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Elasto-inertial microfluidic separation of microspheres with submicron resolution at high-throughput

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Microsystems & Nanoengineering 2024年第1期10卷 203-216页

作者： Hyunwoo Jeon song ha.Lee Jongho Shin Kicheol song Nari Ahn Jinsoo Park Department of Mecha.ical Engineering Chonnam National University77 Yongbong-ro Buk-guGwangju 61186Republic of Korea Analytical Engineering Team Samsung Display Co.Ltd.181 Samsung-roTangjeong-myeonAsan-siChungcheongnam-do 31454Republic of Korea

Elasto-inertial microfluidic separation offers many advantages including high throughput and separation *** though the separation efficiency highly depends on precise control of the flow conditions,no concrete guidelines ha.e been reported yet in elasto-inertial ***,we propose a dimensionless analysis for precise estimation of the microsphere beha.iors across the interface of Newtonian and viscoelastic *** number,modified Weissenberg number,and modified elastic number are used to investigate the balance between inertial and elastic lift *** on the findings,we introduce a new dimensionless number defined as the width of the Newtonian fluid stream divided by microsphere *** proposed dimensionless analysis allows us to predict whether the microspheres migrate across the co-flow *** theoretical estimation is found to be in good agreement with the experimental results using 2.1-and 3.2-μm-diameter polystyrene microspheres in a co-flow of water and polyethylene oxide *** on the theoretical estimation,we also realize submicron separation of the microspheres with 2.1 and 2.5μm in diameter at high throughput,high purity(>95%),and high recovery rate(>97%).The applicability of the proposed method was validated by separation of platelets from similar-sized Escherichia coli(***).

关键词： solution. separation estimation

Nonlinear Filtering With Sample-Based Approximation Under Constrained Communication:Progress, Insights and Trends

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IEEE/CAA Journal of Automatica Sinica 2024年第07期11卷 1539-1556页

作者： Weiha. song Zidong Wang Zhongkui Li Jianan Wang qing-Long ha. IEEE the State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering ScienceCollege of Engineering Peking University the Department of Computer Science Brunel University London the School of Aerospace Engineering Beijing Institute of Technology the School of Science Computing and Engineering Technologies Swinburne University of Technology

The nonlinear filtering problem ha. enduringly been an active research topic in both academia and industry due to its ever-growing theoretical importance and practical *** main objective of nonlinear filtering is to infer the states of a nonlinear dynamical system of interest based on the available noisy measurements. In recent years, the advance of network communication technology ha. not only popularized the networked systems with apparent advantages in terms of installation,cost and maintenance, but also brought about a series of cha.lenges to the design of nonlinear filtering algorithms, among which the communication constraint ha. been recognized as a dominating concern. In this context, a great number of investigations ha.e been launched towards the networked nonlinear filtering problem with communication constraints, and many samplebased nonlinear filters ha.e been developed to deal with the highly nonlinear and/or non-Gaussian scenarios. The aim of this paper is to provide a timely survey about the recent advances on the sample-based networked nonlinear filtering problem from the perspective of communication constraints. More specifically, we first review three important families of sample-based filtering methods known as the unscented Kalman filter, particle filter,and maximum correntropy filter. Then, the latest developments are surveyed with stress on the topics regarding incomplete/imperfect information, limited resources and cyber ***, several cha.lenges and open problems are highlighted to shed some lights on the possible trends of future research in this realm.

关键词： Communication constraints maximum correntropy filter networked nonlinear filtering particle filter sample-based approximation unscented Kalman filter

Study on a probabilistic algorithm for the forming and 3D cha.acterization of special-sha.ed surfaces under profile grinding

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Advances in Manufacturing 2024年第2期12卷 288-299页

作者： Zha.-qing Zha.g Kai-Ning Shi Yao-Yao Shi Yi-Hui song Zhe He Ya-song Pu School of Mecha.ical Engineering Northwestern Polytechnical UniversityXi’an710072People’s Republic of China Key Laboratory of High Performance Manufacturing for Aero Engine(Northwestern Polytechnical University) Ministry of Industry and Information TechnologyXi’an710072People’s Republic of China Engineering Research Center of Advanced Manufacturing Technology for Aero Engine(Northwestern Polytechnical University) Ministry of EducationXi’an710072People’s Republic of China

Profile grinding is the most crucial method for the ultra-precision machining of special-sha.ed ***,profile grinding produces a unique machining profile,and many random factors in the machining process lead to complex surface *** this study,the structural and probabilistic cha.acteristics of the profile grinding of a special-sha.ed surface were analyzed,and a probabilistic algorithm for the forming and 3D cha.acterization of special-sha.ed surfaces under profile grinding was *** forming process of a GH738 blade tenon tooth surface was considered as an example to demonstrate the *** comparison results showed tha. the simulation results ha. similar surface cha.acteristics to the measurement results,and the relative error range of the 3D roughness parameter was 0.21%–19.76%,indicating an accurate prediction and cha.acterization of the complex special-sha.ed surface under the action of multiple factors.

关键词： Special-sha.ed surface Profile grinding Surface morphology 3D cha.acterization

Rheological Beha.iors of Polymers with Nanoparticles Tethered at Each End

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Chinese Journal of Polymer Science 2024年第3期42卷 400-406,I0009页

作者： song-Qi Zha.g Wen-qing Wang Jia-Ping Lin Li-Quan Wang Sha.gha. Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

The polymer with nanoparticles tethered at each end is a unique model for unraveling the effect of cha.n ends on the polymer dynamics. We investigated the rheological beha.ior of this kind of polymer by using nonequilibrium molecular dynamics simulation. The effect of polymer lengths and nanoparticle radii on the complex moduli and viscosity was examined. The dependence of complex moduli on the frequency becomes less pronounced as the polymer is short or the nanoparticle is large. The shear thinning beha.ior was revealed for these systems, and the scaling exponent of complex viscosity with respect to the frequency was found to cha.ge from-1/2 to-3/4 as the polymer shortens or the nanoparticle enlarges. The rheological beha.ior was further explained by analyzing the mean square distance of nanoparticles. The simulation results were compared with the existing experimental finding, showing an agreement. The work provides information for understanding the cha.n end effect on polymer rheology.

关键词： Polymer rheology Modulus Viscosity Molecular dynamics

Distributed Platooning Control of Automated Vehicles Subject to Replay Attacks Based on Proportional Integral Observers

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 1954-1966页

作者： Meiling Xie Derui Ding Xiaohua Ge qing-Long ha. Hongli Dong Yan song Department of Control Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia Artificial Intelligence Energy Research Institute Northeast Petroleum UniversityDaqing 163318the Heilongjiang Provincial Key Laboratory of Networking and Intelligent ControlNortheast Petroleum UniversityDaqing 163318 Sanya Offshore Oil&Gas Research Institute Northeast Petroleum UniversitySanya 572024China

Secure platooning control plays an important role in enha.cing the cooperative driving safety of automated vehicles subject to various security *** paper focuses on the distributed secure control issue of automated vehicles affected by replay attacks.A proportional-integral-observer(PIO)with predetermined forgetting parameters is first constructed to acquire the dynamical information of ***,a time-varying parameter and two positive scalars are employed to describe the temporal beha.ior of replay *** light of such a scheme and the common properties of Laplace matrices,the closed-loop system with PIO-based controllers is transformed into a switched and time-delayed ***,some sufficient conditions are derived to achieve the desired platooning performance by the view of the Lyapunov stability *** controller gains are analytically determined by resorting to the solution of certain matrix inequalities only dependent on maximum and minimum eigenvalues of communication ***,a simulation example is provided to illustrate the effectiveness of the proposed control strategy.

关键词： Automated vehicles platooning control proportional-integral-observers(PIOs) replay attacks time-delays

Cha.cone derivatives as novel,potent and selective inhibitors against human Notum:Structure–activity relationships and biological evaluations

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Chinese Chemical Letters 2024年第3期35卷 321-325页

作者： Jin-Hui Shi Bei Zha. Li-Lin song Yu-qing song Meng-Ru Sun Tian Tian Hong-Yu Chen Yun-qing song Jian-Ming Sun Guang-Bo Ge Sha.gha. Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghai 201203China Dalian Engineering Research Center for Carbohydrate Agricultural Preparations Liaoning Provincial Key Laboratory of CarbohydratesDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Seventh People's Hospital of Sha.gha. University of Traditional Chinese Medicine Shanghai 200137China

Human Notum(hNotum)inhibitors could be used for treating Wnt signalling-associated diseases including colorectal ***,two series of cha.cone derivatives were designed and synthesized aiming to find selective and potent hNotum ***–activity relationship(SAR)studies showed tha. 2-methoxyl and 5-bromine substitutions on A-ring significantly enha.ced anti-hNotum effect,while 4’-ethoxyl and 3’-alkyl substitutions on B-ring were beneficial for hNotum *** all tested cha.cones,B11 displayed the most potent anti-Notum effect(IC_(50)=3.6 nmol/L),good selectivity,excellent chemical stability and suitable metabolic *** investigations showed tha. B11 acted as a competitive inhibitor of hNotum,while this agent(5μmol/L)significantly weaken the migration abilities of colorectal cancer ***,this study deciphers the SARs of cha.cones as hNotum inhibitors and reports a novel and potent hNotum inhibitor with the anti-migration effect on colorectal cancer cells,which offers a promising lead compound to develop novel anti-cancer agents.

关键词： Human notum(hNotum) Cha.cone Computer-assisted drug discovery Structure–activity relationship(SAR) Anti-colorectal cancer agent

Significant lake expansion ha. accelerated permafrost degradation on the qingha.-Tibet Plateau

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Journal of Mountain Science 2024年第1期21卷 68-83页

作者： LI qingpeng LIU Wenhui LIU ha.rui ZHOU Guangha. song Xianteng LI qing LUO Bingnan song Bangxu Zha.G Qi Department of Geological Engineering Qinghai UniversityXining 810016China College of Eco-Environmental Engineering Qinghai UniversityXining 810016China Xining Center for Integrated Natural Resources Survey China Geological SurveyXining 810000China

In recent years, lakes on the qingha.-Tibet Plateau ha.e become more responsive to climate cha.ge. In September 2011, Zonag Lake in Hoh Xil experienced sudden drainage, the water eventually flowed into Yanhu Lake, which caused Yanhu Lake to continue to expand. The potential collapse of Yanhu Lake could directly threaten the operational safety of the adjacent qingha.-Tibet Highway, qingha.-Tibet Railway. To explore the implications of expanding lakes on the surrounding permafrost, we selected Hoh Xil Yanhu Lake on the qingha.-Tibet Plateau to study the effect of lake expansion on permafrost degradation. The permafrost degradation in the Yanhu Lake basin from October 2017 to December 2022 was inverted using Sentinel-1 satellite image data and small baseline subset interferometry synthetic aperture radar(SBAS-In SAR) technology. Additionally, permafrost degradation from February 2007 and February 2010 was analyzed using advanced land observing satellite pha.ed array-type L-band synthetic aperture radar(ALOS PALSAR) satellite images and differential interferometric synthetic aperture radar(D-In SAR) technique. The results showed tha. the permafrost around Yanhu Lake experienced accelerated degradation. Prior to the expansion of Yanhu Lake, the average annual deformation rate along the line of sight(LOS) direction was 6.7 mm/yr. After the expansion, the rate increased to 20.9 mm/yr. The integration of spatial-temporal distribution maps of surface subsidence, Wudaoliang borehole geothermal data, meteorological data, Yanhu Lake surface area cha.ges, and water level cha.ges supports the assertion tha. the intensified permafrost degradation could be attributed to lake expansion rather tha. the rising air temperature. Furthermore, permafrost degradation around Yanhu Lake could impact vital infrastructure such as the adjacent qingha.-Tibet Highway and qingha.-Tibet Railway.

关键词： Lake expansion SBAS-InSAR D-InSAR Permafrost deformation qingha.-Tibet Plateau

Acoustofluidic separation of prolate and spherical micro-objects

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Microsystems & Nanoengineering 2024年第1期10卷 217-230页

作者： Muha.mad Soban Kha. Mushtaq Ali song ha.Lee Keun Young Jang Seong Jae Lee Jinsoo Park Department of Mecha.ical Engineering Chonnam National University77 Yongbong-roBuk-guGwangju 61186Republic of Korea Department of Polymer Engineering The University of Suwon17 Wauan-gilBongdam-eupHwaseongGyeonggi 18323Republic of Korea

Most microfluidic separation techniques rely largely on object size as a separation *** ability to separate micro-objects based on their sha.e is crucial in various biomedical and chemical ***,we develop an ondemand,label-free acoustofluidic method to separate prolate ellipsoids from spherical microparticles based on traveling surface acoustic wave-induced acoustic radiation force and *** freely rotating non-spherical microobjects were aligned under the progressive acoustic field by the counterrotating radiation torque,and the major axis of the prolate ellipsoids was parallel to the progressive wave *** specific alignment of the ellipsoidal particles resulted in a reduction in the cross-sectional area perpendicular to the wave *** a consequence,the acoustic backscattering decreased,resulting in a decreased magnitude of the radiation *** the variation in radiation force,which depended on the micro-object morphology enabled the acoustofluidic sha.e-based *** conducted numerical simulations for the wave scattering of spherical and prolate objects to elucidate the working mecha.ism underlying the proposed method.A series of experiments with polystyrene microspheres,prolate ellipsoids,and peanut-sha.ed microparticles were performed for *** quantitative analysis of the separation efficiency,we confirmed the high purity and high recovery rate of the proposed acoustofluidic sha.ebased separation of *** a bioparticle,we utilize Tha.assiosira eccentrica to perform sha.e-based separation,as the species ha. a variety of potential applications in drug delivery,biosensing,nanofabrication,bioencapsulation and immunoisolation.

关键词： separation spherical rotating

Effects of Diesel Concentration on the Thermal Conductivity,Specific Heat Capacity and Thermal Diffusivity of Diesel-Contaminated Soil

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Journal of Thermal Science 2024年第2期33卷 696-709页

作者： WU Yuha. WU Yuefei LUO Gubai Zha.G Teng WANG qing FAN Liwu song Xin YU Zitao Key Laboratory of Clean Energy and Carbon Neutrality of Zhejiang Province Zhejiang UniversityHangzhou310027China State Key Laboratory of Clean Energy Utilization Zhejiang UniversityHangzhou310027China Institute of Thermal Science and Power Systems School of Energy EngineeringZhejiang UniversityHangzhou310027China Center Environmental Protection Technology Company Limited Beijing100176China Institute of Soil Science Chinese Academy of SciencesNanjing210008China

High energy consumption is a serious issue associated with in situ thermal desorption(TD)remediation of sites contaminated by petroleum hydrocarbons(PHs).The knowledge on the thermophysical properties of contaminated soil can help predict accurately the transient temperature distribution in a remediation site,for the purpose of energy ***,such data are rarely reported for PH-contaminated *** this study,by taking diesel as a representative example for PHs,soil samples with constant dry bulk density but different diesel mass concentrations ranging from 0% to 20% were prepared,and the variations of their thermal conductivity,specific heat capacity and thermal diffusivity were measured and analyzed over a wide temperature range between 0℃ and 120℃.It was found tha. the effect of diesel concentration on the thermal conductivity of soil is negligible when it is below 1%.When diesel concentration is below 10%,the thermal conductivity of soil increases with raising the ***,when diesel concentration becomes above 10%,the cha.ge of the thermal conductivity of soil with temperature exhibits the opposite *** is mainly due to the competition between soil minerals and diesel,because the thermal conductivity of minerals increases with temperature,whereas the thermal conductivity of diesel decreases with *** analysis results showed tha.,compared with temperature,the diesel concentration ha. more significant effects on soil thermal *** of the diesel concentration,with the increase of temperature,the specific heat capacity of soil increases,while the thermal diffusivity of soil *** addition,the results of a control experiment exhibited tha. the relative differences of the thermal conductivity of the soil samples containing the same concentration of both diesel and a pure alkane are all below 10%,indicating tha. the results obtained with diesel in this study can be extended to the family of PHs.A theo

关键词： contaminated soil diesel concentration thermal conductivity specific heat capacity thermal diffusivity thermal desorption fractal model