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Bacterial infection triggers and complicates acute-on-chronic liver failure in patients with hepatitis B virus-decompensated cirrhosis: A retrospective cohort study

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World Journal of Gastroenterology 2020年第6期26卷 645-656页

作者： Zhu-Jun Cao Yu-han liu Chuan-Wu Zhu Shan Yin Wei-Jing Wang Wei-liang Tang gang-De zhao Yu-Min Xu Lu Chen Tian-Hui Zhou Ming-Hao Cai Hui Wang Wei Cai Shi-San Bao Hai li qing Xie Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Infectious Diseases The Affiliated Infectious Diseases Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Gastroenterology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Infectious Diseases Ruijin Hospital NorthShanghai Jiao Tong University School of MedicineShanghai 201801China Discipline of Pathology School of Medical Sciences and Bosch InstituteUniversity of SydneySydneyNSW 2006Australia

BACKGROUND Reports on bacterial infection(BI)in decompensated cirrhosis(DC)is mainly from alcoholic *** role of BI as a trigger or complication of acute-onchronic liver failure(ACLF)in patients with hepatitis B virus decompensated cirrhosis(HBV-DC)remains to be *** To investigate the impact of BI on the outcomes of the patients with HBV-DC admitted into the hospital with or without *** This retrospective study included patients with HBV-DC admitted to two tertiary centers in ***-hospital overall survival,90-d transplant-free survival,5-year post-discharge survival,and cumulative incidence of ACLF were *** factors for death were analyzed considering liver transplantation as a competing *** A total of 1281 hospitalized HBV-DC patients were included;284 had ACLF at *** overall prevalence of BI was 28.1%.The patients with BI had a significantly lower in-hospital survival and transplant-free 90-d survival than those without,in both the patients admitted with and without *** presence of BI significantly increased the risk of developing ACLF[subdistribution hazard ratio(sHR)=2.52,95%CI:1.75-3.61,Plive,those who had an episode of BI had a significantly lower 5-year transplant-free *** was an independent risk factor for death in the patients admitted without ACLF(sHR=3.28,95%CI:1.93-5.57),while in ACLF admissions,the presence of pneumonia,but not other type of BI,independently increased the risk of death(sHR=1.87,95%CI:1.24-2.82).CONCLUSION BI triggers ACLF in patients with HBV-DC and significantly impairs short-term ***-DC patients should be monitored carefully for the development of BI,especially pneumonia,to avoid an adverse outcome.

关键词： Hepatitis B virus Cirrhosis Decompensation Bacterial infection Acute-onchronic liver failure Survival

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BF_3·Et_2O催化“一锅法”合成硫脲基烷基萘酚类衍生物

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化学试剂 2012年第11期34卷 1017-1019,1024页

作者：李清寒陈峰赵志刚西南民族大学化学与环境保护工程学院四川成都610041

CH2Cl2为溶剂,BF3·Et2O可有效催化2-萘酚、醛和硫脲及其衍生物三组分通过"一锅法"合成标题化合物,得到了较好的收率。考察了溶剂条件及催化剂用量对产率的影响。产物的结构通过熔点、IR、1HNMR和质谱进行测定和结构表征。同时给出了该... 详细信息

CH2Cl2为溶剂,BF3·Et2O可有效催化2-萘酚、醛和硫脲及其衍生物三组分通过"一锅法"合成标题化合物,得到了较好的收率。考察了溶剂条件及催化剂用量对产率的影响。产物的结构通过熔点、IR、1HNMR和质谱进行测定和结构表征。同时给出了该反应可能的反应机理。

关键词：多组分反应一步缩合硫脲基烷基萘酚 BF3·Et2O

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Real world effectiveness of PCSK-9 inhibitors combined with statins versus statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease in China(RWE-PCSK study)

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Journal of Geriatric Cardiology 2021年第4期18卷 261-270页

作者： Yu-Qi liU Dan-Dan li Meng CHAI Hong-liang CONG Xiao-Qiang CONG Jun DAI Rong-Pin DU Ming GAO Jin-Cheng GUO Yan-qing GUO Xiao-Jian HONG Rong-Chong HUANG Feng-Shun JIA Jia-Yu li qing li Jia-Mei liU Xin-Ping liU Yu-Guo liU Hong-gang NIE Bing SHAO Xiao-Yu SHEN Hai-qing SONG Yi-Jun SONG li-Jun WANG Shuo WANG Dong-Mei WU Jing XIA zhi-Yong YANG Hong-Ying YU Hui ZhanG Tie-Mei ZhanG Ji-Yi zhao liang-Chen zhao Ming-Qi ZHENG Yun-Dai CHEN Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic DiseaseClinical Center for Coronary Heart DiseaseCapital Medical UniversityBeijingChina Department of Cardiology Tianjin Chest HospitalTianjinChina Department of Cardiology the First Hospital of Jilin UniversityChangchunChina Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Hebei People’s HospitalShijiazhuangChina Department of Cardiology Kailuan General HospitalHebei Union UniversityTangshanChina Department of Cardiology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Cardiology Shanxi Cardiovascular HospitalTaiyuanChina Department of Cardiology the Fourth Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Cardiology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Cardiology Tangshan Worker’s HospitalTangshanChina Department of Cardiology China-Japan Friendship Hospital Affiliated Jilin UniversityChangchunChina Department of Cardiology Handan Central HospitalHebeiChina Heart Center Beijing Key Laboratory of HypertensionBeijing Chao-Yang HospitalCapital Medical UniversityBeijingChina Department of Cardiology the First Affiliated Hospital of Dalian Medical UniversityLiaoningChina Department of Cardiology the Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Cardiology the Second Affiliated Hospital of Shenyang Medical CollegeShenyangChina Department of Cardiology the Second Hospital of Shanxi Medical UniversityTaiyuanChina Department of Neurology Xuanwu Hospital Capital Medical UniversityBeijingChina Department of Neurology Tianjin Medical University Gen

BACKGROUND The efficacy and safety of proprotein convertase subtilisin/kexin type 9(PCSK-9) inhibitors were confirmed by several clinical trials, but its effectiveness in routine clinical practice in China has not been evaluated. This study aims to describe the real world effectiveness of PCSK-9 inhibitors combined with statins compared with statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease(ASCVD).METHODS This is a multi-center observational study, enrolled patients from 32 hospitals who underwent percutaneous coronary intervention(PCI) from January to June in 2019. There are 453 patients treated with PCSK-9 inhibitors combined with statins in PCSK-9 inhibitor group and 2,610 patients treated with statins-based lipid lowering therapies in statins-based group. The lipid control rate and incidence of major adverse cardiovascular events(MACE) over six months were compared between two groups.A propensity score-matched(PSM) analysis was used to balance two groups on confounding factors. Survival analysis using Kaplan-Meier methods was applied for *** In a total of 3,063 patients, 89.91% of patients had received moderate or high-intensity statins-based therapy before PCI, but only 9.47% of patients had low-density lipoprotein cholesterol(LDL-C) levels below 1.4 mmol/L at baseline. In the PSM selected patients, LDL-C level was reduced by 42.57% in PCSK-9 inhibitor group and 30.81%(P < 0.001) in statins-based group after six months. The proportion of LDL-C ≤ 1.0 mmol/L increased from 5.29% to 29.26% in PCSK-9 inhibitor group and 0.23% to 6.11% in statins-based group, and the proportion of LDL-C ≤ 1.4 mmol/L increased from 10.36% to 47.69% in PCSK-9 inhibitor group and 2.99% to 18.43% in statins-based group(P < 0.001 for both). There was no significant difference between PCSK-9 inhibitor and statins-based treatment in reducing the risk of MACE(hazard ratio = 2.52, 95% CI: 0.49-12.97, P = 0.250).CONCLUSIONS In the real

关键词： LDL RWE-PCSK study Real world effectiveness of PCSK-9 inhibitors combined with statins versus statins-based therapy among patients with very high r

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Effect of Dietary Alanyl-glutamine Supplementation on Growth Performance, Development of Intestinal Tract, Antioxidant Status and Plasma Non-specific Immunity of Young Mirror Carp(Cyprinus carpio L.)

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Journal of Northeast Agricultural University(English Edition) 2014年第4期21卷 37-46页

作者： Xu Hong Zhu qing Wang Chang-an zhao zhi-gang Luo ling Wang lian-sheng li Jin-nan Xu Qi-you Heilongjiang River Fisheries Research Institute of Chinese Academy of Fishery Sciences

Exogenous alanyl-glutamine（Aln-Gln） was evaluated for its effects on growth performance, intestinal structure and function, antioxidant status and non-specific immunity of young carp（Cyprinus carpio L.）. Six diets supplemented with 0, 2.5, 5.0, 7.5, 10.0, or 15.0 g · kg-1 of Aln-Gln were fed to fish for 12 weeks. Supplementation with 7.5, 10.0, or 15.0 g · kg-1 of Aln-Gln significantly increased weight gain rate（WGR）, protein efficiency ratio（PER）, but feed conservation rate（FCR） and survival were not affected（P〉0.05）. The intestinal fold height and number, digestive enzyme, Na＋, K＋-ATPase activities was found to be significantly high（P〈0.05） with increasing dietary Aln-Gln supplementation up to 7.5 g · kg-1, but there were no significant differences for Aln-Gln supplementation from 7.5 to 15.0 g · kg-1. The glutathione peroxidase（GPX） activity, glutathione（GSH）, superoxide dismutase（SOD） activity increased and malondialdehyde（MDA） levels decreased significantly（P〈0.05） in the intestine, hepatopancreas, plasma and muscles. The plasma complement-3（C3） and complement-4（C4） levels were significantly（P〈0.05） improved at 5.0 g · kg-1 level and decreased when over 7.5 g · kg-1. The plasma lysozyme（LSZ） activity increased significantly（P〈0.05） at 7.5, 10.0, or 15.0 g · kg-1 level. In summary, the results showed that Aln-Gln improved growth performance, development and function of the intestine, the activity of the antioxidant defense system and the plasma non-specific immunity of the carps. The optimal Aln-Gln level was 8.24 g · kg-1 diet for WGR based on broken-line regression model analysis.

关键词： alanyl-glutamine carp growth intestine antioxidation properties non-specific immunity

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Armarium facilitating angina management post myocardial infarction concomitant with coronavirus disease 2019

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Journal of Geriatric Cardiology 2020年第4期17卷 217-220页

作者： Xiao-qing CAI Pi-Qi JIAO Tao WU Fu-Ming CHEN Bao-Shi han Jiu-Cong ZhanG Yong-Jiu XIAO zhi-Feng CHEN Jun li Yu-Ying zhao ling MA Yan liU Ya-Jun SHI Pei-Jun DAI Yun-Dai CHEN Department of Cardiology the 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouChina Department of Cardiology the First Medical Center of Chinese PLA General HospitalBeijingChina Department of Cardiology the 980th Hospital of Joint Logistics Support Force of Chinese PLAShijiazhuangChina Department of Infectious Diseases Huoshenshan HospitalWuhanChina

The outbreak and spread of coronavirus disease 2019(COVID-19)are not only a disaster of people’s life and health over the world,[1–3]but also the challenge for medical practitioner in clinical *** to many diagnostic instruments are not suitable or convenient to use any more in contagious ward considering the risk of cross infections,such as traditional stethoscope or electrocardiogram(ECG).In this scenarios,wireless and digital equipment are optimal choices for epidemic management in order to exert rapid diagnosis and disease ***,we reported a case of the patient suffering both COVID-19 and myocardial infarction,for which the tele-ECG and wireless stethoscope facilitated the accurate diagnosis and instant management.

关键词： Acute myocardial infarction Angina Coronavirus disease 2019 Electrocardiogram Stethoscope

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口腔黏膜黑色素瘤冷冻消融治疗专家共识

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实用口腔医学杂志 2024年第2期40卷 149-155页

作者：任国欣孙沫逸唐瞻贵李龙江孟箭孙志军刘绍严何悦尚伟李刚张杰武和明李一黄绍辉张世周龚忠诚王军王安训李志勇黄志权苏彤李吉辰杨凯李伟忠谢卫红席庆赵科玄云泽黄立孙传政韩冰陈彦平陈文革吴云腾魏东亮郭伟上海交通大学医学院附属第九人民医院 200011 口颌系统重建与再生全国重点实验室国家口腔疾病临床医学研究中心陕西省口腔疾病临床医学研究中心空军军医大学第三附属医院口腔颌面头颈肿瘤科中南大学湘雅口腔医院四川大学华西口腔医院徐州市中心医院武汉大学口腔医院中国医学科学院肿瘤医院青岛大学附属医院西安交通大学口腔医院北京大学口腔医院南京医科大学附属口腔医院中国医科大学附属口腔医院山东第一医科大学附属省立医院新疆医科大学第一附属医院甘肃省肿瘤医院中山大学附属第一医院浙江大学医学院附属口腔医院中山大学孙逸仙纪念医院中南大学湘雅医院哈尔滨医科大学附属第一医院重庆医科大学附属第一医院南方医科大学南方医院郑州大学第一附属医院解放军总医院贵州省人民医院延边大学附属医院福州医科大学附属第一医院云南省肿瘤医院吉林大学附属口腔医院河北医科大学第四医院山西省人民医院

冷冻消融治疗有着悠久的历史,其抗肿瘤机制、组织病理变化已较明确,且大量临床实践表明冷冻消融治疗安全有效,理论上是一种理想的肿瘤治疗手段。以往一直受冷媒和冷冻设备的限制,制约了其疗效和临床应用。随着以氩氦刀为代表的新一代冷... 详细信息

冷冻消融治疗有着悠久的历史,其抗肿瘤机制、组织病理变化已较明确,且大量临床实践表明冷冻消融治疗安全有效,理论上是一种理想的肿瘤治疗手段。以往一直受冷媒和冷冻设备的限制,制约了其疗效和临床应用。随着以氩氦刀为代表的新一代冷冻消融设备的出现,在制冷效率、消融范围、精准测温等方面取得了长足的进步,极大地推动了肿瘤冷冻消融技术的推广。该共识系统性地总结了冷冻消融技术的机制、口腔黏膜黑色素瘤冷冻治疗的适应证、临床治疗流程、不良反应及处理、冷冻联合治疗等,旨在为口腔黏膜黑色素瘤冷冻消融治疗的规范化开展提供参考。

关键词：口腔黏膜黑色素瘤冷冻消融治疗专家共识

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Neurological Abnormality Could be the First and Only Symptom of Familial Hemophagocytic Lymphohistiocytosis: Report of Two Families

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Chinese Medical Journal 2018年第24期131卷 3004-3006页

作者： Yun-Ze zhao Hua Cheng Chang-Hong Ding Hong-Hao Ma Tong-li han Jiu-Wei li Dong Wang zhi-gang li Tian-You Wang Rui Zhang Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics (Capital Medical University)Key Laboratory of Major Diseases in ChildrenMinistry of EducationHematology Oncology CenterBeijing Children's HospitalCapital Medical UniversityNational Center for Children's Health Beijing 100045China Department of Radiology Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Neurology Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China

To the Editor:Hemophagocytic lymphohistiocytosis (HLH)is a life-threatening disease which impacts many parts of the body including the digestive,circulatory,and respiratory *** central nervous system (CNS)can also be affected,particularly in patients with familial HLH-2 (FHL-2),responsible for approximately 20% of all ***-2 is a result of mutations to the perforin 1 (PRF1)gene,which can occur at numerous sites on the gene.

关键词： Neurological Abnormality Symptom of Familial Hemophagocytic Lymphohistiocytosis

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Analysis of Chinese Medical Syndrome Features of Ischemic Stroke Based on Similarity of Symptoms Subgroup

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Chinese Journal of Integrative Medicine 2023年第5期29卷 441-447页

作者： liU Xiao-qing ZhanG Run-shun ZHOU Xue-zhong ZHOU Hong HE Yu-yao han Shu ZhanG Jing SHU Zi-xin ZhanG Xue-bin JI Jing-hui ZHONG Quan ZhanG li-li MOU Zi-jun HE li-yun ZhanG Lun-zhong YANG Jie HU Yan-jie CHEN Zheng-guang li Xiao-zhen TAN Yan YAN Zhan-feng CAO Ke-gang MENG Wei zhao He ZhanG Wei ZHONG li-qun Department of Neurology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing(100700)China Department of Gastroenterology Guanganmen HospitalChina Academy of Chinese Medical SciencesBeijing(100053)China School of Computer and Information Technology and Beijing Key Lab of Traffic Data Analysis and Mining Beijing Jiaotong UniversityBeijing(100044)China Department of Neurology Weifang Hospital of Traditional Chinese MedicineWeifangShandong Province(261041)China Beijing Zhong Teng Bai Mai Medical Technology Co.Ltd. Beijing(100027)China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing(100700)China Department of Radiology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing(100700)China School of life Sciences Beijing University of Chinese MedicineBeijing(100029)China Department of Otolaryngology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing(100029)China Department of Psychiatry Massachusetts General HospitalHarvard Medical SchoolBoston(MA 02115)United States

Objective: To derive the Chinese medicine(CM) syndrome classification and subgroup syndrome characteristics of ischemic stroke patients. Methods: By extracting the CM clinical electronic medical records(EMRs) of 7,170 hospitalized patients with ischemic stroke from 2016 to 2018 at Weifang Hospital of Traditional Chinese Medicine, Shandong Province, China, a patient similarity network(PSN) was constructed based on the symptomatic phenotype of the patients. Thereafter the efficient community detection method BGLL was used to identify subgroups of patients. Finally, subgroups with a large number of cases were selected to analyze the specific manifestations of clinical symptoms and CM syndromes in each subgroup. Results: Seven main subgroups of patients with specific symptom characteristics were identified, including M3, M2, M1, M5, M0, M29and M4. M3 and M0 subgroups had prominent posterior circulatory symptoms, while M3 was associated with autonomic disorders, and M4 manifested as anxiety;M2 and M4 had motor and motor coordination disorders;M1 had sensory disorders;M5 had more obvious lung infections;M29 had a disorder of consciousness. The specificity of CM syndromes of each subgroup was as follows. M3, M2, M1, M0, M29 and M4 all had the same syndrome as wind phlegm pattern;M3 and M0 both showed hyperactivity of Gan(liver) yang pattern;M2 and M29 had similar syndromes, which corresponded to intertwined phlegm and blood stasis pattern and phlegm-stasis obstructing meridians pattern, respectively. The manifestations of CM syndromes often appeared in a combination of 2 or more syndrome elements. The most common combination of these 7 subgroups was wind-phlegm. The 7 subgroups of CM syndrome elements were specifically manifested as pathogenic wind, pathogenic phlegm,and deficiency pathogens. Conclusions: There were 7 main symptom similarity-based subgroups in ischemic stroke patients, and their specific characteristics were obvious. The main syndromes were wind phlegm pat

关键词： ischemic stroke patient similarity network subgroup syndrome Chinese medicine

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2,4-双[3-芳基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑-6-基]吡啶类衍生物的微波合成与结构表征

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有机化学 2010年第5期30卷 764-767页

作者：王晓庆赵志刚李伟杰刘兴利韩涛西南民族大学化学与环境保护工程学院成都610041

在微波辐射下,经三氯氧磷催化作用,1,2,4-三唑与2,4-吡啶二甲酸反应,高产率合成了10个未见文献报道的含双枝三唑并噻二唑稠环的吡啶类衍生物,以期为新药筛选提供先导化合物.所有化合物的结构均经1HNMR,IR,MS和元素分析进行了表征.

关键词：三唑双三唑并[3,4—6]噻二唑微波合成

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SAPT:a synchrotron-based proton therapy facility in Shanghai

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Nuclear Science and Techniques 2023年第10期34卷 36-46页

作者： Man-Zhou Zhang De-Ming li li-Ren Shen Hai-Rong Zhang zhi-ling Chen han-Wen Du Ming Gu Rui li De-Kang liu Yue-Hu Pu Jun-Feng Yu Jian-Feng Chen Chu Chen Chun-Long Guo Hao Guo Ge-Yang Jiang zhi-Qiang Jiang lin Jin Wen-Jing li Xiu-Fang li Ye lin Ming liu Yong-Hao liu Ya-Juan liu Ming Lv qing-Ru Mi lian-Hua Ouyang Wei-Guo Shi hang Shu Qi-Sheng Tang Kun Wang zhi-Shan Wang Jun Wu Xiao-Bing Wu Jia-Qiang Xu Wen-Zhen Xu Chong-Xian Yin Cheng Yu Ren-Xian Yuan Qi-Bing Yuan Hai-Qun Zhang Miao Zhang Wen-zhi Zhang li-Ying zhao Wei-Min Zhou Shou-Xian Fang Xi-Dong Sun Zhen-Tang zhao Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China APACTRON Particle Equipment Co. Ltd.Shanghai 201815China The Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in *** synchrotron,beam delivery system,and other technical systems were commissioned and reached their expected *** a clinical trial of 47 patients was finished,the proton therapy facility obtained a registration certificate from the National Medical Products *** characteristics of the accelerator and treatment systems are described in this article.

关键词： Proton therapy Synchrotron Slow extraction Gantry Beam delivery system

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