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An unexpected Hoffmann elimination during the alkylation of dihydrotetrabenazine

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Chinese Chemical Letters 2010年第11期21卷 1334-1337页

作者： zhang Yu yao Hao zhang Huan ming sheng Xiao ming Wu hong Bin Sun Center for Drug Discovery College of PharmacyChina Pharmaceutical UniversityNanjing 210009China

Dihydrotetrabenazine(DTBZ) is the major pharmacologically active form of tetrabenazine(TBZ),which was approved by FDA for the treatment of chorea associated with Huntington’s disease(HD).An unexpected Hoffmann elimination was observed during the treatment of DTBZ with sodium hydrogen and alkyl halides,leading to the formation of both eliminated products(major) and hydroxyl-alkylated products(minor).

关键词： Tetrabenazine Dihydrotetrabenazine Alkylation Hoffmann elimination

植物精油对犊牛生长性能、血清免疫指标及血清抗氧化指标的影响

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饲料研究 2024年第15期47卷 1-5页

作者：朱元芳李伟韩永胜孙芳张建胜王艳菲姚美玲李青莹黑龙江省农业科学院畜牧兽医分院黑龙江齐齐哈尔161005 黑龙江省农业科学院畜牧研究所黑龙江哈尔滨150080

试验旨在研究植物精油对荷斯坦犊牛生长性能及血清指标的影响。选取60头年龄、体重相近的荷斯坦犊牛,随机分为2组,分别为对照组(基础精料)和试验组(基础精料+200 g/t植物精油),每组3个重复,每个重复10头牛。预试验7 d,正式试验期30 d。... 详细信息

试验旨在研究植物精油对荷斯坦犊牛生长性能及血清指标的影响。选取60头年龄、体重相近的荷斯坦犊牛,随机分为2组,分别为对照组(基础精料)和试验组(基础精料+200 g/t植物精油),每组3个重复,每个重复10头牛。预试验7 d,正式试验期30 d。结果显示,与对照组相比,试验组犊牛末重和平均日增重有所增加(P>0.05),体斜长和胸围均显著升高(P<0.05)。与对照组相比,试验组犊牛血清尿素氮(BUN)含量显著降低(P<0.05),免疫球蛋白A(IgA)、免疫球蛋白M(IgM)含量显著升高(P<0.05),总抗氧化能力(T-AOC)显著升高(P<0.05),丙二醛(MDA)含量显著降低(P<0.05)。与对照组相比,试验组犊牛腹泻率降低了20%,死亡率降低了7%。研究表明,本试验条件下,精料中添加植物精油能够增加犊牛平均日增重、体尺指标,增强犊牛免疫系统机能,提高抗氧化能力,减少腹泻率和死亡率。

关键词：犊牛植物精油血清指标腹泻生长性能

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Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addiction

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The Journal of Biomedical Research 2013年第5期27卷 345-356页

作者： ming-Hai Wang Ruiwen zhang yong-qing Zhou Hang-Ping yao Cancer Biology Research Center School of Pharmacy Texas Tech University Health Sciences Center Department of Biomedical Sciences School of Pharmacy Texas Tech University Health Sciences Center Department of Pharmaceutical Sciences School of Pharmacy Texas Tech University Health Sciences Center Department of Neurosurgery & Treatment of Infectious Diseases First Affiliated Hospital Zhejiang University School of Medicine Viral Oncogenesis Section in State Key Laboratory for Diagnosis & Treatment of Infectious Diseases First Affiliated Hospital Zhejiang University School of Medicine

The RON receptor tyrosine kinase, a member of the MET proto-oncogene family, is a pathogenic factor im- plicated in tumor malignancy. Specifically, aberrations in RON signaling result in increased cancer cell growth, survival, invasion, angiogenesis, and drug resistance. Biochemical events such as ligand binding, receptor over- expression, generation of structure-defected variants, and point mutations in the kinase domain contribute to RON signaling activation. Recently, functional crosstalk between RON and signaling proteins such as MET and EFGR has emerged as an additional mechanism for RON activation, which is critical for tumorigenic develop- ment. The RON signaling crosstalk acts either as a regulatory feedback loop that strengthens or enhances tumor- igenic phenotype of cancer cells or serves as a signaling compensatory pathway providing a growth/survival ad- vantage for cancer cells to escape targeted therapy. Moreover, viral oncoproteins derived from Friend leukemia or Epstein-Barr viruses interact with RON to drive viral oncogenesis. In cancer cells, RON signaling is integrated into cellular signaling network essential for cancer cell growth and survival. These activities provide the mo- lecular basis of targeting RON for cancer treatment. In this review, we will discuss recent data that uncover the mechanisms of RON activation in cancer cells, review evidence of RON signaling crosstalk relevant to cancer malignancy, and emphasize the significance of the RON signaling addiction by cancer cells for tumor therapy. Understanding aberrant RON signaling will not only provide insight into the mechanisms of tumor pathogenesis, but also lead to the development of novel strategies for molecularly targeted cancer treatment.

关键词： Receptor tyrosine kinase (RON) signaling pathway activation mechanism signaling crosstalk on-cogene addiction tumorigenesis

Handgrip Strength as a Predictor of Nutritional Status in Chinese Elderly Inpatients at Hospital Admission

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Biomedical and Environmental Sciences 2017年第11期30卷 802-810页

作者： zhang Xin sheng LIU Ying Hua zhang yong XU qing YU Xiao ming YANG Xue Yan LIU Zhao LI Hui Zi LI Feng XUE Chang yong Department of Nutrition Chinese PLA General Hospital Department of Nutrition Chinese PLA General Hospital of Rocket Forces

Objective To assess nutritional status and define gender-and age-specific handgrip strength（HGS） cut-point values for malnutrition or nutritional risk in elderly inpatients. Methods A cross-sectional study of 1,343 elderly inpatients was conducted in the Chinese PLA General Hospital. Nutrition Risk Screening（NRS 2002） and Subjective Global Assessment（SGA） were administered. Anthropometric measurements and blood biochemical indicators were obtained using standard techniques. The gender-and age-specific receiver operating characteristic（ROC） curves were constructed to evaluate the HGS for nutritional status by SGA and NRS 2002. Sensitivity, specificity, and areas under the curves（AUCs） were calculated. Results According to NRS 2002 and SGA, 63.81% of elderly inpatients were at nutritional risk and 28.22% were malnourished. Patients with higher HGS had an independently decreased risk of malnutrition and nutritional risk. The AUCs varied between 0.670 and 0.761. According to NRS 2002, the optimal HGS cut-points were 27.5 kg（65-74 years） and 21.0 kg（75-90 years） for men and 17.0 kg（65-74 years） and 14.6 kg（75-90 years） for women. According to SGA, the optimal HGS cut-points were 24.9 kg（65-74 years） and 20.8 kg（75-90 years） for men and 15.2 kg（65-74 years） and 13.5 kg（75-90 years） for women. Conclusion Elderly inpatients had increased incidence of malnutrition or nutritional risk. HGS cut-points can be used for assessing nutritional status in elderly inpatients at hospital admission in China.

关键词： Handgrip strength Elderly inpatients Nutrition assessment Nutrition status Malnutrition

Potential Risk of Hybridization in Ex Situ Collections of Two Endangered Species of Sinojackia Hu （Styracaceae）

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Journal of Integrative Plant Biology 2006年第7期48卷 867-872页

作者： Qi-Gang Ye Xiao-hong yao sheng-Ju zhang ming Kang hong-Wen Huang Wuhan Botanical Garden the Chinese Academy of Sciences Wuhan 430074 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China

Spontaneous hybridization in ex situ facilities can undermine the genetic integrity of ex situ collections and potentially contaminate open-pollinated seeds or seedlings destined for the reintroduction of endangered plant species into the wild. In the present study, the potential risk of hybridization between two endangered Chinese endemic species, namely Sinojackia xylocarpa Hu and S. rehderiana Hu, which are naturally allopatric species but were conserved ex situ in Wuhan Botanical Garden （WBG）, Wuhan, China, were investigated over three consecutive years from 2003 to 2005. The entire overlapping flowering period of the two species was 14-20 d and the two species shared the same pollinator insects during the entire flowering season in WBG. The floral isolation between the two species was not an issue in the ex sltu collection at WBG. The results suggest an opportunity for pollen transfer between species and a potential risk of genetic Introgression and loss of genetic identity of open-pollinated seeds produced in the ex sltu Collection of these two endangered species. An artificial reciprocal cross between S xylocarpa and S. rehderlana confirmed that the two congener species could readily set seeds, indicating no post-pollination barriers to hybridization and the importance of spatial isolation as a barrier to inter-specific crossing. Therefore, to manage these crossable species with overlapping flowering times and shared pollination vectors in ex situ facilities, spatial isolation should be carefully considered to minimize the possibility of spontaneous hybridization.

关键词： endangered species ex situ conservation hybridization risk phenology pollination Sinojackia rehderiana Sinojackia xylocarpa.

A LINEAR DYNAMIC MODEL DESCRIBING LYMPH CIRCULATION

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Journal of Hydrodynamics 2009年第1期21卷 118-123页

作者： yao Wei WANG sheng-zhang DING Guang-hong SHEN Xue-yong Department of Mechanics and Engineering Science Fudan University Shanghai 200433 China Shanghai Research Center of Acupuncture and Meridian Shanghai 201203 China Acupuncture Department of Shanghai University of Traditional Chinese Medicine Shanghai 200032 China

The lymph circulation plays an important role in interstitial fluid balance, protein transport, and immune system. However, its mechanism is poorly understood, and associated pathologies are mostly untreatable. By following Sungawa＇s method of discussing the heart output, a hemodynamic model of lymph circulation was set up. The model was used to demonstrate how the lymphatic fluid formation, investigate the relationship between the lymph flow rate QL and physiological parameters, and explore how local massage influences QL Computer simulation results show that QL is linearly proportional to the interstitial fluid pressure P~, which is similar to experimental observations. Comparing the simulated value of QL during the massage of different frequency with the experimental data from Ikomi shows that they are identical, which indicates that the presented model is rational to explain the mechanism of massage treatment in traditional Chinese medicine （TCM）.

关键词： lymph circulation pressure-volume circle equivalent elastance massage treatment in TCM

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釉烧温度对铁系钧瓷釉呈色影响及显微分析

中国陶瓷 2024年第9期60卷 56-61页

作者：李旭朱聪旭法文君张艳鸽郭志勇刘琳冯铭华孔春生郑直许昌学院化工与材料学院(表面微纳米材料研究所) 许昌461000 许昌市产品质量检验检测与研究中心许昌461000 国家市场监管重点实验室(陶瓷制品有害物质分析与评估) 许昌461000 禹州市神后镇孔家钧窑有限公司禹州461670

采用纳米氧化铁作为着色剂,在还原气氛下调控釉烧温度条件,探究烧制温度对铁系钧瓷釉呈色与显微结构的影响。通过分光测色仪、X-射线粉末衍射仪、STA热分析仪、扫描电子显微镜等测试表征手段研究了釉烧温度改变对钧瓷釉面呈色及显微结... 详细信息

采用纳米氧化铁作为着色剂,在还原气氛下调控釉烧温度条件,探究烧制温度对铁系钧瓷釉呈色与显微结构的影响。通过分光测色仪、X-射线粉末衍射仪、STA热分析仪、扫描电子显微镜等测试表征手段研究了釉烧温度改变对钧瓷釉面呈色及显微结构影响。结果表明:烧制温度由1260℃升高到1300℃时,釉面蓝色区域显著增加;烧制温度在1260~1300℃范围内,釉层表面具有明显的二氧化硅晶体衍射峰,而当烧制温度为1320℃时,二氧化硅晶相消失,釉面呈现玻璃态;伴随温度的升高,釉层表面分相液滴尺寸减小;钧瓷中心与边缘呈色差异可能是由于中心显微结构尺寸大于边缘显微结构尺寸。

关键词：钧瓷温度呈色显微分析

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新疆冬小麦籽粒品质性状遗传差异与关联分析

作物学报 2024年第6期50卷 1394-1405页

作者：马艳明娄鸿耀王威孙娜颜国荣张胜军刘杰倪中福徐麟新疆农业科学院农作物品种资源研究所新疆乌鲁木齐830091 中国农业大学农学院北京100193 北京市农林科学院杂交小麦研究所北京100097 新疆伊犁哈萨克自治州农业科学研究所新疆伊宁835011

小麦籽粒品质与面粉加工的食品品质密切相关,是小麦早期品质选择的重要依据。本研究以产自新疆的134个冬小麦地方品种和54个育成品种为材料,对连续2年种植收获于新疆乌鲁木齐市、新疆伊宁市共计4个试验点的小麦籽粒进行品质检测与全基... 详细信息

小麦籽粒品质与面粉加工的食品品质密切相关,是小麦早期品质选择的重要依据。本研究以产自新疆的134个冬小麦地方品种和54个育成品种为材料,对连续2年种植收获于新疆乌鲁木齐市、新疆伊宁市共计4个试验点的小麦籽粒进行品质检测与全基因组关联分析。结果表明,7个小麦籽粒品质性状的广义遗传力在62.14%~85.35%之间,由大到小排序依次为:硬度(85.35%)>湿面筋含量(78.44%)>出粉率(73.13%)>容重(72.50%)>沉降值(66.70%)>籽粒蛋白质含量(65.24%)>淀粉含量(62.14%)。在4个不同环境下,7个小麦籽粒品质性状表现为蛋白质含量、湿面筋含量、沉降值的变异相对较大,籽粒硬度的变异居中,淀粉含量、出粉率、容重的变异较小,多数籽粒品质性状间呈极显著相关性。设定阈值P<0.01,经关联分析,7个性状共检测到6605个显著性SNP标记,可解释6.021%~31.467%的变异。4个环境下检测到2个以上性状共有的多性状位点12个,可以解释6.233%~17.708%的表型变异。分别是蛋白质含量/沉降值、蛋白质含量/容重共有位点各1个,分别位于6A、2B上;蛋白质含量/湿面筋含量共有位点5个,分别位于3A、1B、6B、7B和7D上;沉降值/容重/籽粒硬度3个性状共有位点1个,位于5B上;蛋白质含量/沉降值/湿面筋含量3个性状共有位点3个,位于7A、3B和2D上,蛋白质含量/沉降值/湿面筋含量/容重4个性状共有位点1个,染色体位置未知。筛选出11个多性状、多环境品质相关基因,其中TraesCS6B01G347500编码一种储运蛋白,TraesCS1B01G395400编码碳水化合物转运蛋白/糖转运蛋白,TraesCS2D01G246500基因编码具有耐冷、耐盐、节水相关的蛋白ESKIMO1,可作为候选基因进行等位变异分析和标记开发,为小麦标记辅助选择育种提供分子工具。

关键词：新疆冬小麦籽粒品质遗传差异关联分析

A novel real-time RT-PCR with TaqM an-MGB probes and its application in detecting BVDV infections in dairy farms

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Journal of Integrative Agriculture 2015年第8期14卷 1637-1643页

作者： zhang yong-qiang LIU Hai-sheng WU Xiao-dong WANG Xiao-zhen LI Jin-ming ZHAO yong-gang Lü Yan REN Wei-jie GE sheng-qiang WANG zhi-liang China Animal Health and Epidemiology Center Beijing Dabeinong Technology Group Co. Ltd.

A real-time RT-PCR assay using Taq Man-MGB probes was developed to detect and type the bovine viral diarrhea virus（BVDV） in *** primers and Taq Man-MGB probes were designed from the 5′-untranslated region of known pestiviral *** to optimizing the assay, c RNAs were transcribed in vitro from the BVDV 1 and BVDV 2 RTPCR products to make standard *** detection limit of the assay was 1.72×102 copies for BVDV 1 and 2.14×102copies for BVDV *** specificity of the assay evaluated on several BVDV strains including bovine herpesvirus 1（BHV 1）, foot and mouth disease virus（FMDV） and several classical swine fever virus（CSFV） strains showed specific detection of the positive virus over 40 *** assay was highly reproducible with the coefficient of variance ranging from 1.04 to 1.33% for BVDV 1 and from 0.83 to 1.48% for BVDV 2, *** this method, we tested a total of 2 327 cattle from three dairy farms for the presence of BVDV persistently infected（PI） *** this assay, each RT-PCR template contained a mixture of ten samples from different *** occurrence rate of PI cattle in three farms ranging from 0.9 to 2.54% could represent partly the PI rates in cattle farm in *** conclusion, using our real-time PCR assay, we could effectively detect and type BVDV and identify PI cattle in a rapid and cost-effective manner.

关键词： bovine viral diarrhea virus(BVDV) real-time RT-PCR persistently infected(PI) animals Taq Man-MGB occurrence rate of PI cattle