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Consensus for criteria of running a pediatric inflammatory bowel disease center using a modified Delphi approach

World Journal of Pediatrics 2023年第10期19卷 939-948页

作者： You-You Luo Kai-Chun Wu Si-tang Gong Ying Huang Hong yang qing-ya tang Ying-kit Leung Jie Wu Lan-Lan Geng Wei Zhou Mei Sun Chao-Min Wan Zai-Ling Li Ying Fang Xiao-Qin Li Mei Li Zhao-Xia Wang Yuan Xiao Xue-Mei Zhong Xiao-Fei Chen Jie Chen Department of Gastroenterology Children’s HospitalZhejiang University School of MedicineHangzhou 310052China National Clinical Research Center for Child Health Hangzhou 310051China Department of Gastroenterology Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Gastroenterology Guangzhou Women and Children’s Medical Center of Guangzhou Medical UniversityGuangzhou 510623China Department of Gastroenterology Children’s Hospital of Fudan UniversityShanghai 201102China Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical College&Chinese Academy of Medical ScienceBeijing 100730China Department of Clinical Nutrition Xinhua Hospital School of MedicineShanghai Jiao Tong UniversityShanghai 200092China Department of Pediatric Gastroenterology The First Hospital of Jilin UniversityJilin 130061China Department of Gastroenterology Beijing Children’s HospitalCapital Medical UniversityBeijing 100045China Department of General Surgery Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhou 310016China Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004China Department of Pediatrics West China Second HospitalWest China Women’s and Children’s HospitalChengdu 610041China Department of Pediatrics Peking University Third HospitalBeijing 100191China Department of Gastroenterology Xi’an Children’s HospitalXi’an 710003China Department of Gastroenterology Children’s Hospital of Zhengzhou UniversityZhengzhou 450053China Department of Gastroenterology Children’s Hospital of Nanjing Medical UniversityNanjing 210008China Department of Gastroenterology Shenzhen Children’s HospitalShenzhen 518034China Department of Pediatrics Ruijing HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 350025China Department of Gastroenterology Children’s HospitalCapital Institute of PediatricsBeijing 100020China

Background Good quality of care for inflammatory bowel disease(IBD)depends on high-standard management and facility in the IBD ***,there are no clear measures or criteria for evaluating pediatric IBD(PIBD)center in *** aim of this study was to develop a comprehensive set of quality indicators(QIs)for evaluating PIBD center in *** A modified Delphi consensus-based approach was used to identify a set of QIs of structure,process,and outcomes for defining the *** process included an exhaustive search using complementary approaches to identify potential QIs,and two web-based voting rounds to select the QIs defining the criteria for PIBD *** A total of 101 QIs(35 structures,48 processes and 18 outcomes)were included in this *** QIs focused on the composition of multidisciplinary team,facilities and services that PIBD center should *** QIs highlight core requirements in diagnosing,evaluating,treating PIBD,and disease *** QIs mainly included criteria evaluating effectiveness of various interventions in PIBD *** The present Delphi consensus developed a set of main QIs that may be useful for managing a PIBD center.

关键词： Crohn’s disease Pediatric inflammatory bowel disease Quality indicators Ulcerative colitis

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Methods in Analyzing Abdominal Fat of Obese Children and Adolescents

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临床儿科杂志 2009年第1期27卷 1-6页

作者： Xiao-fei Zheng qing-ya Tan Ye-xuan Tao Wei Lu Wei Cai Department of Clinical Nutrition Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai Institute for Pediatric Research Shanghai 200092 China

Objectives To assess the clinical value of ultrasonography ( US) and bioelectrical impedance analysis (BIA) in analyzing abdominal fat contents of obese children and adolescents through comparison with MRI. A correlation with other obese related metabolic parameters was conducted. Methods Ninety 7-17-y-old obese children and adolescents (60 boys and 30 girls with mean age of 9.6±2.9 y and mean BMI of 24.5±4.5 kg / m^2) were recruited. Metabolic parameters were measured, and insulin resistance was estimated according to homeostasis model assessment (HOMA-IR). On the same day abdomen subcutaneous fat thickness (SFTUS) was measured by US. Body fat mass (FMBIA) and abdominal visceral fat area (VFABIA) were analyzed by bioelectrical impedance analysis (BIA). After obtaining informed consent, abdominal MRI was performed in 20 subjects. Each section of umbilicus level was analyzed by image threshold value segmentation using SigmaScan Pro 5 and abdominal subcutaneous fat area (SFAMRI) and visceral fat area (VFAMRI) were calculated. Results (1) A strong positive association was found between SFTUS and SFAMRI (P < 0.05), VFABIA and VFAMRI (P < 0.01) respectively. (2) FMBIA and SFAMRI, VFAMRI, SFTUS also showed significant correlations (P < 0.05). (3) VFAMRI showed extremely significant positive correlations with TG, Insulin, C-peptide and HOMA-IR (P < 0.01); SFAMRI was also correlated positively with them (P < 0.05). (4) SFTUS was correlated positively with UA (uric acid) , Insulin, 2HIns ( insulin measured at 2 hours after meal) , C-peptide, 2HC-peptide (C-peptide measured at 2 hours after meal) and HOMA-IR (P < 0.01). (5) VFABIA was correlated significant positively with UA, insulin, TG, 2HIns and HOMA-IR. FMBIA showed positive correlation with UA, Insulin, 2HIns, C-peptide, 2HC-peptide and HOMA-IR. Conclusions abdominal subcutaneous and visceral fat of obese children and adolescents evaluated by US and BIA are correlated well with those assessed by MRI, and also correlated

关键词：肥胖儿童核磁共振成像超声检查临床分析

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Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie Liu qinghua Zeng qing tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

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新生儿肠外营养相关胆汁淤积因素612例分析

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中华儿科杂志 2007年第11期45卷 838-842页

作者：汤庆娅王莹冯一陶晔璇吴江蔡威上海交通大学医学院附属新华医院临床营养中心 200092 上海儿科医学研究所消化营养研究室上海交通大学医学院附属新华医院临床营养中心 200092

目的为提高危重新生儿肠外营养支持的安全性和有效性提供依据。方法对1985.4-2005.3行5 d 以上静脉营养支持的612例住院新生儿资料进行分析。612例分为甲组(1985.4-1995.3)和乙组(1995.4-2005.3)。其中甲组70例再分为肠外营养相关胆汁... 详细信息

目的为提高危重新生儿肠外营养支持的安全性和有效性提供依据。方法对1985.4-2005.3行5 d 以上静脉营养支持的612例住院新生儿资料进行分析。612例分为甲组(1985.4-1995.3)和乙组(1995.4-2005.3)。其中甲组70例再分为肠外营养相关胆汁淤积组(PNAC 组)6例和非 PNAC 组64例,乙组542例也分为 PNAC 组12例和非 PNAC 组530例。比较甲乙两组新生儿 PNAC 发生率及相关因素。结果接受5 d 以上静脉营养支持的新生儿 PNAC 总发生率为2.94%,甲组 PNAC 发生率为8.57%,乙组发生率为2.21%,后10年 PNAC 发病率有明显下降(OR 值为0.242,95% CI 为0.088～0.666)。PNAC 组的胎龄、出生体重均小于非 PNAC 组(其中胎龄33±5周比(36±4)周,P=0.009;OR 值为0.827,95% CI 为0.698～0.980。出生体重2003 g±743 g比2393 g±764 g,P=0.045;OR 值为1.001,95% CI 为0.999～1.002),而平均 PN 持续时间、热卡摄入量均大于非 PNAC 组(其中 PN 持续时间32 d±30 d 比13 d±10 d,P=0.000;OR 值为1.072,95%CI 为1.032～1.112。PN 摄入量(272±46)kJ/(kg·d)[(65.0±10.9 kcal/(kg·d),(1 kcal=4.184 kJ)]比(232±55)kJ/(kg·d)[(55.5±13.1)kcal/(kg·d)],P=0.002;OR 值为1.066,95% CI 为1.012～1.122)。非 PNAC 组体重增加与 PNAC 组相比有增加趋势[(20±27)g/d 比(9±19)g/d,P=0.175]。结论 PNAC 发生与早产、低出生体重、PN 持续时间超过2周、PN 提供的热卡量过高有关。

关键词：婴儿新生胃肠外营养胆汁淤积

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A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： Quan Shi Yun-Hao Xu Ming-Hui Chen Peng Zhao Wen-Bo Deng Ji Xiong Kai Guo ya-qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han tang Jianian Hu Siying Kang Song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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Spectral Characteristics of White Organic Light-emitting Diodes Based on Novel Phosphorescent Sensitizer

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Chinese Journal of Chemical Physics 2008年第6期21卷 510-514页

作者： Xiao-qing tang Jun-sheng Yu Lu Li Wen Wen ya-dong Jiang State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Information University of Electronic Science and Technology of China Chengdu 610054 China

White organic light-emitting diodes were fabricated by using a novel phosphorescence bis（1,2-diphenyl-1H-benzoimidazole）iridium（acetylacetonate）[（pbi）2Ir（acac）] as sensitizer and a fluorescent dye of 4- （dicyanomethylene）-2-t-butyl-6-（1,1,7,7-tetramethyljulolidyl-9-enyl）-4H-pyran （DCJTB） codoped into a carbazole polymer of poly（N-vinylcarbazole）（PVK）. Through characterizing the UV-Vis absorption spectra, the photoluminescence spectra of （pbi）2Ir（acac） and DCJTB, and the electroluminescence spectral properties of the WOLEDs, the energy transfer mechanisms of the codoped polymer system were deduced. The results demonstrate that the luminescent spectra with different intensity of （pbi）2Ir（acac） and DCJTB were co-existent in the EL spectra of the blended system, which is ascribed to an incomplete energy transfer process in the EL process. The efficient Forster and Dexter energy transfer between the host and the guests enabled a strong yellow emission from （pbi）2Ir（acac） and DCJTB, where （pbi）2Ir（acac） plays an important role as a phosphorescent sensitizer for DCJTB. With the blue emitting-layer of N,N＇-diphenyl-N,N＇-bis（1- naphthyl）（1,1＇-biphenyl）-4,4＇-diamine, the codoped system device achieved white emission. The codoped system showed that its Commissions Internationale de 1＇Eclairage coordinates were more independent of the variation of bias voltage than those of phosphorescent doped PVK systems.

关键词： White organic light-emitting diode Phosphorescent sensitizer Spectrum analysis

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Bright White Organic Light-emitting Device Based on 1,2,3,4,5,6-Hexakis(9,9-diethyl-9H-fluoren-2-yl)benzene

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Chemical Research in Chinese Universities 2009年第4期25卷 590-594页

作者： MA Tao YU Jun-sheng LOU Shuang-ling tang Xiao-qing JIANG ya-dong ZHANG qing State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Information University of Electronic Science and Technology of China Chengdu 610054 P. R. China Department of Polymer Science School of Chemistry and Chemical Technology Shanghai Jiaotong University Shanghai 200240 P. R. China

Organic light-emitting devices（OLEDs） with the structure of indium-tin-oxide（ITO）/N,N＇-bis-（1-naphthyl）-N,N＇-diphenyl-（1,1＇-biphenyl）-4,4＇-diamine（NPB）/2,9-dimenthyl-4,7-diphenyl-1,10-phenanthroline（BCP）/tris（8-hydroxyquinoline）aluminum（Alq3）/Mg：Ag or that of ITO/NPB/1,2,3,4,5,6-hexakis（9,9-diethyl-9H-fluoren-2-yl）benzene（HKEthFLYPh）/Alq3/Mg：Ag were *** light emission was achieved with the two devices when the thicknesses of BCP and HKEthFLYPh were 1.5 nm（device B） and 5 nm（device Ⅱ）,*** obvious difference was that the EL spectrum of device Ⅱ was not sensitive to the thickness of HKEthFLYPh compared to that of BCP ***,the maximum luminance of device Ⅱ was about 1000 cd/m^2 higher than that of device B at a forward bias of 15 V,and it exhibited a maximum power efficiency of 1.0 lm/W at 5.5 V,which is nearly twice that of device *** performance of device Ⅱ using a novel star-shaped hexafluorenylbenzene organic material was improved compared with that of BCP.

关键词： Organic light-emitting diode Star-shaped hexafluorenylbenzene White light BCP Energy transfer

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New Expected Value Expansions of Rooted Graphs

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Acta Mathematicae Applicatae Sinica 2015年第1期31卷 81-88页

作者： Xiao-qing tang School of Mathematics & Information Shanghai Lixin University of Commerce

We propose a new expected value of rooted graph in this article,that is, when G is a rooted graph that each vertex may independently succeed with probability p when catastrophic thing happened, we consider the expected number of edges in the operational component of G which containing the root. And we get a very important and useful compute formula which is called deletion-contraction edge formula. By using this formula, we get the computational formulas of expected value for some special graphs. We also discuss the mean of expected value when parameter p has certain prior distribution. Finally, we propose mean-variance optimality when rooted graph has the equilibrium point which has larger mean and smaller variance.

关键词： rooted graph expected value deletion-contraction edge formula mean-variance optimality

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基于CNN和Transformer交叉教学的半监督医学图像分割

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陕西科技大学学报 2025年第1期43卷 185-192页

作者：杨云胡雯青杨虹吴亚男陕西科技大学电子信息与人工智能学院陕西西安710021 西安富德医疗电子有限公司陕西西安710075 西安计量技术研究院陕西西安710199

由于医学图像分割领域缺乏高质量的标注数据,半监督学习方法在医学图像语义分割任务中受到高度重视.为了充分利用卷积神经网络(Convolutional Neural Network,CNN)和Transformer在半监督学习中的优势,本文提出一种基于CNN与Transformer... 详细信息

由于医学图像分割领域缺乏高质量的标注数据,半监督学习方法在医学图像语义分割任务中受到高度重视.为了充分利用卷积神经网络(Convolutional Neural Network,CNN)和Transformer在半监督学习中的优势,本文提出一种基于CNN与Transformer交叉教学的半监督医学图像分割方法.该方法将经典的深度协同训练从一致性正则化简化为交叉教学,利用循环伪标签方案使两个网络的预测差异转换为无监督损失,以鼓励两个网络具有一致的低熵预测.所提方法在ISIC 2018数据集上进行实验,在采用20%的标注比例时,Dice系数和Jaccard系数分别达到87.25%和79.17%,相比于监督U-Net++的训练结果分别提升了2.89%和3.53%,并且优于目前主流的半监督学习方法,验证了所提方法在半监督医学图像分割上的有效性和泛化性.

关键词：半监督学习图像语义分割交叉教学循环伪标签

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