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Adiponectin levels are associated with the number and activity of circulating endothelial progenitor cells in patients with coronary artery disease

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第5期10卷 368-374页

作者： Zhi-qiang YING Dan-dan ZHONG Geng XU Miao-yan chen qing-yu chen Department of Cardiology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Internal Medicine the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

Objective:To study the relationship between plasma adiponectin concentration and the functional activities of circulating endothelial progenitor cells(EPCs) in patients with coronary artery disease(CAD).Methods:Circulating EPCs were enumerated as AC133+/KDR+ cells via flow cytometry and identified by co-staining with DiI-acLDL and fluorescein isothiocy-anate(FITC)-conjugated lectin under a fluorescent *** migratory capacity of EPCs was measured by modified Boyden chamber *** capacity was performed to count adherent cells after replating EPCs on six-well culture dishes coated with ***:The number of circulating EPCs(AC133+/KDR+ cells) decreased significantly in CAD patients,compared with control subjects [(74.2±12.3) vs(83.5±12.9) cells/ml blood,P<0.01].In addition,the number of EPCs also decreased in CAD patients after ex vivo cultivation [(54.4±8.6) vs(71.9±11.6) EPCs/field,P<0.01].Both circulating EPCs and differentiated EPCs were positively correlated with plasma adiponectin *** functional activities of EPCs from CAD patients,such as migratory and adherent capacities,were also impaired,compared with control subjects,and positively correlated with plasma adiponectin ***:The study demonstrates that the impairment of the number and functional activities of EPCs in CAD patients is correlated with their lower plasma adiponectin concentrations.

关键词： Adiponectin Adipokines Endothelial progenitor cells (EPCs) Coronary artery disease (CAD)

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Time-dependent changes in eye-specific segregation in the dorsal lateral geniculate nucleus and superior colliculus of postnatal mice

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第10期15卷 807-812页

作者： yu-qing chen yu-pu DIAO Jing-gang DUAN Li-yuan CUI Jia-yi ZHANG Institutes of Brain Science and State Key Laboratory of Medical Neurobiology Fudan University

Eye-specific segregation in the dorsal lateral geniculate nucleus(dLGN) and superior colliculus(SC) starts from the embryonic stage and continues to develop postnatally until eye-opening in mice. However, there have been few systematic studies on the details of this developmental process. Here, we carried out time-dependent studies of eye-specific segregation in the dLGN and SC. Our results demonstrated that the development of eye-specific segregation in the SC is completed before postnatal day 12(P12), which is earlier than in the dLGN(P20). During the whole period, ipsilateral and overlapping axonal projections decreased continuously in both the dLGN and SC. On the other hand, contralateral axonal projections showed little change, except for a slight decrease between P8 and P20 in the dLGN.

关键词： Eye segregation Dorsal lateral geniculate nucleus(dLGN) Superior colliculus Mouse visual system

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Acquired double pylorus:A case report

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Asian Pacific Journal of Tropical Medicine 2012年第6期5卷 503-504页

作者： qing-yu chen Yan chen Liang Jing Wang Qin Du Jian-Ting Cai Jia-Min chen Department of Gastroenterology Second Affiliated HospitalZhejiang University College of MedicineChina

Double pylorus is one of the rare anomalies of the gastrointestinal tract,it can be congenital or *** this case we report a case of double pylorus because of chronic peptic *** GI endoscopy revealed gastroduodenal fistula located on the lesser curve of the antrum,the patient’s symptoms were improved rapidly by intensive antiulcer treatment.

关键词： Acquired double pylorus Gastric endoscopy Gastroduodenal fistula

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Activation and shutdown dose-rate analyses for the EAST NBI test facility

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Nuclear Science and Techniques 2016年第4期27卷 60-66页

作者： yu-qing chen Ji Wang Bin Wu Jun Li Ya-Hong Xie Guo-Qiang Zhong Chun-Dong Hu Institute of Plasma Physics Chinese Academy of Sciences

An analysis of the neutron activation and shutdown dose rates was performed for the EAST high-power deuterium neutral beam injector test facility(EAST NBITF) by using the multiparticle transport code FLUKA2011.2. Also, the neutron and neutron-induced gamma spectra of the facility's vacuum vessel were evaluated. The results identified the major radionuclides^(99) Mo,^(65)Ni,^(58) Co,^(56)Mn, and^(51) Cr for the vacuum vessel and the primary nuclide^(64) Cu for both the ion dump and the *** simulated results indicated that, when the EAST NBITF operates within the design parameters of deuterium energy 80 ke V, current 50 A, and pulse 100 s, the neutron intensity will achieve 10^(11)n/s with no radiation safety problems after the EAST NBITF shuts down.

关键词：剂量率测试设备停机 NBI 放射性核素激活中性束注入器试验设施

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VX-765 reduces neuroinflammation after spinal cord injury in mice

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Neural Regeneration Research 2021年第9期16卷 1836-1847页

作者： Jing chen yu-qing chen yu-Jiao Shi Shu-Qin Ding Lin Shen Rui Wang Qi-Yi Wang cheng Zha Hai Ding Jian-Guo Hu He-Zuo Lü Clinical Laboratory the First Affiliated Hospital of Bengbu Medical CollegeBengbuAnhui ProvinceChina Anhui Key Laboratory of Tissue Transplantation the First Affiliated Hospital of Bengbu Medical CollegeBengbuAnhui ProvinceChina Department of Immunology Bengbu Medical Collegeand Anhui Key Laboratory of Infection and Immunity at Bengbu Medical CollegeBengbuAnhui ProvinceChina

Inflammation is a major cause of neuronal injury after spinal cord injury. We hypothesized that inhibiting caspase-1 activation may reduce neuroinflammation after spinal cord injury, thus producing a protective effect in the injured spinal cord. A mouse model of T9 contusive spinal cord injury was established using an Infinite Horizon Impactor, and VX-765, a selective inhibitor of caspase-1, was administered for 7 successive days after spinal cord injury. The results showed that:(1) VX-765 inhibited spinal cord injury-induced caspase-1 activation and interleukin-1β and interleukin-18 secretion.(2) After spinal cord injury, an increase in M1 cells mainly came from local microglia rather than infiltrating macrophages.(3) Pro-inflammatory Th1 Th17 cells were predominant in the Th subsets. VX-765 suppressed total macrophage infiltration, M1 macrophages/microglia, Th1 and Th1 Th17 subset differentiation, and cytotoxic T cells activation;increased M2 microglia;and promoted Th2 and Treg differentiation.(4) VX-765 reduced the fibrotic area, promoted white matter myelination, alleviated motor neuron injury, and improved functional recovery. These findings suggest that VX-765 can reduce neuroinflammation and improve nerve function recovery after spinal cord injury by inhibiting caspase-1/interleukin-1β/interleukin-18. This may be a potential strategy for treating spinal cord injury. This study was approved by the Animal Care Ethics Committee of Bengbu Medical College(approval No. 2017-037) on February 23, 2017.

关键词： immune cell subsets immune function inflammasomes leukocyte infiltration macrophages microglia pathways spinal cord injury

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Gastric foregut cystic developmental malformation: Case series and literature review

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World Journal of Gastroenterology 2015年第2期21卷 432-438页

作者： Yan-Hua Geng Chang-Xing Wang Jiang-Tao Li qing-yu chen Xiu-Zhen Li Hao Pan Department of Pathology Second Affiliated Hospital of Zhejiang University College of Medicine Department of Osteology Second Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine Department of Surgery Second Affiliated Hospital of Zhejiang University College of Medicine Department of Gastroenterology Second Affiliated Hospital of Zhejiang University College of Medicine

Foregut cystic developmental malformation(FCDM) is a very rare lesion of the alimentary tract, especially in the stomach. We discuss the concepts of gastric duplication cyst, bronchogenic cysts, and FCDM. Nomenclature has been inconsistent and confusing, but, by some definitions, gastric duplication cysts involve gastric mucosa and submucosal glands, bronchogenic cysts involve respiratory mucosa with underlying cartilage and glands, and FCDM lacks gastric mucosa or underlying glands or cartilage but has pseudostratified ciliated columnar epithelium(PCCE). We searched our departmental case files from the past 15 years and identified 12 cases of FCDM in the alimentary tract. We summarize the features of these 12 cases including a report in detail on a 52-year-old man with a submucosal cyst lined with simple PCCE and irregular and stratified circular muscle layers that merged with gastric smooth muscle bundles near the lesser curvature of the gastric cardia. A literature review of cases with this histology yielded 25 cases. We propose the term gastric-FCDM for such cases. Our own series of 12 cases confirms that preoperative recognition of the entity is infrequent and problematic. The rarity of this developmental disorder, as well as a lack of understanding of its embryologic origins, may contribute to missing the diagnosis. Not appreciating the diagnosis preoperatively can lead to an inappropriate surgical approach. In contrast, presurgical recognition of the entity will contribute to a good outcome and reduced risk of complications.

关键词： Endoscopic ultrasound-guided fine-needle aspiratio

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Effect of a High Magnetic Field on the Microstructure During Directionally Solidified Sn-20wt.%Pb Hypoeutectic Alloy

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Journal of Iron and Steel Research International 2012年第S2期19卷 1116-1122页

作者： DU Da-fan LI Xi Yves FAUTRELLE REN Zhong-ming LU Zhen-yuan yu qing-chen Department of Materials Engineering Shanghai University SIMAP-EPM-Madylam/CNRS Grenoble Institute of Technology

The microstructures of Sn-20wt.%Pb hypoeutectic alloy directionally solidified under a longitudinal magnetic field were *** results show that the application of a high magnetic field has a great influence on the morphology of primary β-Sn phase at a temperature gradient of G_L=52 K/*** a certain growth speed,with the increase of magnetic field intensity,the magnetic field causes the primary β-Sn phase irregular and to be deformed,further,the magnetic field promotes the columnar to equaixed transition(CET).Further,the thermoelectric magnetic force(TEMF) imposed on the dendrite under a high magnetic field has been calculated and the results show that the numerical magnitude of the TEMF during directional solidification under a 10 T high magnetic field is about 10~4N/m^3 and this force should be responsible for the occurrence of the CET in the Sn-Pb *** may act as an experimental proof that the coupling of temperature gradient and high magnetic field will induce the occurrence of the CET in Sn-Pb *** phenomena may be attributed to the thermoelectric magnetic force(TEMF)in solid.

关键词： high magnetic field Pb-Sn hypoeutectic alloy directional solidification columnar-to-equiaxed transition

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Relationship between Gut Microbiota and Phosphorus Metabolism in Hemodialysis Patients:A Preliminary Exploration

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Chinese Medical Journal 2018年第23期131卷 2792-2799页

作者： yuan-Yi Miao Cong-Min Xu Min Xia Huai-Qiu Zhu yu-qing chen Renal Division Department of MedicinePeking University First HospitalInstitute of NephrologyPeking UniversityKey Laboratory of Renal DiseaseMinistry of Health of ChinaKey Laboratory of Chronic Kidney Disease Prevention and TreatmentMinistry of EducationBeijing 100034China Department of Biomedical Engineering State Key Laboratory for Turbulence and Complex SystemsCollege of Engineedngand Centre for Quantitative BiologyPeking UniversityBeijing 100871China

Background:Hyperphosphatemia is a risk factor associated with mortality in patients on maintenance *** absorption of phosphate is the major *** studies indicated that the intestinal flora of uremic patients changed a lot compared with the healthy population,and phosphorus is an essential element of bacterial survival and *** purpose of this study was to explore the role of intestinal microbiota in phosphorus metabolism. Methods:A prospective self-control study was performed from October 2015 to January *** DNA was isolated from the stools of 20 healthy controls and 21 maintenance hemodialysis *** out of the 21 patients were treated with lanthanum carbonate for 12 ***,stools were also collected before and after the *** bacterial composition was analyzed based on 16S ribosomal RNA *** tools,including sequence alignment,abundance profiling,and taxonomic diversity, were used in microbiome data *** between genera and the serum phosphorus were detected with Pearson's correlation. For visualization of the internal interactions and further measurement of the microbial community,SparCC was used to calculate the Spearman correlation coefficient with the corresponding P value between each two genera. Results:Thirteen genera closely correlated with serum phosphorus and the correlation coefficient was above 0.4(P <0.05).We also found that 58 bacterial operational taxonomic units (OTUs)were significantly different and more decreased OTUs were identified and seven genera (P <0.05)were obviously reduced after using the phosphate ***,the microbial richness and diversity presented downward trend in hemodialysis patients compared with healthy controls and more downward trend after phosphorus *** co-occurrence network of genera revealed that the network complexity of hemodialysis patients was significantly higher than that of controls,whereas

关键词： Gut Microbiota Hemodialysis Patients Lanthanum Carbonate Phosphorus

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Robust color image hiding method in DCT domain

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Optoelectronics Letters 2006年第3期2卷 217-220页

作者： LI qing-zhong yu chen CHU Dong-sheng Engineering College Ocean University of China Qingdao 266071

This paper presents a robust color image hiding method based on YCbCr color system in discrete cosine transform （DOT） domain,which can hide a secret color image behind a public color cover image and is compatible with the international image compression standard of JPEG. To overcome the grave distortion problem in the restored secret image,this paper proposes a new embedding scheme consisting of reasonable partition of a pixel value and sign embedding. Moreover, based on human visual system （HVS） and fuzzy theory,this paper also presents a fuzzy classification method for DOT sub-blocks to realize the adaptive selection of embedding strength. The experimental results show that the maximum distortion error in pixel value for the extracted secret image is ±1. And the color cover image can provide good quality after embedding large amount of data.

关键词： DCT 域值图象隐藏鲁棒性离散分析

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现代教育学体系的实践取向与逻辑成分

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教育学报 2014年第1期10卷 11-17页

作者：余清臣北京师范大学教育学部北京100875

在教育学的发展历史中,是否坚持为教育实践服务以及如何为教育实践服务的实践取向问题一直以来都是一个基本问题,不同时期的教育学研究在此问题上持有不同的立场。面对自身的价值危机,现代教育学体系需要实现更为彻底的实践取向,即在整... 详细信息

在教育学的发展历史中,是否坚持为教育实践服务以及如何为教育实践服务的实践取向问题一直以来都是一个基本问题,不同时期的教育学研究在此问题上持有不同的立场。面对自身的价值危机,现代教育学体系需要实现更为彻底的实践取向,即在整体上转变为实践教育学体系,为情境性、自由性教育行动提供支持应成为整个教育学体系的根本取向。实践教育学体系在逻辑上应该包括提供教育认识的教育学板块和支持具体教育行动的教育学板块,可以分别称为教育认识论与教育行动论。从现代教育学体系发展的总体状况来看,发展实践教育学体系需要重点建设为情境性、自由性教育实践提供明智建议的教育行动论,并在关注教育复杂性的背景下加强对教育的整体认识。

关键词：实践教育学体系教育认识论教育行动论

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