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Postoperative neuropsychological change and its underlying mechanism in patients undergoing coronary artery bypass grafting

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Chinese Medical Journal 2007年第22期120卷 1951-1957页

作者： YIN Yi-qing LUO Ai-lun GUO Xiang-yang LI Li-huan HUANG yu-guang Department of Anesthesiology China-Japan Friendship HosptialBeijing 100029 China Department of Anesthesiology Peking Union Medical CollegeHospital Beijing 100730 China Department of Anesthesiology Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical. College Cardiovascular Institute Beijing 100037 China

Background The high incidence of neuropsychologic deficits after cardiac surgery, including cognitive dysfunction and mood status, has significantly influenced the prognosis, outcome of treatment and long-term quality of life of patients. With a circadian secretion pattern, melatonin and cortisol are capable of modulating the human physiological processes and neuropsychological status, whereas disorder of their secretion pattern may lead to many diseases. However, it is unclear whether neuroendocrine variations are related to the neuropsychologic status in patients undergoing coronary artery bypass grafting （CABG）. Methods Forty male patients scheduled for CABG with hypothermic cardiopulmonary bypass （CPB）（n=20） or off-pump coronary artery bypass （OPCAB）（n=20） were studied. Blood samples were taken intraoperatively at specific time-points and every 3 hours within the first postoperative 24 hours to determine plasma concentrations of melatonin and cortisol. A neuropsychologic test battery including depression and anxiety was administered preoperatively and 7 to 10 days postoperatively. Statistical methods included the nonparametric analysis, multiple linear regression and cosinor analysis. Results The patients in the CPB group exhibited more severe neuropsychologic deficits and more anxious than those in the OPCAB group after surgery. In both groups, patients were more depressed postoperatively than preoperatively and recovered 3 months after surgery. Depression and anxiety were correlated with some factors of cognitive dysfunctions. In the postoperative 24 hours, 2 patients in the CPB group, and 6 patients in the OPCAB group showed a circadian rhythm of melatonin secretion. As for cortisol secretion, there were 3 patients in the CPB group and 7 in the OPCAB group respectively. Parameters of circadian rhythm of melatonin in the CPB group and those of secretion rhythm of cortisol in both groups were correlated with depression and some neuropsychologic tests. C

关键词： neuropsychology melatonin cortisol circadian rhythm coronary artery bypass grafting anesthesia

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民族共同体与民族文学的身份认同

海南大学学报（人文社会科学版） 2021年第5期39卷 186-192页

作者：廖宇婷西北大学文学院陕西西安710127

民族共同体到中华民族共同体再到人类命运共同体,中国将西方单一、狭隘与排他的共同体思想转换成了多元、开放与包容的共同体思想。但在美人之美、兼收并蓄的同时,由于文学传统、历史语境、血缘关系、身份标识、权力意志等问题难以厘清... 详细信息

民族共同体到中华民族共同体再到人类命运共同体,中国将西方单一、狭隘与排他的共同体思想转换成了多元、开放与包容的共同体思想。但在美人之美、兼收并蓄的同时,由于文学传统、历史语境、血缘关系、身份标识、权力意志等问题难以厘清,部分少数民族作家易于陷入自我身份认同和书写边界模糊的困惑之中。他们片面强调民族身份的异质性,将异族文学的身份作为自我标榜的噱头,弱化了文学的美学价值和历史意义。学者在编写民族文学史时,也难免涉及切入视角、文化传统、民族语言、历史叙述以及作品的虚构性与想象性等问题,这些都容易使民族文学主体性的建构陷入桎梏之中。文章直击民族文学创作中存在的问题,试图通过对这些"症结"进行论析,为中国当代民族文学的健康发展提供学理支持。

关键词：民族文学身份认同主体性探寻民族共同体

Non-flammable long chain phosphate ester based electrolyte via competitive solventized structures for high-performance lithium metal batteries

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Journal of Energy Chemistry 2024年第10期97卷 156-165,I0004页

作者： Li liao Zhiqiang Han Xuanjie Feng Pan Luo Jialin Song Yin Shen Xiaoshuang Luo Xinpeng Li Xuanzhong Wen Bo yu Junchen Chen Bingshu Guo Mingshan Wang yun Huang Hongmei Zhang Mengmeng Yin Jiangtao Liu yuanhua Lin Xing Li School of New Energy and Materials Southwest Petroleum UniversityChengdu 610500SichuanChina State Key Laboratory of Advanced Chemical Power Sources Guizhou Meiling Power Sources Co.LtdZunyi 563003GuizhouChina Beijing Advanced Innovation Center for Materials Genome Engineering Center for Green InnovationSchool of Mathematics and PhysicsUniversity of Science and Technology BeijingBeijing 100083China

Safety remains a persistent challenge for high-energy-density lithium metal batteries(LMBs).The development of safe and non-flammable electrolytes is especially important in harsh conditions such as high ***,a flame-retardant,low-cost and thermally stable long chain phosphate ester based(tributyl phosphate,TBP)electrolyte is reported,which can effectively enhance the cycling stability of highly loaded high-nickel LMBs with high safety through co-solvation *** interfacial compatibility between TBP and electrode is effectively improved using a short-chain ether(glycol dimethyl ether,DME),and a specially competitive solvation structure is further constructed using lithium borate difluorooxalate(LiDFOB)to form the stable and inorganic-rich electrode *** from the presence of the cathode electrolyte interphase(CEI)and solid electrolyte interphase(SEI)enriched with LiF and Li_(x)PO_(y)F_(z),the electrolyte demonstrates excellent cycling stability assembled using a 50μm lithium foil anode in combination with a high loading NMC811(15.4 mg cm^(-2))cathode,with 88%capacity retention after 120 ***,the electrolyte exhibits excellent high-temperature characteristics when used in a 1-Ah pouch cell(N/P=0.26),and higher thermal runaway temperature(238℃)in the ARC(accelerating rate calorimeter)demonstrating high *** novel electrolyte adopts long-chain phosphate as the main solvent for the first time,and would provide a new idea for the development of extremely high safety and high-temperature electrolytes.

关键词： Non-flammable electrolyte Long chain phosphate ester Solvation structure Lithium metal batteries Battery safety

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图像叙述的权力机制与听觉性在场

海南大学学报（人文社会科学版） 2022年第4期40卷 169-176页

作者：廖宇婷西北大学文学院陕西西安710127

后现代社会人类精神的非理性、消解性与网络开放的话语权结合,使得视觉文化更具张力。图像叙述铺天盖地,编码者更是“无所不用其极”,随之而来的是人们对道德失范的焦虑、对图像叙述功能的怀疑,以及对视觉审美品质的龃龉。这些“图像叙... 详细信息

后现代社会人类精神的非理性、消解性与网络开放的话语权结合,使得视觉文化更具张力。图像叙述铺天盖地,编码者更是“无所不用其极”,随之而来的是人们对道德失范的焦虑、对图像叙述功能的怀疑,以及对视觉审美品质的龃龉。这些“图像叙述”问题,一方面的确存在于社会的每一个“犄角旮旯”,另一方面也是保守者偏激宣扬“科技毁灭人文”的结果。因此,在关注图像叙述问题时,还需挖掘其背后技术、审美、资本共同运作的权力机制,强调图像研究中一直被忽略的重要维度——听觉性在场。力求阐明以往将图像与语言、理性与感性、精英与大众视为“二元对立”的不合理性,并试图为狭隘的图像叙述研究提供些许可资借鉴的思想与路径。

关键词：图像叙述权力机制二元对立听觉性在场

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线路电磁场测量数据的移动最小二乘拟合处理

高电压技术 2010年第3期36卷 661-665页

作者：张淮清俞集辉重庆大学输配电装备及系统安全与新技术国家重点实验室重庆400044

为可靠评估输电线路周围电磁环境,针对有限的实测数据,将移动最小二乘近似方法引入到测量数据的拟合处理中。阐述了移动最小二乘逼近的原理,剖析其对数据移动加窗处理本质,给出了MLS应用于拟合的实施方案。具体以线路磁场测量数据为例,... 详细信息

为可靠评估输电线路周围电磁环境,针对有限的实测数据,将移动最小二乘近似方法引入到测量数据的拟合处理中。阐述了移动最小二乘逼近的原理,剖析其对数据移动加窗处理本质,给出了MLS应用于拟合的实施方案。具体以线路磁场测量数据为例,分别进行了分段拟合和MLS拟合处理,通过拟合曲线和误差的对比分析,反映MLS拟合具有参数调整方便、拟合曲线的连续性和光滑性好以及误差小的特点和优势。同时对权函数进行研究,给出参数选取的原则和方法。

关键词：移动最小二乘曲线拟合分段最小二乘输电线路电磁场测量数据

A case of severe preeclampsia diagnosed as post-partum hemolytic uremic syndrome

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Chinese Medical Journal 2012年第6期125卷 1189-1192页

作者： WANG Yong-qing WANG Jing JIANG yuan-hui YE Rong-hua ZHAO Yang-yu Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China Department of Obstetrics and Gynecology Maternal and Child Health Hospital of Haidian District Beijing 100080 China

Post-partum hemolytic uremic syndrome （PHUS） is a severe thrombotic microangiopathy clinically characterized by hemolytic anemia, renal dysfunction, and low platelets after birth with rapid progression and poor prognosis. Here, we reported a rare case of severe preeclampsia diagnosed as hemolytic uremic syndrome after birth. The patient was diagnosed with PHUS and underwent intermittent plasma exchange with supportive treatment including glucocorticoid injections and transfusion of suspended red blood cells. After these treatments, the patient experienced no apparent remission and chronic renal dysfunction occurred on her. PHUS is a severe emergency with acute onset, rapid progress, and poor prognosis. Early detection, diagnosis, and treatment can significantly improve the prognosis.

关键词： preeclampsia hemolytic uremic syndrome thrombotic microangiopathy end-stage renal disease

Diagnosis,treatment,and prevention of severe acute hepatitis of unknown etiology in children

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World Journal of Pediatrics 2022年第8期18卷 538-544页

作者： Ying‑Hu Chen Jin‑Gan Lou Zi‑Hao Yang qing‑Jiang Chen Chun‑Zhen Hua Sheng Ye Chen‑Mei Zhang Jie Chen Zong‑Wei Huang Jin‑Dan yu Zhi‑Gang Gao Qiang Shu Infectious Disease Department National Clinical Research Center for Child HealthChildren’s HospitalZhejiang University School of MedicineHangzhou 310052China Gastroenterology Department National Clinical Research Center for Child HealthChildren’s HospitalZhejiang University School of MedicineHangzhou 310052China PICU National Clinical Research Center for Child HealthChildren’s HospitalZhejiang University School of MedicineHangzhou 310052China General Surgery Department National Clinical Research Center for Child HealthChildren’s HospitalZhejiang University School of MedicineBinsheng Road 3333Hangzhou 310052China

Background Severe acute hepatitis of unknown etiology in children has recently exhibited a global trend of concentrated *** review aimed to summarize the current available information regarding the outbreak of severe acute hepatitis and introduce our hospital’s previous experiences with the diagnosis and treatment of severe acute hepatitis for *** sources Websites including the UK Health Security Agency,European Centre for Disease Prevention and Control,CDC,WHO,and databases including PubMed/Medline,Cochrane Library,Embase and Web of Science were searched for articles on severe acute hepatitis in *** As of May 26,2022,a total of 650 cases have been reported in 33 countries;at least 38(6%)children required liver transplantation,and nine(1%)*** are predominantly aged between 3 and 5 years old,and there are no epidemiological links among *** common manifestations are jaundice,vomiting and pale *** tested positive in most cases,and SARS-CoV-2 and other viruses were detected in a few cases,but virus particles were not found in liver *** immunohistochemistry showed immunoreactivity in the intrasinusoidal lumen from some liver *** hierarchical treatment includes symptomatic and supportive therapy,management of coagulation disorders and hepatic encephalopathy,artifcial liver support,and liver transplantation(approximately 6%–10%of cases require liver transplant).Conclusions The etiology of this severe acute hepatitis in children is not *** clinical features are severe acute hepatitis with signifcantly elevated liver *** need to be alert to children with hepatitis.

关键词： Acute Hepatitis Diagnosis Epidemiology Pediatrics Treatment

Role of tumor necrosis factor-alpha in the pathogenesis of atrial fibrillation

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Chinese Medical Journal 2011年第13期124卷 1976-1982页

作者： DENG Hai XUE yu-mei ZHAN Xian-zhang liao Hong-tao GUO Hui-ming WU Shu-lin Department of Cardiology Guangdong Cardiovascular InstituteGuangdong General Hospital Guangdong Academy of MedicalSciences Guangzhou Guangdong 510100 China

Background Tumor necrosis factor-alpha （TNF-a） is a pleiotropic proinflammatory cytokine and contributes to many kinds of cardiovascular diseases via its receptors （TNFR1/TNFR2）. We hypothesize that TNF-a plays a role in the pathogenesis of chronic atrial fibrillation （AF）. Methods Sixty-seven consecutive patients who were scheduled to have cardiac surgery were enrolled into the study. Thirty-one patients with rheumatic heart disease （RHD） and AF were enrolled as study group （AF group）. The sinus rhythm （SR） control groups consisted of 20 patients with RHD and 16 patients with coronary artery disease （CAD）. Peripheral blood sample was collected before the operation. About 5 mm3 left atrial tissue was disserted during the operation and was separated into three parts for Western blotting, real time polymerase chain reaction （RT-PCR） and immunohistochemistry （IHC） analysis. Results Compared with the controls （RHD SR and CAD SR）, the levels of TNF-α （（14.40±5.45） pg/ml vs. （4.20±3.19） pg/ml vs. （2.68±2.20） pg/ml, P=0.000） and its soluble receptor 1 （sTNFR1）（（1623.9±558.6） pg/ml vs. （1222.3±175.6） pg/ml vs. （1387.5±362.2） pg/ml, P=0.001） in plasma were higher in patients with AF. TNF-a level had positive correlation with the left atrial diameter （LAD）（r=0.642, P=0.000）. Western blotting analysis showed that the protein levels of TNF-α （0.618±0.236 vs. 0.234±0.178 vs. 0.180±0.103, P=0.000） were higher in patients with AF. The RT-PCR analysis results demonstrated that the mRNA expression of TNF-a （0.103±0.047 vs. 0.031±0.027 vs. 0.023±0.018, P=0.000） increased in patients with AF. IHC analysis displayed that, comparing to the SR, the expression of TNF-α （0.125±0.025 vs. 0.080±0.027 vs. 0.070±0.023, P=0.000） increased in the AF group. The protein level and mRNA expression of TNF-α also had positive correlation with left atrium diameter （LAD）（r=0.415, P=0.000 and r=0.499, P=0.000）. Conclusions The results revealed that TNF-α elevated in the plasma and left atrial tissue a

关键词： tumor necrosis factor alpha atrial fibrillation left atrial diameter

Influence of PPV,PRV and PRRSV on Efficacy of the Lapinized Hog Cholera Vaccine and Pathogenicity of Classical swine fever virus

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Journal of Integrative Agriculture 2012年第11期11卷 1892-1897页

作者： NING Yi-bao ZHAO yun WANG Qin FAN Xue-zheng QIN yu-ming ZHANG Guang-chuan XU Lu QIU Hui-shen WANG Zai-shi SONG Li SHEN qing-chun ZHAO Qi-zu China National Classical Swine Fever Reference Laboratory/China Institute of Veterinary Drug Control Beijing 100081 P.R. China

Classical swine fever caused by Classical swine fever virus （CSFV） is a serious problem for swine industries in developing countries, which successful control of the disease have been relying on vaccination. However, classical swine fever still occurs in some immunized swine herds for various reasons. In this study, we conducted animal experiments to examine the influence of single or mixed infection with Porcine parvo virus （PPV）, Pseudorabies virus （PRV） and Porcine reproductive and respiratory syndrome virus （PRRSV） on the protective immunity induced by the Lapinized hog cholera virus （HCLV） vaccine and the pathogenicity of CSFV. In experiment 1, pigs were first inoculated with PPV, PRV or PRRSV, then immunized with HCLV, and finally challenged with a highly virulent CSFV Shimen strain. All of the pigs immunized with HCLV survived after the challenge, while all of the pigs in the non-immunized control group died after the challenge. The pigs in the group immunized with HCLV did not show any clinical symptoms of classical swine fever and were negative with CSFV after the challenge. The pigs infected with the non-CSFV before HCLV immunization did not display any clinical symptoms after the challenge with CSFV Shiman strain, but 11 of the 12 pigs were positive with CSFV. In experiment 2, pre-infections with PPV, PRV, and PRRSV were followed by inoculation with a low-virulence CSFV strain （CSFV 39）, and then the pigs were challenged with the CSFV Shimen strain. Infections by either PPV, PRV or PRRSV did not enhance the virulence of CSFV-39, but pigs infected by a mixture of the 3 viruses developed clinical symptoms after inoculation with CSFV-39. The mixed infection also increased mortality caused by the challenge with the CSFV Shimen strain. Together, these results showed PPV, PRV and PRRSV infections in pigs can reduce the efficacy of the HCLV vaccine and enhance the pathogenicity of CSFV, which may partly explain the immunization failure against CSFV in some swine

关键词： Lapinized hog cholera virus vaccination pathogenicity mixed infection influence