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The effectiveness of zinc supplementation in men with isolated hypogonadotropic hypogonadism

Asian Journal of Andrology 2017年第3期19卷 280-285页

作者： Yan-Ling Liu Man-Na Zhang guo-Yu Tong Shou-YueSun Yan-hua Zhu Ying Cao Jie Zhang Hong huang Ben Niu Hong Li qing-hua guo Yan Gao Da-Long Zhu Xiao-Ying Li Shanghai Institute of Endocrinology and Metabolism Department of Endocrinology and Metabolism Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Endocrinology Drum Tower Hospital Affiliated to Nanjing University Medical School Nanjing 210008 China Department of Endocrinology The Third Affiliated Hospital Sun Yat-sen University Guangzhou 510630 China Department of Endocrinology and Metabolism Nanfang Hospital Southern Medical University Guangzhou 510515 China Department of Endocrinology Guangxi Medical University and First Affiliated Hospital Nanning 530021 China Department of Endocrinology The First People's Hospital of Yunnan Province Kunming 650032 China Department of Endocrinology The Affiliated Hospital of Guiyang Medical College Guiyang 550004 China 00853 China.

A multicenter, open-label, randomized, controlled superiority trial with 18 months of follow-up was conducted to investigate whether oral zinc supplementation could further promote spermatogenesis in males with isolated hypogonadotropic hypogonadism （IHH） receiving sequential purified urinary follicular-stimulating hormone/human chorionic gonadotropin （uFSH/hCG） replacement. Sixty-seven Chinese male IHH patients were recruited from the Departments of Endocrinology in eight tertiary hospitals and randomly allocated into the sequential uFSH/hCG group （Group A, n = 34） or the sequential uFSH plus zinc supplementation group （Group B, n = 33）. In Group A, patients received sequential uFSH （75 U, three times a week every other 3 months） and hCG （2000 U, twice a week） treatments. In Group B, patients received oral zinc supplementation （40 mg day-1） in addition to the sequential uFSH/hCG treatment given to patients in Group A. The primary outcome was the proportion of patients with a sperm concentration 〉1.0 × 106 ml-1 during the 18 months. The comparison of efficacy between Groups A and B was analyzed. Nineteen of 34 （55.9%） patients receiving sequential uFSH/hCG and 20 of 33 （60.6%） patients receiving sequential uFSH/hCG plus zinc supplementation achieved sperm concentrations ≥1.0 × 106 ml-1 by intention to treat analyses. No differences between Group A and Group B were observed as far as the efficacy of inducing spermatogenesis （P = 0.69）. We concluded that the sequential uFSH/hCG plus zinc supplementation regimen had a similar efficacy to the sequential uFSH/hCG treatment alone. The additional improvement of 40 mg day-1 oral zinc supplementation on spermatogenesis and masculinization in male IHH patients is very subtle.

关键词： gonadotropin isolated hypogonadotropic hypogonadism masculinization spermatogenesis zinc supplementation

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Bilateral adrenocortical adenomas causing adrenocorticotropic hormone-independent Cushing's syndrome: A case report and review of the literature

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World Journal of Clinical Cases 2019年第8期7卷 961-971页

作者： Yu-Lin Gu Wei-Jun Gu Jing-Tao Dou Zhao-Hui Lv Jie Li Sai-Chun Zhang guo-qing Yang qing-hua guo Jian-Ming Ba Li Zang Nan Jin Jin Du Yu Pei Yi-Ming Mu Department of Endocrinology Chinese People's Liberation Army General Hospital Department of Pathology Chinese People's Liberation Army General Hospital

BACKGROUND Adrenocorticotropic hormone(ACTH)-independent Cushing's syndrome(CS) is mostly due to unilateral tumors, with bilateral tumors rarely reported. Its common causes include primary pigmented nodular adrenocortical disease,ACTH-independent macronodular adrenal hyperplasia, and bilateral adrenocortical adenomas(BAAs) or carcinomas. BAAs causing ACTHindependent CS are rare; up to now, fewer than 40 BAA cases have been reported. The accurate diagnosis and evaluation of BAAs are critical for determining optimal treatment options. Adrenal vein sampling(AVS) is a good way to diagnose ACTH-independent *** SUMMARY A 31-year-old woman had a typical appearance of CS. The oral glucose tolerance test showed impaired glucose tolerance and obviously increased insulin and Cpeptide levels. Her baseline serum cortisol and urine free cortisol were elevated and did not show either a circadian rhythm or suppression with dexamethasone administration. The peripheral 1-deamino-8-D-arginine-vasopressin(DDVAP)stimulation test showed a delay of the peak level, which was 1.05 times as high as the baseline level. Bilateral AVS results suggested the possibility of *** computed tomography showed bilateral adrenal adenomas with atrophic adrenal glands(right: 3.1 cm × 2.0 cm × 1.9 cm; left: 2.2 cm × 1.9 cm × 2.1 cm). Magnetic resonance imaging of the pituitary gland demonstrated normal findings. A left adenomectomy by retroperitoneoscopy was performed first,followed by resection of the right-side adrenal mass 3 mo later. Biopsy results of both adenomas showed cortical tumors. Evaluations of ACTH and cortisol showed a significant decrease after left adenomectomy but could still not be suppressed, and the circadian rhythm was absent. Following bilateral adenomectomy, this patient has been administered with prednisone until now,all of her symptoms were alleviated, and she had normal blood pressure without edema in either of her lower *** BAAs causing ACTH-inde

关键词： Bilateral adrenocortical adenomas Adrenocorticotropic hormone-independent Cushing's syndrome Adrenal venous sampling Case report

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RFES: a real-time fire evacuation system for Mobile Web3D

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Frontiers of Information Technology & Electronic Engineering 2019年第8期20卷 1061-1075页

作者： Feng-ting YAN Yong-hao HU Jin-yuan JIA qing-hua guo He-hua ZHU Zhi-geng PAN School of Electronic and Electrical Engineering Shanghai University of Engineering ScienceShanghai201620China School of Software Engineering Tongji UniversityShanghai201804China School of Civil Engineering Tongji UniversityShanghai200092China Research Center of Digital Media and Human-Computer Interaction Hangzhou Normal UniversityHangzhou310013China

There are many bottlenecks that limit the computing power of the Mobile Web3 D and they need to be solved before implementing a public fire evacuation system on this *** this study,we focus on three key problems:(1)The scene data for large-scale building information modeling(BIM)are huge,so it is difficult to transmit the data via the Internet and visualize them on the Web;(2)The raw fire dynamic simulator(FDS)smoke diffusion data are also very large,so it is extremely difficult to transmit the data via the Internet and visualize them on the Web;(3)A smart artificial intelligence fire evacuation app for the public should be accurate and *** address these problems,the following solutions are proposed:(1)The large-scale scene model is made lightweight;(2)The amount of dynamic smoke is also made lightweight;(3)The dynamic obstacle maps established from the scene model and smoke data are used for optimal path planning using a heuristic *** propose a real-time fire evacuation system based on the ant colony optimization(RFES-ACO)algorithm with reused dynamic *** results show that the public could use Mobile Web3 D devices to experience fire evacuation drills in real time *** real-time fire evacuation system(RFES)is efficient and the evacuation rate is better than those of the other two algorithms,i.e.,the leader-follower fire evacuation algorithm and the random fire evacuation algorithm.

关键词： Fire evacuation drill Building information modeling(BIM)building space Mobile Web3D Real-time fire evacuation system based on ant colony optimization(RFES-ACO)algorithm

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Three-dimensional assessment of movement patterns of Sichuan snub-nosed monkeys affected by habitat structure in temperate forests

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Zoological Research 2023年第2期44卷 361-365页

作者： Hai-Tao Yang Shun Li Rong Hou Wen-Tao Song Yan-Wen Fu Yong-Bo Li Xiao-Wei Wang Gang He Colin A.Chapman qing-hua guo Bao-guo Li Shaanxi Key Laboratory for Animal Conservation College of Life SciencesNorthwest UniversityXi’anShaanxi 710069China Institute of Remote Sensing and Geographic Information System School of Earth and Space SciencesPeking UniversityBeijing 100871China Ministry of Education Key Laboratory of Poyang Lake Wetland and Watershed Research College of Geography and EnvironmentJiangxi Normal UniversityNanchangJiangxi 330022China College of Life Sciences Beijing Normal UniversityBeijing 100875China Shaanxi Key Laboratory for Animal Conservation Shaanxi Institute of ZoologyShaanxi Academy of SciencesXi’anShaanxi 710032China Biology Department Vancouver Island UniversityBritish ColumbiaV5K0A1 Canada School of Life Sciences University of KwaZulu-NatalPietermaritzburg 3200South Africa

DEAR EDITOR,Movement patterns can reflect species-specific characteristics of individuals and animal groups at a given scale. Accurate three-dimensional(3D) assessment can quantify the relationship between movement patterns of an animal and its unique habitat. Here, we evaluated the effects of habitat structure on movement patterns of the golden snub-nosed monkey(Rhinopithecus roxellana). We used airborne light detection and ranging(LiDAR) to map the 3D structure of the temperate forest in the Qinling Mountains(Shaanxi, China).

关键词： habitat movement temperate

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Paget’s disease of bone: Report of 11 cases

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World Journal of Clinical Cases 2021年第14期9卷 3478-3486页

作者： Xin-Yu Miao Xian-Ling Wang Zhao-Hui Lyu Jian-Ming Ba Yu Pei Jing-Tao Dou Wei-Jun Gu Jin Du qing-hua guo Kang Chen Yi-Ming Mu Department of Endocrinology The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Endocrinology The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China

BACKGROUND Paget’s disease of bone(PDB)is a rare metabolic bone disease in China and is characterized by increased bone resorption and disorganized bone *** main clinical symptoms of PDB are focal or multiple bone pain and deformity with high *** disease has high missed diagnosis and misdiagnosis *** report summarizes the clinical manifestations,imaging and pathological features,and treatments of 11 patients with PDB at our hospital from 1993 to 2020 in order to improve the recognition and prognosis of *** SUMMARY There were eight male and three female patients whose average age was 48.7±11.0 years with a PDB course of 1-16 *** patients had bone pain and bone deformities in different parts of the body,the majority of which involved the long *** examinations revealed elevated serum alkaline phosphatase(ALP)in all patients with an average of 618±460 IU/L(normal range 0-130 IU/L),and serum calcium and phosphorus levels were in the normal *** showed that osteolysis was usually combined with osteosclerosis and/or bone deformities in single or multiple bones.^(99m)Tc-methylene diphosphonate bone scintigraphy revealed increased radionuclide uptake in the bone *** patients underwent bone tissue biopsy,and the typical pathological changes were a mosaic structure of the bone trabeculae with irregularly arranged cement lines and multinuclear *** of the 11 patients were effectively treated with *** Early diagnosis of the rare disease PDB can be made through elevated ALP levels and typical presentations on bone X-ray and from bone tissue biopsy.

关键词： Paget’s disease of bone Metabolic bone diseases Chinese Case report

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Enhanced efficacy of CTLA-4 fusion anti-caries DNA vaccines in gnotobiotic hamsters

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Acta Pharmacologica Sinica 2007年第8期28卷 1236-1242页

作者： Feng ZHANG~3 Yu-hong LI~3 Ming-wen FAN~2 Rong JIA qing-an XU Ji-hua guo Fei YU Qi-wei TIAN Key Laboratory for Oral Biomedical Engineering of Ministry of Education,School and Hospital of Stomatology,Wuhan University,Wuhan 430079,China Key Laboratory for Oral Biomedical Engineering of Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China

Aim:To evaluate the comparative immunogenicity and protective efficacy of thecytotoxic T-lymphocyte-associated antigen 4(CTLA-4)fusion anti-caries DNAvaccines pGJA-P/VAX1,pGJA-P,and non-fusion anti-caries DNA constructpGLUA-P in *** addition,the ability of CTLA-4 to target pGJA-P/VAX 1-encoding antigen to dendritic cells was tested in ***:All DNAconstructs contain genes encoding the A-P regions of a cell surface protein(PAc)and the glucan binding(GLU)domain of glucosyltransferases(GTFs)of cari-ogenic organism Streptococcus *** dendritic cells were mixed withthe CTLA-4-Ig-GLU-A-P protein expressed by pGJA-P/VAX1-transfected cellsand analyzed by flow *** hamsters were immunized with anti-caries DNA vaccines by intramuscular injection or intranasal *** responses to a representative antigen PAc were assayed by ELISA,andcaries protection was evaluated by Keyes caries ***:A flow cytometricanalysis demonstrated that CTLA-4-Ig-GLU-A-P protein was capable of bind-ing to human dendritic cells,pGJA-P/VAX1 and pGJA-P induced significantlyhigher specific salivary and serum anti-PAc antibody responses than pGLUA-ESignificantly fewer caries lesions were also observed in hamsters immunized withpGJA-P/VAX1 and *** was no significant difference in the anti-PAcantibody level or caries scores between pGJA-P/VAX1 and ***:Antigen encoded by CTLA-4 fusion anti-caries DNA vac-cine pGJA-P/VAX1 could specifically bind to human dendritic cells through theinteraction of CTLA-4 and B7 *** antigen to CTLA-4 has beenproven to greatly enhance the immunogenicity and protective efficacy of anti-caries DNA vaccines.

关键词： DNA vaccines Streptococcus mutans dendritic cells cytotoxic T-lymphocyteassociated antigen 4

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基于重量法的页岩气超临界吸附特征实验研究

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煤炭学报 2016年第11期41卷 2806-2812页

作者：周尚文薛华庆郭伟卢斌郭峰中国石油勘探开发研究院廊坊分院河北廊坊065007 中国石油非常规油气重点实验室河北廊坊065007 国家能源页岩气研发(实验)中心河北廊坊065007 中国石油华北油田公司长治煤层气勘探开发分公司山西长治046000

为了有效分析页岩气体的超临界吸附特征,利用重量法等温吸附仪,借助高精度的磁悬浮天平系统,直接测试了不同压力条件下甲烷气体密度及其过剩吸附量。实验测试结果表明,当压力较小时,过剩吸附量随着压力增大而增大;当压力大于8 MPa后,过... 详细信息

为了有效分析页岩气体的超临界吸附特征,利用重量法等温吸附仪,借助高精度的磁悬浮天平系统,直接测试了不同压力条件下甲烷气体密度及其过剩吸附量。实验测试结果表明,当压力较小时,过剩吸附量随着压力增大而增大;当压力大于8 MPa后,过剩吸附量会随着压力的增大而减小,这主要是由于甲烷吸附相密度与游离相密度差值随压力先增大后减小导致的。页岩中超临界甲烷的等温吸附曲线在压力较大时,必然存在下降的趋势,这并非异常现象,而是超临界甲烷过剩吸附量的本质特征。此外,利用高压段甲烷过剩吸附量随压力直线递减的规律,确定了甲烷吸附相体积的计算方法,并且采取定吸附相体积的方法对绝对吸附量进行了校正,校正结果表明,超临界甲烷在页岩中的绝对吸附量依旧能很好的利用Langmuir吸附模型进行拟合及分析,可以将该经典的吸附理论扩展到超临界温度领域。

关键词：页岩气超临界等温吸附重量法 Langmuir模型

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A Phase Ⅱ Clinical Trial of Celecoxib Combined with Platinum-Based Regimen as First-Line Chemotherapy for Advanced Non-Small Cell Lung Cancer Patients with Cyclooxygenase-2 Positive Expression

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Chinese Journal of Cancer Research 2009年第1期21卷 1-12页

作者： Jun Zhao Zhi-jie Wang Jian-chun Duan qing-zhi guo hua Bai Lu Yang Tong-tong An Xin Wang Yu-yan Wang Mei-na Wu Xu-yi Liu Jie Wang Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department of Thoracic Medical Oncology Peking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing 100142 China

Objective： To evaluate the efficacy and safety of celecoxib treatment of advanced non-small cell lung cancer （NSCLC）, and combined therapy by molecular analysis. plus platinum-doublet as first-line chemotherapy in to determine the subgroup benefiting from celecoxib Methods： A total of 44 treatment-naive patients of advanced NSCLC with positive cyclooxygenase-2 （COX-2） expression confirmed by immunohistochemical （IHC） staining were designed to receive celecoxib plus platinum-doublet chemotherapy （cisplatin plus gemcitabine, novelbine or docetaxol） from February 2005 to May 2007. On 5-7 day before chemotherapy, 400 mg celecoxib was administered twice a day orally until obvious evidence of disease progression or intolerable toxicity was found. Adverse events were recorded according to NCI-CTC criteria. The primary endpoint was overall survival （OS）. The secondary endpoints included progression-free survival （PFS）, 1-year survival rate, response rate （RR） and safety. Additionally, we detected epithelial growth factor receptor （EGFR） status including EGFR gene amplification by real-time PCR and gene mutations by DHPLC followed by sequencing. Results： The response rate was 45% （20/44）, and the disease control rate （DCR） was 59% （26/44）. The median progression-free survival time and median survival time were 6 m and 18 m, respectively. The l-year survival rate was 68%. Chemotherapy cycle numbers and best response were found to be the predictive factors for PFS by COX model analysis （P=0.023 and P=0.000, respectively）. No factor was found to affect OS. The most common toxicities included neutropenia and nausea/vomit. EGFR gene amplification was an independent prognostic factor influencing OS （P=0.0002）. Patients with EGFR mutations （exon 21） had a tendency of disease progression （P=0.041）. Conclusion： Encouraging activities of celecoxib combined with platinum-doublet chemotherapy were demonstrated in treatment-naive patients with advanced NSCLC, with good tolerances. For

关键词： Cyclooxygenase-2 Epithelial growth factor receptor Non-small-cell lung cancer

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TD-LTE 256QAM高阶调制关键技术探索

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移动通信 2018年第3期42卷 1-6,12页

作者：张庆郭华中国移动通信集团江苏有限公司江苏南京210029

为了满足高速热点接入速率的要求,系统需要能支持更高阶的调制方式,比如256QAM。因此详细介绍TDLTE高阶调制技术256QAM的技术原理,及基于BICM-ID与MLC的256QAM传输技术方案,利用高端频谱资源,可实现新型高低频段协作组网结构设计;利用... 详细信息

为了满足高速热点接入速率的要求,系统需要能支持更高阶的调制方式,比如256QAM。因此详细介绍TDLTE高阶调制技术256QAM的技术原理,及基于BICM-ID与MLC的256QAM传输技术方案,利用高端频谱资源,可实现新型高低频段协作组网结构设计;利用低频段传输信令、高频段传输业务,解决小区覆盖问题,同时提高系统频谱利用率。

关键词： TD-LTE 256QAM BICM-ID MLC 高端频游资原

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Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-qing Qiao guo Hui Bojing Sun Dongfang Hou Meidi Wang Xueqian Wu Tao Wu Dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect

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