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Effects of Adalimumab Entering National Reimbursement on Medical Costs for Patients With Psoriasis:A 4-Year Single-Center Retrospective Study in China

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International Journal of Dermatology and Venereology 2024年第2期7卷 84-88页

作者： Yu Li Bo-Kun Zhu qing-sheng min Mei Ju min Li Department of Medical Affairs Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Hospital Network Information Center Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Department of Physiotherapy Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China

Objective:Adalimumab(ADA)is expensive and rarely used among ***,its cost for moderate to severe chronic plaque psoriasis can now be reimbursed since its addition to the National Reimbursement Drug List(NRDL)in January ***,we conducted this study to estimate the medical cost of ADA and its influencing factors in patients with psoriasis using ADA and thus gain a better understanding of the effect of the NRDL adjustment in ***:This retrospective study evaluated the medical cost of ADA before and after the addition of ADA to the NRDL(2018—2022)among 320 patients in a large professional dermatology specialty *** analysis,Welch’s analysis of variance,and multiple regression analysis were used to evaluate the medical cost and influencing ***:Before ADA was added to the NRDL,patients’mean total cost and ADA cost were¥24,243.56±16,346.53 and¥20,391.11±14,440.69,*** ADA became covered by the NRDL,the above 2 expenses decreased to¥10,461.19±7,554.66 and¥8,775.27±7,092.16,*** significant decrease in the cost of ADA resulted in a significant 110.5-times increase in ADA *** significant differences were found in the total cost,patient type(outpatient/inpatient),insurance status(yes/no),reimbursement status(before/after),and *** insurance reimbursement(P<0.001,β=-0.468,before reimbursement=1,after reimbursement=2)was the most significant influencing factor,followed by patient type(P=0.018,β=-0.215,outpatient=1,inpatient=2)and age(P=0.0046,β=-0.174).Conclusion:Medical insurance reimbursement is the most important factor affecting patients’total cost of ADA by reducing the economic burden,enhancing the availability of ADA,and stimulating the need for treatment.

关键词： adalimumab biological agent psoriasis medical cost medical insurance

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脉冲激光沉淀制备锂电池LiMn_2O_4薄膜技术(英文)

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光散射学报 2005年第1期17卷 78-80页

作者： OUYANGChu-ying YEZhi-qing LEImin-sheng XIAOXin-min JiangXiProvinceKeyLaboratoryforOptElectronics JiangxiNormalUniversityNanchang330027China

LiMn2O4 thin films were deposited by pulsed laser deposition techniques, two types of substrates were used: LaAlO3 (100) monocrystalline and stainless *** and SEM results show that the film grown on LaAlO3 (100) shown very good preferred orientations, and the surface texture is very *** LiMn2O4 nano-crystal of the film grown on stainless steel is grain like scattered on the surface, and the size of the nano-crystal is about 300 to 500 nm.……

关键词： LiMn2O4 薄膜技术脉冲激光锂电池制备沉淀

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Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-qing Qiao Guo Hui Bojing Sun Dongfang Hou Meidi Wang Xueqian Wu Tao Wu Dong-sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Cadmium sulfide

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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-min Xing Hai-Dong Qian Qiao Gao sheng-Lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

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Extramedullary plasmacytoma with the uvula as first affected site:A case report

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World Journal of Clinical Oncology 2025年第1期16卷 53-58页

作者： Jing Yang Hui Peng sheng-Ke Tu min Li Kui Song Department of Hematology The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina

BACKGROUND Extramedullary plasmacytoma(EMP)represents one of the rarer forms of plasma cell malignancies,capable of impacting a variety of tissues and organs throughout the *** majority of EMP cases are predominantly found in the head and neck region,especially within the laryngopharynx,as well as in the gastrointestinal *** there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature,it is important to note that EMP specifically affecting the uvula is exceedingly ***,it is noteworthy that over 60% of epithelial carcinomas in the upper respiratory tract and oropharynx tend to metastasize to the cervical lymph nodes,indicating a propensity for regional spread in these types of *** this context,we present a rare case of extramedullary plasmacytoma where the uvula served as the initially affected *** case emphasizes the need for heightened awareness among clinicians regarding such unusual comorbidities,as early recognition and diagnosis can significantly influence patient management and treatment *** addition,a review of the relevant literature is included to further educate and inform healthcare professionals about this rare presentation,ultimately aiming to enhance clinical understanding and improve patient care in similar *** SUMMARY A 51-year-old man was admitted to our hospital because of a slowly enlarging neck mass.A physical examination revealed a palpable left lymph node,and magnetic resonance imaging(MRI)of the oropharynx and the neck showed a soft tissue mass in the oropharynx and enlargement of multiple lymph nodes in the *** soft tissue mass was diagnosed as plasmacytoma by immunohistochemical *** immunoglobulins and bone marrow biopsy showed normal ***,we diagnosed that as EMP of the *** four cycles of adjuvant chemotherapy dominated by bortezomib,MRI reexamination showed a significant reduction of the mass

关键词： Extramedullary plasmacytoma Plasmacytoma Uvula Multiple myeloma Case report

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烟台市职业健康教育对工人个人防护用品使用行为的影响

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职业与健康 2019年第15期35卷 2130-2132,2136页

作者：陈超盛青敏嵇平钟烟台市疾病预防控制中心职业卫生与辐射防护科山东烟台264003 烟台市芝罘区医疗保险服务中心生育保险科山东烟台264008

目的探讨影响工人个人防护用品(PPE)使用行为的职业健康教育措施,提高PPE使用率。方法2018年随机抽取烟台市15家用人单位进行PPE使用情况调查,然后将15家用人单位随机分为3组,分别采取职业健康知识培训、发放职业健康知识宣传单页和微... 详细信息

目的探讨影响工人个人防护用品(PPE)使用行为的职业健康教育措施,提高PPE使用率。方法2018年随机抽取烟台市15家用人单位进行PPE使用情况调查,然后将15家用人单位随机分为3组,分别采取职业健康知识培训、发放职业健康知识宣传单页和微信群职业健康知识宣传方式对工人进行干预,评价不同干预措施对工人PPE使用行为的影响效果。结果本次研究共发放问卷1394份,回收有效问卷1385份。职业健康教育措施干预前有718名工人能正确使用PPE,正确使用率为51.8%;干预后933名工人能正确使用PPE,正确使用率为67.4%;干预前后工人PPE正确使用率差异有统计学意义(P0.05),微信群职业健康知识宣传及职业健康知识培训组干预前后正确使用率差异有统计学意义(P<0.05),且微信群职业健康知识宣传效果优于职业健康知识培训组。结论应当创新职业健康教育方法和内容,推动行为医学在职业健康领域应用,规范工人PPE使用,保护工人职业健康。

关键词：职业健康教育个人防护用品行为

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Syntheses, Crystal Structures and Properties of Two New W-Ag 1D Chain Complexes: [W_2Ag_2S_8·Ca(DMF)_6]_n and [WAgS_4·Na(DMF)_3]_n

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Chinese Journal of Structural Chemistry 2005年第6期24卷 716-722页

作者： LIYa-min XIAsheng-qing ZHANGJian-Jun WUXin-Tao WANGLong-sheng DUWen-Xin HUsheng-min StateKeyLaboratory.ofStructuralChemistry FujianInstituteofResearchontheStructureofMatterTheChineseAcademyofSciencesFuzhouFujian350002China

Two new complexes, [W2Ag2S8?Ca(DMF)6]n 1 and [WAgS4?Na(DMF)3]n 2, have been synthesized and characterized. Single-crystal X-ray analyses show both 1 and 2 have {WAgS4}n anion linear chains, but 1 has a discrete [Ca(DMF)6]2+ cation while 2 is a linear chain. UV-Visible-Near-IR spectroscopy data show that the bandgaps of the two complexes are 1.86 and 1.99 eV, respectively. Electrical conductivity measurements reveal the conductivities of 1 and 2 are 10?7 and 10?8 Scm?1, respectively and they exhibit thermally activated temperature depen- dence, which may be attributed to semiconductors.

关键词： W/Ag/S complexes linear chain conductivity

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CT diagnosis of 52 patients with lymphoma in abdominal lymph nodes

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World Journal of Gastroenterology 2006年第48期12卷 7869-7873页

作者： Ri-sheng Yu Wei-min Zhang Yi-qing Liu Department of Radiology Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009 Zhejiang Province China

AIM： To assess CT manifestations and its diagnostic value for lymphoma in the abdominal lymph nodes （LALN）.METHODS： CT findings in 52 cases of LALN proved by surgery or biopsy, including Hodgkin＇s disease （HD） in 16 cases and non-Hodgkin＇s lymphoma （NHL） in 36 cases, were retrospectively analyzed.RESULTS：（1） CT manifestations based on distribution of the lesions of LALN： Solitary mass type was found in 10 cases, including solitary, round, uniform-density, enlarged lymph nodes in 3 cases; and multiple, enlarged lymph nodes fusing into singular Iobular mass in 7 cases. Thirty-feur cases of multiple-nodular type showed multiple, round, enlarged lymph nodes with uniform density and clear margins. Vessels-embedded signs, including mesenteric vessels, renal vessels, abdominal aorta or inferior vena cava, were seen in 6 cases, and duodenum-embedded signs were seen in 2 cases. Eight cases of diffuse type showed characteristic ＂cobblestone signs＂. （2） CT manifestations correlated with pathological type： CT manifestations of 12 cases of HD were different from those of 40 cases of NHL in distribution, size, quantity and fused lesion of enlarged lymph nodes. （3） Twenty-eight cases of 52 patients were accompanied with extra-nodal lymphoma in the abdomen, especially gastrointestinal lymphoma, which had characteristic CT findings. （4） In follow-up examinations, CT images showed uniform, heterogeneous or rim enhancement in 15 cases, and occasional calcifications accompanied with reduction of the lesion size and quantity in 12 cases, whereas the lesions disappeared in 3 cases after treatment.CONCLUSION： CT images show many characteristic manifestations valuable for qualitative diagnosis of LALN, and it is also helpful for pathological classification of LALN and therapeutic evaluation in follow-up of patients.

关键词： Lymphoma Lymph nodes Computed tomography Diagnosis Classification

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碱性介质中腐植酸电化学氧化动力学研究

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现代化工 2025年第1期45卷 207-213页

作者：冯晴晴何德民范玉强关珺大连理工大学化工学院辽宁大连116024

采用三电极体系的H型隔膜电解池对腐植酸(humic acid,HA)在碱性条件下的电化学氧化过程进行动力学研究,考察了温度、阳极电位、碱液质量浓度对电化学氧化反应的影响。结果表明,HA电化学氧化符合二级反应动力学模型,活化能为19.94 kJ/mol... 详细信息

采用三电极体系的H型隔膜电解池对腐植酸(humic acid,HA)在碱性条件下的电化学氧化过程进行动力学研究,考察了温度、阳极电位、碱液质量浓度对电化学氧化反应的影响。结果表明,HA电化学氧化符合二级反应动力学模型,活化能为19.94 kJ/mol,各反应条件对HA进一步氧化成高附加值的煤酸(CA)有不同程度的影响。对各反应条件下的氧化过程进行分析发现,温度影响分子间键能和双电层充放电速率;阳极电位影响相应的电流密度,进而影响电子转移效率;碱液质量浓度改变溶液的电导性。HA电化学氧化后分子结构发生改变,可为进一步研究煤电化学氧化这一复杂反应提供参考。

关键词：腐植酸碱性电化学氧化动力学反应条件

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Influence of systemic immune and cytokine responses during the acute phase of zoster on the development of postherpetic neuralgia

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第8期10卷 625-630页

作者： sheng-mei ZHU Yong-min LIU Er-dan AN qing-lian CHEN Department of Anesthesiology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Department of Anesthesiology the Second People's Hospital Jiaxing 314000 China

Postherpetic neuralgia(PHN) is a severe sequela of herpes zoster(HZ).Until now,only age and pain severity were considered predisposing factors for the development of *** evaluated 49 patients with acute phase HZ,10 of whom developed PHN(Group A) and 39 of whom did not develop PHN(Group B).Twenty-five healthy volunteers similar in age and gender distribution to the study group were recruited as controls(Group C).Numbers of serum CD3+(pan-T lymphocytes),CD4+(helper/inducer),and CD8+(suppressor/cytotoxic) lymphocytes were decreased significantly in Groups A and B relative to the control group,but there were no statistical differences between Groups A and ***(IL)-1β,IL-6,tumor necrosis factor(TNF)-α,IL-8,and IL-10 were significantly elevated in Groups A and B relative to Group ***-6 was significantly higher in Group A than in Group B,and was significantly positively correlated with pain severity scored on a visual analog ***,we suggest that the inflammatory response,especially that of IL-6,in the acute phase of HZ may be associated with hyperalgesia and the development of PHN.

关键词： T lymphocyte Cytokines Postherpetic neuralgia (PHN) Herpes zoster (HZ)

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