检索结果-南通市图书馆

Feasibility Analysis of Oxygen-Glucose Deprivation-Nutrition Resumption on H9c2 Cells In vitro Models of Myocardial Ischemia-Reperfusion Injury

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2018年第19期131卷 2277-2286页

作者： Gui-Zhen Yang Fu-Shan xue Ya-Yang Liu Hui-Xian Li qing Liu xu Liao Department of Anesthesiology Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100144 China

Background： Oxygen-glucose deprivation-nutrition resumption （OGD-NR） models on H9c2 cells are commonly used in vitro models of simulated myocardial ischemia-reperfusion injury （M1RI）, but no study has assessed whether these methods for establishing in vitro models can effectively imitate the characteristics of MIRI in vivo. This experiment was designed to analyze the feasibility of six OGD-NR models of MIRI. Methods： By searching the PubMed database using the keywords ＂myocardial reperfusion injury H9c2 cells,＂ we obtained six commonly used OGD-NR in vitro models of MIRI performed on H9c2 cells from more than 400 published papers before January 30, 2017. For each model, control （C）, simulated ischemia （SI）, and simulated ischemia-reperfusion （SIR） groups were assigned, and cell morphology, lactate dehydrogenase （LDH） release, adenosine triphosphate （ATP） levels, reactive oxygen species （ROS）, mitochondrial membrane potential （MMP）, and inflammatory cytokines were examined to evaluate the characteristics of cell injury. Subsequently, a coculture system of cardiomyocyte-endothelial-macrophage was constructed. The coeulture system was dealt with SI and SIR treatments to test the effect on cardiomyocytes survival. Results： For models l, 2, 3, 4, 5, and 6, SI treatment caused morphological damage to cells, and subsequent SIR treatment did not cause further morphological damage. In the models 1, 2, 3, 4, 5 and 6, LDH release was significantly higher in the SI groups than that in the C group （P 〈 0.05）, and was significantly lower in the SIR groups than that in the SI groups （P 〈 0.05）, except tbr no significant differences in the LDH release between C, SI and SIR groups in model 6 receiving a 3-h SI treatment. In models 1, 2, 3, 4, 5, and 6, compared with the C group, ATP levels of the S1 groups significantly decreased （P 〈 0.05）, ROS levels increased （P 〈 0.05）, and MMP levels decreased （P 〈 0.05）. Compared with the SI group, ATP level of the SIR groups was significantly

关键词： Feasibility In vitro Models Myocardial Ischemia-Reperfusion Injury

PICARD ITERATION FOR NONSMOOTH EQUATIONS

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Computational Mathematics 2001年第6期19卷 583-590页

作者： Song-bai Sheng Hui-fu xu College of Science Nanjing University of Aeronautics and AstronauticsNanjing 210016China Australian Graduate School of Management the University of New South WalesSydneyAustralia

Presents an analysis of the generalized Newton method, approximate Newton methods, and splitting methods for solving nonsmooth equations from Picard iteration viewpoint. Details of the radius of the weak Jacobian of P... 详细信息

关键词： nonsmooth equations picard iteration weak Jacobian convergence

Sample Generation for Security Region Boundary Identification Based on Topological Features of Historical Operation Data

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1087-1095页

作者： Xiaokang Wu Wei xu Feng xue College of Energy and Electrical Engineering Hohai UniversityNanjingChina NARI Group Corporation NanjingChina State Grid Electric Power Research Institute NanjingChina

Since the scale and uncertainty of the power system have been rapidly increasing,the computation efficiency of constructing the security region boundary(SRB)has become a prominent *** on the topological features of historical operation data,a sample generation method for SRB identification is proposed to generate evenly distributed samples,which cover dominant security *** boundary sample pair(BSP)composed of a secure sample and an unsecure sample is defined to describe the feature of *** resolution,sampling,and span indices are designed to evaluate the coverage degree of existing BSPs on the SRB and generate samples closer to the *** on the feature of flat distribution of BSPs over the SRB,the principal component analysis(PCA)is adopted to calculate the tangent vectors and normal vectors of ***,the sample distribution can be expanded along the tangent vector and corrected along the normal vector to cover different security ***,a sample set is randomly gen-erated based on the IEEE standard example and another new sample set is generated by the proposed *** results indicate that the new sample set is closer to the SRB and covers different security modes with a small calculation time cost.

关键词： Clustering analysis principal component analysis(PCA) sample generation security region boundary(SRB)

Reliability Assessment for Integrated Power-gas Systems Considering Renewable Energy Uncertainty and Cascading Effects

在线全文

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2023年第3期9卷 1214-1226页

作者： Yucui Wang Yongbiao Yang qingshan xu School of Cyber Science and Engineering Southeast UniversityNanjing 210096China School of Electrical Engineering Southeast UniversityNanjing 210096China and Nanjing Center for Applied MathematicsNanjing 210096China

Integrated power-gas systems(IPGSs)make the power system and natural gas system(NGS)as a whole,and strengthen interdependence between the two *** to bidirectional energy conversion in IPGS,a disturbance may turn into a catastrophic ***,increasing proportion of renewable energy brings challenges to reliability of ***,partial failure or degradation of system performance leads IPGS operate at multiple performance ***,this paper proposes a reliability assessment model of IPGSs which represents multiple performance of components and considers cascading effects,as well as renewable energy ***,a framework of IPGS reliability assessment is proposed:multistate models for main elements in the IPGS are *** a gas-power-generation calculation operator and a power-to-gas calculation operator are utilized to bi-directionally convert a multi-state model between NGS and power ***,nodal reliability indices for IPGS are given to display impacts of cascading effects and renewable energy uncertainty on reliabilities of *** results on IPGS test system demonstrate the proposed methods.

关键词： Cascading effects integrated power-gas systems multi-state model reliability renewable energy uncertainty

Screening biomarkers for spinal cord injury using weighted gene co-expression network analysis and machine learning

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第12期19卷 2723-2734页

作者： Xiaolu Li Ye Yang Senming xu Yuchang Gui Jianmin Chen Jianwen xu Department of Rehabilitation Medicine The First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Rehabilitation Medicine Guilin People’s HospitalGuilinGuangxi Zhuang Autonomous RegionChina Department of Rehabilitation Medicine The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina

Immune changes and inflammatory responses have been identified as central events in the pathological process of spinal co rd *** can greatly affect nerve regeneration and functional ***,there is still limited understanding of the peripheral immune inflammato ry response in spinal cord inju *** this *** obtained microRNA expression profiles from the peripheral blood of patients with spinal co rd injury using high-throughput *** also obtained the mRNA expression profile of spinal cord injury patients from the Gene Expression Omnibus(GEO)database(GSE151371).We identified 54 differentially expressed microRNAs and 1656 diffe rentially expressed genes using bioinformatics *** enrichment analysis revealed that various common immune and inflammation-related signaling pathways,such as neutrophil extracellular trap formation pathway,T cell receptor signaling pathway,and nuclear factor-κB signal pathway,we re abnormally activated or inhibited in spinal cord inju ry patient *** applied an integrated strategy that combines weighted gene co-expression network analysis,LASSO logistic regression,and SVM-RFE algorithm and identified three biomarke rs associated with spinal cord injury:ANO10,BST1,and *** verified the expression levels and diagnostic perfo rmance of these three genes in the original training dataset and clinical samples through the receiver operating characteristic *** polymerase chain reaction results showed that ANO20 and BST1 mRNA levels were increased and ZFP36L2 mRNA was decreased in the peripheral blood of spinal cord injury *** also constructed a small RNA-mRNA interaction network using ***,we evaluated the proportion of 22 types of immune cells in the peripheral blood of spinal co rd injury patients using the CIBERSORT *** proportions of naive B cells,plasma cells,monocytes,and neutrophils were increased while the proportions of memory B cells,C

关键词： bioinformatics analysis biomarker CIBERSORT GEO dataset LASSO miRNA-mRNA network RNA sequencing spinal cord injury SVM-RFE weighted gene co-expression network analysis

Multivariate time delay analysis based local KPCA fault prognosis approach for nonlinear processes

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2016年第10期24卷 1413-1422页

作者： Yuan xu Ying Liu Qunxiong Zhu College of Information Science and Technology Beijing University of Chemical Technology

Currently, some fault prognosis technology occasionally has relatively unsatisfied performance especially for in- cipient faults in nonlinear processes duo to their large time delay and complex internal connection. To overcome this deficiency, multivariate time delay analysis is incorporated into the high sensitive local kernel principal component analysis. In this approach, mutual information estimation and Bayesian information criterion （BIC） are separately used to acquire the correlation degree and time delay of the process variables. Moreover, in order to achieve prediction, time series prediction by back propagation （BP） network is applied whose input is multivar- iate correlated time series other than the original time series. Then the multivariate time delayed series and future values obtained by time series prediction are combined to construct the input of local kernel principal component analysis （LKPCA） model for incipient fault prognosis. The new method has been exemplified in a sim- ple nonlinear process and the complicated Tennessee Eastman （TE） benchmark process. The results indicate that the new method has suoerioritv in the fault prognosis sensitivity over other traditional fault prognosis methods.

关键词： Fault prognosis Time delay estimation Local kernel principal component analysis

Recent advances in geosynthetic-reinforced retaining Nails for highway applications

在线全文

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2018年第2期12卷 239-247页

作者： Jie HAN Yan JIANG Chao xu Department of Civil Environmental and Architectural Engineering University of Kansas Lawrence KS 66044 USA Terracon Consultants Inc. 2201 Rowland Ave Savannah Georgia 31404 USA Department of Geotechnical Engineering College of Civil Engineering Tongji University Shanghai 200092 China

Geosynthetic-reinforced retaining （GRR） walls have been increasingly used to support roadways and bridge abutments in highway projects. In recent years, advances have been made in construction and design of GRR walls for highway applications. For example, piles have been installed inside GRR walls to support bridge abutments and sound barrier walls. Geosynthetic layers at closer spacing are used in GRR walls to form a composite mass to support an integrated bridge system. This system is referred to as a geosynthetic-reinforced soil （GRS）-integrated bridge systems （IBS） or GRS-IBS. In addition, short geosynthetic layers have been used as secondary reinforcement in a GRR wall to form a hybrid GRR wall （HGRR wall） and reduce tension in primary reinforcement and facing deflections. These new technologies have improved performance of GRR walls and created more economic solutions; however, they have also created more complicated problems for analysis and design. This paper reviews recent studies on these new GRR wall systems, summarizes key results and findings including but not limited to vertical and lateral earth pressures, wall facing deflections, and strains in geosynthetic layers, discusses design aspects, and presents field applications for these new GRR wall systems.

关键词： bridge geosynthetic highway reinforced wall

ESTIMATION AND INFERENCE FOR VARYING-COEFFICIENT REGRESSION MODELS WITH ERROR-PRONE COVARIATES

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2014年第6期27卷 1263-1285页

作者： xu Yongqing LI Xiaoli CHEN Gemai School of Statistics and Management Shanghai University of Finance and Economics Department of Mathematics & Statistics University of CalgaryCalgaryAlberta T2N1N4Canada

This paper studies the estimation and inference for a class of varying-coefficient regression models with error-prone *** authors focus on the situation where the covariates are unobserved,there are no repeated measurements,and the covariance matrix of the measurement errors is unknown,but some auxiliary information is *** authors propose an instrumental variable type local polynomial estimator for the unknown varying-coefficient functions,and show that the estimator achieves the optimal nonparametric convergence rate,is asymptotically normal,and avoids using undersmoothing to allow the bandwidths to be selected using data-driven methods.A simulation is carried out to study the finite sample performance of the proposed estimator,and a real date set is analyzed to illustrate the usefulness of the developed methodology.

关键词： Error-prone covariate instrumental variable local polynomial efficient estimation varying-coefficient.

在线全文

学校读者我要写书评

暂无评论

名中医许昕辨治绝经综合征经验

陕西中医 2025年第1期46卷 114-117页

作者：刘帅刘君许昕首都医科大学附属北京中医医院北京100010

绝经综合征是妇科常见病、多发病,又称围绝经期综合征、更年期综合征,中医称绝经前后诸证,西医常激素治疗。许昕教授认为肾气衰,天癸竭为初始病因,主要病机是肾阴不足,精血亏少,阴阳失调,天癸衰竭而月经闭止,涉及心肝脾胃肺多脏腑,可兼... 详细信息

绝经综合征是妇科常见病、多发病,又称围绝经期综合征、更年期综合征,中医称绝经前后诸证,西医常激素治疗。许昕教授认为肾气衰,天癸竭为初始病因,主要病机是肾阴不足,精血亏少,阴阳失调,天癸衰竭而月经闭止,涉及心肝脾胃肺多脏腑,可兼郁夹瘀,变化多端;治疗要标本兼顾,调整阴阳平衡,调和脏腑,调畅气机,帮助患者解除病痛,平稳度过绝经期阶段。

关键词：绝经综合征许昕名中医经验阴阳平衡调和脏腑调畅气机