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Comparison of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein cholesterol for the prediction of thin-cap fibroatheroma determined by intravascular optical coherence tomography

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Journal of Geriatric Cardiology 2020年第11期17卷 666-673页

作者： Yao WANG Si-Si ZHANG qing-bo lv Ya LI Jin ZHAO Jia HAN Guo-Sheng FU Wen-Bin ZHANG Department of Cardiology Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang ProvinceSir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouChina Department of Infection Control Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouChina

Background The correlation among the ratios of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol(LDL-C/HDL-C), total cholesterol/high-density lipoprotein cholesterol(TC/HDL-C) and thin-cap fibroatheroma has not yet been established. Methods It was a single center, retrospective observational study. In total, we recruited 421 patients(82.4% men;mean age 65.73 ± 10.44 years) with one culprit vessel which determined by intravascular optical coherence tomography(OCT). The thinnest-capped fibroatheroma(TCFA) group was defined as lipid contents in > 2 quadrants, with the thinnest fibrous cap measuring less than 65 μm. Univariate and multivariate logistic regression were carried out to explore the relationship between lipoprotein ratios, TCFA and other characteristics of plaque. To compare different ratios, the area under curve(AUC) of receiver-operating characteristic(ROC) curve was assessed. Results OCT was performed in 421 patients(TCFA group(n = 109), non-TCFA group(n = 312)). LDL-C/HDL-C in the TCFA group was significantly higher than in the non-TCFA group(2.95 ± 1.20 vs. 2.43 ± 0.92, P both LDL-C/HDL-C(OR: 1.002(1.002-1.003), P < 0.05) and TC/HDL-C(OR: 1.001(1.001-1.004), P < 0.05) were considered independent factors for the prediction of TCFA according to the logistic regression. Based on the AUC comparison, LDL-C/HDL-C and TC/HDL-C had no significant difference statistically(LDL-C/HDL-C AUC: 0.63;TC/HDL-C AUC: 0.61;P = 0.10) for the prediction of TCFA. Conclusions LDL-C/HDL-C and TC/HDL-C could be the independent factors for predicting the presence of TCFA, indicating coronary plaque vulnerability in CAD patients. Moreover, TC/HDL-C also showed a comparative performance for the prediction of TCFA as LDL-C/HDL-C.

关键词： Lipoproteins Optical coherence tomography Total cholesterol

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Effects of bilirubin on perioperative myocardial infarction and its long-term prognosis in patients undergoing percutaneous coronary intervention

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World Journal of Clinical Cases 2022年第6期10卷 1775-1786页

作者： Ya Li Duan-Bin Li Li-Ding Zhao qing-bo lv Yao Wang Ya-Fei Ren Wen-Bin Zhang Department of Cardiovascular Diseases Sir Run Run Shaw HospitalCollege of Medicine of Zhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Department of Rehabilitation Medicine Qilu Institute of TechnologyJinan 250200Shandong ProvinceChina

BACKGROUND Although bilirubin is known to be an antioxidant,any relationship with coronary heart disease remains *** the best of our knowledge,no previous study has investigated the association between bilirubin and perioperative myocardial infarction(PMI),including its long-term *** To investigate the impact of bilirubin levels on PMI in patients undergoing percutaneous coronary intervention(PCI),and long-term prognosis in post-PMI *** Between January 2014 and September 2018,10236 patients undergoing elective PCI were enrolled in the present *** bilirubin(TB)and cardiac troponin I(cTnI)levels were measured prior to PCI and cTnI at further time-points,8,16 and 24 h after *** were stratified by pre-PCI TB levels and divided into three groups:14.4μmol/*** was defined as producing a post-procedural cTnI level of>5×upper limit of normal(ULN)with normal baseline *** adverse cardiovascular events(MACEs)included cardiac death,MI,stroke and revascularization during a maximum 5-year *** PMI was detected in 526(15.3%),431(12.7%)and 424(12.5%)of patients with pre-PCI TB levels of14.4μmol/L(P=0.001),*** logistical analysis indicated that patients with TB 10.2-14.4 and>14.4μmol/L had a lower incidence of PMI[TB 10.2-14.4μmol/L:Odds ratio(OR):0.854;95%confidence interval(CI):0.739-0.987;P=0.032;TB>14.4μmol/L:OR:0.846;95%CI:0.735-0.975;P=0.021]compared with patients with TB14.4μmol/L was associated with a reduced risk of MACEs compared with a TB level<10.2μmol/L(hazard ratio 0.667;95%CI:0.485-0.918;P=0.013).CONCLUSION Bilirubin was a protective f

关键词： Bilirubin Perioperative myocardial infarction Percutaneous coronary intervention Major adverse cardiovascular events Coronary heart disease Retrospective cohort study

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Laser direct writing of flexible multifunctional airflow sensors on the Kevlar fabric

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Nano Research 2025年第1期18卷 443-454页

作者： Wei Wang Zi-qing Chen Yong-Qi Li Yu-Long Wang Mei-Chen Liu Yun-bo Ruan Yang Zhang Shu-Juan Liu Qiang Zhao College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China State Key Laboratory of Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Zhe Jiang Topsun Logistic Control CO. LTD.Yuhuan 317600China Department of Rehabilitation Medicine School of Acupuncture-Moxibustion and Tuina and School of Health Preservation and RehabilitationNanjing University of Chinese MedicineNanjing 210023China

The growing interest in flexible devices has emerged as a global trend due to their advantages in flexibility,lightweight structure,and wearability,addressing the limitations of traditional *** wearable airflow sensors have been previously reported,the development of flexible fabric-based airflow sensors capable of functioning in environments with open flames—critical for fire rescue operations—has yet to be explored,largely due to the poor fire resistance of conventional *** this work,we first present a flexible,wearable,and multifunctional airflow sensor with excellent fire-resistant properties,fabricated through a simple direct laser writing *** sensor maintains airflow detection capabilities even in the presence of open ***,the fabrication of fabric-based sensors involves complex procedures such as carbon materials doping or vapor-phase deposition,leading to lengthy preparation cycles and high ***,fabric-based devices are inherently prone to *** address these challenges,we introduce twice-vertical laser-induced graphene(TVLIG)as a sensitive and reliable component for fire-resistant airflow *** resulting TVLIG/Kevlar fabric can be integrated into various garments,particularly protective suits,to form sensitive and fire-resistant airflow sensors capable of detecting airflow velocity and direction in both two-dimensional(2D)and three-dimensional(3D)spaces during fire ***,the TVLIG patterns can be expanded to multifunctional platforms,such as glucose detection for injured individuals,offering further applications in rescue *** functional expansion reduces the burden on rescue personnel and streamlines device *** its outstanding sensing capabilities,fire resistance,and expandability,the developed flexible airflow sensor shows great potential for various real-world rescue scenarios,promising advancements in wearable sensing technology for rescue enginee

关键词： flexible airflow sensor direct laser writing twice-vertical laser-induced graphene fire accident rescue Kevlar fabric

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Dimesitylborylphenyl substituted 1,3,4-oxadiazole:Synthesis,characterization and sensitivity to F^-

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Chinese Chemical Letters 2011年第5期22卷 599-602页

作者： Xiang Hong Li bo Xu, Kang Le lv Ai qing Zhang College of Chemistry and Materials South-Central University for Nationalities Wuhan 430074 China

A new 1,3,4-oxadiazole compound with a dimesitylboryl group was synthesized and characterized by ~1H NMR,MS,element analysis and X-ray single-crystal *** exhibits good blue emission at 425 nm and high sensitivity to f... 详细信息

关键词： 1 3.4-Oxadiazole Dimesitylboryl Fluoride anion Chemo-sensor

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Non-commutative Arithmetics on Thompson's Monoid

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Acta Mathematica Sinica,English Series 2021年第10期37卷 1586-1626页

作者： bo qing XUE Institute of Mathematical Sciences ShanghaiTech UniversityShanghai 201210P.R.China

The main purpose of this paper is to define prime and introduce non-commutative arithmetics based on Thompson's group *** primes in a non-abelian monoid is highly non-trivial,which relies on a concept called"castling".Three types of castlings are essential to grasp the *** divisor functionτon Thompson's monoid S satisfiesτ(uv)≤τ(u)τ(v)for any u,v∈*** the limitτ_(0)(u)=lim_(n→∞)(τ(u~n))^(1/n)*** quantityC(S)=sup_(1≠u∈S)τ_(0)(u)/τ(u)describes the complexity for castlings in *** show thatC(S)=***,the MCbius function on S is *** the Liouville functionCon S is studied.

关键词： Thompson's group non-commutative arithmetics castling complexity divisor function M?bius function

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电刺激诱导miR-741-3p调控Radil促进施万细胞的迁移

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中国组织工程研究 2025年第19期29卷 4038-4043页

作者：刘庆高博杨霄姜宇王培承德医学院附属医院河北省承德市067000 承德医学院河北省承德市067000

背景:越来越多的动物实验和临床研究证实电刺激可以促进周围神经损伤修复,具体的机制尚未完全明确。目的:探讨电刺激诱导miR-741-3p调控Radil对施万细胞迁移的影响。方法:①12只雄性SD大鼠,随机分为电刺激组和对照组,电刺激组在坐骨神... 详细信息

背景:越来越多的动物实验和临床研究证实电刺激可以促进周围神经损伤修复,具体的机制尚未完全明确。目的:探讨电刺激诱导miR-741-3p调控Radil对施万细胞迁移的影响。方法:①12只雄性SD大鼠,随机分为电刺激组和对照组,电刺激组在坐骨神经挤压伤后连续电刺激7 d,对照组在坐骨神经挤压后不做任何处理。术后第7天取损伤处神经,利用荧光原位杂交技术检测两组miR-741-3p的表达差异。②通过miRDB、TargetScan和miRWalk数据库预测miR-741-3p靶基因。③将miR-741-3p模拟物及其对照、miR-741-3p抑制物及其对照、Radil siRNA及其对照、miR-741-3p抑制物+Radil siRNA及miR-741-3p抑制物+siRNA对照对施万细胞进行转染,采用RT-PCR检测转染效率,Transwell小室检测施万细胞的迁移能力。结果与结论:①电刺激组神经残端miR-741-3p荧光强度低于对照组;②数据库预测结果显示有69个基因可能是miR-741-3p靶基因,Radil是预测靶基因之一,主要参与细胞黏附和迁移;③与miR-741-3p抑制物对照组相比,miR-741-3p抑制物组施万细胞迁移数增多(P<0.05);与miR-741-3p模拟物对照组相比,miR-741-3p模拟物组施万细胞迁移数减少(P<0.05);与siRNA对照组相比,Radil siRNA组施万细胞迁移数减少(P<0.05);④与miR-741-3p抑制物对照组相比,miR-741-3p抑制物组Radil的表达水平升高;与miR-741-3p模拟物对照组相比,miR-741-3p模拟物组Radil的表达水平降低;⑤与miR-741-3p抑制物+siRNA对照组相比,miR-741-3p抑制物+Radil siRNA组施万细胞迁移数减少(P<0.05)。结果表明,电刺激通过下调miR-741-3p调控Radi的表达来促进施万细胞迁移。

关键词：施万细胞电刺激 miR-741-3p Radil 细胞迁移神经再生

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Application of the concept of continuous dopaminergic stimulation for the management of Parkinson's disease

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Neuroscience Bulletin 2013年第5期29卷 661-669页

作者： qing lv Baorong Zhang Department of Neurology Second Affiliated Hospital School of Medicine Zhejiang University

Continuous dopaminergic stimulation（CDS）is a prominent therapeutic concept for the treatment of Parkinson＇s disease（PD）,which proposes that continuous brain dopamine-receptor stimulation,rather than intermittent doses of oral L-dopa,prevents or manages L-dopa-induced dyskinesias（LIDs）.In the normal situation,dopaminergic neurons in the substantia nigra pars compacta fire tonically to keep the dopamine receptor stimulation at a steady-state *** when the dopaminergic pathway is impaired,the dopamine receptor stimulation becomes intermittent or *** pulsatile stimulation causes a series of gene and protein changes in striatal neurons,leading to alterations in the firing patterns of basal ganglia neurons that result in *** in animal models and clinical trials of PD have shown that approaches providing CDS,currently including patches,extended-release formulations of L-dopa or dopamine agonists,continuous delivery of apomorphine and duodenal L-dopa infusion,are associated with a decreased risk of *** this review,we summarize both preclinical and clinical evidence for the five methods that may provide CDS in theory and compare the advantages and disadvantages of these methods.

关键词： continuous dopaminergic stimulation application Parkinson's disease L-dopa-induced dyskinesias

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Time Decay Rates of the Isotropic Non-Newtonian Flows in R^n

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Acta Mathematicae Applicatae Sinica 2007年第1期23卷 99-106页

作者： bo-qing Dong School of Mathematical Sciences Nankai University Tianjin 300071 China

This paper is concerned with time decay rates for weak solutions to a class system of isotropic incompressible non-Newtonian fluid motion in R^n. With the use of the spectral decomposition methods of Stokes operator, the optimal decay estimates of weak solutions in L^2 norm are derived under the different conditions on the initial velocity. Moreover, the error estimates of the difference between non-Newtonian flow and Navier-Stokes flow are also investigated.

关键词： L^2 decay spectral decomposition non-Newtonian flows

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On a Certain Sum-product Estimate in Fields of Prime Order

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Acta Mathematica Sinica,English Series 2014年第11期30卷 1861-1866页

作者： bo qing XUE Academy of Mathematics and Systems Science Chinese Academy of Sciences

Let Fp be the finite field of p elements with p *** A is a subset of Fp and g is an element of F＊p with order ν,then max{｜A ＋ g·A｜,｜A·A｜} （ν/（ν ＋｜A｜2））1/12｜A｜13/12.

关键词： Sum-product estimate different sets fields of prime order

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Numerical Study on Local Flow and Heat Transfer Characteristics of Supercritical CO_(2) in PCHE with Sinusoidal Channels

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Journal of Thermal Science 2024年第1期33卷 41-55页

作者： WENZhexi lv Yigao LI qing WU Jinglin School of Energy Science and Engineering Central South UniversityChangsha 410083China

Local heat transfer and flow characteristics,which is crucial to the overall performance of supercritical CO_(2) recuperators,is rarely examined in details in reported *** this paper,the local heat transfer and flow characteristics of supercritical CO_(2) in sinusoidal channel printed circuit heat exchangers are numerically investigated under the working conditions of *** on the simplified physical model constituted by10 pitches,the variations of Re,heat flux,Nu,secondary flow and other relevant parameters along the flow direction are analyzed *** is further made between the high and low temperature recuperators(HTR and LTR).It's observed that the local heat transfer and flow characteristics vary greatly from the inlet to the outlet,especially in the *** of 127.5% and 61.7% can be observed on the cold side of the LTR for Re and heat transfer coefficient h, *** indicate that the temperature difference and heat transfer coefficient h should not be regarded as constant and the distribution of h should be carefully considered in the design of the *** complicated interactions among the varying thermophysical properties,buoyancy and the periodically changed centrifugal force are believed to be the key that shapes the flow ***,the changes of the wavy angle θ are found to have greater influence than the changes of mass flow rate in reshaping the flow field when θ>25°.Though gravity direction strongly affects the local heat transfer and flow characteristics,it's also found that the effects on the overall thermal-hydraulic performance are relatively *** the installation direction that yields a_y=g should better be avoided for the sinusoidal channel printed circuit heat exchanger.

关键词： printed circuit heat exchanger supercritical CO_(2) sinusoidal channel heat transfer recuperator

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