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共同性外斜视内直肌病理与手术效果的关系(英文)

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国际眼科杂志 2009年第5期9卷 828-830页

作者：王遵敬孔庆兰赵桂秋青岛大学医学院眼科中国山东省青岛市266003

目的:评价内直肌肌细胞数与共同性外斜视手术效果的关系。方法:收集18例共同性外斜视内直肌和14例正常内直肌,行HE染色观察,用斜视积分法评价手术效果。结果:间歇性外斜视组手术前后的斜视积分差显著高于恒定性外斜视(P<0.01);光镜下斜... 详细信息

目的:评价内直肌肌细胞数与共同性外斜视手术效果的关系。方法:收集18例共同性外斜视内直肌和14例正常内直肌,行HE染色观察,用斜视积分法评价手术效果。结果:间歇性外斜视组手术前后的斜视积分差显著高于恒定性外斜视(P<0.01);光镜下斜视组内直肌横断面肌纤维排列疏松,间质成分多;斜视组内直肌肌细胞数极显著低于正常内直肌(P<0.01),与病程和手术前后的斜视积分差显著相关(P<0.05)。结论:内直肌肌细胞减少是导致共同性外斜视的直接原因,是斜视手术效果下降的重要因素。

关键词：共同性外斜视内直肌病理手术效果

不同类型斜视患者术后双眼视觉重建的临床分析

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国际眼科杂志 2013年第1期13卷 193-195页

作者：时肖孔庆兰张莹陈杰青岛大学医学院附属医院眼科中国山东省青岛市266003

目的:探讨先天性上斜肌麻痹性斜视、共同性外斜视和共同性内斜视患者手术前后双眼视功能的恢复情况及临床早期变化规律。方法:选择年龄介于3～20岁斜视矫正术后的斜视患者106例作为研究对象,按斜视类型分为三组,三组平均发病年龄分别为:... 详细信息

目的:探讨先天性上斜肌麻痹性斜视、共同性外斜视和共同性内斜视患者手术前后双眼视功能的恢复情况及临床早期变化规律。方法:选择年龄介于3～20岁斜视矫正术后的斜视患者106例作为研究对象,按斜视类型分为三组,三组平均发病年龄分别为:7.7±1.2,8.5±1.4,8.1±1.3岁;病程分别为6.75±1.20,3.42±2.42和3.80±2.10a;斜视度分别为31.50△±5.50△,50.50△±12.56△和52.25△±13.80△。采用三棱镜加交替遮盖法检查手术前后远近斜视度,《颜少明立体视觉检查图》检查近立体视觉,同视机检查远立体视觉及融合功能,分析3种类型斜视术后眼融合功能恢复率及立体视功能恢复率情况,术后随访8wk。结果:三组术前平均发病年龄差异无统计学意义(P>0.05),先天性麻痹性斜视组与共同性斜视组病程、斜视度数差异有统计学意义(P0.05)。术后2,4,6,8wk随访先天性上斜肌麻痹性斜视组融合功能恢复率分别为12.5%,37.5%,62.5%,68.8%,立体视功能恢复率分别为0,18.8%,50.0%,56.3%;共同性外斜视组融合功能恢复率分别为14.1%,40.8%,64.8%,69.0%,立体视功能恢复率分别为1.4%,31.0%,54.9%,59.2%;共同性内斜视组融合功能恢复率分别为26.3%,47.4%,73.7%,78.9%,立体视功能恢复率分别为5.3%,47.4%,63.2%,68.4%;术后2,4,6,8wk共同性外斜视组与共同性内斜视组术后眼正位率、立体视功能与融合功能恢复率差异均无统计学意义(P>0.05)。结论:先天性上斜肌麻痹性斜视患者斜视病程相对较长,术后近期立体视功能及融合功能恢复缓慢,且恢复率较低,于术后4wk开始明显提高,而共同性外斜视患者与共同性内斜视患者术后立体视功能及融合功能最早可于术后2wk恢复,且远期恢复率明显提高。

关键词：麻痹性斜视共同性外斜视共同性内斜视视功能手术

Synergistic effects of planting density and nitrogen fertilization on chlorophyll degradation and leaf senescence after silking in maize

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The Crop Journal 2024年第2期12卷 605-613页

作者： Tianqiong lan Lunjing Du Xinglong Wang Xiaoxu Zhan Qinlin Liu Gui Wei Chengcheng Lyu Fan Liu Jiaxu Gao Dongju Feng Fanlei kong Jichao Yuan Key Laboratory of Crop Physiology Ecologyand Cultivation SouthwestMinistry of AgricultureSichuan Agricultural UniversityChengdu 611130SichuanChina Chongqing Academy of Agricultural Sciences Chongqing 401329China College of Agronomy Sichuan Agricultural UniversityChengdu 611130SichuanChina

Regulating planting density and nitrogen(N)fertilization could delay chlorophyll(Chl)degradation and leaf senescence in maize *** study measured changes in ear leaf green area(GLA_(ear)),Chl content,the activities of Chl a-degrading enzymes after silking,and the post-silking dry matter accumulation and grain yield under multiple planting densities and N fertilization *** dynamic change of GLA_(ear)after silking fitted to the logistic model,and the GLA_(ear) duration and the GLAearat 42 d after silking were affected mainly by the duration of the initial senescence period(T_(1))which was a key factor of the leaf *** average chlorophyllase(CLH)activity was 8.3 times higher than pheophytinase activity and contributed most to the Chl content,indicating that CLH is a key enzyme for degrading Chl a in *** density increased the CLH activity and decreased the Chl content,T1,GLAear,and GLA_(ear) *** high density,appropriate N application reduced CLH activity,increased Chl content,prolonged T1,alleviated high-density-induced leaf senescence,and increased post-silking dry matter accumulation and grain yield.

关键词： Density Nitrogen fertilization Leaf senescence Chlorophyll-degrading enzyme Logistic model

Association of Pringle maneuver with postoperative recurrence and survival following hepatectomy for hepatocellular carcinoma: a multicenter propensity score and competing-risks regression analysis

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 412-424,I0003-I0010页

作者： Shi-Chuan Tang Yong-Kang Diao kong-Ying Lin Chao Li Xiao Xu Lei Liang Jie kong qing-Jing Chen Xian-Ming Wang Fu-Bao Liu Wei-Min Gu Ya-Hao Zhou Ying-Jian Liang Hong-Zhi Liu Ming-Da Wang lan-qing Yao Timothy M.Pawlik Feng Shen Wan Yee Lau Tian Yang Yong-Yi Zeng Department of Hepatobiliary Surgery Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhouChina Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalNavy Medical University(Second Military Medical University)ShanghaiChina Department of Hepatobiliary Surgery Affiliated Hospital of Nantong UniversityNantongChina Department of Hepatobiliary Surgery People’s Hospital of Zhejiang ProvincialPeople’s Hospital of Hangzhou Medical CollegeHangzhouChina Department of Hepatobiliary Heze Municiple HospitalHezeChina Department of General Surgery First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalJinanChina Department of Hepatobiliary Surgery First Affiliated Hospital of Anhui Medical UniversityHefeiChina The First Department of General Surgery Fourth Hospital of HarbinHarbinChina Department of Hepatobiliary Surgery Pu’er People’s HospitalPu’erChina Department of Hepatobiliary Surgery First Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Surgery Ohio State UniversityWexner Medical CenterColumbusOHUSA Faculty of Medicine The Chinese University of Hong KongHong KongChina Department of Hepatopancreatobiliary Surgery First Affiliated Hospital of Fujian Medical UniversityFuzhouChina The Liver Disease Research Center of Fujian Province FuzhouChina

Background:The application of Pringle maneuver(PM)during hepatectomy reduces intraoperative blood loss and the need for perioperative transfusion,but its effect on long-term recurrence and survival for patients with hepatocellular carcinoma(HCC)remains *** sought to determine the association between the application of PM and post-hepatectomy oncologic outcomes for patients with ***:Patients who underwent curative hepatectomy for HCC at 9 Chinese hospitals from January 2010 to December 2018 were *** two propensity score methods[propensity score matching(PSM)and inverse probability of treatment weight(IPTW)],cumulative recurrence rate and cancer-specific mortality(CSM)were compared between the patients in the PM and non-PM *** competing-risks regression models were performed to adjust for the effect of non-cancer-specific mortality and other prognostic risk ***:Of the 2,798 included patients,2,404 and 394 did and did not adopt PM(the PM and non-PM groups),*** rates of intraoperative blood transfusion,postoperative 30-day mortality and morbidity were comparable between the two groups(all P>0.05).In the PSM cohort by the 1:3 ratio,compared to 382 patients in the non-PM group,1,146 patients in the PM group also had the higher cumulative 5-year recurrence rate and CSM(63.9%and 39.1%vs.55.3%and 31.6%,both P<0.05).Similar results were also yielded in the entire cohort and the IPTW *** competing-risks regression analyses demonstrated that no application of the PM was independently associated with lower recurrence rate and CSM based on various analytical cohorts[hazard ratio(HR),0.82 and 0.77 in the adjusted entire cohort,HR 0.80 and 0.73 in the PSM cohort,and HR 0.80 and 0.76 in the IPTW cohort,respectively].Conclusions:The findings suggested that no application of PM during hepatectomy for patients with HCC reduced the risk of postoperative recurrence and cancer-specific death by appr

关键词： Hepatocellular carcinoma(HCC) Pringle maneuver(PM) recurrence survival hepatectomy

Injectable Nanorobot-Hydrogel Superstructure for Hemostasis and Anticancer Therapy of Spinal Metastasis

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Nano-Micro Letters 2024年第12期16卷 59-80页

作者： qing Chen Miao Yan Annan Hu Bing Liang Hongwei Lu Lei Zhou Yiqun Ma Chao Jia Dihan Su Biao kong Wei Hong Libo Jiang Jian Dong Department of Orthopaedic Surgery Zhongshan HospitalFudan UniversityShanghai 200032People’s Republic of China Department of Chemistry Fudan UniversityShanghai 200438People’s Republic of China Department of Surgery Yong Loo Lin School of MedicineNational University of Singapore1E Kent Ridge RoadSingapore 119228Singapore Department of Geriatrics and Gerontology Huadong HospitalFudan UniversityShanghai 200438People’s Republic of China State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai 200438People’s Republic of China Department of Orthopaedic Surgery Zhongshan Hospital Wusong Branch Fudan UniversityShanghai 200940People’s Republic of China

Surgery remains the standard treatment for spinal ***,uncontrolled intraoperative bleeding poses a significant challenge for adequate surgical resection and compromises surgical *** this study,we develop a thrombin(Thr)-loaded nanorobothydrogel hybrid superstructure by incorporating nanorobots into regenerated silk fibroin nanofibril *** superstructure with superior thixotropic properties is injected percutaneously and dispersed into the spinal metastasis of hepatocellular carcinoma(HCC)with easy bleeding characteristics,before spinal surgery in a mouse *** near-infrared irradiation,the self-motile nanorobots penetrate into the deep spinal tumor,releasing Thr in a controlled ***-induced thrombosis effectively blocks the tumor vasculature and reduces bleeding,inhibiting tumor growth and postoperative recurrence with Au nanorod-mediated photothermal *** minimally invasive treatment platform provides a novel preoperative therapeutic strategy for HCC spinal metastasis effectively controlling intraoperative bleeding and tumor growth,with potentially reduced surgical complications and enhanced operative outcomes.

关键词： Silk fibroin Nanofibril hydrogels Nanorobots Thrombin Spinal metastasis

Modulation of starch synthesis in Arabidopsis via phytochrome B-mediated light signal transduction

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Journal of Integrative Plant Biology 2024年第5期66卷 973-985页

作者： qingbiao Shi Ying Xia Na Xue Qibin Wang qing Tao Mingjing Li Di Xu Xiaofei Wang Fanying kong Haisen Zhang Gang Li National Key Laboratory of Wheat Improvement College of Life SciencesShandong Agricultural UniversityTai'an 271018China National Key Laboratory of Wheat Improvement College of AgronomyShandong Agricultural UniversityTai'an 271018China

Starch is a major storage carbohydrate in plants and is critical in crop yield and *** synthesis is intricately regulated by internal metabolic processes and external environmental cues;however,the precise molecular mechanisms governing this process remain largely *** this study,we revealed that high red to far-red(high R:FR)light significantly induces the synthesis of leaf starch and the expression of synthesis-related genes,whereas low R:FR light suppress these *** phytochrome B(phyB),the primary R and FR photoreceptor,was identified as a critical positive regulator in this *** of phyB,basic leucine zipper transcription factor ELONGATED HYPOCOTYL5(HY5)was found to enhance starch synthesis,whereas the basic helix-loop-helix transcription factors PHYTOCHROME INTERACTING FACTORs(PIF3,PIF4,and PIF5)inhibit starch synthesis in Arabidopsis ***,HY5 and PIFs directly compete for binding to a shared G-box cis-element in the promoter region of genes encoding starch synthases GBSS,SS3,and SS4,which leads to antagonistic regulation of their expression and,consequently,starch *** findings highlight the vital role of phyB in enhancing starch synthesis by stabilizing HY5 and facilitating PIFs degradation under high R:FR light ***,under low R:FR light,PIFs predominantly inhibit starch *** study provides insight into the physiological and molecular functions of phyB and its downstream transcription factors HY5 and PIFs in starch synthesis regulation,shedding light on the regulatory mechanism by which plants synchronize dynamic light signals with metabolic cues to module starch synthesis.

关键词： Arabidopsis thaliana HY5 light signal phyB PIFs starch synthesis

Competition of Composition Fluctuation Modes in Weakly Segregated Salt-doped Symmetric Diblock Copolymers

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Chinese Journal of Polymer Science 2024年第9期42卷 1375-1385,I0008页

作者： Yuan-Xin Zhou Xian kong South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou510640China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou510640China

Salt-doped block copolymers have widespread applications in batteries,fuel cells,semiconductors,and various industries,where their properties crucially depend on phase separation ***,investigations into salt-doped diblock copolymers have predominantly focused on microphase separation,overlooking the segregation between ionic and polymeric *** study employs weak segregation theory to explore the interplay between phase separation dominated by the polymer-modulated mode and the salt-out-modulated mode,corresponding to microscopic and macroscopic phase separations,*** comparing diblock copolymers doped with salts to those doped with neutral solvents,we elucidate the significant role of charged species in modulating phase *** phase separation mode exhibits a transition between the polymer-modulated and salt-out-modulated modes at different *** systems doped with neutral solvents,this transition is stepwise,while in salt-ion-doped systems,it is *** a sufficiently large Flory-Huggins parameter between ions and polymers,the salt-out-modulated mode becomes dominant,promoting macrophase *** to the solvation effect of salt ions,salt-doped systems are more inclined to undergo microphase ***,we explore factors influencing the critical wavenumber of phase separation,including doping level and the Flory-Huggins parameters between two blocks and between ions and polymeric *** findings reveal that in a neutral solvent environment,these factors alter only the boundary between micro-and macro-phase separations,leaving the critical wavenumber unchanged in microphase separation ***,in a salt-doped environment,the critical wavenumber of microphase separation varies with these *** provides valuable insights into the pivotal role of electrostatics in the phase separation of salt-doped block copolymers.

关键词： Block copolymer Phase separation Field theory Salt-doped

Non-dimensional analysis on blast wave propagation in foam concrete:Minimum thickness to avoid stress enhancement

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Defence Technology（防务技术） 2024年第6期36卷 30-46页

作者： Ya Yang Xiangzhen kong Qin Fang State Key Laboratory of Disaster Prevention&Mitigation of Explosion&Impact Army Engineering University of PLANanjing 210007JiangsuChina

Foam concrete is a prospective material in defense engineering to protect structures due to its high energy absorption capability resulted from the long plateau ***,stress enhancement rather than stress mitigation may happen when foam concrete is used as sacrificial claddings placed in the path of an incoming blast *** investigate this interesting phenomenon,a one-dimensional difference model for blast wave propagation in foam concrete is firstly proposed and numerically solved by improving the second-order Godunov *** difference model and numerical algorithm are validated against experimental results including both the stress mitigation and the stress *** difference model is then used to numerically analyze the blast wave propagation and deformation of material in which the effects of blast loads,stress-strain relation and length of foam concrete are *** particular,the concept of minimum thickness of foam concrete to avoid stress enhancement is ***,non-dimensional analysis on the minimum thickness is conducted and an empirical formula is proposed by curve-fitting the numerical data,which can provide a reference for the application of foam concrete in defense engineering.

关键词： Foam concrete Blast wave propagation Non-dimensional analysis Stress enhancement

CNT array-induced nanobubble assembly,nanodisk fabrication and enhanced spectral detection of CNT bundle density

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Nano Research 2024年第8期17卷 7737-7745页

作者： Zhiyuan Xia Ziming Ye Bo Zhao Tingsong Zhang Qi Wang Kun Chen Meng Li Xiaobing kong Yu-qing Zheng Enzheng Shi Yuanyuan Shang Anyuan Cao School of Materials Science and Engineering Peking UniversityBeijing 100871China School of Integrated Circuits Peking UniversityBeijing 100871China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China School of Engineering Westlake UniversityHangzhou 310024China

Alignment,functionalization and detection of carbon nanotube(CNT)bundles are vital processes for utilizing this onedimensional nanomaterial in ***,we report a polymer-assisted wet shearing method to acquire super-aligned craterpatterned CNT arrays by nanobubble(NB)self-assembly with a"migrate and aggregation"mechanism and use craters to controllably mold even-sized nanodisks periodically along CNT bundles with tunable *** green,low-cost method can be extended to diverse substrates and fabricate different *** an example,the Ag-nanodisk-patterned CNT arrays are utilized as substrates of surface-enhanced Raman scattering(SERS)for rhodamine 6G(R6G)and methylene blue(MB)in which a linear correlation is found between the SERS intensity and the CNT bundle density due to the periodic distribution of hot spots,enabling a spectral detection of CNT bundles and their densities by conventional dye *** from routine morphological characterization,this spectral method possesses an enhanced accuracy and a detection range of 0.1–2μm^(–1),showing its uniqueness in the detection of CNT bundle density since the intensity of traditional spectral merely relates to the quantity of CNTs,exhibiting its potential in future CNT-bundle-based electronics.

关键词： CNT arrays nanobubbles self-assembly nanodisks surface-enhanced Raman scattering(SERS)