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Reductive acid leaching of valuable metals from spent lithium-ion batteries using hydrazine sulfate as reductant

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Transactions of Nonferrous Metals Society of China 2020年第8期30卷 2256-2264页

作者： Jian YANG Liang-xing JIANG Fang-yang LIU Ming JIA Yan-qing lai School of Metallurgy and Environment Central South UniversityChangsha 410083China

Hydrazine sulfate was used as a reducing agent for the leaching of Li,Ni,Co and Mn from spent lithium-ion *** effects of the reaction conditions on the leaching mechanism and kinetics were characterized and examined.97%of the available Li,96%of the available Ni,95%of the available Co,and 86%of the available Mn are extracted under the following optimized conditions:sulfuric acid concentration of 2.0 mol/L,hydrazine sulfate dosage of 30 g/L,solid-to-liquid ratio of 50 g/L,temperature of 80℃,and leaching time of 60 *** activation energies of the leaching are determined to be 44.32,59.37 and 55.62 k J/mol for Li,Ni and Co,*** performing X-ray diffraction and scanning electron microscopy in conjunction with energy dispersive X-ray spectroscopy,it is confirmed that the main phase in the leaching residue is *** results show that hydrazine sulfate is an effective reducing agent in the acid leaching process for spent lithium-ion batteries.

关键词： spent lithium-ion batteries reductive acid leaching hydrazine sulfate leaching mechanism kinetics

浅基础在水平荷载与力矩荷载作用下的承载能力

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水利学报 2010年第10期40卷 1201-1207页

作者：范庆来栾茂田鲁东大学岩土工程重点实验室山东烟台264025 大连理工大学海岸和近海工程国家重点实验室辽宁大连116024

联合采用swipe加载模式和固定位移比加载模式,通过数值模拟,对条形浅基础在水平与力矩荷载作用下的承载性能进行了比较系统地分析,主要探讨了埋深、地基土不排水强度的各向异性对于复合加载条件下浅基础破坏包络面的影响,揭示了地基在... 详细信息

联合采用swipe加载模式和固定位移比加载模式,通过数值模拟,对条形浅基础在水平与力矩荷载作用下的承载性能进行了比较系统地分析,主要探讨了埋深、地基土不排水强度的各向异性对于复合加载条件下浅基础破坏包络面的影响,揭示了地基在水平和力矩荷载的不同组合条件下的失稳破坏机理。计算结果表明:当浅基础埋深与宽度之比大于0.5时,基础的破坏包络面出现比较显著的倾斜,而且不满足前人建议的包络面方程;在归一化荷载平面内,埋深对于包络面的形状有较大影响,而在给定埋深情况下,其形状与地基土强度的各向异性无关。

关键词：浅基础承载力复合加载各向异性破坏包络面失稳破坏机理

Epigenetic and transcriptional landscapes during cerebral cortex development in a microcephaly mouse model

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Journal of Genetics and Genomics 2024年第4期51卷 419-432页

作者： qing Yang Qiang Cao Yue Yu Xianxin lai Jiahao Feng Xinjie Li Yinan Jiang Yazhou Sun Zhong-Wei Zhou Xin Li School of Medicine Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdong 518107China Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China Scientific Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong 518107China Guangdong Provincial Key Laboratory of Digestive Cancer Research The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong 518107China

The cerebral cortex is a pivotal structure integral to advanced brain functions within the mammalian central nervous *** methylation and hydroxymethylation play important roles in regulating cerebral cortex ***,it remains unclear whether abnormal cerebral cortex development,such as microcephaly,could rescale the epigenetic landscape,potentially contributing to dysregulated gene expression during brain *** this study,we characterize and compare the DNA methylome/hydroxymethylome and transcriptome profiles of the cerebral cortex across several developmental stages in wild-type(WT)mice and Mcph1 knockout(Mcph1-del)mice with severe ***,we discover a global reduction of 5′-hydroxymethylcytosine(5hmC)level,primarily in TET1-binding regions,in Mcph1-del mice compared to WT mice during juvenile and adult ***,genes exhibiting diminished 5hmC levels and concurrently decreased expression are essential for neurodevelopment and brain ***,genes displaying a delayed accumulation of 5hmC in Mcph1-del mice are significantly associated with the establishment and maintenance of the nervous system during the adult *** findings reveal that aberrant cerebral cortex development in the early stages profoundly alters the epigenetic regulation program,which provides unique insights into the molecular mechanisms underpinning diseases related to cerebral cortex development.

关键词： Microcephaly Epigeneticmodification Tet1 Cerebral cortexdevelopment DNA hydroxymethylome Transcriptome

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教学监控能力与医学教学质量相关性研究

中国现代医学杂志 2011年第36期21卷 4531-4533页

作者：赖青长沙卫生职业学院湖南长沙410100

目的明确教学监控力与教学质量的相关性,旨在使教育部门、教师认识教学监控能力的作用,并应用于教育教学实践。方法应用SPSS 17.0统计软件,对计量资料采用t检验,计数资料采用χ2检验,取实验组、对照组外科护理学成绩、教师评学资料作统... 详细信息

目的明确教学监控力与教学质量的相关性,旨在使教育部门、教师认识教学监控能力的作用,并应用于教育教学实践。方法应用SPSS 17.0统计软件,对计量资料采用t检验,计数资料采用χ2检验,取实验组、对照组外科护理学成绩、教师评学资料作统计学处理。结果实验组与对照组的学生学业成绩、教师评学分数的P<0.05,在统计学上有意义,教学监控能力与医学教学质量之间有显著的相关性。结论通过强化教学监控能力可以提高教学效果,提升教学质量。

关键词：教学监控医学教学质量研究

A Polyvinyl Alcohol/Acrylamide Hydrogel with Enhanced Mechanical Properties Promotes Full-Thickness Skin Defect Healing by Regulating Immunomodulation and Angiogenesis Through Paracrine Secretion

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Engineering 2024年第6期37卷 138-151页

作者： Peng Wang Liping Qian Huixin Liang Jianhao Huang Jing Jin Chunmei Xie Bin Xue Jiancheng lai Yibo Zhang Lifeng Jiang Lan Li qing Jiang State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive SurgeryDepartment of Orthopedic SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing UniversityNanjing 210008China Jiangsu Engineering Research Center for 3D Bioprinting Nanjing 210008China Institute of Medical 3D Printing Nanjing UniversityNanjing 210093China Centre for Experimental Animals Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing UniversityNanjing 210008China College of Aeroplane Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China National Laboratory of Solid State Microstructures Department of PhysicsNanjing UniversityNanjing 210093China Department of Chemical Engineering Stanford UniversityStanfordCA 94305USA Department of Orthopedic Surgery The Second Affiliated Hospital Zhejiang University School of MedicineOrthopedic Research Institute of Zhejiang UniversityKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang ProvinceHangzhou 310009China

Hydrogel-based tissue-engineered skin has attracted increased attention due to its potential to restore the structural integrity and functionality of ***,the mechanical properties of hydrogel scaffolds and natural skin are substantially ***,we developed a polyvinyl alcohol(PVA)/acrylamide based interpenetrating network(IPN)hydrogel that was surface modified with polydopamine(PDA)and termed *** Dopa-gel exhibited mechanical properties similar to native skin tissue and a superior ability to modulate paracrine ***,a tough scaffold with tensile resistance was fabricated using this hydrogel by three-dimensional *** results showed that the interpenetration of PVA,alginate,and polyacrylamide networks notably enhanced the mechanical properties of the *** modification with PDA endowed the hydrogels with increased secretion of immunomodulatory and proangiogenic *** an in vivo model,Dopa-gel treatment accelerated wound closure,increased vascularization,and promoted a shift in macrophages from a proinflammatory M1 phenotype to a prohealing and anti-inflammatory M2 phenotype within the wound ***,the focal adhesion kinase(FAK)/extracellular signal-related kinase(ERK)signaling pathway may mediate the promotion of skin defect healing by increasing paracrine secretion via the ***,proangiogenic factors can be induced through Rho-associated kinase-2(ROCK-2)/vascular endothelial growth factor(VEGF)-mediated paracrine secretion under tensile stress *** together,these findings suggest that the multifunctional Dopa-gel,which has good mechanical properties similar to those of native skin tissue and enhanced immunomodulatory and angiogenic properties,is a promising scaffold for skin tissue regeneration.

关键词： Polyvinyl alcohol/acrylamide hydrogel Mechanical property enhancement Paracrine effect Skin regeneration Signaling pathways

Therapeutic genome editing of an aberrant splice site inβ-thalassemia by CRISPR/Cas9 with multiple sgRNAs

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Genes & Diseases 2024年第1期11卷 15-18页

作者： Fei Yang Shuqian Xu Chao Huang Zhiqiang Shao Yuefen Hu Yang Yang Yongrong lai qing Ke Dan Liang Yuxuan Wu Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Department of Obstetrics and Gynecology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University) HefeiAnhui 230032China Department of Hematology Qilu HospitalCheeloo College of MedicineShandong UniversityJinanShandong 250012China BRLMedicine Inc. Shanghai 201108China Department of Hematology The First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530000China Department of Neurology The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China

Genetic mutations cause aberrant splicing,one of the important molecular mechanisms in human ***2-654,a mutation causing aberrant splicing ofβ-globin premRNA and contributing toβ-globin deficiency,is one of the most common diseases in Southeast Asia and China."In our previous work,we found a TTTV protospacer adjacent motif(PAM)by the Cas12a system and the editing efficiency of Ivs2-654 C>T achieving 76.7%.

关键词： CRISPR/Cas9 China thalassemia

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弱视发病的神经突触机制的研究进展

中华眼科杂志 2008年第11期44卷 1045-1049页

作者：解来青赵堪兴天津医科大学眼科临床学院天津市眼科医院天津市眼科研究所 300020

视觉经验对视觉神经系统的发育和成熟发挥着重要作用。Hebb突触可塑性机制是视觉经验依赖的视觉神经环路重塑过程中的重要神经机制。近年来双光子成像（two—photon imaging）技术的应用使人们可以从形态学方面观察到弱视发生过程中突... 详细信息

视觉经验对视觉神经系统的发育和成熟发挥着重要作用。Hebb突触可塑性机制是视觉经验依赖的视觉神经环路重塑过程中的重要神经机制。近年来双光子成像（two—photon imaging）技术的应用使人们可以从形态学方面观察到弱视发生过程中突触细微结构的改变，从而实现对突触由功能到结构重塑过程的全面认识。外界视觉刺激的时空模式如何决定眼优势转移（OD shifts）的方向，其内在神经机制是什么？眼优势转移如何实现从功能到结构的转变？成年动物是否存在一定的眼优势可塑性，其机制与幼年动物有何不同？本文综述了由神经环路功能重塑性改变到解剖结构性改变的弱视发病过程。

关键词：弱视突触优势,眼神经元可塑性树突棘

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建议一种新的主观主义价值论

人文杂志 2005年第6期 21-26页

作者：盛庆(王来) 台湾淡江大学

在价值论中,至少有下列四种理论:(1)价值是主观的;(2)价值是客观的;(3)价值是非主观的,又非客观的,而是关系的;(4)价值既是主观的,又是客观的。本文认为,这四种学说,都不够周延,所以提出一种新的主观主义价值论,即认为价值是主观的,因... 详细信息

在价值论中,至少有下列四种理论:(1)价值是主观的;(2)价值是客观的;(3)价值是非主观的,又非客观的,而是关系的;(4)价值既是主观的,又是客观的。本文认为,这四种学说,都不够周延,所以提出一种新的主观主义价值论,即认为价值是主观的,因为价值必须有一个主体,但我们都在追求对许多价值的共识,如果对某一价值的共识度很高,那么主观的价值看起来像是客观的,这样的价值称为“准客观”;同时认为价值具有统计性。文中论述了价值与效用、评价、幸福等名词有区别,并批评了客观主义价值论、关系价值论等非主观主义价值论。

关键词：竹值论新主观主义准客观

Room-temperature phonon-coupled single-photon emission in hexagonal boron nitride

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 109-114页

作者： Jia-Min lai qing-Hai Tan Feilong Song Haonan Chang Yanpei Lv Xue-Lu Liu Jinghua Teng Weibo Gao Ping-Heng Tan Jun Zhang State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing100083China Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education&Research Institute of Materials Science Shanxi Normal UniversityTaiyuan 030000China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)Singapore 138634Singapore

Photon-lattice(phonon)coupling is fundamental to light-matter interaction,particularly when it reaches the quantum limit of the phonon-coupled single-photon emission,which holds great potential for quantum manipulation and quantum information ***,we report single defect state-phonon coupling in hexagonal boron nitride(h BN)at room *** ultrabroad spectrum of single-photon emissions can be achieved by selecting the excitation *** photoluminescence excitation spectroscopy,we observe single-phonon-assisted resonance-enhanced single-photon emission,along with multiple phonon replicas that herald the creation of phonon Fock *** also develop a transition model to gain insight into the physical process behind the single defect state-phonon *** work sets the stage for manipulating electron-phonon coupling state with single quantum-level precision at room temperature.

关键词： temperature phonon hexagonal