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Sleep Deprivation Selectively Down-Regulates Astrocytic 5-HT2B Receptors and Triggers Depressive-like Behaviors via Stimulating P2X7 Receptors in Mice

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Neuroscience Bulletin 2020年第11期36卷 1259-1270页

作者： Maosheng Xia Zexiong li Shuai li Shanshan liang Xiaowei li Beina Chen Manman Zhang Chengyi dong Alexei Verkhratsky Dawei Guan Baoman li Practical Teaching Centre School of Forensic MedicineChina Medical UniversityShenyang 110122China Department of Orthopaedics The First HospitalChina Medical UniversityShenyang 110001China Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUK Department of Forensic Pathology School of Forensic MedicineChina Medical UniversityShenyang 110122China Department of Poison Analysis School of Forensic MedicineChina Medical UniversityShenyang 110122China

Chronic loss of sleep damages health and disturbs the quality of ***-lasting sleep deprivation(SD)as well as sleep abnormalities are substantial risk factors for major depressive disorder,although the underlying mechanisms are not ***,we showed that chronic SD in mice promotes a gradual elevation of extracellular ATP,which activates astroglial P2X7 receptors(P2X7Rs).Activated P2X7Rs,in turn,selectively down-regulated the expression of 5-HT2B receptors(5-HT2BRs)in *** of P2X7Rs induced by SD selectively suppressed the phosphorylation of AKT and FoxO3 a in astrocytes,but not in *** overexpression of FoxO3a in astrocytes inhibited the expression of ***-regulation of 5-HT2BsRs instigated by SD suppressed the activation of STAT3 and relieved the inhibition of Ca2+-dependent phospholipase *** latter cascade promoted the release of arachidonic acid and prostaglandin *** depression-like behaviors induced by SD were alleviated in P2X7R-KO *** study reveals the mechanism underlying chronic SD-induced depression-like behaviors and suggests 5-HT2BRs as a key target for exploring therapeutic strategies aimed at the depression evoked by sleep disorders.

关键词： Astrocyte Sleep deprivation P2X7 receptor 5-HT2B receptor FoxO3a

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Pressureless reactive sintering mechanism of nanocrystalline Bi_2O_3-Y_2O_3 solid electrolyte

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Journal of University of Science and Technology Beijing 2006年第1期13卷 87-91页

作者： Qiang Zhen liangyan dong Gang Shi Rong li Weiming He Jianqiang liu Nano-science and Nano-technology Research Center School of Materials Science and Engineering Shanghai University Shanghai 200444 China Railway Worker College of Qiqihar Qiqihar 161002 China School of Materials Science and Engineering Shanghai University Shanghai 200072 China

The nanocrystalline Bi2O3-Y2O3 solid electrolyte material was synthesized by pressureless reactive sintering process with Bi2O3 and Y2O3 nano mixed powder as raw materials, which was prepared by a chemical coprecipitation process. The study on the behavior of nano δ-Bi2O3 formation and its grain growth showed that the solid solution reaction of Y2O3 and δ-Bi2O3 to form δ-Bi2O3 occurs mainly in the initial stage of sintering process, and nano δ-Bi2O3 crystal grains grow approximately following the rule of paracurve （（D-D0）^2=K.t） during sintering process. After sintered at 600℃ for 2 h, the samples could reach above 96% in relative density and have dense microstructure with few remaining pores, the δ-Bi2O3 grains are less than 100 nm in size.

关键词： nanocrystalline bismuth oxide-yttrium oxide solid electrolyte pressureless reactive sintering process crystal grain growth phase transformation

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Vapor growth of V‑doped MoS_(2)monolayers with enhanced B‑exciton emission and broad spectral response

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Frontiers of Optoelectronics 2023年第4期16卷 109-120页

作者： Biyuan Zheng Xingxia Sun Weihao Zheng Chenguang Zhu Chao Ma Anlian Pan dong li Shengman li Key Laboratory for Micro-Nano Physics and Technology of Hunan Province State Key Laboratory of Chemo/Biosensing and ChemometricsHunan Institute of Optoelectronic IntegrationCollege of Materials Science and EngineeringHunan UniversityChangsha 410082China College of Advanced Interdisciplinary Studies and Hunan Provincial Key Laboratory of Novel Nano Optoelectronic Information Materials and Devices National University of Defense TechnologyChangsha 410073China Wuhan National Laboratory for Optoelectronics(WNLO) Huazhong University of Science and Technology(HUST)Wuhan 430074China

Dynamically engineering the optical and electrical properties in two-dimensional(2D)materials is of great signifcance for designing the related functions and *** introduction of foreign-atoms has previously been proven to be a feasible way to tune the band structure and related properties of 3D materials;however,this approach still remains to be explored in 2D ***,we systematically demonstrate the growth of vanadium-doped molybdenum disulfde(V-doped MoS_(2))monolayers via an alkali metal-assisted chemical vapor deposition *** transmission electron microscopy demonstrated that V atoms substituted the Mo atoms and became uniformly distributed in the MoS_(2)*** was also confrmed by Raman and X-ray photoelectron ***-dependent photoluminescence spectra clearly revealed the enhanced B-exciton emission characteristics in the V-doped MoS_(2)monolayers(with low doping concentration).Most importantly,through temperature-dependent study,we observed efcient valley scattering of the B-exciton,greatly enhancing its emission *** transport experiments indicated that typical p-type conduction gradually arisen and was enhanced with increasing V composition in the V-doped MoS_(2),where a clear n-type behavior transited frst to ambipolar and then to lightly p-type charge carrier *** addition,visible to infrared wide-band photodetectors based on V-doped MoS_(2)monolayers(with low doping concentration)were *** V-doped MoS_(2)monolayers with distinct B-exciton emission,enhanced p-type conduction and broad spectral response can provide new platforms for probing new physics and ofer novel materials for optoelectronic applications.

关键词： Atomic substitution.V-doped MoS_(2) Distinct B-exciton Broad spectral response

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Wavelet analysis of spring climate characteristics in arid aeolian area of agro-pastoral ecotone in China

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Water Science and Engineering 2012年第3期5卷 269-277页

作者： Chun-xia ZOU Xiang-dong SHEN Hong-yun li Xia-zi li Zhang-jun li College of Water Conservancy and Civil Engineering Inner Mongolia Agricultural University Hohhot 010018 P. R. China College of Ecology and Environmental Science Inner Mongolia Agricultural University Hohhot 010018 P. R. China Inner Mongolia Weather Bureau Hohhot 010051 P. R. China

The unique regional climate characteristics are among the main reasons for the frequent wind-sand activity in arid and cold areas in the agro-pastoral ecotone in Inner Mongolia, China. This paper focuses on the time series of temperature and precipitation in spring when sandstorms often occur in the area. Based on meteorological data for a 46-year period from 1959 to 2004, multi-scale variations and abrupt changes in temperature and precipitation were analyzed with the Mexican hat function （MHF） wavelet method, showing the multi-scale variation characteristics of temperature and precipitation, as well as the periods and change points at different time scales. The relationship between temperature and precipitation was obtained using the wavelet analysis method. Obvious staggered features of the variations of spring temperature and precipitation were observed in this agro-pastoral ecotone. The strongest oscillation periods of spring temperature variations were 1 and 22 years, while for precipitation, the strongest oscillation periods of variations were 2, 8, and 22 years. In addition, lower spring temperature corresponded to lower precipitation, whereas higher temperature yielded higher precipitation rate.

关键词： spring temperature spring precipitation climate characteristics MHF waveletmethod," arid aeolian area," agro-pastoral ecotone

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Influence of cooling rate on phase transformation and precipitation behavior of Ti-bearing steel in continuous cooling process

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Journal of Iron and Steel Research International 2022年第1期29卷 165-174页

作者： Xiao-lin li Chi Jin Hao-zhe li Xiao-xiao Hao Yi He Xiang-tao Deng Zhao-dong Wang State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi’an 710072ShaanxiChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina

The influence of cooling rate on microstructural evolution and precipitation behavior in Ti,Ti–Nb and Ti-Mo low-carbon steels during the continuous cooling process was studied by dilatometer method,optical microscopy,and transmission electron *** results indicated that austenite transformation temperature decreased with the increasing cooling rate in three *** addition of Nb and Mo promoted bainite and martensite transformation and improved the hardenability of *** addition,precipitates formed in deformed austenite and ferrite can be observed *** in the austenite non-recrystallization zone can introduce a large number of deformation bands,and then,the precipitates preferentially nucleated in these deformation *** the following process,randomly distributed precipitates and interphase precipitates will be formed in *** precipitates formed in deformed austenite obey Kurdjumov-Sachs orientation relationship with the matrix,while the precipitates formed in ferrite obey Baker-Nutting orientation relationship with the *** addition of Nb and Mo in Ti-bearing steels decreased the precipitates size and increased the number density of precipitates and then improved the precipitation *** the effect of Mo addition is more obvious than that of Nb addition.

关键词： Ti-microalloyed steel Continuous cooling transformation Precipitation behavior Precipitate-free zone Orientation relationship

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Neutral excitation and bulk gap of fractional quantum Hall liquids in disk geometry

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Chinese Physics B 2019年第6期28卷 20-26页

作者： Wu-qing Yang Qi li lin-Peng Yang Zi-Xiang Hu Department of Physics Chongqing UniversityChongqing 401331China Department of Physics South University of Science and Technology of ChinaShenzhen 518055China School of Physics and Technology Wuhan UniversityWuhan 430072China

For the numerical simulation of the fractional quantum Hall(FQH) effects on a finite disk, the rotational symmetry is the only symmetry that is used in diagonalizing the Hamiltonian. In this work, we propose a method of using the weak translational symmetry for the center of mass of the many-body system. With this approach, the bulk properties, such as the energy gap and the magneto-roton excitation are consistent with those in the closed manifolds like the sphere and torus. As an application, we consider the FQH phase and its phase transition in the fast rotated dipolar fermions. We thus demonstrate the disk geometry having versatility in analyzing the bulk properties beside the usual edge physics.

关键词： fractional quantum Hall bulk states edge states magneto-roton dipolar–dipolar interaction

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AN AMPEROMETRIC BIOSENSOR BASED ON COVALENT IMMOBIliZATION OF ASCORBATE OXIDASE ON BIOCOMPATIABLE AND LOW-TOXIC POLY(THIOPHENE-3-ACETIC ACID) MATRIX

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Chinese Journal of Polymer Science 2012年第5期30卷 705-718页

作者： dong li Yang-ping Wen 徐景坤贺浩华 Ming liu Jiangxi Key Laboratory of Organic Chemistry Jiangxi Science and Technology Normal University Key Laboratory of Crop Physiology Ecology and Genetic BreedingMinistry of EducationKey Laboratory of PhysiologyEcology and Cultivation of Double Cropping RiceMinistry of AgricultureJiangxi Agricultural University

The biocompatiable and low-toxic poly（thiophene-3-aeetic acid）（PTAA） matrix was successfully electrosynthesized in ionic liquid 1-butyl-3-metbylimidazolium hexafluorophosphate （BmimPF6） in comparison with the electrosynthesis of PTAA matrix in acetonitrile （ACN）. Ascorbate oxidase （AO） was used as a model for the development and application of biosensor. Vitamin C （VC） biosensors were facilely fabricated by the covalent immobilization of AO molecules on PTAA matrices electrosynthesized in ACN containing tetrabutylammonium tetrafluoroborate and BmimPF6, respectively. Electrochemical impedance spectroscopy, scanning electron microscopy and FTIR spectroscopy indicated that AO molecules were covalently immobilized on PTAA matrices. Parameters of the as-obtained biosensors such as working potential, pH and temperature have been optimized. The amperometric biosensor based on PTAA matrix electrosynthesized in BmimPF6 exhibited wider linear range, lower detection limit, higher sensitivity and bioaffinity, and better operational and storage stability than that electrosynthesized in ACN under optimal conditions. The as-obtained biosensor based on PTAA matrix electrosynthesized in BmimPF6 was employed for the detection of VC content in comme：rcial juices, and the result was close to the data given by manufacturers. Excellent results indicate that the PTAA matrix electrosynthesized in ionic liquid is a promising platform for the covalent immobilization of biologically-active species and the development of biosensors.

关键词： Poly(thiophene-3-acetic acid) Ionic liquids Ascorbate oxidase Vitamin C Biosensor.

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Are There Magnetars in High-mass X-Ray Binaries?

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Research in Astronomy and Astrophysics 2022年第1期22卷 46-59页

作者： Kun Xu Xiang-dong li Zhe Cui Qiao-Chu li Yong Shao Xilong liang Jifeng liu School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Department of Astronomy Nanjing UniversityNanjing 210023China Key Laboratory of Modem Astronomy and Astrophysics Nanjing UniversityMinistry of EducationNanjing 210023China WHU-NAOC Joint Center for Astronomy Wuhan UniversityWuhanChina

Magnetars form a special population of neutron stars with strong magnetic fields and long spin periods. About 30 magnetars and magnetar candidates known currently are probably isolated, but the possibility that magnetars are in binaries has not been excluded. In this work, we perform spin evolution of neutron stars with different magnetic fields in wind-fed high-mass X-ray binaries and compare the spin period distribution with observations, aiming to find magnetars in binaries. Our simulation shows that some of the neutron stars, which have long spin periods or are in widely-separated systems, need strong magnetic fields to explain their spin evolution. This implies that there are probably magnetars in high-mass X-ray binaries. Moreover, this can further provide a theoretical basis for some unclear astronomical phenomena, such as the possible origin of periodic fast radio bursts from magnetars in binary systems.

关键词： stars:magnetars stars:neutron stars:rotation (stars:)supergiants accretion accretion disks X-rays:binaries

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Synthesis of N-TiO2@NH2-M IL-88(Fe)Core-shell Structure for Efficient Fenton Effect Assisted Methylene Blue Degradation Under Visible light

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Chemical Research in Chinese Universities 2020年第6期36卷 1068-1075页

作者： YUAN Huiting REN Huizhen li Minning li Zetong liU Mingrui dong Wenjun WANG Ge ZHUANG Tao Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory of Function Materials for Molecule&Structure ConstructionSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083P.R.China

Core-shell TiO2-based photocatalysts with specific composition,morphology,and functionality have attracted considerable attention for their excellent degradation properties on organic pollutants via a photocatalytic oxidation ***,a N-TiO2@NH2-MIL-88(Fe)core-shell structure was prepared by coating NH2-MIL-88(Fe)on nitrogen-doped TiO2(N-TiO2)*** of heteroatom nitrogen to pure TiOz expands the spectra response range,leading to enhanced quantum efficiency of *** NH2-MIL-88(Fe)or N-TiOz improved the adsorption ability of the nanocomposites due to the porous tunnels of NH2-MIL-88(Fe).The resulted core-shell N-TiO2@NH2-MIL-88(Fe)nanocomposites realized the transfer of photo excited electrons from N-TiOz to NH2-MIL-88(Fe)rapidly,partially reduced Fe to Fe^2+in NH^2+MIL-88(Fe),and further enhanced the Fenton effect on efficiently degrading methylene blue dye(MB)under visible light(>420 nm)with the assistance of H2O2.

关键词： NH2-MIL-88(Fe) N-TiO2 Photocatalysis Fenton effect

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***:a probabilistic voting-based enhancer-promoter interaction prediction platform

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Journal of Genetics and Genomics 2023年第7期50卷 519-527页

作者： Yuyang Zhang Haoyu Wang Jing liu Junlin li qing Zhang Bixia Tang Zhihua Zhang CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciencesand China National Center for BioinformationBeijing 100101China College of life Sciences University of Chinese Academy of SciencesBeijing 100049China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China

Enhancer promoter interaction(EPI)involves most of gene transcriptional regulation in the high *** the EPIs from given genomic loci or DNA sequences is not a trivial *** benchmarking work so far for EPI predictors is more or less empirical and lacks quantitative model-based comparisons,posing challenges for molecular biologists to obtain reliable EPI ***,we present an EPI prediction platform,namely *** on a statistic model of the data integration,*** is capable of comprehensively assessing the predictions from four state-of-the-art EPI *** with a userfriendly interface and visualization platform,*** presents the sorted results with the confidence of EPI relevance,which may guide the molecular biologists who lack the pre-knowledge of the algorithms of EPI ***,we showcase the utility of *** with a case *** provides a powerful tool to fuel the gene regulation and 3D genome studies by ease-to-access EPI *** can be freely accessed at https://***/deltaEPI/.

关键词： Enhancer-promoter interaction Hi-C Prediction Benchmark Web server

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