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Morphology-controlled growth of large-area PtSe_(2) films for enhanced hydrogen evolution reaction

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Rare Metals 2022年第4期41卷 1314-1322页

作者： Rui Hao qing-liang feng Xiao-Jian Wang Yi-Chen Zhang Kan-She Li College of Chemistry and Chemical Engineering Polymer Research InstituteXi’an University of Science and TechnologyXi’an 710054China Key Laboratory of Special Functional and Smart Polymer Materials of MIIT School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China

Transition metal dichalcogenides(TMDs)have emerged as a promising electrocatalyst for hydrogen evo-lution reaction(HER)due to its excellent conductivity and abundant electrocatalytic active sites of its *** nanowall can expose abundant of edges so that they tend to show better catalytic performance for hydrogen evolution ***,PtSe_(2) nanowall films with morphology controlled at centimeters level are synthesized by selenizing Pt *** dynamic and thermodynamics of selenation reaction are *** nanowall structure can be obtained by controlling the growth temperature,and the thickness of nanowall can be tuned by the original thickness of Pt *** Pt atoms can be rearranged into ordered distribution at 550℃ and can be induced to well-ordered PtSe_(2) nanowalls *** well-ordered PtSe_(2) nanowall films show excellent HER performance,with an overpotential of 0.3 V at-10 mA·cm^(-2) and a Tafel slope of~52 mV·dec^(-1).This work demonstrates the great potential of activated 2D PtSe_(2) as an ultrathin film catalyst for the HER,which is valuable to provide instruction and afford experience for further application at industrial level.

关键词： Large area PtSe2 Nanowall Morphology controlled HER

Progress in the basic and clinical research on the Schlemm’s canal

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 816-821页

作者： Le-Ying Wang Guan-Yu Su Zhen-Yu Wei Zi-Jun Zhang qing-feng liang Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual SciencesBeijing 100005China

Glaucoma is a leading cause of irreversible blindness in the *** pressure(IOP)plays a key role in glaucoma development and ***’s canal(SC),an important structure of the anterior chamber angle,regulates the flow of aqueous humor and maintains *** of its special function of aqueous outflow,the SC has been intensive investigated *** characteristics of SC in anatomy,physiology and pathophysiology have been *** to normal,glaucomatous SC cells are more sensitive to substrate stiffness,have higher stiffness and and lower porosity leading to higher outflow *** SC collapse caused by acute IOP increase is partially or totally *** advanced inspection techniques,high-quality images of the SC can be obtained in vivo,which facilitates SC quantitative measurements clinically and allows us to investigate a new therapy paradigm for *** this review,we summarize the basic and clinical research that focused on mechanisms of aqueous outflow resistance and SC changes in physiological,pathological,and posttreatment states.

关键词： Schlemm's canal physiology pathophysiology glaucoma progress

Systematic review and Meta-analysis comparing modified cross-linking and standard cross-linking for progressive keratoconus

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International Journal of Ophthalmology(English edition) 2017年第9期10卷 1419-1429页

作者： Yang Liu Yi Liu Ying-Nan Zhang Ai-Peng Li Jing Zhang qing-feng liang Ying Jie Zhi-Qiang Pan Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key LaboratoryBeijing 100005China Department of Ophthalmology First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical University Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing 100005China

AIM：To compare the effectiveness and safety between modified cross-linking（MC）and standard cross-linking（SC）in mild or moderate progressive ***：Eligible studies were retrieved from four electronic databases,including CENTRAL,Clinical Trials gov,Pup Med and OVID *** set post-surgical maximum K value（Kmax）as the primary *** addition,uncorrected and corrected distant visual acuity（UDVA and UDVA）,spherical equivalent（SE）,endothelial cell density（ECD）,central cornea thickness（CCT）and depth of demarcation line（DDL）were Meta-analyzed as secondary *** differences for these outcomes were pooled through either a random-effect model or fixed-effect model according to data ***：Twenty-four comparative studies either on accelerated cross-linking（AC）compared with SC or on transepithelial cross-linking（TC）compared with SC were included and pooled for *** results indicated that MC was significantly inferior to SC at delaying Kmax deterioration[AC vs SC 0.49（95%CI：0.04-0.94,I2=75%,P=0.03）;TC vs SC 1.15（95%CI：0.54-1.75,I2=50%,P=0.0002）].SE decreased significantly for SC when compared to AC[0.62（95%CI：0.38-0.86,I2=22%,P〈0.00001）].DDL of SC was more significantly deeper than that of TC[-133.49（95%CI：-145.94 to-121.04,I2=33%,P〈0.00001）].Other outcomes demonstrated comparable results between MC and ***：SC is more favorable at halting the progression of keratoconus,but visual acuity improvement showed comparable results between MCs and SC.

关键词： progressive keratoconus cross-linking standardcross-linking accelerated cross-linking trans-epithelial cross-linking Meta-analysis

Epidemiology of pterygium in aged rural population of Beijing, China

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Chinese Medical Journal 2010年第13期123卷 1699-1701页

作者： liang qing-feng XU liang JIN Xiu-ying YOU Qi-sheng YANG Xiao-hui and CUI Tong-tong Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing 100005 China

Background Pterygium is a common ophthalmic disease and an important public health problem. It may be affected by many factors such as age, gender, ultraviolet radiation exposure, and time spent outdoors. This study aimed to investigate the prevalence of pterygium and evaluate the risk factors for the development of pterygium in the aged rural population of Beijing. Methods The investigation is a population-based cross-sectional study. Participants from 198 villages of 13 suburban districts, aged 55-85 years old, were invited to complete a medical record, and 37 067 individuals were taken external ocular and fundus photos at Beijing ocular disease survey in 2008-2009. The information was uploaded by Internet and diagnosed with stages and grades by ophthalmological specialists. The prevalence, stages and grades of pterygia were observed. Results Of the 37 067 individuals, 1395 （3.76%） had pterygium. There was a significantly higher prevalence in male （5.13%） than in female （3.17%, P=0.000）. The prevelence rate increased obviously with ages （X2=7.939, P=0.019） in rural Beijing. The average prevalence of 5.91% in Daxing and Fangshan districts with low latitude and low precipitation was significantly higher than that in Miyun and Huairou districts with high latitude and deep precipitation （3.17%, P=-0.000）. The majority of the pterygia （43.5%） were in active stage and 46.5% pterygia involved pupil area corneas. Conclusions There is a statistically significant association between latitude and precipitation of habitation region and pterygium formation. Solar radiation, especially ultraviolet exposure represents a significant environment hazard to pterygium development.

关键词： pterygium prevalence Beijing, peasant

Current Research of Chlamydial Infection Diseases in China

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Chinese Medical Journal 2018年第4期131卷 486-489页

作者： Xue Li qing-feng liang Guan-Yu Su Li-Yuan Wu Xin-Xin Lu Ning-LiWang Department of Laboratory Medicine Beijing Tongren Hospital Capital Medical University Beijing 100730 China Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Key Laboratory of Ophthalmology and Visual Sciences Beijing 100005 China

To the Editor： Cblam.~zti^t organisms belong to intracellular bacterial pathogens which are responsible for a range of human diseases, including trachoma, sexually transmitted disease, pneumonia, and other diseases. Some Chlamydia-infected diseases were old and had long time impacted on the people＇s health in China and worldwide, but people cannot put enough emphasis on it in local areas.

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Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： qing Qiu Mengting Yang Danfeng Gong Haiying liang Tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

Exploration of action mechanisms of Resina Draconis(Daemonorops draco Bl.)against pain by network pharmacology and molecular docking analysis

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TMR Pharmacology Research 2022年第3期2卷 21-30页

作者： Wen-Jie Lai Chu-Yun Zhao Shu-Zhen Lin Hui Peng Si-Ni Chen qing-feng liang Shu-Mei Wang Dan Tang School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhou 510006China School of Traditional Chinese Medicine Guangdong Pharmaceutical UniversityGuangzhou 510006China Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM and Engineering Technology Research Center for Chinese Materia Medica Quality of Guangdong Province Guangdong Pharmaceutical UniversityGuangzhou 510006China

Background:Resina Draconis is a traditional Chinese medicine mainly used to treat ***,the pharmacological mechanisms and chemical composition of Resina Draconis are not clear ***:In this study,based on the 21 main active components of Resina Draconis previously analyzed by our group,the potential action targets of the active components were predicted and screened out by using the databases such as Swiss Target Prediction and *** genes corresponding to the related targets were retrieved by UniProt and GeneCards,and then the"component-target"network model was established using Cytoscape 3.9.1 *** protein-protein interaction network was constructed by using STRING database for *** STRING database was used for enrichment analysis of gene ontology and Kyoto Encyclopedia of Genes and Genome pathways to explore the underlying action ***:A total of 21 main analgesic active components of Resina Draconis and 77 intersecting targets of Resina Draconis and pain were screened *** network analysis indicated that such targets as albumin(ALB),tumor necrosis factor(TNF),RAC-alpha serine/threonine-protein kinase 1(AKT1)and epidermal growth factor receptor(EGFR)might be the core targets of *** gene ontology enrichment analysis,a total of 169 gene ontology entries were obtained(P<0.01),including 111 biological processes,31 molecular functions and 27 cellular *** enrichment analysis of KEGG pathways,a total of 112(P<0.01)signaling pathways were ***:Dracaenogenins A,Resveratrol and 7,4′-dihydroxyflavone in Resina Draconis may be the main material basis for analgesia,which can interact with multiple targets such as AlB,AKT1,TNF,and EGFR,and exerts analgesic effect through signaling pathways such as mitogen-activated protein kinase(MAPK)signaling pathway,PI3K-Akt signaling pathway,and Rap1 signaling pathway.

关键词： Resina Draconis pain network pharmacology molecular docking

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惯性力本质探讨

辽宁师专学报（自然科学版） 2019年第1期21卷 4-6,87页

作者：冯清亮广州地铁集团有限公司监审部

惯性力来源何方,至今仍是一个谜.通过分析地球引力、自由落体运动及惯性力三者的关系后,认为地球引力场与物体发生能量传输,其能量传输强度以力和加速度两种方式体现,二者随物体的加速运动状态此消彼长.当外力试图改变物体的加速运动状... 详细信息

惯性力来源何方,至今仍是一个谜.通过分析地球引力、自由落体运动及惯性力三者的关系后,认为地球引力场与物体发生能量传输,其能量传输强度以力和加速度两种方式体现,二者随物体的加速运动状态此消彼长.当外力试图改变物体的加速运动状态时,必定遭到来自引力场的抵抗,此抵抗力既是引力,也是惯性力,只是二者起算点不同.惯性力、引力本质上都是引力场抵抗变化的结果.

关键词：惯性惯性力惯性力本质惯性质量引力

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职校生品德不良的原因及教育对策

河南职业技术师范学院学报（职业教育版） 2005年第1期 68-71页

作者：冯清亮新郑市中等专业学校，河南新郑451100

职业学校的品德不良学生,是指经常违反社会公德行为规范,或犯有较严重道德过错的学生.学生品德不良往往是在某种客观条件的影响下逐渐形成的.本文具体分析了职校生不良品德形成的主观原因和客观原因,进而论述了职业学校矫正学生品德不... 详细信息

职业学校的品德不良学生,是指经常违反社会公德行为规范,或犯有较严重道德过错的学生.学生品德不良往往是在某种客观条件的影响下逐渐形成的.本文具体分析了职校生不良品德形成的主观原因和客观原因,进而论述了职业学校矫正学生品德不良的教育对策.

关键词：职校生品德不良家庭教育社会影响学校教育道德情境意志锻炼