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Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng Deng Dan Yang Lingxi qing Yifei Chen Jilian Zou Meiling Jia Qian Wang Runda jiang Lihua Huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological *** coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological *** study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

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L-苹果酸在酮类溶剂中溶解度的测定及关联

石油化工高等学校学报 2002年第4期15卷 54-56页

作者：叶青马江权姜艳江苏石油化工学院化工系江苏常州213016

通过测定NaCl的溶解度校核了溶解度测定装置 ,其平均误差为 0 .6 91% ,并用该装置测定了L -苹果酸在丙酮、丁酮中的溶解度。实验结果表明 ,L -苹果酸在丙酮及丁酮中有一定的溶解能力 ,且随着温度的增大溶解度变大 ,因此可利用类溶剂与L ... 详细信息

通过测定NaCl的溶解度校核了溶解度测定装置 ,其平均误差为 0 .6 91% ,并用该装置测定了L -苹果酸在丙酮、丁酮中的溶解度。实验结果表明 ,L -苹果酸在丙酮及丁酮中有一定的溶解能力 ,且随着温度的增大溶解度变大 ,因此可利用类溶剂与L -苹果酸中的微量水开成恒沸物 ,除去L -苹果酸中的微量水再结晶 ,从而改进晶形。实验数据用Wilson、NRTL、UNIQUAC活度系数模型进行了关联 ,用UNIQUAC方程关联的平均误差最小 ,在丙酮及丁酮中的平均误差分别为 0 .11和 0 .12℃。用Wilson、NRTL方程关联也可得到较满意的结果。

关键词： L-苹果酸酮类溶剂溶解度测定关联活度系数

不同组合冷冻干燥方法对水蜜桃脆片品质的影响

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食品与发酵工业 2018年第7期44卷 173-178页

作者：王海鸥扶庆权陈守江张李阳王蓉蓉张伟南京晓庄学院食品科学学院江苏南京211171

为了研究不同组合干燥方法对水蜜桃脆片品质的影响,以真空冷冻干燥方法为基础和对照,并将其与热风、微波、气流膨化3种方法进行组合干燥对比实验和品质测试分析。结果表明,冻干-微波组脆片样品色泽改变最大,综合色差ΔE值显著高于其他3... 详细信息

为了研究不同组合干燥方法对水蜜桃脆片品质的影响,以真空冷冻干燥方法为基础和对照,并将其与热风、微波、气流膨化3种方法进行组合干燥对比实验和品质测试分析。结果表明,冻干-微波组脆片样品色泽改变最大,综合色差ΔE值显著高于其他3组(p<0.05);在微观组织结构方面,冻干组形成了饱满的多孔网络骨架,孔隙率高,而冻干-微波组样品细胞组织坍塌严重、结构致密,冻干-热风组、冻干-气流组的微观组织形态相近且介于冻干、冻干-微波组2组之间;4组样品直径收缩率由高到低分别是冻干-微波、冻干-热风、冻干-气流、冻干,差异显著(p<0.05);冻干-微波组脆片吸湿率显著低于其他3组,冻干组脆片吸湿率最高;冻干-微波组脆片硬度和脆度远高于其他3组,冻干组脆片最小;组织微观形态观察结果能较好地反映水蜜桃脆片上述品质的差异。4组水蜜桃脆片中,冻干-微波组综合品质最差,冻干组最佳,而其他2组综合品质介于中间。

关键词：水蜜桃脆片冷冻干燥组合干燥

Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao Zhang Li Jia Xiu-Jun Zhan Charity Ngina qing-Rui Zhang Xiao-Ge Li Qi-Bao jiang Shi Bai Miao-Miao jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie quan Hao Liang Yong-Hong Tang Li jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

Correction to Hawking Radiation Characteristics of Stationary Demianski-Newman Black Hole

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Communications in Theoretical Physics 2006年第6期45卷 1026-1030页

作者： jiang qing-quan YANG Shu-Zheng Institute of Theoretical Physics China West Normal University Nanchong 637002 China

The pure thermal spectrum in dragging coordinate system and the tunneling radiation characteristics across the event horizon for stationary Demianski-Newman black hole are researched. The result shows that the tunneling rate of the particle is relevant to Bekenstein-Hawking entropy, and the derived radiate spectrum is not strictly pure thermal, but is consistent with underlying unitary theory. Finally, we use the obtained results to reduce to stationary Kerr black hole and static Schwarzschild black hole, and lind that only when ignoring the spectrum at higher energies is the tunneling radiation spectrum consistent with Hawking pure thermal one.

关键词： Demianski-Newman black hole energy conservation angular momentum conservation tunneling rate Bekenstein-Hawking entropy

高职高专基础化学课程体系及教材的现状与建设

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天津农学院学报 2002年第3期9卷 61-64页

作者：钟国清曾仁权蒋礼西南农业大学荣昌校区基础部重庆荣昌402460

指出了现行的一些高职高专基础化学课教材中存在的问题 ,提出了农林院校高职高专教育基础化学课程体系改革与教材建设的思路和做法 ,逐步建立理论与实验课程既相互联系又相对独立的新体系 ,以必须够用为度 ,突出实践技能与创新意识的培养。

关键词：基础化学课程体系教材现状高等职业教育高等专科教育教学改革教材建设

Multi-track Storage of 10000 Holograms in a Disk-Type Photorefractive Crystal

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Chinese Physics Letters 2000年第9期17卷 675-677页

作者： TAO Shi-quan XU Min LIU Guo-qing YUAN quan jiang Zhu-qing Applied Physics Department Beijing Polytechnic UniversityBeijing 100022

Three-dimensional disk-type holographic storage using spatioangular multiplexing with a spherical reference beam is analyzed and experimentally *** overlapping factors between adjacent holograms in a track and between adjacent tracks in a disk are determined based on the selective angles calculated by coupled-wave *** are 10000 holograms stored along 5 tracks in a sector of a single iron-doped lithium niobate crystal.

关键词： theory. holographic lithium

Entropy of Dirac Field in Non-stationary and Slowly Changing Reissner-Nordstrom Black Hole

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Communications in Theoretical Physics 2005年第5X期44卷 955-960页

作者： LI Hui-Ling YANG Shu-Zheng jiang qing-quan Institute of Theoretical Physics China West Normal University Nanchong 637002 China

Using the thin film brick-wall model and WKB approximation, the entropy of the Dirac field in the non-stationary and slowly changing Reissner-Nordstrom (R-N) black hole is calculated. The result shows that the entropy... 详细信息

关键词： slowly changing thin brick-wall model Dirac field entropy of black hole