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Chinese Medical Sciences Journal 2006年第3期21卷 175-178页

作者： Gang Li qing-bo yan Liang-ming Wei Division of Cardiology Department of Geriatrics the First Affiliated Hospital Chongqing University of Medical Sciences Chongqing 400016 Department of Nuclear Medicine the Second Affiliated Hospital Chongqing University of Medical Sciences Chongqing 400010

Objective To explore the role of serum fibrotic indices including hyaluronic acid （HA）, procollagen type Ⅲ NH2-terminal peptide （PCIIIP）, and laminin （LN） in assessing the severity of myocardial fibrosis in chronic congestive heart failure （CHF）. Methods Serum levels of HA, PCIIIP, and LN in 39 patients with CHF E [14 with New York Heart Association （NYHA） functional class II, 21 with class Ⅲ, 4 with class Ⅳ] and in 46 patients with NYHA functional class I were assessed by radioimmunoassay. Results The serum concentrations of HA, PCMP, and LN were 359.75 ± 84.59 μg/L, 77.88 ± 24. 67 μg/L, 86. 73 ± 23.90 μg/L in CHF group, and 211.60 ±54. 80 μg/L, 64.82 ±23.99 μg/L, 82. 26 ±23.98 μg/L in NYHA functional class Ⅰ group, respectively. The HA level was significantly higher in CHF patients as compared with NYHA functional class Ⅰ group （ P 〈 0.05 ）. However, no difference was found in the levels of PCIIIP and LN between CHF group and NYHA functional class Ⅰ group. The serum HA concentration was negatively correlated with left ventricular ejection fraction （ r = - 0.71, P 〈 0.05 ）. Conclusion Serum HA level may act as an indicator for myocardial fibrosis.

关键词： congestive heart failure hyaluronic acid procollagen type Ⅲ NH2-terminal peptide laminin

A comparative study of surface characterization and corrosion behavior of micro-arc oxidation treated Ti-6Al-4V alloy prepared by SEBM and SLM

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Journal of Iron and Steel Research International 2023年第1期30卷 165-175页

作者： qing-bo yan Tong Xue Shi-feng Liu Wan-lin Wang yan Wang Xi Song Xin yang Wei-wei Shang Xi’an University of Architecture and Technology Xi’an 710055ShaanxiChina School of Metallurgical and Engineering Xi’an University of Architecture and TechnologyXi’an 710055ShaanxiChina School of Materials Science and Engineering Xi’an University of TechnologyXi’an 710048ShaanxiChina Shaanxi Steel Group Industrial Innovation Research Institute Co. Ltd.Hanzhong 723000ShaanxiChina

Additively manufactured Ti-6Al-4V(TC4)parts have been successfully employed as artificial implants in dental and orthopedic surgery due to their excellent mechanical ***,the suboptimal corrosion resistance limits their *** surface characterization and corrosion behavior of micro-arc oxidation(MAO)treated TC4 alloy prepared by selective electron beam melting(SEBM)and selective laser melting(SLM)technologies were *** corrosion resistance mechanism of SLM-MAO and SEBM-MAO was clarified through the analysis of the microstructure evolution,surface morphology,and electrochemical *** results show that the anatase-type TiO_(2) is partially transformed into the slankite phase after MAO *** surface roughness of SEBM sample was reduced by MAO coating,while the surface roughness of SLM sample increased after MAO,which is related to the difference between the microstructure of the deposited samples caused by different additive manufacturing *** MAO time was 15 min,SLM-MAO and SEBM-MAO coating displayed the best and the worst corrosion resistance,respectively.

关键词： TC4 alloy Selective laser melting Selective electron beam melting Micro-arc oxidation Corrosion resistance

The atlas of ferroicity in two-dimensional MGeX_(3) family:Room-temperature ferromagnetic half metals and unexpected ferroelectricity and ferroelasticity

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Nano Research 2021年第12期14卷 4732-4739页

作者： Kuan-Rong Hao Xing-Yu Ma Hou-Yi Lyu Zhen-Gang Zhu qing-bo yan Gang Su School of Physical Sciences University of Chinese Academy of SciencesBeijing100049China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing100049China Center of Materials Science and Optoelectronics Engineering College of Materials Science and Optoelectronic TechnologyUniversity of Chinese Academy of SciencesBeijing100049China Kavli Institute for Theoretical Sciences and CAS Center of Excellence in Topological Quantum ComputationUniversity of Chinese Academy of SciencesBeijing100190China

Two-dimensional(2D)ferromagnetic and ferroelectric materials attract unprecedented attention due to the spontaneous-symmetry-breaking induced novel properties and multifarious potential *** we systematically investigate a large family(148)of 2D MGeX3(M=metal elements,X=O/S/Se/Te)by means of the high-throughput first-principles calculations,and focus on their possible ferroic properties including ferromagnetism,ferroelectricity,and *** discover eight stable 2D ferromagnets including five semiconductors and three half-metals,212D antiferromagnets,and 11 stable 2D ferroelectric semiconductors including two multiferroic ***,MnGeSe3 and MnGeTe3 are predicted to be room-temperature 2D ferromagnetic half metals with Tc of 490 and 308 K,*** is probably for the first time that ferroelectricity is uncovered in 2D MGeX3 family,which derives from the spontaneous symmetry breaking induced by unexpected displacements of Ge-Ge atomic pairs,and we also reveal that the electric polarizations are in proportion to the ratio of electronegativity of X and M atoms,and IVB group metal elements are highly favored for 2D *** tunnel junction and water-splitting photocatalyst based on 2D ferroic MGeX3 are proposed as examples of wide potential *** atlas of ferroicity in 2D MGeX3 materials will spur great interest in experimental studies and would lead to diverse applications.

关键词： two-dimensional materials ferroicity ferroelectricity ferroelasticity ferromagnetic half metal

Effects of a carbohydrate-electrolyte beverage on blood viscosity after dehydration in healthy adults

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Chinese Medical Journal 2010年第22期123卷 3220-3225页

作者： CHANG Cui-qing CHEN yan-bo CHEN Zhi-min ZHANG Lan-tao Institute of Sports Medicine Peking University Third HospitalBeijing 100191 China

Background The consumption of carbohydrate-electrolyte beverages （CEs） has been known to be more effective than plain water for recovery from dehydration. This phenomenon suggests that the ingestion of CEs after dehydration is better than water for maintaining body fluid and plasma volume, and for the recovery from hemoconcentration and high blood viscosity as well. High blood viscosity causes infarction and other cardiovascular events. In this study, CE was compared with water and tea for the ability to reduce increased blood viscosity after dehydration. Methods A crossover random control study was conducted to assess the effectiveness of three beverages for rehydration and decreasing of blood viscosity. Following exercise-induced dehydration of 2.2% of body weight in a permanent warm environment, 10 male subjects rested in a thermoneutral environment for 3 hours （rehydration period, REP）. The subjects ingested test beverages equal to their body weight loss during the first 20 minutes in REP. Blood and urine samples were obtained throughout the experiments to assess the rehydration effect. Results The change in blood viscosity at a shear rate of 5/s was significantly lower in CE （（-1.66±0.21） mPa.s） in comparison to water （（-0.95±0.26） mPa.s） or tea （（-0.92±0.14） mPa.s） at 60th minute during the REP. The fluid retention rate was significantly greater for CE （（77.0±3.9）%） than water （（61.2±3.4）%） and tea （（60.5±3.7）%） for 3 hours of rest in REP. Conclusions The recovery from high blood viscosity induced by dehydration was higher with CE consumption than with water or tea. These results suggest that CE is useful for normalizing increased blood viscosity due to exercise-induced dehydration.

关键词： carbohydrate-electrolyte beverages blood viscosity hemoconcentration plasma volume fluid retention

Inhibitory effect of 2＇-o-methoxyethyl-modified antisense oligonucleotides targeting vascular endothelial growth factor A on SKOV3 human ovarian cancer cells

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Chinese Medical Journal 2011年第10期124卷 1573-1575页

作者： FU Yi-bing WEN Ze-qing ZHAO Xing-bo yan Lei ZHANG Chun-hua WANG Fei Department of Obstetrics and Gynaecology Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China

Background Ovarian cancers are often at an advanced stage at diagnosis because early detection is difficult. The poor prognosis of ovarian cancers highlights the crucial need to develop better therapeutic agents and strategies. The objective of this study was to investigate the inhibitory effects of a new modified antisense oligonucleotides targeting vascular endothelial growth factor A （VEGF-A） in SKOV3 ovarian cancer *** Antisense oligonucleotides targeting VEGF-A was designed, synthesized and transfected into SKOV3ovarian cancer cells. Western blotting and real-time RT-PCR were used to analyze the inhibitory effects of antisense oligonucleotides on VEGF-A protein and mRNA expression. Transwell matrix assay was used to detect cell migration *** The antisense oligonucleotides targeting VEGF-A significantly decreased VEGF-A protein and mRNA expression and inhibited cell migration in SKOV3 ovarian cancer *** This new modified antisense oligonucleotides targeting VEGF-A can decrease VEGF-A expression and inhibit cell migration in SKOV3 ovarian cancer cells. This new oligonucleotides may be a promising therapeutic agent for ovarian cancers

关键词： vascular endothelial growth factor A ovarian cancer antisense oligonucleotides transfection

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世界卫生组织打击假冒医药产品行动

中国新药杂志 2008年第1期17卷 91-93页

作者： Valerio Reggi 卜擎燕(译) Department of Technical Cooperation for Essential Drugs and Traditional Medicine World Health Organization 南京中医药大学附属医院临床药理科南京210029

假冒医药产品的危害很大,但尚无切实可靠的数据能反映这一问题的存在范围与严重程度,对其重视程度也远远不够。国际药品打假工作小组(IMPACT)是由世界卫生组织发起的打击假药的专项工作组,聚集了所有最重要的国际行动者,旨在协调国际有... 详细信息

假冒医药产品的危害很大,但尚无切实可靠的数据能反映这一问题的存在范围与严重程度,对其重视程度也远远不够。国际药品打假工作小组(IMPACT)是由世界卫生组织发起的打击假药的专项工作组,聚集了所有最重要的国际行动者,旨在协调国际有关方面,打击假冒医药产品,目标是促进和保护公众健康,重点在立法和行政管理的基础结构、行政管理的实施、执法、打假技术和信息交流5个方面采取行动。

关键词：假冒医药产品国际药品打假工作小组世界卫生组织

Response of Element Distribution of Various Organs of Maize to Fertilizer Application

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Agricultural Sciences in China 2010年第3期9卷 401-407页

作者： HU Hao, BAI You-lu, yanG Li-ping, KONG qing-bo, LU yan-li, WANG Lei and WANG Zhi-yong Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences/Key Laboratory of Plant Nutrition and Nutrient Cycling, Ministry of Agriculture, Beijing 100081, P.R.China Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences/Key Laboratory of Plant Nutrition and Nutrient Cycling Ministry of Agriculture Beijing 100081 P.R.China

The effect of fertilizer application on biomass dry weight and element distribution of various organs of maize was investigated from the aspect of microscopic view to disclose the internal mechanism of fertilizer effect on crop. Five fertilizer treatments： no fertilizer （CK）, nitrogen phosphorus fertilizer （NP）, nitrogen potassium fertilizer （NK）, phosphorus potassium （PK）, and nitrogen phosphorus potassium fertilizer （NPK） were designed. Field experiment on the response of biomass dry weight and N, P, K, Cu, Zn, Fe, and Mn element distribution of stem, leaf and seed of maize （Zea mays L.） to different fertilizer treatments application was carried out. The results showed that dry weight and element content of various organs of maize were different. N content of various organs followed this order leaf〉 seed 〉 stem; P content of various organs was seed 〉 leaf〉 stem; K content was stem 〉 leaf〉 seed; and Fe content was leaf〉 stem 〉 seed. Fertilizer application reduced the differences of N, P, K, and Fe contents of various organs, and changed the size order of the dry weight and the Cu and Zn contents of leaf, seed and stem. Except for individual treatment, the response direction of N, P and Fe elements to fertilizer application was similar to Cu and Zn. The response of element content of various organs of maize to different fertilizer combinations was also different. The response extent of N, P and K major elements to fertilizer application was larger than microelement of Cu, Zn, Fe, and Mn; the response extent of stem and leaf was larger than seed; the response to NPK fertilizer treatment was bigger than NP, NK and PK. In the whole, response differences of element distribution to various fertilizer treatments were not remarkable. Besides, element distribution of various organs of maize was also influenced by the mutual effect of fertilizer varieties. The response direction and extent of various element distributions to different fertilizer treatments had both similarit

关键词： element distribution fertilizer application maize

Large family of two-dimensional ferroelectric metals discovered via machine learning

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Science Bulletin 2021年第3期66卷 233-242,M0003页

作者： Xing-Yu Ma Hou-Yi Lyu Kuan-Rong Hao Yi-Ming Zhao Xiaofeng Qian qing-bo yan Gang Su School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Center of Materials Science and Optoelectronics Engineering College of Materials Science and Optoelectronic TechnologyUniversity of Chinese Academy of SciencesBeijing 100049China Department of Materials Science and Engineering College of Engineering and College of ScienceTexas A&M UniversityCollege StationTX 77843USA Kavli Institute for Theoretical Sciences and CAS Center for Excellence in Topological Quantum ComputationUniversity of Chinese Academy of SciencesBeijing 100190China

Ferroelectricity and metallicity are usually believed not to coexist because conducting electrons would screen out static internal electric *** 1965,Anderson and Blount proposed the concept of"ferroelectric metal",however,it is only until recently that very rare ferroelectric metals were ***,by combining high-throughput ab initio calculations and data-driven machine learning method with new electronic orbital based descriptors,we systematically investigated a large family(2964)of two-dimensional(2D)bimetal phosphates,and discovered 60 stable ferroelectrics with out-of-plane polarization,including 16 ferroelectric metals and 44 ferroelectric semiconductors that contain seven *** ferroelectricity origins from spontaneous symmetry breaking induced by the opposite displacements of bimetal atoms,and the full-d-orbital coinage metal elements cause larger displacements and polarization than other *** 2D ferroelectric metals,the odd electrons per unit cell without spin polarization may lead to a half-filled energy band around Fermi level and is responsible for the *** is revealed that the conducting electrons mainly move on a single-side surface of the 2D layer,while both the ionic and electric contributions to polarization come from the other side and are vertical to the above layer,thereby causing the coexistence of metallicity and *** der Waals heterostructures based on ferroelectric metals may enable the change of Schottky barrier height or the Schottky-Ohmic contact type and induce a dramatic change of their vertical transport *** work greatly expands the family of 2D ferroelectric metals and will spur further exploration of 2D ferroelectric metals.

关键词： Ferroelectric metal 2D ferroelectricity Multiferroics Ab initio calculations Machine learning

Designing a durable high-rate K_(0.45)Ni_(0.1)Fe_(0.1)Mn_(0.8)O_(2) cathode for K-ion batteries:A joint study of theory and experiment

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Science China Materials 2022年第7期65卷 1741-1750页

作者： Rongbin Dang qing-bo yan Enyue Zhao Na Li Kang Wu Zhongjun Chen Zhonghua Wu Xiangfeng Liu Zhongbo Hu Xiaoling Xiao College of Materials Science and Optoelectronic Technology Center of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

K-ion batteries(KIBs)hold great promise for large-scale energy ***,the absence of suitable cathode materials limits their practical ***,rationally designing advanced cathode materials for KIBs remains an open *** this work,based on density functional theory calculations,we find that the bond stability of Fe–O is higher than that of Co–O in layered transitional metal(TM)***,the K-ion migration in the Fe-based layered TM oxide has a significantly lower activation energy barrier than that in the Co-based *** on this theoretical prediction,we successfully synthesized a low-cost K_(0.45)Ni_(0.1)Fe_(0.1)Mn_(0.8)O_(2)cathode,which shows excellent structural stability and superior K-storage properties,including durable cycle life and high-rate ***,the designed K_(0.45)Ni_(0.1)Fe_(0.1)Mn_(0.8)O_(2)cathode possesses a great full-cell performance with a discharge capacity of~75 mA h g^(-1) and capacity retention of~80%after 100 *** results show that Fe has better structural stability and K-ion diffusion than high-cost Co in layered oxide cathodes,and this finding provides new insights into the design of low-cost and high-performance KIB layered *** work highlights the feasibility of a theory-guided experiment in screening promising battery materials.

关键词： K-ion batteries layered oxide cathode density functional theory K_(0.45)Ni_(0.1)Fe_(0.1)Mn_(0.8)O_(2)

boosting charge extraction and efficiency of inverted perovskite solar cells through coordinating group modification at the buffer layer/cathode interface

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Nano Research 2025年第1期18卷 415-423页

作者： Zhiqing Liang Ziqiu Ren Ziyu Wang Nan yan Ling Li bo Zhang yanlin Song College of Chemistry Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education Shaanxi Key Laboratory for Advanced Energy DevicesShaanxi Engineering Lab for Advanced Energy Technology School of Materials Science and EngineeringShaanxi Normal UniversityXi’an 710119China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of Sciences(ICCAS)Beijing Engineering Research Center of Nanomaterials for Green Printing TechnologyNational Laboratory for Molecular Sciences(BNLMS)Beijing 100190China

In inverted perovskite solar cells (PSCs),effective modification of the interface between the metalcathode and electron transport layer (ETL) is crucial forachieving high performance and stability. Herein, sulfonatedbathocuproine, commonly known as disodium bathocuproinedisulfonate (BCDS), was employed as a cathode buffer layerto address the interfacial issues at the [6,6]-phenyl-C61-butyricacid methyl ester (PCBM)/Ag interface. BCDS possesses theability to form coordinate bonds with Ag electrodes. Theutilization of the BCDS buffer layer enhanced the chargeextraction capability at the cathode interface whilesimultaneously achieving interfacial defect passivation,improving interfacial contact and increasing the built-in electricfield. Consequently, a power conversion efficiency (PCE) of25.06% was achieved. Furthermore, owing to the excellent filmforminguniformity of BCDS on PCBM, the stability of thedevice was also improved. After storage in dry air for morethan 2000 h, the device maintained 96% of its initial efficiency. This work underscores the remarkable potential of tailoringcoordination groups to enhance charge extraction efficiency at the ETL-cathode interface, unveiling a promising newfrontier in buffer layer development and performance optimization strategies for PSCs.

关键词： perovskite solar cells buffer layer bathocuproine disulfonate coordination group modification electron transport layer(ETL)-cathode interface