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Penetration performance of W/Cu double-layer shaped charge liners

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Rare Metals 2016年第2期35卷 184-191页

作者： Wen-Jian Dong Jin-Xu Liu Xing-Wang Cheng Shu-Kui Li qing-he zou Wen-Qi Guo School of Materials Science and Engineering Beijing Institute of Technology Mudanjiang North Alloy Tool Co. Ltd.

Two kinds of W/Cu double-layer shaped charge liner（SCL） were prepared by chemical vapor deposition（CVD） combined with electroforming technique： A SCL with W inner layer and Cu outer layer, B SCL with Cu inner layer and W outer layer. The penetration properties of A and B SCLs were researched. The results show that the two SCLs can form continuous jet and the tip velocities of A and B jets are 7.4 and 6.3 km s^（-1）, respectively. The kinetic energy density（5.3 9 1011 J m-3） of A jet tip increases by 194.4 %compared with that（1.8 9 1011 J m-3） of B jet tip. B jet,however, exhibits deeper penetration depth at the same experimental conditions. The chemical component and microstructure of the area nearby the ballistic perforation were researched. Component analysis shows that both the jets are formed only from inner layer metal. Microstructure analysis shows that martensite and intermetallic form around ballistic perforation penetrated by A SCL due to the intensive interaction between W jet and steel target. The two kinds of newly formed ultrahard phases also hinder the jet from penetrating target further. As a result of relatively alleviative interaction between Cu jet and target, only solid solution rather than ultrahard phases forms around ballistic perforation penetrated by B SCL.

关键词： Shaped charge liner Jet Penetration performance Chemical vapor deposition Electroforming technique

Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng Deng Dan Yang Lingxi qing Yifei Chen Jilian zou Meiling Jia Qian Wang Runda Jiang Lihua Huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological *** coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological *** study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

Transarterial injection of H101 in combination with chemoembolization overcomes recurrent hepatocellular carcinoma

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World Journal of Gastroenterology 2011年第18期17卷 2353-2355页

作者： qing he Yang Liu qing zou Yong-Song Guan Department of Oncology West China Hospital of Sichuan University Chengdu 610041 Sichuan Province China

Transcatheter arterial chemoembolization (TACE) has become the standard treatment modality for unresectable hepatocellular carcinoma (HCC). Nonetheless, the clinical outcomes in patients with unresectable HCC are often unsatisfactory, especially in those with recurrent HCC. H101, an E1B gene deleted adenovirus, is known to have a significant antitumor activity. In addition, local injection of H101 can enhance the effect of antitumor therapies (chemotherapy and radiotherapy). Transarterial H101 gene injection in combination with TACE may help to control refractory and recurrent HCC. In this study, we report a 55-year-old patient with recurrent HCC which was treated with transarterial injection of H101 in combination with TACE, leading to a good clinical prognosis of the patient.

关键词： hepatocellular carcinoma H101 Transcatheter arterial chemoembolization Therapy

UiLog： Improving Log-Based Fault Diagnosis by Log Analysis

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Journal of Computer Science & Technology 2016年第5期31卷 1038-1052页

作者： De-qing zou Services Computing Technology and System Laboratory Huazhong University of Science and Technology Wuhan ~3007~ China Big Data Technology and System Laboratory Huazhong University of Science and Technology Wuhan 430074 China Cluster and Grid Computing Laboratory Huazhong University of Science and Technology Wuhan 430074 China School of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

In modern computer systems, system event logs have always been the primary source for checking system status. As computer systems become more and more complex, the interaction between software and hardware increases frequently. The components will generate enormous log information, including running reports and fault information. The sheer quantity of data is a great challenge for analysis relying on the manual method. In this paper, we implement a management and analysis system of log information, which can assist system administrators to understand the real-time status of the entire system, classify logs into different fault types, and determine the root cause of the faults. In addition, we improve the existing fault correlation analysis method based on the results of system log classification. We apply the system in a cloud computing environment for evaluation. The results show that our system can classify fault logs automatically and effectively. With the proposed system, administrators can easily detect the root cause of faults.

关键词： fault diagnosis system event log log classification fault correlation analysis

CONTINUOUS IMPROVEMENT THROUGH INTEGRATION OF QUALITY TOOLS

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Chinese Journal of Mechanical Engineering 2006年第1期19卷 72-75页

作者： he Zhen zou Feng CUI qing＇an QI Ershi LlU Zixian School of Management Tianjin University Tianjin 300072 China

The relationship between major quality tools such as quality function development （QFD）, failure mode and effects analysis （FMEA）, design of experiments （DOE） and statistical process control （SPC） is analyzed through an extensive review of the literature and the concurrent quality engineering philosophy, and a basic structure for the integration of quality tools is presented. An integrated quality management system （IQMS） is developed using C＋＋ Builder, running in the Windows 2000 Server environment with the basic internet connections, and SQL Server 2000 as the platform for developing the database, An illustrative example applying IQMS to the continuous quality improvement for a crane equipment manufacturing is reported. The result shows that the application of IQMS can optimize the process of design and manufacturing, shorten the cycle time of product, reduce the cost, and realize quality improvement continuously, The proposed integrated framework with IOMS is believed to be applicable to continuous quality improvement in many manufacturing companies.

关键词： Concurrent quality engineering Integration of quality Continuous improvement Integrated quality management system (IQMS)

Adenovirus-mediated wild-type p53 gene transfer in combination with bronchial arterial infusion for treatment of advanced non-small-cell lung cancer,one year follow-up

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第5期10卷 331-340页

作者： Yong-song GUAN Yuan LIU qing zou qing he Zi LA Lin YANG Ying HU Department of Oncology West China Hospital of Sichuan University Chengdu 610041 China State Key Laboratory of Biotherapy West China Medical School Sichuan University Chengdu 610041 China

Objective： In the present study, we have examined the safety and efficacy of recombinant adenovirus encoding human p53 tumor suppressor gene （rAd-p53） injection in patients with advanced non-small-cell lung cancer （NSCLC） in the combination with the therapy of bronchial arterial infusion （BAI）. Methods： A total of 58 patients with advanced NSCLC were enrolled in a non-randomized, two-armed clinical trial. Of which, 19 received a combination treatment of BAI and rAd-p53 （the combo group）, while the remaining 39 were treated with only BAI （the control group）. Patients were followed up for 12 months, with safety and local response evaluated by the National Cancer lnstitute＇s Common Toxicity Criteria and response evaluation criteria in solid tumor （RECIST）, respectively. Time to progression （TTP） and survival rates were also analyzed by Kaplan-Meier method. Results In the combo group, 19 patients received a total of 49 injections ofrAd-p53 and 46 times of BAI, respectively, while 39 patients in the control group received a total of 113 times of BAI. The combination treatment was found to have less adverse events such as anorexia, nausea and emesis, pain, and leucopenia （P〈0.05） but more arthralgia, fever, influenza-like symptom, and myalgia （P〈0.05）, compared with the control group. The overall response rates （complete response （CR）＋partial response （PR）） were 47.3% and 38.4% for the combo group and the control group, respectively （P〉0.05）. Patients in the combo group had a longer TTP than those in the control group （a median 7.75 vs 5.5 months, P-0.018）. However, the combination treatment did not lead to better survival, with survival rates at 3, 6, and 12 months in the combo group being 94.74%, 89.47%, and 52.63%, respectively, com- pared with 92.31%, 69.23%, and 38.83% in the control group （P=0.224）. Conclusion： Our results show that the combination of rAd-p53 and BAI was well tolerated in patients with NSCLC and may have improved the quality of life and delayed the

关键词： RAd-p53 gene therapy Clinical trial Non-small-cell lung cancer (NSCLC) Bronchial arterial infusion (BAI)

单层Cs_(2)PbI_(2)Cl_(2)中点缺陷的形成与稳定性

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原子与分子物理学报 2025年第5期42卷 130-136页

作者：何诗颖赵宇清邹代峰许英廖雨洁禹卓良湖南科技大学物理与电子科学学院湘潭411201 智能传感器与新型传感器材料湖南省重点实验室湘潭411201 湖南理工学院物理与电子科学学院岳阳414006

Cs_(2)PbI_(2)Cl_(2)是卤化铅钙钛矿材料的新成员,由于其高的光吸收系数和长的载流子迁移距离等优异的光电物理性能,在太阳能电池、光电探测器、场效应晶体管以及发光二极管等领域受到广泛的关注.其中光电材料及器件的优良特性由电子结... 详细信息

Cs_(2)PbI_(2)Cl_(2)是卤化铅钙钛矿材料的新成员,由于其高的光吸收系数和长的载流子迁移距离等优异的光电物理性能,在太阳能电池、光电探测器、场效应晶体管以及发光二极管等领域受到广泛的关注.其中光电材料及器件的优良特性由电子结构决定,而钙钛矿的点缺陷对电子结构具有重要的调控,且单层Cs_(2)PbI_(2)Cl_(2)中点缺陷的研究尚且缺乏.本文基于密度泛函理论的第一性原理计算,对单层Cs_(2)PbI_(2)Cl_(2)的铯空位、碘空位、氯空位、铯替代铅、碘替代铯、碘替代铅、碘替代氯、氯替代铯、氯替代铅和氯替代碘的缺陷形成能和稳定性进行了研究.结果表明:在富铅和缺铅条件下,碘替代氯和氯替代碘的缺陷形成能偏低,且氯替代碘能有效降低体系总能,提高体系稳定性.在缺铅条件下铯空位缺陷形成能低于富铅条件,在缺铅条件下更易形成铯空位;富铅和缺铅条件下对碘替代氯和氯替代碘的缺陷形成能基本无影响.上述研究结果有助于理解点缺陷对钙钛矿材料稳定性的影响,同时也为未来实验上设计基于Cs_(2)PbI_(2)Cl_(2)的高效的光电子器件提供理论依据.

关键词：单层Cs_(2)PbI_(2)Cl_(2) 形成能点缺陷稳定性

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体相二硫化铼中点缺陷的形成与稳定性

原子与分子物理学报 2025年第5期42卷 143-150页

二硫化铼是过渡金属二硫族化合物的成员,由于层间的范德华作用、合适的带隙、高的光吸收系数和长的载流子迁移距离在光电子研究领域引起广泛的关注.其中光电材料及器件的优良特性由电子结构决定,而半导体的缺陷能级对电子结构具有重要... 详细信息

二硫化铼是过渡金属二硫族化合物的成员,由于层间的范德华作用、合适的带隙、高的光吸收系数和长的载流子迁移距离在光电子研究领域引起广泛的关注.其中光电材料及器件的优良特性由电子结构决定,而半导体的缺陷能级对电子结构具有重要的调控,且体相二硫化铼的缺陷研究尚且缺乏.本文基于密度泛函理论的第一性原理计算,对体相二硫化铼的铼空位、硫空位、钨掺杂(或替代)铼、钨掺杂硫、锝掺杂铼和锝掺杂硫的缺陷形成能和稳定性进行了研究.结果表明:钨掺杂硫和锝掺杂硫形成深施主能级缺陷,铼空位形成浅施主能级缺陷.在富铼和富硫条件下,钨掺杂铼的缺陷形成能低且能有效降低体系总能,提高体系稳定性.钨掺杂硫的缺陷虽然能降低体系的总能提高二硫化铼的稳定性,但较大的缺陷形成能表明钨掺杂硫缺陷难以形成.上述研究结果有助于理解缺陷能级对半导体深浅能级和稳定性的影响,同时也为未来实验上设计基于二硫化铼的高效的光电子器件提供理论依据.

关键词：体相二硫化铼形成能缺陷能级稳定性

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InSe单层中点缺陷的第一性原理研究

原子与分子物理学报 2025年第6期42卷 167-173页

作者：何诗颖谢瑞恬刘娟邹代峰赵宇清许英廖雨洁湖南科技大学物理与电子科学学院湘潭411201 智能传感器与新型传感器材料湖南省重点实验室湘潭411201 山西大学化学化工学院太原030006 武汉大学动力与机械学院武汉430072

InSe是Ⅲ-Ⅵ族化合物中的主要成员,由于其具有优异的电学性能,在太阳能电池、固体电池组等领域受到广泛的关注.光电材料及器件的优良特性由电子结构决定,而Ⅲ-Ⅵ族化合物中的点缺陷对电子结构具有重要的调控,且单层InSe中点缺陷的Perdew... 详细信息

InSe是Ⅲ-Ⅵ族化合物中的主要成员,由于其具有优异的电学性能,在太阳能电池、固体电池组等领域受到广泛的关注.光电材料及器件的优良特性由电子结构决定,而Ⅲ-Ⅵ族化合物中的点缺陷对电子结构具有重要的调控,且单层InSe中点缺陷的Perdew-Burke-Ernzerhof(PBE)和heyd-Scuseria-Ernzerhof(HSE)对比研究尚且缺乏.本文基于密度泛函理论的第一性原理计算,对单层InSe的硒空位、铟空位、溴替代硒、硫替代硒、碲替代硒、镓替代铟、锡替代铟和铊替代铟的缺陷形成能和稳定性进行了研究.结果表明:在缺铟和富铟条件下,硫替代硒和镓替代铟的缺陷形成能低且可以有效的降低体系总能,提高体系的稳定性.溴替代硒具有较小的缺陷形成能,但较大的体系总能表明溴替代硒的缺陷体系不稳定.在缺铟条件下易形成铊替代铟缺陷;在富铟条件下易形成碲替代硒缺陷.上述研究结果有助于理解点缺陷对Ⅲ-Ⅵ族化合物稳定性的影响,同时也为未来实验上设计基于InSe的高效的光电子器件提供理论依据.

关键词：单层InSe 稳定性形成能点缺陷

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