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Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPβ-SCD activation in non-alcoholic fatty liver disease

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Zoological Research 2024年第1期45卷 79-94页

作者： Ya-Ling Zhu Lei-Lei Meng Jin-Hu Ma Xin Yuan Shu-Wen Chen Xin-Rui Yi Xin-Yu Li Yi Wang Yun-Shu Tang Min Xue Mei-Zi Zhu Jin Peng Xue-Jin Lu Jian-Zhen Huang Zi-Chen Song Chong Wu Ke-Zhong Zheng qing-qing dai Fan Huang Hao-Shu Fang Department of Pathophysiology Anhui Medical UniversityHefeiAnhui 230032China Laboratory Animal Research Center School of Basic Medical SciencesAnhui Medical UniversityHefeiAnhui 230032China Department of Hepatobiliary Surgery First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China College of Animal Science and Technology Jiangxi Agricultural UniversityNanchangJiangxi 330045China

Non-alcoholic fatty liver disease(NAFLD)is associated with mutations in lipopolysaccharide-binding protein(LBP),but the underlying epigenetic mechanisms remain understudied.Herein,LBP^(-/-)rats with NAFLD were established and used to conduct integrative targetingactive enhancer histone H3 lysine 27 acetylation(H3K27ac)chromatin immunoprecipitation coupled with high-throughput and transcriptomic sequencing analysis to explore the potential epigenetic pathomechanisms of active enhancers of NAFLD exacerbation upon LBP deficiency.Notably,LBP^(-/-)reduced the inflammatory response but markedly aggravated high-fat diet(HFD)-induced NAFLD in rats,with pronounced alterations in the histone acetylome and regulatory transcriptome.In total,1128 differential enhancer-target genes significantly enriched in cholesterol and fatty acid metabolism were identified between wild-type(WT)and LBP^(-/-)NAFLD rats.Based on integrative analysis,CCAAT/enhancer-binding proteinβ(C/EBPβ)was identified as a pivotal transcription factor(TF)and contributor to dysregulated histone acetylome H3K27ac,and the lipid metabolism gene SCD was identified as a downstream effector exacerbating NAFLD.This study not only broadens our understanding of the essential role of LBP in the pathogenesis of NAFLD from an epigenetics perspective but also identifies key TF C/EBPβand functional gene SCD as potential regulators and therapeutic targets.

关键词： Non-alcoholic fatty liver disease C/EBPβ Lipopolysaccharide-binding protein H3K27ac Integrative analysis Enhancer

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A Successfully Resuscitated Case of Air Embolism during Vitrectomy

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Chinese Medical Journal 2018年第12期131卷 1509-1510页

作者： qing-qing dai Wen-Hua Liu Yue Li Huai-Quan Wang Department of Critical Care Medicine The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150086 China

To the Editor： Air embolism is a well-recognized complication during surgery. While thousands of publications exist on intraoperative venous air embolism （VAE）, during eye surgery, it occurs only rarely and so can ... 详细信息

关键词： EYE SURGERY

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Clinical efficacy of extracorporeal membrane oxygenation in cardiogenic shock patients:a multi-center study

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Chinese Medical Journal 2020年第18期133卷 2242-2243页

作者： qing-qing dai Yan Liu Yu-Dong Ren Kai-Jiang Yu Hong-Liang Wang Department of Critical Care Medicine The Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150001China Department of Medical Statistics Harbin Medical UniversityHarbinHeilongjiang 150001China Department of Critical Care Medicine The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150001China

Cardiogenic shock(CS)is a life-threatening condition in intensive care unit,which leads to death of many critically ill patients.Although survival of CS patients seems to have improved,it continues to carry a poor pro... 详细信息

关键词： patients mortality prognosis

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Remote nursing training model combined with proceduralization in the intensive care unit dealing with patients with COVID-19

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World Journal of Clinical Cases 2021年第5期9卷 999-1004页

作者： Hui Wang Kai Kang Yang Gao Bo Yang Jing Li Lei Wang Ying Bi Kai-Jiang Yu qing-qing dai Ming-YanZhao Department of Critical Care Medicine The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Institute of Critical Care Medicine The Sino Russian Medical Research Center of Harbin Medical UniversityHarbin 150081Heilongjiang ProvinceChina Department of Critical Care Medicine The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086Heilongjiang ProvinceChina

The shortage of personal protective equipment and lack of proper nursing training have been endangering health care workers dealing with coronavirus disease 2019(COVID-19).In our treatment center,the implementation of a holistic care model of time-sharing management for severe and critical COVID-19 patients has further aggravated the shortage of intensive care unit(ICU)professional nurses.Therefore,we developed a short-term specialized and targeted nursing training program to help ICU nurses to cope with stress and become more efficient,thus reducing the number of nurses required in the ICU.In order to avoid possible human-to-human spread,small teaching classes and remote training were applied.The procedural training mode included four steps:preparation,plan,implementation,and evaluation.An evaluation was conducted throughout the process of nursing training.In this study,we documented and shared experiences in transitioning from traditional face-to-face programs to remote combined with proceduralization nursing training mode from our daily work experiences during the COVID-19 pandemic,which has shown to be helpful for nurses working in the ICU.

关键词： Nursing training model Remote Proceduralization COVID-19 Heilongjiang province Intensive care unit

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COVID-19 patient with an incubation period of 27 d:A case report

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World Journal of Clinical Cases 2021年第21期9卷 5955-5962页

作者： Xue Du Yang Gao Kai Kang Yang Chong Mei-Ling Zhang Wei Yang Chang-Song Wang Xiang-Lin Meng Dong-Sheng Fei qing-qing dai Ming-Yan Zhao Department of Critical Care Medicine The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Critical Care Medicine The Sixth Affiliated Hospital of Harbin Medical UniversityHarbin 150028Heilongjiang ProvinceChina Institute of Critical Care Medicine The Sino Russian Medical Research Center of Harbin Medical UniversityHarbin 150081Heilongjiang ProvinceChina Department of Critical Care Medicine The Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina Department of Critical Care Medicine The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086Heilongjiang ProvinceChina

BACKGROUND As a highly contagious disease,coronavirus disease 2019(COVID-19)is wreaking havoc around the world due to continuous spread among close contacts mainly via droplets,aerosols,contaminated hands or surfaces.Therefore,centralized isolation of close contacts and suspected patients is an important measure to prevent the transmission of COVID-19.At present,the quarantine duration in most countries is 14 d due to the fact that the incubation period of severe acute respiratory syndrome coronavirus type 2(SARS-CoV-2)is usually identified as 1-14 d with median estimate of 4-7.5 d.Since COVID-19 patients in the incubation period are also contagious,cases with an incubation period of more than 14 d need to be evaluated.CASE SUMMARY A 70-year-old male patient was admitted to the Department of Respiratory Medicine of The First Affiliated Hospital of Harbin Medical University on April 5 due to a cough with sputum and shortness of breath.On April 10,the patient was transferred to the Fever Clinic for further treatment due to close contact to one confirmed COVID-19 patient in the same room.During the period from April 10 to May 6,nucleic acid and antibodies to SARS-CoV-2 were tested 7 and 4 times,respectively,all of which were negative.On May 7,the patient developed fever with a maximum temperature of 39℃,and his respiratory difficulties had deteriorated.The results of nucleic acid and antibody detection of SARS-CoV-2 were positive.On May 8,the nucleic acid and antibody detection of SARS-CoV-2 by Heilongjiang Provincial Center for Disease Control were also positive,and the patient was diagnosed with COVID-19 and reported to the Chinese Center for Disease Control and Prevention.CONCLUSION This case highlights the importance of the SARS-CoV-2 incubation period.Further epidemiological investigations and clinical observations are urgently needed to identify the optimal incubation period of SARS-CoV-2 and formulate rational and evidence-based quarantine policies for COVID-19 accordingly.

关键词： COVID-19 Incubation period Quarantine duration SARS-CoV-2 Case report

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Holistic care model of time-sharing management for severe and critical COVID-19 patients

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World Journal of Clinical Cases 2020年第22期8卷 5513-5517页

作者： Bo Yang Yang Gao Kai Kang Jing Li Lei Wang Hui Wang Ying Bi qing-qing dai Ming-Yan Zhao Kai-Jiang Yu Department of Critical Care Medicine The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Critical Care Medicine The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086Heilongjiang ProvinceChina Institute of Critical Care Medicine The Sino Russian Medical Research Center of Harbin Medical UniversityHarbin 150081Heilongjiang ProvinceChina

The rapid global outbreak of coronavirus disease 2019(COVID-19)and the surge of infected patients have led to the verge of exhaustion of critical care medicine resources worldwide,especially with regard to critical care staff.A holistic care model on time-sharing management for severe and critical COVID-19 patients is proposed,which includes formulation of individualized care objectives and plans,identification of care tasks in each shift and making detailed checklist,and management of quality of care.This study was conducted in the COVID-19 treatment center of Harbin,Heilongjiang Province.The data collected from the treatment center were recorded and analyzed.From the results we can deduce that it is especially suitable for non-intensive care unit(non-ICU)nurses to adapt care management mode of ICU as soon as possible and ensure the quality and efficiency of care during the epidemic.The holistic care model on time-sharing management for severe and critical cases with COVID-19 proposed based on our daily work experiences can assist in improving the quality and efficiency of care,thus reducing the mortality rate of patients in ICU.

关键词： Holistic care model Time-sharing management COVID-19 Quality of care Efficiency of care Hierarchical management

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Clinical characteristics of patients with COVID-19 presenting with gastrointestinal symptoms as initial symptoms: Retrospective case series

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World Journal of Clinical Cases 2020年第14期8卷 2950-2958页

作者： Yun Yang Yuan-Chao Li Si-Cong Wang qing-qing dai Xue-Song Jiang Shu Zuo Liu Jia Jun-Bo Zheng Hong-Liang WangDepartment of Critical Care Medicine the Second Affiliated Hospital of Harbin Medical University Harbin 150001Heilongjiang ProvinceChina Department of Critical Care Medicine the Cancer Hospital of Harbin Medical UniversityHarbin 150081Heilongjiang ProvinceChina

BACKGROUND A large number of pneumonia cases due to coronavirus disease 2019(COVID-19)have been first reported in China.Meanwhile,the virus is sweeping all around the world and has infected millions of people.Fever and pulmonary symptoms have been noticed as major and early signs of infection,whereas gastrointestinal symptoms were also observed in a significant portion of patients.The clinical investigation of disease onset was underestimated,especially due to the neglection of cases presenting with gastrointestinal symptoms.AIM To characterize the clinical features of coronavirus-infected patients with gastrointestinal symptoms as initial symptoms.METHODS This is a retrospective,single-center case series of the general consecutive hospitalized patients with confirmed COVID-19 at Wuhan Union Hospital from February 2,2020 to February 13,2020.According to their initial symptoms,these patients were classified into two groups.Patients in group one presented with pulmonary symptoms(PS)as initial symptoms,and group two presented with gastrointestinal symptoms(GS).Epidemiological,demographic,clinical,laboratory,and treatment data were collected for analysis.RESULTS Among the 50 patients recruited,no patient has been admitted to intensive care units,and no patient died during the study.The duration of hospitalization was longer in the GS group than in the PS group(12.13±2.44 vs 10.00±2.13,P<0.01).All of the 50 patients exhibited decreased lymphocytes.However,lymphocytes in the GS group were significantly lower compared to those in the PS group(0.94±0.06 vs 1.04±0.15,P<0.01).Procalcitonin and hs-CRP were both significantly higher in the GS group than in the PS group.Accordingly,the duration of viral shedding was significantly longer in the GS group compared to the PS group(10.22±1.93 vs 8.15±1.87,P<0.01).CONCLUSION COVID-19 patients presenting with gastrointestinal symptoms as initial symptoms need more days of viral shedding and hospitalization than the patients presenting with pulmonary symptoms.

关键词： COVID-19 Initial symptoms Gastrointestinal symptoms Hospitalization Viral transmission

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Standardization of critical care management of non-critically ill patients with COVID-19

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World Journal of Clinical Cases 2021年第12期9卷 2696-2702页

作者： Chang-Song Wang Yang Gao Kai Kang Dong-Sheng Fei Xiang-Lin Meng Hai-Tao Liu Yun-Peng Luo Wei Yang qing-qing dai Yan Gao Ming-Yan Zhao Kai-Jiang Yu Department of Critical Care Medicine Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina Department of Critical Care Medicine The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Critical Care Medicine The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086Heilongjiang ProvinceChina Department of Critical Care Medicine The Fourth Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Institute of Critical Care Medicine The Sino Russian Medical Research Center of Harbin Medical UniversityHarbin 150081Heilongjiang ProvinceChina

The large global outbreak of coronavirus disease 2019(COVID-19)has seriously endangered the health care system in China and globally.The sudden surge of patients with severe acute respiratory syndrome coronavirus 2 infection has revealed the shortage of critical care medicine resources and intensivists.Currently,the management of non-critically ill patients with COVID-19 is performed mostly by non-intensive care unit(ICU)physicians,who lack the required professional knowledge,training,and practice in critical care medicine,especially in terms of continuous monitoring of the respiratory function,intervention,and feedback on treatment effects.This clinical problem needs an urgent solution.Therefore,here,we propose a series of clinical strategies for non-ICU physicians aimed at the standardization of the management of non-critically ill patients with COVID-19 from the perspective of critical care medicine.Isolation management is performed to facilitate the implementation of hierarchical monitoring and intervention to ensure the reasonable distribution of scarce critical care medical resources and intensivists,highlight the key patients,timely detection of disease progression,and early and appropriate intervention and organ function support,and thus improve the prognosis.Different management objectives are also set based on the high-risk factors and the severity of patients with COVID-19.The approaches suggested herein will facilitate the timely detection of disease progression,and thus ensure the provision of early and appropriate intervention and organ function support,which will eventually improve the prognosis.

关键词： Non-critically ill patients COVID-19 SARS-CoV-2 infection Standardized management Isolation management Hierarchical monitoring and intervention Different management objectives

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Effects of acute kidney injury on acute pancreatitis patients’ survival rate in intensive care unit: A retrospective study

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World Journal of Gastroenterology 2021年第38期27卷 6453-6464页

作者： Ni Shi Guo-Dong Sun Yuan-Yuan Ji Ying Wang Yu-Cheng Zhu Wan-Qiu Xie Na-Na Li Qiu-Yuan Han Zhi-Dong Qi Rui Huang Ming Li Zhen-Yu Yang Jun-Bo Zheng Xing Zhang qing-qing dai Gui-Ying Hou Yan-Song Liu Hong-Liang Wang Yang Gao Department of Critical Care Medicine The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086Heilongjiang ProvinceChina Department of Critical Care Medicine The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Critical Care Medicine The First People Hospital of Mudanjiang cityMudanjiang 157000Heilongjiang ProvinceChina Department of Critical Care Medicine The Hongxinglong Hospital of Beidahuang GroupShuangyashan 155811Heilongjiang ProvinceChina Department of Critical Care Medicine The Sixth Affiliated Hospital of Harbin Medical UniversityHarbin 150028Heilongjiang ProvinceChina

BACKGROUND Acute kidney injury(AKI)is one of the most common acute pancreatitis(AP)-associated complications that has a significant effect on AP,but the factors affecting the AP patients’survival rate remains unclear.AIM To assess the influences of AKI on the survival rate in AP patients.METHODS A total of 139 AP patients were included in this retrospective study.Patients were divided into AKI group(n=72)and non-AKI group(n=67)according to the occurrence of AKI.Data were collected from medical records of hospitalized patients.Then,these data were compared between the two groups and further analysis was performed.RESULTS AKI is more likely to occur in male AP patients(P=0.009).AP patients in AKI group exhibited a significantly higher acute physiologic assessment and chronic health evaluation II score,higher Sequential Organ Failure Assessment score,lower Glasgow Coma Scale score,and higher demand for mechanical ventilation,infusion of vasopressors,and renal replacement therapy than AP patients in non-AKI group(P<0.01,P<0.01,P=0.01,P=0.001,P<0.01,P<0.01,respectively).Significant differences were noted in dose of norepinephrine and adrenaline,duration of mechanical ventilation,maximum and mean values of intra-peritoneal pressure(IPP),maximum and mean values of procalcitonin,maximum and mean serum levels of creatinine,minimum platelet count,and length of hospitalization.Among AP patients with AKI,the survival rate of surgical intensive care unit and in-hospital were only 23%and 21%of the corresponding rates in AP patients without AKI,respectively.The factors that influenced the AP patients’survival rate included body mass index(BMI),mean values of IPP,minimum platelet count,and hospital day,of which mean values of IPP showed the greatest impact.CONCLUSION AP patients with AKI had a lower survival rate and worse relevant clinical outcomes than AP patients without AKI,which necessitates further attention to AP patients with AKI in surgical intensive care unit.

关键词： Acute kidney injury Acute pancreatitis Surgical intensive care unit Survival rate Risk factors Intra-peritoneal pressure

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Switching,explosion,and chaos of multi-wavelength soliton states in ultrafast fiber lasers

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 82-90页

作者： Zhi-Zeng Si Yue-Yue Wang Chao-qing dai College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityLin’an 311300China

Because of the complexity and difficulty of realizing a multi-wavelength soliton state,reports on its internal dynamic characteristics are scarce.In this study,the switching and periodic soliton explosion processes of the multi-wavelength soliton state in a negative dispersion passively mode-locked fiber laser are realized.The generation of the multi-wavelength soliton state undergoes the process of noise,oscillation,and stable mode-locking,and the splitting and annihilation of solitons with different group velocities directly impact the generation and disappearance of three wavelengths.Positive and negative dispersion lead to different group velocities of solitons.The presence and displacement of solitons with different group velocities cause soliton collisions,which lead to soliton explosions.A soliton experiences relative phase oscillation,chaos,and oscillation,as well as convergence and separation before and after an explosion.With an increase in parameters related to pump power,single-soliton oscillation,multi-wavelength solitons,and chaos are found in experiments and simulations,proving the relevance and reliability between simulation and experimental results.This work promotes the dynamical study of multi-soliton collisions in nonlinear science and the development of chaos theory in multi-comb lasers.

关键词： multi-wavelength fiber laser soliton explosion chaos state switching real-time dynamics

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