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The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

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Neural Regeneration Research 2025年第5期20卷 1505-1512页

作者： Jieying wu Shan Ye Xiangyi Liu Yingsheng Xu Dongsheng Fan Department of Neurology Peking University Third HospitalBeijingChina Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina Key Laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor *** bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to ***,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is *** address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral *** used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis *** factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb *** results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis *** findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

关键词： amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread

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A mild, configurable, flexible CoNi-LDH（v）/Zn battery based on H-vacancy-induced reversible Zn2+ intercalation

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Journal of Energy Chemistry 2025年第1期100卷 498-508页

作者： Xinyue Cheng Dingsheng wu Hao Gao qingqing Wang Pengfei Lv Sam S.Yoon Qufu Wei Key Laboratory of Eco-textiles Ministry of Education Jiangnan University School of Mechanical Engineering Korea University

Flexible Zn-based batteries have attracted increasing research interest as essential components of wearable energy storage ***,the advancement of flexible aqueous Zn-based batteries based on Co-Ni layered double hydroxide （CoNi-LDH） as the cathode material is hampered by their poor cycling stability and the corrosiveness of alkaline ***,CoNi-LDH nanosheets enriched with H vacancies (CoNi-LDH（v）) were constructed on a flexible carbon cloth （CC） substrate via electrochemical deposition and *** Zn-based battery comprising CoNi-LDH（v）@CC as the cathode exhibited highly reversible conversion reactions and stable operation in 3 M ZnSO4electrolyte （pH=4）.The battery delivered an excellent specific capacity (225 mA h g-1,0.26 mA h cm-2),acceptable cycling stability（53.9%,900 cycles）,and high discharging *** abundant H vacancies served as active sites for the reversible intercalation of Zn2+and the extravasation of NO3-generated channels and space for Zn2+transport and storage,together enabling an excellent Zn2+storage ***,a sandwich-structured solid-state CoNi-LDH（v）@CC//Zn@CC battery was fabricated and was found to exhibit a noteworthy electrochemical performance and mechanical *** a proof of concept,the unencapsulated battery powered a digital watch under various deformation conditions and operated stably for 80 ***,the flexible battery displayed outstanding customizability,maintaining an open-circuit voltage of 1.42 V even after being cut *** proposed engineering strategy contributes to the realization of textiles with truly wearable energy-storage devices.

关键词： CoNi/Zn battery H vacancies Mild aqueous electrolyte Tailorable battery Wearable energy storage device

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Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy

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Neural Regeneration Research 2025年第8期20卷 2264-2278页

作者： You wu Lijie Yang Wanrong Jiang Xinyuan Zhang Zhaohui Yao Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative *** current therapeutic strategies,primarily based on cholinesterase inhibitors and N-methyl-Daspartate receptor antagonists,offer limited symptomatic relief without halting disease progression,highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's *** studies have provided insights into the critical role of glycolysis,a fundamental energy metabolism pathway in the brain,in the pathogenesis of Alzheimer's *** in glycolytic processes within neurons and glial cells,including microglia,astrocytes,and oligodendrocytes,have been identified as significant contributors to the pathological landscape of Alzheimer's *** changes impact neuronal health and function,thus offering promising targets for therapeutic *** purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and *** focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments,emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

关键词： Alzheimer’s disease glial cells glycolysis neuronal metabolism pathogenesis therapeutic targets

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Nanostructured ZnO/BiVO_(4)I-scheme heterojunctions for piezocatalytic degradation of organic dyes via harvesting ultrasonic vibration energy

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 488-497页

作者： Yiling Li Xiaoyao Yu Yingjie Zhou Yao Lin Ying wu Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China

BiVO_(4)porous spheres modified by ZnO were designed and synthesized using a facile two-step *** resulting ZnO/BiVO_(4)composite catalysts have shown remarkable efficiency as piezoelectric catalysts for degrading Rhodamine B(RhB)unde mechanical vibrations,they exhibit superior activity compared to pure *** 40wt%ZnO/BiVO_(4)heterojunction composite displayed the highest activity,along with good stability and *** enhanced piezoelectric catalytic activity can be attributed to the form ation of an I-scheme heterojunction structure,which can effectively inhibit the electron-hole ***,hole(h+)and superoxide radical(·O_(2)^(-))are proved to be the primary active ***,ZnO/BiVO_(4)stands as an efficient and stable piezoelectric catalyst with broad potential application in the field of environmental water pollution treatment.

关键词： piezoelectric catalytic heterojunction dye degradation ultrasonic vibration

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A new horizon for neuroscience:terahertz biotechnology in brain research

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Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu Yu wu Zhongjie Zhu Hongwei Zhao Donghong Cui Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

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Scheduling Reconfigurable Service Function Chain

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Chinese Journal of Electronics 2019年第6期28卷 1244-1249页

作者： ZHU kai wu Chunming ZHOU Boyang College of Computer Science Zhejiang University Zhejiang Lab

Network function virtualization(NFV),has been widely adopted in existing networks since it brings lower capital expenditure and operating expense,as well as flexible and elastic deployment. Based on NFV, dynamic Service function chain(SFC) provides more comprehensive and thorough traffic steering over a series of middleboxes, e.g., DPI, and IDS. Nevertheless, dynamic SFC involves internal state migration in middleboxes, making it hard to allocate SFC *** propose a reconfigurable SFC scheduling approach with consideration on resource constraints and race of the state migration to collaborate the execution of the SFC reconfiguration, in the reasonable fashion based on a heuristic algorithm. The evaluation is conducted through discrete event simulation to validate the efficiency of our reconfigurable SFC scheduling, and the results demonstrate that the proposed method outperforms First Come First Serve scheduling and random scheduling.

关键词： Network function virtualization(NFV) Service function chain(SFC) State migration SDN

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Electronegativity-assisted optimized electronic structure of functionalized-Pt catalysts for boosting oxygen reduction kinetics

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Rare Metals 2024年第5期43卷 1965-1976页

作者： Jin Long kai-Wen Zhuang Wei Liao Yan An Bin Wang Chen-Zhong wu Jian-Xin Cao qing Wang Jun-Song Chen qing-Mei Wang Guizhou University Key Laboratory of Green Chemical and Clean Energy Technology School of Chemistry and Chemical EngineeringGuizhou UniversityGuiyang 550025China Guizhou University Engineering Research Center of Effcient Utilization for Industrial Waste Guizhou UniversityGuiyang 550025China Institute of Dual-Carbon and New Energy Technology Innovation and Development of Guizhou Province Guiyang 550025China Department of Dermatology West China HospitalSichuan UniversityChengdu610041China Institute for Catalysis Hokkaido UniversitySapporo 001-0021Japan School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China Interdisciplinary Materials Research Center Institute for Advanced StudyChengdu UniversityChengdu 610106China

Opportunity to harmonize aspects of oxygen reduction reaction(ORR)performance and structure,and morphology,as well as composition,is urgent for the commercialization of proton exchange membrane fuel ***,we demonstrate the design and synthesis of a functionalized-supported-Pt catalyst(Pt@HNC)featuring a hollow nitrogen-modified dodecahedral carbon substrate obtained by a stress-induced-shrink tailoring *** as-obtained Pt@HNC catalyst possesses enhanced ORR per-formance,in particular with half-wave potential,mass activity(MA)and specific activity,which greatly exceed the commercial Pt/*** density functional theory(DFT)calculations further confirmed that the charge redistribution induced by the electronegativity differences improved the electron interaction between Pt and HNC *** optimized electronic structure of Pt weakens the reaction energy barrier on the Pt@HNC surface and adsorption of^(*)OH species,thus cooperatively improving the intrinsic activity toward ***,our work indeed provides a guide for the future design of functional nanomaterials in the field of catalysts and clean energy.

关键词： Proton exchange membrane fuel cell(PEMFC) Oxygen reduction catalysis Supported Pt-based catalyst Stability

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Study on macro and micro shear strength of continuously graded and gap-graded sand

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Particuology 2024年第3期86卷 101-116页

作者： Peiran Zhao Songyu Liu kai wu School of Transportation Southeast UniversityNanjing210096China

The particle gradation of sand has a significant influence on its shear strength,yet the similarities and differences between the effects of continuous and gap grading have yet to be fully *** this study,the discrete element method(DEM)was used to simulate biaxial tests on granular samples that were both continuously graded and *** macroscopic analysis revealed that the shear strength of continuously graded sands increases initially and then decreases as the uniformity of particle size distribution *** the other hand,the lack of medium particles in gap-graded sands amplifies the difference in particle size between coarse and fine particles,leading to a decrease in shear ***,both continuous and gap gradings affect the internal packing structure of the particle assembly,which consequently affects particle stress distributions,contact forces,coordination numbers,stress-induced anisotropies,and contact force networks,thus having an impact on the macroscopic shear *** global uniformity of particle size distribution was unidirectionally affected by continuous grading,while gap grading had a locally bidirectional *** findings provide a better understanding of the effects of particle grading on the macroscopic shear strength of sands.

关键词： Biaxial test Shear strength Particle gradation Discrete element method Micromechanics

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Pulp revascularization on an adult mandibular right second premolar:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5833-5840页

作者： Ye-qing Yang Bu-Ling wu Jun-kai Zeng Chong Jiang Ming Chen Department of Stomatology Stomatological Hospital of Southern Medical UniversityGuangzhou 510280Guangdong ProvinceChina School of Stomatology Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Shenzhen Stomatology Hospital(Pingshan) Southern Medical UniversityShenzhen 518118Guangdong ProvinceChina Department of Stomatology Guangdong Provincial People’s Hospital/Guangdong Academy of Medical SciencesGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Pulp revascularization has become a new method for the treatment of periapical diseases in young permanent teeth in recent *** root canal flushing and disinfection,avoiding mechanical preparation,guiding apical stem cells into the root canal and promoting the continuous development of tooth roots,it has achieved good clinical curative *** in adult patients with chronic periapical periodontitis with immature roots and open apices,apical barrier technology is often used to treat these *** SUMMARY Pulp revascularization of a 26-year-old patient's tooth was performed using cefaclor instead of minocycline and iRoot BP instead of mineral trioxide aggregate as intracanal *** case was followed up for 36 *** showed evidence of regression of clinical signs and symptoms,resolution of apical periodontitis and no discolouration of affected *** For adult patients with chronic periapical periodontitis with immature roots and open apices,pulp revascularisation showed favourable results in treating these teeth.

关键词： Pulp revascularization Chronic periapical periodontitis Immature roots Open apices Abnormal central tip Case report

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Intelligent Transformation and Upgrading of Oil Refining & Petrochemical Industries in China:Investigation & Application

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China Petroleum Processing & Petrochemical Technology 2019年第2期21卷 1-9页

作者： wu qing CNOOC Oil & Petrochemicals Co. Ltd

The oil refining and petrochemical industry in China has made great achievements after decades of development, and its capacity has already ranked second in the world. However, the refining industry is suffering some challenges, such as severe overcapacity at present, and has entered a new economic normal, in which the technological progress develops rapidly, the demand for green and low-carbon development is stricter, the market competition is increasingly fiercer and the profit margins are gradually narrowing. In such a situation, informatization and its new technologies are driving the significant reforming of manufacturing patterns, marketing patterns, management and decision-making patterns. Intelligent development is the inevitable choice for the transformation and upgrading of oil refining and petrochemical industry. It is suggested that the intelligent evaluating model and method should be adopted to enterprise’s intelligentializing transformation and upgrading by laying a solid foundation of digital refinery and implemenation of digital upgrading.

关键词： plant oil oil refining and petrochemical enterprise intelligent informatization diagnoses model intelligentializing transformation and upgrading digital refinery intelligent refinery smart refinery

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