technological Sciences) 2020年第7期63卷 1265-1271页

作者： ZHANG Shuqing zou XiaoLong cheng HuiMing Shenzhen Geim Graphene Center(SGC) Tsinghua-Berkeley Shenzhen Institute(TBSI)&Tsinghua Shenzhen International Graduate School(TSIGS)Tsinghua UniversityShenzhen 518055China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

The discovery of intrinsic 2D ferromagnets provides exciting possibilities for spintronics applications. A particularly attractive example is CrI3, whose monolayer is ferromagnetic while bilayer shows antiferromagnetic coupling. Because of weak interlayer coupling, the magnetism of bilayer CrI3 can be easily modulated by external perturbations, such as gating or pressure. Here, we constructed a magnetic phase diagram of bilayer CrI3 under arbitrary biaxial strain(within ±4%) from compression to stretch,and found that compressive strain can effectively convert the antiferromagnetic coupling of bilayer CrI3 to *** analyses on electronic structure were then performed to unravel the underlying mechanism of the magnetic phase transition. It was shown that both band gap and orbital composition at conduction band minimum play important roles in determining magnetic ground states of strained bilayer CrI3. These results strengthen our understanding of the interlayer magnetism of 2D magnets and provide a feasible way to modulate the magnetism in 2D layered materials.

关键词： bilayer Crl3 magnetic coupling strain band gap orbital composition

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Preparation and properties of W–Cu–Zn alloy with low W–W contiguity

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Rare Metals 2016年第3期35卷 242-248页

作者： Ling-Ling Zheng Jin-Xu Liu Shu-Kui Li Shuang Liu qing-He zou Xing-Wang cheng School of Materials Science and Engineering Beijing Institute of Technology Mudanjiang North Alloy Tool Co. Ltd

The W–Cu–Zn alloy with a-brass matrix and low W–W contiguity was prepared by method of electroless copper plating combined with spark plasma sintering（SPS） *** effects of process and parameters on the microstructure and mechanical properties of the alloy were *** W–Cu–Zn alloy with a relative density of 96 % and a W–W contiguity of about 10 % was prepared by original fine tungsten particles combined with wet mixing method and SPS solid-state sintering method at 800℃ for 10 *** microstructure analysis shows that Cu–Zn matrix consists of nano-sized a-brass grains,and the main composition is Cu3Zn *** nano-sized Cu was coated on the surface of tungsten particles by electroless copper plating method,and the fairly low consolidation temperature and short solid-state sintering time result in the nano-sized matrix *** dynamic compressive strength of the W–Cu–Zn alloy achieves to1000 MPa,but the alloy shows poor ductility due to the formation of the hard and brittle Cu3Zn *** fine-grain strengthening and the solution strengthening of the Cu–Zn matrix phase are responsible for the high Vickers microhardness of about 300 MPa for W–Cu–Zn alloy.

关键词： W–Cu–Zn alloy Spark plasma sintering Microstructure Mechanical properties Microhardness

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