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Expression and significance of Musashi-1 in gastric cancer and precancerous lesions

World Journal of Gastroenterology 2013年第39期19卷 6637-6644页

作者： Rong-Guang Kuang Yan Kuang qing-feng luo Cheng-Jun Zhou Rui Ji Jian-Wen Wang Department of Health Care Qianfoshan Hospital Affiliated to Shandong University Laiwu Municipal Center for Disease Control and Prevention Department of Gastroenterology Beijing HospitalMinistry of Health Department of Pathology the Second Hospital of Shandong University Department of Gastroenterology Qilu Hospital of Shandong University

AIM:To investigate expression of stem cell marker Musashi-1(Msi-1)in relationship to tumorigenesis and progression of intestinal-type gastric cancer(GC).METHODS:Endoscopic biopsy specimens and surgical specimens were obtained,including 54 cases of intestinal-type GC,41 high-grade intraepithelial neoplasia,57low-grade intraepithelial neoplasia,31 intestinal metaplasia,and 36 normal gastric *** were fixed in 10%paraformaldehyde,conventionally dehydrated,embedded in paraffin,and sliced in 4-μm-thick serial ***-step immunohistochemical staining was used to detect Msi-1 and proliferating cell nuclear antigen(PCNA)*** analysis was conducted between Msi-1 and PCNA *** relationship between Msi-1 expression and clinicopathological parameters of GC was analyzed ***:There were significant differences in Msi-1and PCNA expression in different pathological tissues(χ2=15.37,P<0.01;χ2=115.36,P<0.01).Msi-1and PCNA-positive cells were restricted to the isthmus of normal gastric *** levels of Msi-1and PCNA in intestinal metaplasia were significantly higher than in normal mucosa(U=392.0,P<0.05;U=40.50,P<0.01),whereas there was no significant difference compared to low or high-grade intraepithelial ***-1 and PCNA expression in intestinaltype GC was higher than in high-grade intraepithelial neoplasia(U=798.0,P<0.05;U=688.0,P<0.01).There was a significantly positive correlation between Msi-1 and PCNA expression(rs=0.20,P<0.01).Msi-1expression in GC tissues was correlated with their lymph node metastasis and tumor node metastasis stage(χ2=12.62,P<0.01;χ2=11.24,P<0.05),but not with depth of invasion and the presence of distant ***:Msi-1-positive cells may play a key role in the early events of gastric carcinogenesis and may be involved in invasion and metastasis of GC.

关键词： Musashi-1 Stem cells Gastric cancer Precancerous lesions Immunohistochemistry.

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内镜下经皮胃造瘘对老年患者生活质量的影响

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世界华人消化杂志 2007年第3期15卷 294-297页

作者：许乐罗庆锋卫生部北京医院消化内科北京市100730

目的:评价内镜下经皮胃造瘘(PEG)在老年患者的应用、安全性及对生活质量的影响.方法:对32例PEG老年患者进行回顾性分析,采用同组对照的方法比较PEG与鼻胃管饲对患者的影响.结果:32例老年患者均在局麻下成功进行了PEG,仅1例发生造瘘口周... 详细信息

目的:评价内镜下经皮胃造瘘(PEG)在老年患者的应用、安全性及对生活质量的影响.方法:对32例PEG老年患者进行回顾性分析,采用同组对照的方法比较PEG与鼻胃管饲对患者的影响.结果:32例老年患者均在局麻下成功进行了PEG,仅1例发生造瘘口周围皮肤感染,抗生素治疗后短期内恢复.PEG较鼻胃管饲患者更易于接受,导管不易堵塞,能降低吸入性肺炎及反流性食管炎(15.6% vs 46.8%,P<0.05)的发生率,提高生活质量.结论:PEG是一种安全有效的治疗方法,较鼻胃管饲能明显降低吸入性肺炎、反流性食管炎的发生率.

关键词：内镜下经皮胃造瘘老年患者生活质量

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肝硬化患者糖代谢变化临床分析46例

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世界华人消化杂志 2005年第17期13卷 2162-2164页

作者：罗庆锋许乐傅亮卫生部北京医院消化内科北京市100730

目的:探讨肝硬化患者糖代谢变化及其可能的致病机制.方法:对46例肝硬化患者及25例正常人分别测定空腹及口服75g葡萄糖耐量试验(oralglucosetolerancetest,OGTT)2h后的血糖、血浆胰岛素及C肽水平,计算胰岛素敏感指数(insulinsensitivityi... 详细信息

目的:探讨肝硬化患者糖代谢变化及其可能的致病机制.方法:对46例肝硬化患者及25例正常人分别测定空腹及口服75g葡萄糖耐量试验(oralglucosetolerancetest,OGTT)2h后的血糖、血浆胰岛素及C肽水平,计算胰岛素敏感指数(insulinsensitivityindex,ISI),并对各项结果进行比较分析.结果:肝硬化组空腹血糖、C肽水平分别为5.58±2.14mmol/L、593±156pmol/L,较对照组差异均没有显著性意义(P>0.05);OGTT2h后血糖、C肽水平分别为:11.97±4.20mmol/L、3411±964pmol/L,均明显高于对照组(P<0.05);而胰岛素测定结果可见肝硬化患者空腹及OGTT2h后胰岛素水平分别为:12.23±5.4mU/L、105.16±40.70mU/L,均明显高于对照组;肝硬化组ISI显著低于对照组(1.47±0.54vs2.73±0.62,P<0.05).结论:肝硬化患者存在明显的糖代谢异常,这种糖代谢异常与胰岛素抵抗有关.

关键词：肝硬化糖代谢胰岛素

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Stability of Nonlinear Networked Control System with uncertainties

Stability of Nonlinear Networked Control System with uncerta...

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2009年中国智能自动化会议

作者： MENG qing-feng,luo Lin,MA Yan (1.91049 troops qingdao,266102,China 2.65017 troops Shenyang,110162,China)

This paper deals with the controller design problem of a networked control system with the presence of network-induced delay and transmitted data *** Takagi-Sugeno(T-S) fuzzy model is adopted for representing networked control systems. And the fuzzy model is used to approximate the nonlinear NCS.A new fuzzy controller of networked control system is *** on a novel Lyapunov-Krasovskii functional and linear matrix inequality(LMI) technique,the sufficient condition for the networked control system(NCS) which is subject to the asymptotic stability is derived,and the method of the controller design is also given in terms of LMI.

关键词： Nonlinear Networked Control System T-S fuzzy model Time-delay LMI

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野生型胃肠间质瘤分子机制研究进展

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世界华人消化杂志 2017年第13期25卷 1166-1172页

作者：姚思敏罗庆锋北京医院消化内科北京市100730

胃肠道间质瘤(gastrointestinal stromal tumor,GIST)是消化系最常见的间叶源性肿瘤,80%-95%GIST存在KIT或PDGFRA基因突变,未突变者称为野生型GIST(WT-GIST).目前证实,突变型GIST对酪氨酸激酶抑制剂(tyrosine kinase inhibitor,TKI)分... 详细信息

关键词：野生型胃肠间质瘤分子机制基因突变

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Designing Electronic Structures of Multiscale Helical Converters for Tailored Ultrabroad Electromagnetic Absorption

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Nano-Micro Letters 2025年第1期17卷 439-455页

作者： Zhaobo feng Chongbo Liu Xin Li Guangsheng luo Naixin Zhai Ruizhe Hu Jing Lin Jinbin Peng Yuhui Peng Renchao Che Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle School of Environmental and Chemical EngineeringNanchang Hangkong UniversityNanchang 330063People’s Republic of China School of Physics and Materials Nanchang UniversityNanchang 330031People’s Republic of China Key Laboratory of Nondestructive Testing Ministry of EducationNanchang Hangkong UniversityNanchang 330063People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering and TechnologyFudan UniversityShanghai 200438People’s Republic of China

Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)***,the relationship between configuration and electromagnetic(EM)loss mechanism has remained ***,drawing inspiration from the DNA transcription process,we report the successful synthesis of novel in situ Mn/N co-doped helical carbon nanotubes with ultrabroad EMWA *** calculation and EM simulation confirm that the orbital coupling and spin polarization of the Mn–N4–C configuration,along with cross polarization generated by the helical structure,endow the helical converters with enhanced EM *** a result,HMC-8 demonstrates outstanding EMWA performance,achieving a minimum reflection loss of−63.13 dB at an ultralow thickness of 1.29 *** precise tuning of the graphite domain size,HMC-7 achieves an effective absorption bandwidth(EAB)of 6.08 GHz at 2.02 mm ***,constructing macroscale gradient metamaterials enables an ultrabroadband EAB of 12.16 GHz at a thickness of only 5.00 mm,with the maximum radar cross section reduction value reaching 36.4 dB *** innovative approach not only advances the understanding of metal–nonmetal co-doping but also realizes broadband EMWA,thus contributing to the development of EMWA mechanisms and applications.

关键词： Metal-nonmetal co-doping 3d-2p orbital coupling Spin polarization Helical structure Broadband EM wave absorption

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Exploring practical methods for detecting k-nonseparability in multipartite quantum states

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 255-256页

作者： Shunlong luo Academy of Mathematics and Systems Science Chinese Academy of Sciences

Quantum entanglement, referred to as “spooky action at a distance” by Einstein, is not only an intriguing and fascinating feature of quantum theory challenging our classical intuitions about locality and correlations, but also has practical and profound implications for quantum technologies. Initially described by Einstein, Podolsky and Rosen, as well as by Schro¨dinger, entanglement now has become a basic and crucial ingredient for both foundational and experimental investigations of the quantum world.

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Tilting homeostatic and dyshomeostatic microglial balance in health and disease:transforming growth factor-beta1 as a critical protagonist

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Neural Regeneration Research 2025年第10期20卷 2895-2897页

作者： Nicolas Hugues Yu luo Department of Molecular and Cellular Biosciences University of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program University of CincinnatiCincinnatiOHUSA Division of Immunobiology Cincinnati Children’s Hospital Medical CenterUniversity of Cincinnati College of MedicineCincinnatiOHUSA

Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the *** the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).

关键词： Figure signature critical

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P2Y1 receptor in Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 440-453页

作者： Shan luo Yifei Wang Tatsuhiro Hisatsune Department of Integrated Biosciences The University of TokyoKashiwaJapan

Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated *** amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last ***,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic *** evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s *** receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s *** review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.

关键词： astrocytes neuroinflammation P2Y1 receptor purinergic receptor

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Effect of Nb-V microalloying on the hot deformation behavior of medium Mn steels

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 360-368页

作者： Yumeng Wang Qinyi Guo Bin Hu Haiwen luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

The influence of Nb-V microalloying on the hot deformation behavior and microstructures of medium Mn steel(MMS)was investigated by uniaxial hot compression *** establishing the constitutive equations for simulating the measured flow curves,we successfully constructed deformation activation energy(Q)maps and processing maps for identifying the region of flow *** concluded the following consequences of Nb-V alloying for MMS.(i)The critical strain increases and the increment diminishes with the increasing deformation temperature,suggesting that NbC precipitates more efficiently retard dynamic recrystallization(DRX)in MMS compared with solute Nb.(ii)The deformation activation energy of MMS is significantly increased and even higher than that of some reported high Mn steels,suggesting that its ability to retard DRX is greater than that of the high Mn content.(iii)The hot workability of MMS is improved by narrowing the hot processing window for the unstable flow stress,in which fine recrystallized and coarse unrecrystallized grains are present.

关键词： medium manganese steel niobium-vanadium microalloying flow behavior dynamic recrystallization hot workability

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