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Bone marrow mesenchymal stem cells promote uterine healing by activating the PI3K/AKT pathway and modulating inflammation in rat models

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World Journal of Stem Cells 2025年第1期17卷 22-39页

作者： Jing Yang Jun yuan Yan-qing Wen Li wu Jiu-Jiang Liao Hong-Bo Qi Women and Children’s Hospital of Chongqing Medical University Chongqing 401147China Chongqing Key Laboratory of Maternal and Fetal Medicine Chongqing Medical UniversityChongqing 400016China Obstetrics and Gynecology Guizhou Provincial People’s HospitalGuiyang 557300Guizhou ProvinceChina Research Laboratory of Reproduction and Development of Chinese Ministry of Education Chongqing Medical UniversityChongqing 400016China

BACKGROUND Uterine injury can cause uterine scarring,leading to a series of complications that threaten women’s *** healing is a complex process,and there are currently no effective *** our previous studies have shown that bone marrow mesenchymal stem cells(BMSCs)promote uterine damage repair,the underlying mechanisms remain ***,exploring the specific regulatory roles of BMSCs in uterine injury treatment is crucial for further understanding their functions and enhancing therapeutic *** To investigate the underlying mechanism by which BMSCs promote the process of uterine *** In in vivo experiments,we established a model of full-thickness uterine injury and injected BMSCs into the uterine *** sequencing was per-formed to determine the enrichment of differentially expressed genes at the wound *** in vitro experiments,we isolated rat uterine smooth muscle cells(USMCs)and cocultured them with BMSCs to observe the interaction between BMSCs and USMCs in the *** We found that the differentially expressed genes were mainly related to cell growth,tissue repair,and angiogenesis,while the phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)pathway was highly *** reverse-transcription polymerase chain reaction was used to validate differentially expressed genes,and the results demonstrated that BMSCs can upregulate genes related to regeneration and downregulate genes related to *** BMSCs promoted the migration and proliferation of USMCs,and the USMC microenvironment promoted the myogenic differentiation of ***,we validated the PI3K/AKT pathway in tissues and cells and showed that BMSCs activate the PI3K/AKT pathway to promote the regeneration of uterine smooth muscle both in vivo and in *** BMSCs upregulated uterine wound regeneration and anti-inflammatory factors and enhanced uterine smooth muscle proliferation throu

关键词： Uterine injury Bone marrow mesenchymal stem cells Uterine smooth muscle cells Phosphoinositide 3-kinase/protein kinase B pathway Cell-cell interactions Cell proliferation Immune regulation Wound regeneration

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Conversion-type cathode materials for high energy density solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 409-425页

作者： Yuhao Ma Shihong qing Hongyu Liu Chuntao Ma yuan Yu Chuang Yu Liping Wang School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina Zhejiang Provincial Key Laboratory of Fiber Materials and Manufacturing Technology Zhejiang Sci-Tech UniversityHangzhou 310018ZhejiangChina State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiChina

Solid-state lithium batteries(SSLBs)are regarded as an essential growth path in energy storage systems due to their excellent safety and high energy *** particular,SSLBs using conversion-type cathode materials have received widespread attention because of their high theoretical energy densities,low cost,and *** the great progress in research and development of SSLBs based on conversiontype cathodes,their practical applications still face challenges such as blocked ionic-electronic migration pathways,huge volume change,interfacial incompatibility,and expensive processing *** review focuses on the advantages and critical issues of coupling conversion-type cathodes with solid-state electrolytes(SSEs),as well as state-of-the-art progress in various promising cathodes(e.g.,FeS_(2),CuS,FeF_(3),FeF_(2),and S)in ***,representative research on conversion-type solid-state full cells is discussed to offer enlightenment for their practical ***,the energy density exhibited by the S cathode stands out impressively,while sulfide SSEs and halide SSEs have demonstrated immense potential for coupling with conversion-type ***,perspectives on conversion-type cathodes are provided at the material,interface,composite electrode,and battery levels,with a view to accelerating the development of conversion-type cathodes for high-energy–density SSLBs.

关键词： Conversion-type cathode Lithium-free cathode Solid-state electrolyte Solid-state lithium battery High energy density

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N^(6)-methyladenosine on the natural antisense transcript of NIA1 stabilizes its mRNA to boost NO biosynthesis and modulate stomatal movement

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Molecular Plant 2025年第1期18卷 151-165页

作者： Jie Li Wen Tian Ting Chen qing-Yan Liu Hua-Wei wu Chuan-Hui Liu yuan-yuan Fang Hui-Shan Guo Jian-Hua Zhao State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of SciencesBeijingChina CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijingChina

Nitric oxide(NO)is a crucial signaling molecule that regulates a wide range of metabolic pathways in different strata of *** plants,nitrate reductase(NR)is a key enzyme for NO *** are two NR-encoding genes in Arabidopsis genome,NIA1 and NIA2,which are precisely regulated and expressed in a tissue-specific *** this study,we found that the natural antisense transcript as-NIA1,transcribed from the 30 UTR of NIA1,stabilizes NIA1 mRNA to maintain its circadian oscillation in plants grown under the light/dark ***,as-NIA1-dependent NIA1 mRNA stability is indispensable for NIA1-mediated NO biosynthesis in guard cells and natural stomatal ***,we revealed that polypyrimidine tract-binding 3(PTB3)regulates the stabilization of NIA1 mRNA by directly binding to UC-rich elements of *** further found that MTA deposits N^(6)-methyladenosine(m6 A)on as-NIA1,facilitating the as-NIA1-PTB3 interaction in vivo,in agreement with RNA structure prediction in that m6 Amediated structural alterations expose the UC-rich elements to enhance the accessibility of *** together,these findings reveal a novel molecular mechanism by which plants precisely manipulate NO biosynthesis to modulate light/dark-regulated stomatal movement,highlighting the coupling of RNA epigenetic modifications and structures shaping RNA-protein interactions in the regulation of hormone biosynthesis.

关键词： natural antisense transcript,NO biosynthesis,N^(6)-methyladenosine,NIA1,stomatal movement

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Photolithographic Microfabrication of Microbatteries for On-Chip Energy Storage

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Nano-Micro Letters 2025年第5期17卷 117-144页

作者： yuan Ma Sen Wang Zhong-Shuai wu State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023People’s Republic of China School of Transportation Engineering Dalian Jiaotong UniversityDalian 116028People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Dalian National Laboratory for Clean Energy Chinese Academy of SciencesDalian 116023People’s Republic of China

Microbatteries(MBs)are crucial to power miniaturized devices for the Internet of *** the evolutionary journey of MBs,fabrication technology emerges as the cornerstone,guiding the intricacies of their configuration designs,ensuring precision,and facilitating scalability for mass *** stands out as an ideal technology,leveraging its unparalleled resolution,exceptional design flexibility,and entrenched position within the mature semiconductor ***,comprehensive reviews on its application in MB development remain *** review aims to bridge that gap by thoroughly assessing the recent status and promising prospects of photolithographic microfabrication for ***,we delve into the fundamental principles and step-by-step procedures of photolithography,offering a nuanced understanding of its operational mechanisms and the criteria for photoresist ***,we highlighted the specific roles of photolithography in the fabrication of MBs,including its utilization as a template for creating miniaturized micropatterns,a protective layer during the etching process,a mold for soft lithography,a constituent of MB active component,and a sacrificial layer in the construction of micro-Swiss-roll ***,the review concludes with a summary of the key challenges and future perspectives of MBs fabricated by photolithography,providing comprehensive insights and sparking research inspiration in this field.

关键词： Microbatteries Photolithography Internet of Things Micropatterns On-chip energy storage

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A high maneuvering motion strategy and stable control method for tandem twin-rotor aerial-aquatic vehicles near the water surface

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Defence Technology(防务技术) 2025年第2期44卷 206-220页

作者： Sifan wu Maosen Shao Sihuan wu Zhilin He Hui Wang Jinxiu Zhang yuan Liu School of Aeronautics and Astronautics Sun Yat-sen UniversityShenzhen518107China Southern Marine Science and Engineering Guangdong Laboratory Zhuhai519000China

The maneuverability and stealth of aerial-aquatic vehicles(AAVs)is of significant importance for future integrated air-sea combat *** improve the maneuverability and stealth of AAVs near the water surface,this paper proposed a high-maneuverability skipping motion strategy for the tandem twin-rotor AAV,inspired by the motion behavior of the flying fish to avoid aquatic and aerial predators near the water *** novel tandem twin-rotor AAV was employed as the research subject and a strategybased ADRC control method for validation,comparing it with a strategy-based PID control *** results indicate that both control methods enable the designed AAV to achieve high stealth and maneuverability near the water surface with robust control *** strategy-based ADRC control method exhibits a certain advantage in controlling height,pitch angle,and reducing impact *** motion strategy will offer an inspiring approach for the practical application of AAVs to some extent.

关键词： Tandem twin-rotor Aerial-aquatic vehicle High maneuvering motion strategy Active disturbance rejection controller Skipping on water surface

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Advances in enhancing hydrodeoxygenation selectivity of lignin-derived oxygenates:From synthetic strategies to fundamental techniques

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Green Energy & Environment 2025年第2期10卷 292-321页

作者： Xinru wu Hongwei Zhang Cejun Hu Xiaojun Bao Pei yuan National Engineering Research Center of Chemical Fertilizer Catalyst College of Chemical EngineeringFuzhou UniversityFuzhou350002China College of Materials Science and Engineering Fuzhou UniversityFuzhou350108China qingyuan Innovation Laboratory Quanzhou362801China

In recent years,studies focusing on the conversion of renewable lignin-derived oxygenates(LDOs)have emphasized their potential as alternatives to fossil-based ***,LDOs,existing as complex aromatic mixtures with diverse oxygen-containing functional groups,pose a challenge as they cannot be easily separated via distillation for direct utilization.A promising solution to this challenge lies in the efficient removal of oxygen-containing functional groups from LDOs through hydrodeoxygenation(HDO),aiming to yield biomass products with singular ***,the high dissociation energy of the carbon-oxygen bond,coupled with its similarity to the hydrogenation energy of the benzene ring,creates a competition between deoxygenation and benzene ring *** hydrogen consumption and lignin properties,the preference is directed towards generating aromatic hydrocarbons rather than saturated ***,the goal is to selectively remove oxygen-containing functional groups while preserving the benzene ring *** on LDOs conversion have indicated that the design of active components and optimization of reaction conditions play pivotal roles in achieving selective deoxygenation,but a summary of the correlation between these factors and the reaction mechanism is *** review addresses this gap in knowledge by firstly summarizing the various reaction pathways for HDO of *** explores the impact of catalyst design strategies,including morphology modulation,elemental doping,and surface modification,on the adsorption-desorption dynamics between reactants and ***,we delve into the application of advanced techniques such as spectroscopic techniques and computational modeling,aiding in uncovering the true active sites in HDO reactions and understanding the interaction of reactive reactants with catalyst ***,fundamental insights into selective deoxygenation obtained through these techniqu

关键词： Hydrodeoxygenation Lignin-derived oxygenates Targeted deoxidation Catalyst design Techniques and theoretical calculation

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Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-qing Qiao Guo Hui Bojing Sun Dongfang Hou Meidi Wang Xueqian wu Tao wu Dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002HubeiChina Hubei Three Gorges Laboratory Yichang 443007HubeiChina College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination ChemistryJinan UniversityGuangzhou 510632GuangdongChina

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo_(2)C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS (c-CdS) and hexagonal-CdS (h-CdS) leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo_(2)C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H_(2)production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions Mo_(2)C LSPR Photocatalyst Phase junction Schottkyjunction Photothermal effect

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Graphene/F_(16)CuPc synaptic transistor for the emulation of multiplexed neurotransmission

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Journal of Semiconductors 2025年第1期46卷 215-223页

作者： Zhipeng Xu Yao Ni Mingxin Sun Yiming yuan Ning wu Wentao Xu Institute of Photoelectronic Thin Film Devices and Technology Key Laboratory of Photoelectronic Thin Film Devices and Technology of TianjinCollege of Electronic Information and Optical EngineeringEngineering Research Center of Thin Film Photoelectronic Technology of Ministry of EducationNankai UniversityTianjin 300350China Shenzhen Research Institute of Nankai University Shenzhen 518000China Smart Sensing Interdisciplinary Science Center Nankai UniversityTianjin 300350China School of Integrated Circuits Guangdong University of TechnologyGuangzhou 510006China

We demonstrate a bipolar graphene/F_(16)CuPc synaptic transistor(GFST)with matched p-type and n-type bipolar properties,which emulates multiplexed neurotransmission of the release of two excitatory neurotransmitters in graphene and F_(16)CuPc channels,*** process facilitates fast-switching plasticity by altering charge carriers in the separated *** complementary neural network for image recognition of Fashion-MNIST dataset was constructed using the matched relative amplitude and plasticity properties of the GFST dominated by holes or electrons to improve the weight regulation and recognition accuracy,achieving a pattern recognition accuracy of 83.23%.These results provide new insights to the construction of future neuromorphic systems.

关键词： synaptic transistor dual excitatory channels fast-switching plasticity multiplexed neurotransmission

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A Novel Vibration-Based Self-Adapting Method to Acquire Real-Time Following Distance for Virtually Coupled Trains

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IEEE/CAA Journal of Automatica Sinica 2025年第1期12卷 27-39页

作者： qinglai Zhang Jianmin Gao qing wu qinglie He Libin Tie Wanming Zhai Shengyang Zhu State Key Laboratory of Rail Transit Vehicle System Southwest Jiaotong University IEEE Centre for Railway Engineering Central Queensland University National Energy Railway Equipment Co. LTDNational Energy Group

Virtual coupling(VC) is an emerging technology for addressing the shortage of rail transportation capacity. As a crucial enabling technology, the VC-specific acquisition of train information, especially train following distance(TFD), is *** this paper, a novel method is proposed to acquire real-time TFD by analyzing the vibration response of the front and following trains, during which only onboard accelerometers and speedometers are required. In contrast to the traditional arts of train positioning, this method targets a relative position between two adjacent trains in VC operation, rather than the global positions of the trains. For this purpose, an adaptive system containing three strategies is designed to cope with possible adverse factors in train operation. A vehicle dynamics simulation of a heavy-haul railway is implemented for the evaluation of feasibility and performance. Furthermore, a validation is conducted using a set of data measured from in-service Chinese high-speed trains. The results indicate the method achieves satisfactory estimation accuracy using both simulated and actual data. It has favorable adaptability to various uncertainties possibly encountered in train operation. Additionally, the method is preliminarily proven to adapt to different locomotive types and even different rail transportation modes. In general, such a method with good performance, low-cost, and easy implementation is promising to apply.

关键词： Adaptive system train following distance (TFD) train positioning vehicle dynamics vibration response virtual coupling (VC)

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W_(18)O_(49)Crystal and ICG Labeled Macrophage:An Efficient Targeting Vector for Fluorescence Imagingguided Photothermal Therapy

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Biomedical and Environmental Sciences 2025年第1期38卷 100-105页

作者： Yang Bai Guoqing Feng Muskan Saif khan qingbin Yang Tingting Hua Haolin Guo yuan Liu Bowen Li Yiwen wu Bin Zheng Niansong Qian qing yuan Department of Stomatology Tianjin Medical University General HospitalHeping DistrictTianjin 300052China Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102401China Tianjin Anding Hospital Tianjin 300222China Beijing National Day School Beijing 100000China Department of Respiratory the Eighth Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Urology The Third Medical CenterChinese People’s Liberation Army(PLA)General HospitalBeijing 100853China

Photothermal therapy(PTT)uses heat generated by photothermal agents to efficiently kill cancer cells in the least invasive *** nanoparticles,such as precious metals and carbon nanoparticles,have been extensively studied for their ability to convert near-infrared(NIR)light(700-900 nm)into heat[1].However,these nanoparticles are easily captured by the reticuloendothelial system,which severely limits their clinical applications[2].Despite targeted and stealth modifications,these issues remain unresolved;therefore,researchers are seeking more effective methods.

关键词： seeking thermal spite

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