检索结果-南通市图书馆

Chinese Journal of Integrative Medicine 2024年第8期30卷 721-728页

作者： WANG Bi-yan BU Hong-shi XIA Li-bo jiang Xiang-yu TONG Yan-qing Department of Traditional Chinese Medicine Changchun University of Traditional Chinese MedicineChangchun130000China

Objective To investigate the effect of low concentration of Wenyang Tonglin Decoction(WTD)on the binding conditions of R45 plasmid conjugative transfer under liquid phase conjugation and its *** Escherichia coli CP9(R45)and Staphylococcus aureus RN450RF were cultured in medium containing WTD,and their minimum inhibitory concentration(MIC)values were *** promoter fusion technology,*** CP9(R45)containing a promoter fusion was obtained.β-Galactosidase activity of TrfAp and TrbBp was tested,and the mRNA expression of regulatory factors(TrbA,KorA,and KorB)was detected by real-time fluorescent quantitative polymerase chain *** The MIC of *** CP9(R45)was 400 g/L and that of *** RN450RF was 200 g/*** the drug concentration in the culture medium was 200 g/L,the highest number of conjugants was(3.47±0.20)×10^(7) CFU/mL At 90 h of conjugation,the maximum number of conjugants was(1.15±0.06)×10^(8) CFU/mL When the initial bacterial concentration was 10^(8) CFU/mL,the maximum number of conjugants was(3.47±0.20)×10^(7) CFU/*** the drug concentration was 200 g/L,theβ-galactosidase activity of TrfAp and TrbBp significantly increased;the relative quantification of TrbA,KorA and KorB were significantly *** Low concentration of WTD promoted the development of bacterial resistance by affecting promoters and inhibiting the expression of regulatory factors.

关键词： urinary tract infection Chinese medicine drug-resistant plasmid heterozygous strains conjugation transfer

Promoted hydrogenation of CO2 to methanol over single-atom Cu sites with Na+-decorated microenvironment

在线全文

学校读者我要写书评

暂无评论

National Science Review 2024年第06期11卷 264-272页

作者： Li-Li ling Xinyu Guan Xiaoshuo Liu Xiao-Mei Lei Zhongyuan lin Hai-Long jiang Hefei National Research Center for Physical Sciences at the Microscale Department of Chemistry University of Science and Technology of China School of Energy and Power Engineering North China Electric Power University School of Energy and Environment Southeast University

Although single-atom Cu sites exhibit high efficiency in CO2hydrogenation to methanol,they are prone to forming Cu nanoparticles due to reduction and aggregation under reaction conditions,especially at high ***,single-atom Cu sites stabilized by adjacent Na+ions have been successfully constructed within a metal-organic framework（MOF）-based catalyst,namely *** is found that the electrostatic interaction between the Na+and Hδ-species plays a pivotal role in upholding the atomic dispersion of Cu in MOF-808-NaCu during CO2hydrogenation,even at temperatures of up to 275℃.This exceptional stabilization effect endows the catalyst with excellent activity(306 g·kgcat-1·h-1),high selectivity to methanol（93%） and long-term stability at elevated reaction temperatures,far surpassing the counterpart in the absence of Na+（denoted as MOF-808-Cu）.This work develops an effective strategy for the fabrication of stable single-atom sites for advanced catalysis by creating an alkali-decorated microenvironment in close proximity.

关键词： single-atom sites metal–organic framework CO2 hydrogenation heterogeneous catalysis alkali-metal decoration

An Improved Modulation Strategy for Single-phase Three-level Neutral-point-clamped Converter in Critical Conduction Mode

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 981-990页

作者： Ning Li Yujie Cao Xiaokang Liu Yan Zhang Ruotong Wang lin jiang Xiao-Ping Zhang School of Electrical Engineering Xi’an University of TechnologyXi’anChina the Department of Electronics Information and BioengineeringPolitecnico di MilanoMilanItaly Xi’an Jiaotong University Xi’anChina the Department of Electrical Engineering and Electronics University of LiverpoolLiverpoolU.K. the Department of Electronic Electrical and Systems EngineeringUniversity of BirminghamBirminghamU.K.

Two-level totem-pole power factor correction(PFC)converters in critical conduction mode(CRM)suffer from the wide regulation range of switching ***,in highfrequency applications,the number of switching times increases,resulting in significant switching *** solve these issues,this paper proposes an improved modulation strategy for the single-phase three-level neutral-point-clamped(NPC)converter in CRM with *** optimizing the discharging strategy and switching state sequence,the switching frequency and its variation range have been efficiently *** detailed performance analysis is also presented regarding the switching frequency,the average switching times,and the effect of voltage gain.A 2 k W prototype is built to verify the effectiveness of the proposed modulation strategy and analysis *** with the totem-pole PFC converter,the switching frequency regulation range of the three-level PFC converter is reduced by 36.48%and the average switching times is reduced by 45.10%.The experimental result also shows a 1.2%higher efficiency for the three-level PFC converter in the full load range.

关键词： Critical conduction mode(CRM) on-board charger switching frequency range switching times power factor correction(PFC) three-level converter

BAR:a branch-alternation-resorting algorithm for locality exploration in graph processing

在线全文

学校读者我要写书评

暂无评论

High Technology Letters 2024年第1期30卷 31-42页

作者：邓军勇 WANG Junjie jiang lin XIE Xiaoyan ZHOU Kai School of Electronic Engineering Xi'an University of Posts and TelecommunicationsXi'an 710121P.R.China School of Computer Xi'an University of Science and TechnologyXi'an 710054P.R.China School of Computer Xi'an University of Posts and TelecommunicationsXi'an 710121P.R.China

Unstructured and irregular graph data causes strong randomness and poor locality of data accesses in graph *** paper optimizes the depth-branch-resorting algorithm(DBR),and proposes a branch-alternation-resorting algorithm(BAR).In order to make the algorithm run in parallel and improve the efficiency of algorithm operation,the BAR algorithm is mapped onto the reconfigurable array processor(APR-16)to achieve vertex reordering,effectively improving the locality of graph *** paper validates the BAR algorithm on the GraphBIG framework,by utilizing the reordered dataset with BAR on breadth-first search(BFS),single source shortest paht(SSSP)and betweenness centrality(BC)algorithms for *** results show that compared with DBR and Corder algorithms,BAR can reduce execution time by up to 33.00%,and 51.00%*** terms of data movement,the BAR algorithm has a maximum reduction of 39.00%compared with the DBR algorithm and 29.66%compared with Corder *** terms of computational complexity,the BAR algorithm has a maximum reduction of 32.56%compared with DBR algorithm and53.05%compared with Corder algorithm.

关键词： graph processing vertex reordering branch-alternation-resorting algorithm(BAR) reconfigurable array processor

STING agonist-conjugated metal-organic framework induces artificial leukocytoid structures and immune hotspots for systemic antitumor responses

在线全文

学校读者我要写书评

暂无评论

National Science Review 2024年第7期11卷 189-204页

作者： Taokun Luo Xiaomin jiang Yingjie Fan Eric Yuan Jinhong Li Langston Tillman Wenbin lin Department of Chemistry University of Chicago Department of Radiation and Cellular Oncology and the Ludwig Center for Metastasis Research University of Chicago

Radiotherapy is widely used for cancer treatment, but its clinical utility is limited by radioresistance and its inability to target metastases. Nanoscale metal-organic frameworks(MOFs) have shown promise as high-Z nanoradiosensitizers to enhance radiotherapy and induce immunostimulatory regulation of the tumor microenvironment. We hypothesized that MOFs could deliver small-molecule therapeutics to synergize with radiotherapy for enhanced antitumor efficacy. Herein, we develop a robust nanoradiosensitizer,GA-MOF, by conjugating a STING agonist, 2,3-cyclic guanosine monophosphate–adenosine monophosphate(GA), on MOFs for synergistic radiosensitization and STING activation. GA-MOF demonstrated strong anticancer efficacy by forming immune-cell-rich nodules(artificial leukocytoid structures) and transforming them into immunostimulatory hotspots with radiotherapy. Further combination with an immune checkpoint blockade suppressed distant tumors through systemic immune activation. Our work not only demonstrates the potent radiosensitization of GA-MOF, but also provides detailed mechanisms regarding MOF distribution, immune regulatory pathways and long-term immune effects.

关键词： metal-organic framework radiosensitization STING agonist artificial leukocytoid structures immune hotspots immunotherapy nanomedicine

Sodium Leak Channel in Glutamatergic Neurons of the Lateral Parabrachial Nucleus Helps to Maintain Respiratory Frequency Under Sevoflurane Anesthesia

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第8期40卷 1127-1140页

作者： lin Wu Donghang Zhang Yujie Wu Jin Liu Jingyao jiang Cheng Zhou Department of Anesthesiology West China HospitalSichuan UniversityChengdu 610041China Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Centre of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengdu 610041China

The lateral parabrachial nucleus(PBL)is implicated in the regulation of respiratory *** leak channel(NALCN)mutations disrupt the respiratory rhythm and influence anesthetic sensitivity in both rodents and ***,we investigated whether the NALCN in PBL glutamatergic neurons maintains respiratory function under general *** results showed that chemogenetic activation of PBL glutamatergic neurons increased the respiratory frequency(RF)in mice;whereas chemogenetic inhibition suppressed *** knockdown in PBL glutamatergic neurons but not GABAergic neurons significantly reduced RF under physiological conditions and caused more respiratory suppression under sevoflurane *** knockdown in PBL glutamatergic neurons did not further exacerbate the respiratory suppression induced by propofol or *** sevoflurane anesthesia,painful stimuli rapidly increased the RF,which was not affected by NALCN knockdown in PBL glutamatergic *** study suggested that the NALCN is a key ion channel in PBL glutamatergic neurons that maintains respiratory frequency under volatile anesthetic sevoflurane but not intravenous anesthetic propofol.

关键词： Glutamatergic neurons Lateral parabrachial nucleus NALCN Respiration General anesthesia

Marginal land in China suitable for bioenergy crops under diverse socioeconomic and climate scenarios from 2020 to 2100

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Big Earth Data 2024年第3期8卷 566-586页

作者： Jingying Fu Qiang Gao Gang lin Dong jiang Yanan Zhao Shuang Lue Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijingChina College of Resources and Environment University of Chinese Academy of SciencesBeijingChina Key Laboratory of Coupling Processes and Effects of Natural Resource Elements Ministry of Natural ResourcesBeijingChina Key Laboratory of Carrying Capacity Assessment for Resource and Environment Ministry of Natural ResourcesBeijingChina College of Geoscience and Surveying Engineering China University of Mining and Technology(Beijing)BeijingChina

Maximizing the development of renewable energy plays a critical role in mitigating the climate *** land provides space for the development of biomass energy;however,it remains unclear how the amount and spatial distribution of marginal land that is suitable for energy crop development will change in the ***,we project energy marginal land changes in China following the shared socioeconomic pathway(SSP)and/or repre-sentative concentration path(RCP).We provide datasets of mar-ginal land,agriculturally suitable land,and potentially suitable for energy crops under historical scenarios and six future scenarios(***1-1.9,SSP1-2.6,SSP4-3.4,SSP2-4.5,SSP4-6.0,and SSP3-7.0)for the period 2020-2100,with a spatial resolution of 5 *** the six scenarios,from 2020-2100,the area of suitable marginal land ranged from 1.90-16.28(Jatropha curcas L.)to 37.37-73.97(Panicum virgatum L.)(×10^(4)km^(2)),depending on the choice of energy crops and climate *** on the growing suitability of eight important bioenergy crops-Ricinus communis L.,Saccharum officinarum L.,Pistacia chinensis Bunge,Panicum virga-tum L.,Jatropha curcas L.,Miscanthus giganteus J.,Manihot esculenta Crantz,and Sorghum bicolor Moench-our dataset can be used to identify suitable locations for specific energy *** new syn-thetic dataset could support the development of multiscenariobased solutions related to carbon neutrality,ecosystem services,and energy transition.

关键词： Marginal land climate change energy crops liquid fuel

Ultra-conservative noncoding RNA uc.243 confers chemo-resistance by facilitating the efflux of the chemotherapeutic drug in ovarian cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2024年第8期48卷 1265-1273页

作者： SHAN jiang XIUFENG lin YANFEI CHEN XINNING LI JIALI KANG Department of Gynecology and Obstetrics The First Affiliated Hospital of Jinan UniversityGuangzhou510180China Reproductive Medical Center Boai Hospital of Zhongshan Affiliated to Southern Medical UniversityZhongshan528400China Department of Gynecology and Obstetrics Boai Hospital of Zhongshan Affiliated to Southern Medical UniversityZhongshan528400China Department of Gynecology and Obstetrics Guangzhou First People’s HospitalGuangzhou Medical UniversityGuangzhou510180China

Background:Despite improvements in objective response rates to cisplatin-based combination chemotherapy,the majority of advanced ovarian cancer remains suboptimal,resulting in poor *** has been found that non-coding RNAs(ncRNAs)not only participate in the transmission of signals between various cells but also participate in tumor immunity and anti-tumor immune responses,thereby regulating tumor occurrence and ***,the function and detailed mechanism of ultraconserved RNA(ucRNA)in ovarian cancer chemoresistance is still ***:Western blotting assay,Quantitative real-time PCR analysis(qPCR),and Kaplan-Meier Plotter analysis were performed to analyze the expression and prognosis of uc.243 in ovarian *** assay and Annexin V assay were performed to analyze the function of uc.243 in cisplatin resistance in ovarian cancer *** pull-down and qPCR experiments were performed to explore the molecular mechanism of uc.243 enhancing cisplatin resistance in ovarian cancer ***:Herein,we found that uc.243 was remarkably upregulated and correlated with patient survival in chemoresistance ovarian cancer patients compared with chemo-sensitive ovarian *** experiment displayed that uc.243 induced cisplatin resistance on ovarian cancer cells by facilitating the efflux of cisplatin(CDDP);but inhibiting the expression of uc.243 significantly reverses this ***,uc.243 can inhibit the binding of RNA binding protein DGCR8 microprocessor complex subunit to pri-miR-155,thereby inhibiting the cleavage of pri-miR-155 and decrease in mature miR-155,subsequently upregulates the expression of ATP binding cassette subfamily B member(ABCB1,ABCC2).Conclusion:Our research findings indicate that uc.243 can induce chemotherapy resistance in ovarian cancer,suggesting that it may become a new prognostic biomarker for malignant ovarian cancer.

关键词： Ultra-conserved non-coding RNA uc.243 Drug efflux Drug transporters Chemoresistance Ovarian cancer

Ultraviolet‑Irradiated All‑Organic Nanocomposites with Polymer Dots for High‑Temperature Capacitive Energy Storage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第3期16卷 398-406页

作者： Jiale Ding Yao Zhou Wenhan Xu Fan Yang Danying Zhao Yunhe Zhang Zhenhua jiang qing Wang College of Chemistry Jilin UniversityChangchun 130012People’s Republic of China Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USAs Deutsches Elektronen-Synchrotron DESY Notkestr.8522607 HamburgGermany

Polymer dielectrics capable of operating efficiently at high electric fields and elevated temperatures are urgently demanded by next-generation electronics and electrical power *** inorganic fillers have been extensively utilized to improved high-temperature capacitive performance of dielectric polymers,the presence of thermodynamically incompatible organic and inorganic components may lead to concern about the long-term stability and also complicate film ***,zero-dimensional polymer dots with high electron affinity are introduced into photoactive allyl-containing poly(aryl ether sulfone)to form the all-organic polymer composites for hightemperature capacitive energy *** ultraviolet irradiation,the crosslinked polymer composites with polymer dots are efficient in suppressing electrical conduction at high electric fields and elevated temperatures,which significantly reduces the high-field energy loss of the composites at 200℃.Accordingly,the ultraviolet-irradiated composite film exhibits a discharged energy density of 4.2 J cm^(−3)at 200℃.Along with outstanding cyclic stability of capacitive performance at 200℃,this work provides a promising class of dielectric materials for robust high-performance all-organic dielectric nanocomposites.

关键词： High-temperature energy storage Polymer dots Ultraviolet irradiation All-organic composite dielectrics

FAM53B promotes pancreatic ductal adenocarcinoma metastasis by regulating macrophage M2 polarization

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1479-1499页

作者： Xuan-Zeng Pei Min Cai Da-Wei jiang Song-Hai Chen qing-qing Wang Hui-Min Lu Yi-Fan Lu Department of Hepatological Surgery The First Hospital of JiaxingJiaxing 314000Zhejiang ProvinceChina Department of General Surgery West China Hospital of Sichuan UniversityChengdu 610044Sichuan ProvinceChina

BACKGROUND Our study investigated the role of FAM53B in regulating macrophage M2 polarization and its potential mechanisms in promoting pancreatic ductal adenocarcinoma(PDAC)*** To further investigate the role of FAM53B in regulating macrophage M2 polarization and its potential mechanism in promoting PDAC *** goal is to determine how FAM53B affects macrophage M2 polarization and to define its underlying mechanism in PDAC *** Cell culture and various experiments,including protein analysis,immunohisto-chemistry,and animal model experiments,were *** compared FAM53B expression between PDAC tissues and healthy tissues and assessed the correlation of FAM53B expression with clinical *** study analyzed the role of FAM53B in macrophage M2 polarization in vitro by examining the expression of relevant ***,we used a murine model to study the role of FAM53B in PDAC metastasis and analyzed the potential underlying *** Our research showed that there was a significant increase in FAM53B levels in PDAC tissues,which was linked to adverse tumor *** findings indicated that FAM53B can enhance macrophage M2 polarization,leading to increased anti-inflammatory factor *** results from the mouse model further supported the role of FAM53B in PDAC metastasis,as blocking FAM53B prevented tumor cell invasion and *** FAM53B promotes PDAC metastasis by regulating macrophage M2 *** discovery could lead to the development of new strategies for treating *** example,interfering with the FAM53B signaling pathway may prevent cancer *** research findings also provide important information for expanding our understanding of PDAC pathogenesis.

关键词： FAM53B Pancreatic ductal adenocarcinoma Tumor metastasis Macrophage polarization