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Synthesis, UV-curing Behavior and Surface Properties of New Fluorine-containing Aromatic Oxetane Monomers

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Chinese Journal of Polymer Science 2018年第4期36卷 521-527页

作者： Shu-qing Fang Yu-Lian Pang Ying-quan Zou College of Chemistry Beijing Normal University

In this paper, we combined high-end cationic UV-curable material with fluorinated chain obtaining a series of new fluorine-containing aromatic oxetane monomers via a mild nucleophilic substitution reaction. The structures and properties of monomers were characterized using ~1 H-NMR, ^（19） F-NMR, dynamic viscosity tests and differential scanning calorimetry（DSC）. It was determined that all of the fluorinated monomers obtained had much lower viscosity and higher thermostability after the introduction of hexafluorobenzene. Then, UV-curable coatings were prepared using four fluorine-containing aromatic oxetane monomers（FOX1-4）; the UV-curing kinetics, with three kinds of initiators, and properties of the cured films were evaluated using real-time Fourier transform infrared（FTIR） spectroscopy, water and diiodomethane contact angle tests, surface energy calculations and scanning electron microscopy（SEM）. The FTIR spectroscopy results showed that the coatings possessed excellent conversion rate（〉 99% with liquid initiator PAG-201 in 150 s）, and as the fluorine content increased, the monomers exhibited decreased mobility with the increasing viscosity and worse solubility with fluorinated monomers, resulting in a lower conversion rate. Moreover, the coatings possessed favorable hydrophobic and oleophobic properties and low surface energies owing to the fluoride chains floating to the membrane-air interface, which was also confirmed by discrete concave structures in SEM images. These new kinds of monomers can replace traditional fluorinated cationic monomers applied to the fingerprint resistant, fouling resistant, scratch resistant and anti-aging coatings, adhesives or printing ink materials.

关键词： Fluorine-containing monomers Oxetane UV-curing kinetics Surface properties

A FIFTH-ORDER ACCURATE WEIGHTED ENN DIFFERENCE SCHEME AND ITS APPLICATIONS

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Journal of Computational Mathematics 2001年第5期19卷 531-538页

作者： Yi-qing Shen Ru-quan Wang Hong-zhi Liao Department of Mathematics Yunnan UniversityKunming 650091China ICMSEC Academy of Mathematics and Systems SciencesChinese Academy of SciencesBeijing 100080China

Presents a study which constructed a high accurate difference scheme based on the ENN scheme. Overview of ENN scheme and several high order accuracy central schemes; Numerical method used; Relation between the weighte... 详细信息

关键词： ENN scheme WENO scheme shock-boundary-layer interaction

All types of base conversions allowed by base editors

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Science China(Life Sciences) 2024年第2期67卷 431-433页

作者： Shun-qing Liang Wen xue RNA Therapeutics Institute UMass Chan Medical SchoolWorcester 01655USA Department of Molecular Cell and Cancer BiologyUMass Chan Medical SchoolWorcester 01655USA Department of Molecular Medicine UMass Chan Medical SchoolWorcester 01655USA Li Weibo Institute for Rare Diseases Research UMass Chan Medical SchoolWorcester 01655USA

Base editors(BEs) hold great promise as tools for introducing single-base-pair changes in both basic research and therapeutic applications(Rees and Liu,2018).Base editors are composed of a Cas9 nickase fused to a DNA-modifying enzyme,which chemically modifies nucleobases within a specific targeting window near the Cas9-binding site.

关键词： base bases allowed

Tuning the Stability of the Polyplex Nanovesicles of Oligonucleotides via a Zinc(Ⅱ)-Coordinative Strategy

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Chinese Journal of Polymer Science 2022年第9期40卷 1034-1042页

作者： quan Zhou Xiang Li Jia-Jia Xiang You-qing Shen Zhejiang Key Laboratory of Smart Biomaterials and Center for Bionanoengineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Department of Cell Biology School of Basic Medical SciencesZhejiang UniversityHangzhou 310058China The Forth Affiliated Hospital Zhejiang University School of MedicineYiwu 322000China Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215China

Oligonucleotide therapeutics have great potential to target the currently undruggable genes and to generate entirely new therapeutic paradigms in multiple types of disease,thus having attracted much attention in recent ***,their applications are greatly hindered by a lack of safe and efficient oligonucleotide-delivery *** nanovesicles formed from oligonucleotides and the cationic block have shown exceptional features for the delivery of therapeutic oligonucleotides and other ***,these polyplex nanovesicles are deeply fraught with difficulty in tolerating physiological ionic *** by the high binding ability between the dipicolylamine(DPA)/zinc(Ⅱ)complex and the phosphodiester moieties of oligonucleotides,herein,we designed a coordinative cationic block to solve the intrinsic stability ***,we found the stability of the resulted polyplex nanovesicles could be easily tuned by the content of coordinated zinc *** vitro cellular studies implied that the prepared zinc(Ⅱ)-coordinative polyplex nanovesicles preferred to retain in the lysosomes upon internalization,making them ideal delivery candidates for the lysosome-targeting oligonucleotide therapeutics.

关键词： Oligonucleotide therapeutics Polyplex nanovesicles Coordinative cationic block Lysosome-targeting

CHARACTERISTICS OF CORRELATION AND SPECTRUM BETWEEN WALL FLUCTUATING PRESSURE AND FLUCTUATING VELOCITY OF IMPINGING JET

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Journal of Hydrodynamics 2002年第3期14卷 21-28页

作者： Dai, Guang-qing Yang, Yong-quan Yang, qing Wang, Hai-Yun Hydraulics Lab. of High Speed Flows Sichuan Univ. Chengdu 610065 China

The correlation, between wall fluctuating pressure and fluctuating velocity, on the bed of plunging pool under the action of single and twin impinging jet, and their spectrum and turbulent scale are investigated in the paper by using 2-D LDA and the dynamic pressure scanning system of multiple points. It is found that the cross correlation between the horizontal fluctuating velocity and the fluctuating pressure of twin jet is bigger than that of single jet, and the spectrums of horizontal fluctuating velocity and fluctuating pressure obviously have approximately same dominant frequency. The relationship between the fluctuation pressure coefficient on wall and the turbulent intensity near the wall can be described with logarithmic curve.

关键词： Hydraulic structures Pressure Pressure measurement Turbulence Velocity

An Overview of Epigenetics in Chinese Medicine Researches

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Chinese Journal of Integrative Medicine 2017年第9期23卷 714-720页

作者： HU xue-qing SU Shi-bing Research Center for Traditional Chinese Medicine Complexity System Shanghai University of Traditional Chinese MedicineShanghai201203China

Chinese medicine（CM） has contributed to human health care for several thousand years and is still popular in Asian countries. But the mechanisms underlying CM remain obscure, and need to be clarified by modern biological subjects and methods. Recently, CM researches on epigenetics have gained obvious improvement following rapidly developed molecular technologies. In this review, we revealed mutual characteristics of epigenetics and CM, such as holism, yin-yang dynamic nature, reversibility and balance, and visceral manifestation. Moreover, epigenetic modifications, including DNA methylation, histone post-transcriptional modifications, micro RNA interference, etc. may help explore the molecular basis of CM syndrome classification, and mechanisms of Chinese herbal medicine（CHM）, CHM compounds and Chinese herbal formulae activities. Meanwhile, CM and epigenetics might promote each other and jointly develop following the continuous progress of epigenetics in CM researches.

关键词： Chinese medicine epigenetics methylation histone modification Chinese herbal medicine,Chinese herbal formula Chinese medicine syndrome

On the Existence and Uniqueness of Solutions to Stochastic Differential Equations Driven by G-Brownian Motion with Integral-Lipschitz Coefficients

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Acta Mathematicae Applicatae Sinica 2014年第3期30卷 589-610页

作者： xue-peng BAI Yi-qing LIN Institut de Recherche Mathématique de Rennes Université de Rennes1 School of Mathematics Shandong University Institut de Recherche Mathématique de Rennes Université de Rennes

In this paper, we study the existence and uniqueness of solutions to stochastic differential equations driven by G-Brownian motion （GSDEs） with integral-Lipschitz coefficients.

关键词： G-Brownian motion G-expectation G-stochastic differential equations G-backward stochastic differential equations integral-Lipschitz condition

Non-homogeneous Tb Theorem for Bi-parameter g-function

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Acta Mathematica Sinica,English Series 2018年第9期34卷 1445-1459页

作者： Ming Ming CAO qing Ying xue School of Mathematical Sciences Beijing Normal University Laboratory of Mathematics and Complex Systems Ministry of Education

The main result of this paper is a bi-parameter Tb theorem for Littlewood-Paley g-function, where b is a tensor product of two pseudo-accretive function. Instead of the doubling measure, we work with a product measure μ = μn × μm, where the measures μn and μm are only assumed to be upper doubling. The main techniques of the proof include a bi-parameter b-adapted Haar function decomposition and an averaging identity over good double Whitney regions. Moreover, the non-homogeneous analysis and probabilistic methods are used again.

关键词： Bi-parameter square function probabilistic method b-adapted Haar functions

Elevated intraspinal pressure in traumatic spinal cord injury is a promising therapeutic target

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Neural Regeneration Research 2022年第8期17卷 1703-1710页

作者： Chao-Hua Yang Zheng-xue quan Gao-Ju Wang Tao He Zhi-Yu Chen Qiao-Chu Li Jin Yang qing Wang Department of Orthopedics The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan ProvinceChina Department of Orthopedics The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

The currently recommended management for acute traumatic spinal cord injury aims to reduce the incidence of secondary injury and promote functional *** intraspinal pressure(ISP)likely plays an important role in the processes involved in secondary spinal cord injury,and should not be ***,the factors and detailed time course contributing to elevated ISP and its impact on pathophysiology after traumatic spinal cord injury have not been reviewed in the ***,we review the etiology and progression of elevated ISP,as well as potential therapeutic measures that target elevated *** ISP is a time-dependent process that is mainly caused by hemorrhage,edema,and blood-spinal cord barrier destruction and peaks at 3 days after traumatic spinal cord *** and hypertonic saline may be promising treatments for reducing ISP within this time *** potential treatments such as decompression,spinal cord incision,hemostasis,and methylprednisolone treatment require further validation.

关键词： blood-spinal cord barrier decompression duraplasty durotomy edema hemorrhage intraspinal pressure myelotomy spinal cord injury therapeutic target