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Preoperative controlling nutritional status as an optimal prognostic nutritional index to predict the outcome for colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 343-353页

作者： Li-Xiang Liu Hao Wang Bo Gao Ting-Ting Xu qing-gang yuan Shi-Zhen Zhou Chao Ding Ji Miao Wen-Xian Guan Department of General Surgery Nanjing Drum Tower HospitalNanjing Drum Tower Hospital Clinical CollegeNanjing Medical UniversityNanjing 210008Jiangsu ProvinceChina Department of General Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Department of Clinical Nutrition Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008Jiangsu ProvinceChina School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210008Jiangsu ProvinceChina Department of General Surgery Nanjing Drum Tower Clinical College of Xuzhou Medical UniversityNanjing 210008Jiangsu ProvinceChina

BACKGROUND The controlling nutritional status(CONUT)score effectively reflects a patient’s nutritional status,which is closely related to cancer *** study invest-igated the relationship between the CONUT score and prognosis after radical surgery for colorectal cancer,and compared the predictive ability of the CONUT score with other *** To analyze the predictive performance of the CONUT score for the survival rate of colorectal cancer patients who underwent potentially curative *** This retrospective analysis included 217 patients with newly diagnosed *** CONUT score was calculated based on the serum albumin level,total lymphocyte count,and total cholesterol *** cutoff value of the CONUT score for predicting prognosis was 4 according to the Youden Index by the receiver operating characteristic *** associations between the CONUT score and the prognosis were performed using Kaplan-Meier curves and Cox regression *** Using the cutoff value of the CONUT score,patients were stratified into CONUT low(n=189)and CONUT high groups(n=28).The CONUT high group had worse overall survival(OS)(P=0.013)and relapse-free survival(RFS)(P=0.015).The predictive performance of CONUT was superior to the modified Glasgow prognostic score,the prognostic nutritional index,and the neutrophil-to-lymphocyte ***,the predictive performances of CONUT+tumor node metastasis(TNM)stage for 3-year OS[area under the receiver operating characteristics curve(AUC)=0.803]and 3-year RFS(AUC=0.752)were no less than skeletal muscle mass index(SMI)+TNM *** CONUT score was negatively correlated with SMI(P<0.01).CONCLUSION As a nutritional indicator,the CONUT score could predict long-term outcomes after radical surgery for colorectal cancer,and its predictive ability was superior to other *** correlation between the CONUT score and skeletal muscle may be one of the factors that play a predictive role.

关键词： Controlling nutritional status Colorectal cancer Prognostic marker Sarcopenia Skeletal muscle

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基于Teager峰值能量的低转速轴承故障特征提取方法

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振动与冲击 2017年第11期36卷 124-128,133页

作者：柯燕亮王华庆唐刚袁洪芳李岭阳北京化工大学机电工程学院北京100029 北京化工大学信息科学与技术学院北京10029

峰值冲击是轴承故障信号中的重要特征之一,明显的峰值冲击有利于其故障诊断,而低转速工况下轴承故障由于振动能量小,峰值冲击微弱,导致故障特征容易被噪声淹没,通常无法通过包络分析等方法提取。为了增强微弱故障信号中的峰值冲击,提取... 详细信息

峰值冲击是轴承故障信号中的重要特征之一,明显的峰值冲击有利于其故障诊断,而低转速工况下轴承故障由于振动能量小,峰值冲击微弱,导致故障特征容易被噪声淹没,通常无法通过包络分析等方法提取。为了增强微弱故障信号中的峰值冲击,提取低转速轴承故障特征,提出了基于Teager峰值能量的故障特征提取方法。采用移动窗口截取原信号,计算截取信号段的峰峰值,从而构造峰峰值特征波形,增强故障信号中的峰值冲击;利用Teager能量算子对峰峰值特征波形进行解调,抑制噪声干扰,提取瞬时冲击成分;根据提取的Teager能量频谱判断轴承的运行状态。实验结果表明,该方法有效提取了低转速轴承的冲击特征,实现了故障的诊断。

关键词：低转速轴承故障诊断峰峰值特征波形 Teager能量算子

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粒子群算法在小波神经网络中的应用

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系统仿真学报 2004年第12期16卷 2783-2785,2788页

作者：岑翼刚秦元庆孙德宝李宁武汉华中科技大学控制科学与工程系武汉430074

利用粒子群(PSO)算法对小波神经网络(WNN)中的参数'{,,(,)}mnmnabwab进行优化,取代了传统的梯度下降法。并将仿真结果与BP网络进行比较,仿真数据表明,PSO算法在叠代次数、函数逼近误差、网络性能方面均比BP网络有着显著的提高,且在粒子... 详细信息

利用粒子群(PSO)算法对小波神经网络(WNN)中的参数'{,,(,)}mnmnabwab进行优化,取代了传统的梯度下降法。并将仿真结果与BP网络进行比较,仿真数据表明,PSO算法在叠代次数、函数逼近误差、网络性能方面均比BP网络有着显著的提高,且在粒子数目较大的情况下能有效避免BP网络无法避免的局部极小值问题。

关键词：粒子群小波神经网络函数逼近局部极小值

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艾灸调节circ Pan3/mi R-667-5p/Ghrelin信号通路减轻膝骨关节炎大鼠的软骨病变

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中国组织工程研究 2025年第12期29卷 2475-2483页

作者：廖晴曾静陈峻袁立霞刘刚南方医科大学中医药学院广东省广州市510000 南方科技大学医院广东省深圳市518000 南方医科大学南方医院康复科广东省广州市510000

背景:既往研究表明艾灸能减轻膝骨关节炎软骨病变,延缓膝骨关节炎进展;课题组前期研究中发现调控circPan3/miR-667-5p/Ghrelin信号通路可增强软骨细胞自噬水平,从而在膝骨关节炎中发挥软骨保护作用。目的:基于circPan3/miR-667-5p/Ghre... 详细信息

背景:既往研究表明艾灸能减轻膝骨关节炎软骨病变,延缓膝骨关节炎进展;课题组前期研究中发现调控circPan3/miR-667-5p/Ghrelin信号通路可增强软骨细胞自噬水平,从而在膝骨关节炎中发挥软骨保护作用。目的:基于circPan3/miR-667-5p/Ghrelin信号通路探究艾灸对大鼠膝骨关节炎软骨的影响。方法:SD大鼠随机分为假手术组、模型组和艾灸组(n=10),对后2组大鼠行右后肢膝关节前交叉韧带横断和内侧半月板部分切除术建立膝骨关节炎大鼠模型;假手术组大鼠仅接受关节囊切开术。6周后,艾灸组大鼠每日艾灸“足三里”“肾俞”穴区20 min,持续4周,其余2组不予以特殊处理。4周后通过组织病理学染色观察膝关节滑膜病变和软骨损伤程度,通过酶联免疫吸附实验检测血清中炎症因子白细胞介素6和肿瘤坏死因子α的变化。此外,取上述3组大鼠右侧膝关节软骨细胞分为:正常对照组、模型组和艾灸组,通过Western blot和qRT-PCR检测各组细胞中软骨基质合成代谢分子(Ⅱ型胶原蛋白和Sox9)、基质降解分子(基质金属蛋白酶13和ADAMTS5)、自噬标志物(ATG5、Beclin-1、微管相关蛋白1轻链3)、Ghrelin、CircPan3以及miR-667-5P的表达水平。结果与结论:①治疗4周后,相对于假手术组,模型组大鼠滑膜显著增厚,炎症细胞浸润显著,关节间隙狭窄,软骨表面粗糙不平,变薄,软骨细胞数量减少,滑膜炎和OARSI评分显著升高,白细胞介素6和肿瘤坏死因子α水平明显上调(P<0.0001);与模型组相比,艾灸组滑膜增厚减轻,炎症细胞浸润减少,关节间隙增宽,软骨更光滑完整、变厚,软骨细胞数量增多,滑膜炎和OARSI评分降低,白细胞介素6和肿瘤坏死因子α水平显著降低(P<0.0001)。②体外实验结果表明,与正常对照组相比,模型组软骨细胞基质金属蛋白酶13、ADAMTS5和miR-667-5P表达增多,Ⅱ型胶原蛋白、Sox9、自噬标志物、Ghrelin和Circpan3表达减少(P<0.01);与模型组相比,艾灸可逆转上述指标改变(P<0.01)。③结果说明艾灸可能通过调节circPan3/miR-667-5p/Ghrelin信号通路增强软骨细胞自噬,抑制膝骨关节炎炎症和软骨破坏,对软骨发挥保护作用。

关键词：膝骨关节炎艾灸 ghrelin 软骨自噬大鼠信号通路

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3D stress simulation and parameter design during twin-roll casting of 304 stainless steel based on the Anand model

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International Journal of Minerals,Metallurgy and Materials 2014年第7期21卷 666-673页

作者： Jing Guo yuan-yuan Liu Li-gang Liu Yue Zhang qing-xiang Yang State Key Laboratory of Metastable Materials Science & Technology Yanshan University Nanjing Iron & Steel Co. School of Material Science and Engineering University of Science and Technology Beijing

This study first investigated cracks on the surface of an actual steel strip. Formulating the Anand model in ANSYS software, we then simulated the stress field in the molten pool of type 304 stainless steel during the twin-roll casting process. Parameters affecting the stress distribution in the molten pool were analyzed in detail and optimized. After twin-roll casting, a large number of transgranular and intergranular cracks resided on the surface of the thin steel strip, and followed a tortuous path. In the molten pool, stress was enhanced at the exit and at the roller contact positions. The stress at the exit decreased with increasing casting speed and pouring temperature. To ensure high quality of the fabricated strips, the casting speed and pouring temperature should be controlled above 0.7 m/s and 1520℃, respectively.

关键词： stainless steel strip metal roll casting stress surface cracks numerical analysis

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Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou yuan-Yan Huang Ding-Yue Shang Ying Chen Meng Tian Cheng-Yu Jin Xin Lu Bing-Chun Yan Han-qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

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A robust beam tracking scheme for millimeter wave HetNets

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Digital Communications and Networks 2022年第6期8卷 1115-1121页

作者： qing Xue gang Feng Chongqing Key Laboratory of Mobile Communications Technology Chongqing University of Posts and Telecommunications(CQUPT)Chongqing400065China National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of China(UESTC)Chengdu611731China State Key Laboratory of Internet of Things for Smart City University of MacaoMacaoChina

Millimeter Wave(mmWave)communication has been widely acknowledged as an attractive solution to address high-speed transmission of massive data in 5G and beyond 5G systems due to the promising spectrum ***,mmWave signals are highly susceptible to blockage and may suffer from rapidly changing ***,directional/beam tracking becomes imperative yet essential for robust mmWave *** address this challenge,we propose a robust beam tracking scheme for mmWave Heterogeneous Networks(HetNets)with *** from most existing schemes,the proposed beam tracking scheme is effective for outage *** first discuss theμWave-assisted beam tracking procedure with and without candidate beams,and then analyze the inherent correlation between mmWave link quality and the operating beamwidth and occlusion range to derive the optimal *** and numerical results show that the proposed beam tracking scheme can improve the robustness of mmWave communications while guaranteeing the rate performance.

关键词： Millimeter wave(mmWave)communication Beam tracking Multi-connectivity Robust

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Exploring Gender Differences in Adolescent Dissociative Symptoms via A Structural Equation Model

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Biomedical and Environmental Sciences 2023年第8期36卷 773-778页

作者： CHENG qing Lin DENG yuan yuan ZHAO gang CHEN Jun Fang XIE Li WANG Le Hangzhou Center for Disease Control and Prevention Hangzhou 310021ZhejiangChina School of Medicine Hangzhou Normal UniversityHangzhou 310021ZhejiangChina

Adolescent dissociative disorders(ADDs)have been recognized as significant psychological issues with an estimated prevalence of 45.2%in psychiatric outpatient clinics^([1]).Previous studies have demonstrated that dissociative symptoms(DSs)manifest as early signs of dissociative disorders(DDs)^([2]).DSs are characterized as aberrations in one's feelings,experiences,and thoughts in the realm of awareness and memory^([3]).

关键词： Equation Ado realm

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Parametric channel modeling based OFDM channel estimation

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The Journal of China Universities of Posts and Telecommunications 2014年第5期21卷 1-8页

作者： qing Hao-bo LIU yuan-an XIE gang LIU Kai-ming LIU Fang Beijing Key Laboratory of Work Safety Intelligent Monitoring Beijing University of Posts and Telecommunications Beijing Key Laboratory of Network System Architecture and Convergence Beijing University of Posts and Telecommunications

A simplified parametric channel estimation approach was proposed for orthogonal frequency division multiplexing （OFDM） systems. Based on parametric channel model, this algorithm is composed of two parts： the estimation of channel parameters and channel interpolation. The exponentially embedded family （EEF） criterion is exploited to determine the number of channel paths as well as the multipath time delays. Consequently, the channel frequency responses is acquired via the estimated parameters. Additionally, the authors＇ scheme is computationally efficient owing to the needless of the eigenvalue decomposition or the estimation of signal parameters by the rotational invariance technique （ESPRIT）. Simulations are provided to validate the performance of this algorithm from perspectives of the probability of correct estimation and the mean square error （MSE）. It is demonstrated that this approach exhibits a superior performance over the existing algorithms.

关键词： channel estimation OFDM mean square error EEF criterion

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Induction of apoptosis of lymphocytes in ratmucosalimmune system

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World Journal of Gastroenterology 1998年第1期4卷 24-28页

作者： CHEN Xue-qing ZHANG Wan-Dai SONG Yu-gang ZHOU Dian-yuan 不详

IM To undergo apoptosis during negative and positive selection processes in rat mucosal immune system which are implicated in the pathogenesis of various mucosal diseases. METHODS Female SpragueDawley rats were given protein synthesis inhibitor, cycloheximide, intravenously or intraperitoneally, an apoptosis was recognized by morphological hallmark under light and electronmicroscopy, and the expression of proliferating cell nuclear antigen was visualized immunohistochemically. RESULTS The apoptosis of mucosal lymphocytes in the digestive tract, as well as in trachea, uterus and lacrimal gland was induced by cycloheximide (>10mg·kg-1 body weight), which were located mainly in lamina propria and germinal centers of lymphoid nodules. At the same time, a portion of crypt epithelial cells of proliferating zone in small and large intestine, and the epithelial cells in genital tract were also found to undergo apoptosis. Immunostainings showed that apoptotic cells expressed proliferating cell nuclear antigen. CONCLUSION Apoptosis of lymphocytes in mucosal immune system can be induced by cycloheximide. This model will facilitate the understanding of normal mucosal immune system and its role in the pathogenesis of related diseases such as inflammatory bowel diseases.

关键词： mucosal immune system cycloheximide proliferating cell nuclear antigen immunohistochemistry

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